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Search results 101 to 200 out of 215 for Mcm6

0.041s
Type Details Score
Publication
First Author: Lee C
Year: 2004
Journal: Nature
Title: Structural basis for inhibition of the replication licensing factor Cdt1 by geminin.
Volume: 430
Issue: 7002
Pages: 913-7
Publication
First Author: You Z
Year: 2005
Journal: Nucleic Acids Res
Title: DNA binding and helicase actions of mouse MCM4/6/7 helicase.
Volume: 33
Issue: 9
Pages: 3033-47
Publication
First Author: Swiech L
Year: 2007
Journal: Int J Dev Biol
Title: Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle.
Volume: 51
Issue: 4
Pages: 283-95
Publication
First Author: You Z
Year: 2008
Journal: J Biol Chem
Title: Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
Volume: 283
Issue: 36
Pages: 24469-77
Publication
First Author: Chuang CH
Year: 2010
Journal: PLoS Genet
Title: Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.
Volume: 6
Issue: 9
Pages: e1001110
Publication
First Author: McNairn AJ
Year: 2019
Journal: Nature
Title: Female-biased embryonic death from inflammation induced by genomic instability.
Volume: 567
Issue: 7746
Pages: 105-108
Publication
First Author: Frank CL
Year: 2010
Journal: J Biol Chem
Title: Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis.
Volume: 285
Issue: 43
Pages: 33324-37
Publication
First Author: Kuipers MA
Year: 2011
Journal: J Cell Biol
Title: Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload.
Volume: 192
Issue: 1
Pages: 29-41
Publication
First Author: Kang YH
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.
Volume: 109
Issue: 16
Pages: 6042-7
Publication
First Author: Furumura M
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Characterization of genes modulated during pheomelanogenesis using differential display.
Volume: 95
Issue: 13
Pages: 7374-8
Publication
First Author: Lee EY
Year: 2009
Journal: Dev Biol
Title: E2F4 cooperates with pRB in the development of extra-embryonic tissues.
Volume: 332
Issue: 1
Pages: 104-15
Publication
First Author: Mi D
Year: 2013
Journal: Neuron
Title: Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb.
Volume: 78
Issue: 2
Pages: 269-84
Publication
First Author: Tu HC
Year: 2015
Journal: Genes Dev
Title: LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.
Volume: 29
Issue: 10
Pages: 1074-86
Publication
First Author: Ouseph MM
Year: 2012
Journal: Dev Cell
Title: Atypical E2F repressors and activators coordinate placental development.
Volume: 22
Issue: 4
Pages: 849-62
Publication
First Author: Sutherland HG
Year: 2001
Journal: Hum Mol Genet
Title: Large-scale identification of mammalian proteins localized to nuclear sub-compartments.
Volume: 10
Issue: 18
Pages: 1995-2011
Publication      
First Author: Goodwin N
Year: 1998
Journal: MGI Direct Data Submission
Title: An embryonic stem cell bank for producing deletion complexes in mice
Publication
First Author: Poché RA
Year: 2016
Journal: Cell Rep
Title: RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina.
Volume: 14
Issue: 7
Pages: 1684-1697
Publication
First Author: Pei L
Year: 2011
Journal: Nat Med
Title: Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.
Volume: 17
Issue: 11
Pages: 1466-72
Publication
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
Publication      
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Gene
Type: gene
Organism: zebrafish
Publication
First Author: Wang Y
Year: 2022
Journal: Theranostics
Title: MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.
Volume: 12
Issue: 15
Pages: 6509-6526
UniProt Feature
Begin: 1
Description: DNA replication licensing factor MCM6
Type: chain
End: 821
Publication
First Author: Wei Z
Year: 2010
Journal: J Biol Chem
Title: Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.
Volume: 285
Issue: 17
Pages: 12469-73
Protein Domain
Type: Domain
Description: The minichromosome maintenance (Mcm) complex is the replicative helicase in eukaryotic species, that plays essential roles in the initiation and elongation phases of DNA replication. During late M and early G(1), the Mcm complex is loaded onto chromatin to form prereplicative complex in a Cdt1-dependent manner. This entry represents the C-terminal domain of human Mcm6 which is the Cdt1 binding domain (CBD). The structure of CBD exhibits a typical winged helix fold that is generally involved in protein-nucleic acid interaction. The CBD failed to interact with DNA in experiments []. The CBD-Cdt1 interaction involves the helix-turn-helix motif of CBD [].
Publication
First Author: Ishimi Y
Year: 1997
Journal: J Biol Chem
Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
Volume: 272
Issue: 39
Pages: 24508-13
Publication
First Author: Adachi Y
Year: 1997
Journal: Genes Cells
Title: A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast.
Volume: 2
Issue: 7
Pages: 467-79
Publication
First Author: Sherman DA
Year: 1998
Journal: Mol Biol Cell
Title: Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.
Volume: 9
Issue: 7
Pages: 1833-45
Publication
First Author: Pasion SG
Year: 1999
Journal: Mol Biol Cell
Title: Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
Volume: 10
Issue: 12
Pages: 4043-57
Protein
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
Publication
First Author: Forsburg SL
Year: 1997
Journal: Genetics
Title: Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.
Volume: 147
Issue: 3
Pages: 1025-41
Protein Domain
Type: Conserved_site
Description: MCM proteins are DNA-dependent ATPases required for the initiation ofeukaryotic DNA replication [, , ]. In eukaryotes there is a family of six proteins, MCM2 to MCM7. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins [].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.The "MCM motif"contains Walker-A and Walker-B type nucleotide binding motifs. The diagnostic sequence defining the MCMs is IDEFDKM. Only Mcm2 (aka Cdc19 or Nda1) has been subjected to mutational analysis in this region, and most mutations abolish its activity []. The presence of a putative ATP-binding domain implies that these proteins may be involved in an ATP-consuming step in the initiation of DNA replication in eukaryotes.The MCM proteins bind together in a large complex [].Within this complex, individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. This core complex in human MCMs has been associated with helicase activity in vitro[], leading to the suggestion that the MCM proteins are the eukaryotic replicative helicase.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].The signature pattern used in this entry represents a perfectly conserved region that is a special version of the B motif found in ATP-binding proteins.
Protein Domain
Type: Family
Description: MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [, , ]. In eukaryotes there is a family of eight proteins, MCM2 to MCM9. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins []. These proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex []in which individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. Mcm2-7 complex is the replicative helicase involved in replication initiation and elongation [], whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].
Protein
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: true
Publication
First Author: Matsuoka S
Year: 2007
Journal: Science
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Volume: 316
Issue: 5828
Pages: 1160-6
Protein
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
Publication
First Author: Nishimura K
Year: 2012
Journal: Mol Cell
Title: Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.
Volume: 47
Issue: 4
Pages: 511-22
Publication  
First Author: Griffin WC
Year: 2019
Journal: DNA Repair (Amst)
Title: The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.
Volume: 76
Pages: 1-10
Protein
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
Publication
First Author: Coxon A
Year: 1992
Journal: Nucleic Acids Res
Title: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.
Volume: 20
Issue: 21
Pages: 5571-7
Publication
First Author: Koonin EV
Year: 1993
Journal: Nucleic Acids Res
Title: A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.
Volume: 21
Issue: 11
Pages: 2541-7
Publication
First Author: Hu B
Year: 1993
Journal: Nucleic Acids Res
Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.
Volume: 21
Issue: 23
Pages: 5289-93
Publication
First Author: Tye BK
Year: 1994
Journal: Trends Cell Biol
Title: The MCM2-3-5 proteins: are they replication licensing factors?
Volume: 4
Issue: 5
Pages: 160-6
Protein
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false