Type |
Details |
Score |
Publication |
First Author: |
Ren K |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development. |
Volume: |
9 |
Issue: |
11 |
Pages: |
e112275 |
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•
•
•
•
•
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Publication |
First Author: |
Zhang M |
Year: |
2017 |
Journal: |
Genes Dev |
Title: |
Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins. |
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•
•
•
•
•
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Publication |
First Author: |
Lo JC |
Year: |
2012 |
Journal: |
PLoS Genet |
Title: |
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e1002969 |
|
•
•
•
•
•
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Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
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Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
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•
•
•
•
•
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Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
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Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
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•
•
•
•
•
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Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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•
•
•
•
•
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
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Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
•
•
•
•
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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•
•
•
•
•
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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•
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•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
•
•
•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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•
•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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|
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dorr C |
Year: |
2015 |
Journal: |
Mol Cancer Res |
Title: |
Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. |
Volume: |
13 |
Issue: |
8 |
Pages: |
1238-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ribar B |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells. |
Volume: |
27 |
Issue: |
8 |
Pages: |
3211-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pae J |
Year: |
2017 |
Journal: |
Dev Cell |
Title: |
GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK. |
Volume: |
42 |
Issue: |
2 |
Pages: |
130-142.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Canning P |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. |
Volume: |
288 |
Issue: |
11 |
Pages: |
7803-14 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhuang M |
Year: |
2009 |
Journal: |
Mol Cell |
Title: |
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. |
Volume: |
36 |
Issue: |
1 |
Pages: |
39-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwon JE |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. |
Volume: |
281 |
Issue: |
18 |
Pages: |
12664-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Geersdaele LK |
Year: |
2013 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP. |
Volume: |
69 |
Issue: |
Pt 9 |
Pages: |
1677-84 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the C-terminal BACK (BTB and C-terminal Kelch) domain of speckle-type POZ protein (SPOP, also known as HIB homologue 1 or Roadkill homologue 1). This domain contains a pair of α-helices which seem to be conserved among Cul3 adaptors [].SPOP is an adaptor protein that forms a complex with Cul3, cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, and is involved in ubiquitination of BMI1, H2AFY, and the death-associated protein 6 (DAXX) []. The C-terminal BACK domain of SPOP, may be involved in oligomer formation and in recruiting Cul3 (together with the adjacent BTB domain), whereas the N-terminal MATH domain recruits substrates [, ]. |
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•
•
•
•
•
|
Publication |
First Author: |
Hyman LE |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Binding to Elongin C inhibits degradation of interacting proteins in yeast. |
Volume: |
277 |
Issue: |
18 |
Pages: |
15586-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lejeune D |
Year: |
2009 |
Journal: |
DNA Repair (Amst) |
Title: |
Yeast Elc1 plays an important role in global genomic repair but not in transcription coupled repair. |
Volume: |
8 |
Issue: |
1 |
Pages: |
40-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2009 |
Journal: |
Mol Cell |
Title: |
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. |
Volume: |
35 |
Issue: |
6 |
Pages: |
841-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao H |
Year: |
2017 |
Journal: |
Nat Plants |
Title: |
Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility. |
Volume: |
3 |
Issue: |
11 |
Pages: |
854-858 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Elongin-C is a highly conserved protein found in a variety of multiprotein complexes in human, rat, fly, worm, and yeast cells []. Budding yeast elongin-C homologue, Elc1, forms a complex with Cul3 that is required for Pol II polyubiquitylation and degradation []. Elc1 also plays a role in global genomic repair []. In humans, elongin-C works as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL) []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a group of BTB/POZ domain-containing proteins, such as BACURD1-3 from humans. They act as the substrate-specific adapters of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of RhoA, leading to its degradation by the proteasome []. This entry also includes EAP3 from Arabidopsis. The BTB/POZ domain of EAP3 displays poor conservation of the residues required for CUL3 binding and is not likely to function as an E3 ligase adaptor []. |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Cullinan SB |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. |
Volume: |
24 |
Issue: |
19 |
Pages: |
8477-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
den Besten W |
Year: |
2012 |
Journal: |
Nat Struct Mol Biol |
Title: |
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. |
Volume: |
19 |
Issue: |
5 |
Pages: |
511-6, S1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Madison JM |
Year: |
2021 |
Journal: |
iScience |
Title: |
Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features. |
Volume: |
24 |
Issue: |
1 |
Pages: |
101935 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai C |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice. |
Volume: |
14 |
Issue: |
1 |
Pages: |
3648 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Root phototropism protein 3 (RPT3), also known as nonphototropic hypocotyl 3 (NPH3), and root phototropism 2 (RPT2) () represent the founding members of a novel plant-specific family []. Three domains define the members of this family: an N-terminal BTB (broad complex, tramtrack, bric a brac) domain (), a centrally located NPH3 domain (), and a C-terminal coiled-coil domain.NPH3 assembles with CUL3 to form a E3 complex that ubiquitinates phototropin 1 (phot1) and modulates phototropic responsiveness [, ]. NPH3 is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening or chloroplast relocation []. Coleoptile phototropism protein 1 (CPT1) is a rice orthologue of Arabidopsis NPH3 also required for phototropism []. This entry also includes DOT3 (AT5G10250) that is involved in shoot and primary root growth; DOT3 mutants produce an aberrant parallel venation pattern in juvenile leaves []. |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi A |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. |
Volume: |
24 |
Issue: |
16 |
Pages: |
7130-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto T |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. |
Volume: |
28 |
Issue: |
8 |
Pages: |
2758-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata S |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. |
Volume: |
110 |
Issue: |
19 |
Pages: |
7838-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cornelius RJ |
Year: |
2018 |
Journal: |
J Am Soc Nephrol |
Title: |
Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway. |
Volume: |
29 |
Issue: |
11 |
Pages: |
2627-2640 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Cayuqueo KI |
Year: |
2018 |
Journal: |
Kidney Int |
Title: |
A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis. |
Volume: |
94 |
Issue: |
3 |
Pages: |
514-523 |
|
•
•
•
•
•
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Publication |
First Author: |
Lin CM |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain. |
Volume: |
33 |
Issue: |
1 |
Pages: |
1051-1061 |
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Publication |
First Author: |
Plafker KS |
Year: |
2009 |
Journal: |
Biochemistry |
Title: |
The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases. |
Volume: |
48 |
Issue: |
15 |
Pages: |
3527-37 |
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Publication |
First Author: |
Frendo-Cumbo S |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation. |
Volume: |
294 |
Issue: |
44 |
Pages: |
16172-16185 |
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Publication |
First Author: |
Baird L |
Year: |
2013 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells. |
Volume: |
433 |
Issue: |
1 |
Pages: |
58-65 |
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Publication |
First Author: |
Ibeawuchi SR |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. |
Volume: |
290 |
Issue: |
31 |
Pages: |
19208-17 |
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Publication |
First Author: |
Zhao M |
Year: |
2021 |
Journal: |
Int J Biol Sci |
Title: |
Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice. |
Volume: |
17 |
Issue: |
15 |
Pages: |
4176-4191 |
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Publication |
First Author: |
Lao L |
Year: |
2022 |
Journal: |
Nucleic Acids Res |
Title: |
ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
143
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Fragment?: |
true |
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Publication |
First Author: |
Petricka JJ |
Year: |
2008 |
Journal: |
Plant J |
Title: |
Vein patterning screens and the defectively organized tributaries mutants in Arabidopsis thaliana. |
Volume: |
56 |
Issue: |
2 |
Pages: |
251-63 |
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Publication |
First Author: |
Gingerich DJ |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis. |
Volume: |
280 |
Issue: |
19 |
Pages: |
18810-21 |
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Publication |
First Author: |
Weems JC |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses. |
Volume: |
290 |
Issue: |
24 |
Pages: |
15030-41 |
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Publication |
First Author: |
Maerki S |
Year: |
2009 |
Journal: |
J Cell Biol |
Title: |
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. |
Volume: |
187 |
Issue: |
6 |
Pages: |
791-800 |
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Publication |
First Author: |
Chen Z |
Year: |
2019 |
Journal: |
Structure |
Title: |
Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase. |
Volume: |
27 |
Issue: |
9 |
Pages: |
1395-1404.e4 |
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Protein Domain |
Type: |
Family |
Description: |
The NRL (for NPH3/RPT2-Like) family is formed by signaling molecules specificto higher plants. Several regions of sequence and predicted structuralconservation define members of the NRL family, with three domains being mostnotable: an N-terminal BTB domain, a centrally located NPH3domain, and a C-terminal coiled coil domain. The function of the NPH3 domainis not yet known [, , , , , , , ].Root phototropism protein 3 (RPT3), also known as nonphototropic hypocotyl 3 (NPH3), and root phototropism 2 (RPT2) () represent the founding members of a novel plant-specific family []. Three domains define the members of this family: an N-terminal BTB (broad complex, tramtrack, bric a brac) domain (), a centrally located NPH3 domain (), and a C-terminal coiled-coil domain.NPH3 assembles with CUL3 to form a E3 complex that ubiquitinates phototropin 1 (phot1) and modulates phototropic responsiveness [, ]. NPH3 is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening or chloroplast relocation []. Coleoptile phototropism protein 1 (CPT1) is a rice orthologue of Arabidopsis NPH3 also required for phototropism []. This entry also includes DOT3 (AT5G10250) that is involved in shoot and primary root growth; DOT3 mutants produce an aberrant parallel venation pattern in juvenile leaves []. |
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Protein Domain |
Type: |
Family |
Description: |
This entry includes SKP1 and SKP1-like protein, elongin-C (also known as TCEB1). SKP1 is part of the E3 ubiquitin ligase complexes. Elongin-C has dual functions, works as a component of RNA polymerase II (Pol II) transcription elongation factor and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase []. Mammlian S-phase kinase-associated protein 1 (SKP1) is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription []. It is also part of the ubiquitin E3 ligase complex (Skp1-Pam-Fbxo45) that controls the core epithelial-to-mesenchymal transition-inducing transcription factors []. Budding yeast Skp1 is a kinetochore protein found in several complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA [], and the RAVE complex that regulates assembly of the V-ATPase []. Elongin-C is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites []. It forms a complex with SIII regulatory subunits B, which serves as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes []. Elongin-C forms a complex with Cul3 that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis []. |
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Protein Domain |
Type: |
Family |
Description: |
Kelch-like protein 17 (KLHL17, also known as actinfilin) and Kelch-like protein 20 (KLHL20, also known as KLEIP) belong to the KLHL family []. KLHL17 binds to the actin cytoskeleton and serves as a substrate-specific adapter in the Cul3-dependent ubiquitin ligase complex that targets GluR6 kainate receptor subunit for degradation []. Kainate receptors (KAR) are ionotropic receptors that respond to the neurotransmitter glutamate and have been implicated in epilepsy, stroke, Alzheimer's and neuropathic pain [].KLHL20 assembles with CUL3 and RBX1 to form a multi-subunit Cullin-RING E3 ligase []. The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ]. |
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Protein Domain |
Type: |
Family |
Description: |
Kelch-like protein 21 (KLHL21) is a substrate adaptor protein in the Cul3-KLHL21 E3 ubiquitin ligase complex. During cytokinesis, it localises to midzone microtubules in anaphase and recruits aurora B and Cul3 to this region [].The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ]. |
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Protein Domain |
Type: |
Homologous_superfamily |
Description: |
TAZ (Transcription Adaptor putative Zinc finger) domains are zinc-containing domains found in the homologous transcriptional co-activators CREB-binding protein (CBP) and the P300. CBP and P300 are histone acetyltransferases () that catalyse the reversible acetylation of all four histones in nucleosomes, acting to regulate transcription via chromatin remodelling. These large nuclear proteins interact with numerous transcription factors and viral oncoproteins, including p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1, and are involved in cell growth, differentiation and apoptosis []. Both CBP and P300 have two copies of the TAZ domain, one in the N-terminal region, the other in the C-terminal region. The TAZ1 domain of CBP and P300 forms a complex with CITED2 (CBP/P300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration []. Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators [].Proteins containing this domain also include a group of land-plant specific proteins, know as the BTB/POZ and TAZ domain-containing (BT) protein. The reports of their interaction with CUL3 are contradictory. They are multifunctional scaffold proteins essential for male and female gametophyte development []. The TAZ domain adopts an all-alpha fold with zinc-binding sites in the loops connecting the helices. The TAZ1 domain in P300 and the TAZ2 (CH3) domain in CBP have each been shown to have four amphipathic helices, organised by three zinc-binding clusters with HCCC-type coordination [, , ]. |
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