Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shao L |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation. |
Volume: |
34 |
Issue: |
1 |
Pages: |
1497-1515 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nayak A |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia. |
Volume: |
27 |
Issue: |
9 |
Pages: |
2725-2736.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yun C |
Year: |
2008 |
Journal: |
J Cell Biol |
Title: |
Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. |
Volume: |
183 |
Issue: |
4 |
Pages: |
589-95 |
|
•
•
•
•
•
|
Allele |
Name: |
tumor necrosis factor (ligand) superfamily, member 13; targeted mutation 1, Raif S Geha |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
tumor necrosis factor (ligand) superfamily, member 13; targeted mutation 1, Avi Ashkenazi |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Castigli E |
Year: |
2004 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Impaired IgA class switching in APRIL-deficient mice. |
Volume: |
101 |
Issue: |
11 |
Pages: |
3903-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Benson MJ |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. |
Volume: |
180 |
Issue: |
6 |
Pages: |
3655-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Howard L |
Year: |
2018 |
Journal: |
Development |
Title: |
TWE-PRIL reverse signalling suppresses sympathetic axon growth and tissue innervation. |
Volume: |
145 |
Issue: |
22 |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Varfolomeev E |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
APRIL-deficient mice have normal immune system development. |
Volume: |
24 |
Issue: |
3 |
Pages: |
997-1006 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matthes T |
Year: |
2015 |
Journal: |
Leukemia |
Title: |
Myelopoiesis dysregulation associated to sustained APRIL production in multiple myeloma-infiltrated bone marrow. |
Volume: |
29 |
Issue: |
9 |
Pages: |
1901-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huard B |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Selective APRIL blockade delays systemic lupus erythematosus in mouse. |
Volume: |
7 |
Issue: |
2 |
Pages: |
e31837 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matthes T |
Year: |
2011 |
Journal: |
Blood |
Title: |
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow. |
Volume: |
118 |
Issue: |
7 |
Pages: |
1838-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hardenberg G |
Year: |
2008 |
Journal: |
Mol Immunol |
Title: |
APRIL affects antibody responses and early leukocyte infiltration, but not influenza A viral control. |
Volume: |
45 |
Issue: |
11 |
Pages: |
3050-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huard B |
Year: |
2008 |
Journal: |
J Clin Invest |
Title: |
APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa. |
Volume: |
118 |
Issue: |
8 |
Pages: |
2887-95 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tnfsf13/Tnfsf13 |
Background: |
B6.129-Tnfsf13 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tnfsf13/Tnfsf13 |
Background: |
involves: 129S4/SvJae |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tnfsf13/Tnfsf13 |
Background: |
involves: 129S4/SvJae * CD-1 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Sentrin/SUMO-specific proteases (SENPs) reversibly regulate the covalent modification of proteins by SUMO. SENP3 and 5 share considerable sequence homology and exhibit similar substrate specificity,as they are active against SUMO-2 and SUMO-3 but less so for SUMO-1. They are more closely related than to SENP1/2. This entry covers the N-terminal region of SENP3/5 containing a conserved domain directly preceding the catalytic domain. This domain is responsible for the subcellular localisation []. SENP3/5 co-localise in the nucleolus and their depletion causes defects in ribosome biogenesis []. |
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•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2021 |
Journal: |
Front Cell Dev Biol |
Title: |
SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates Glucocorticoid-Induced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis. |
Volume: |
9 |
|
Pages: |
693079 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belnoue E |
Year: |
2008 |
Journal: |
Blood |
Title: |
APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells. |
Volume: |
111 |
Issue: |
5 |
Pages: |
2755-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tran NL |
Year: |
2017 |
Journal: |
Eur J Immunol |
Title: |
TACI-dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosus. |
Volume: |
47 |
Issue: |
4 |
Pages: |
713-723 |
|
•
•
•
•
•
|
Publication |
First Author: |
McWilliams TG |
Year: |
2017 |
Journal: |
Exp Neurol |
Title: |
TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo. |
Volume: |
298 |
Issue: |
Pt A |
Pages: |
97-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson RP |
Year: |
2019 |
Journal: |
J Invest Dermatol |
Title: |
IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation. |
Volume: |
139 |
Issue: |
12 |
Pages: |
2477-2487 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mikolajczyk J |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. |
Volume: |
282 |
Issue: |
36 |
Pages: |
26217-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Finkbeiner E |
Year: |
2011 |
Journal: |
EMBO J |
Title: |
The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. |
Volume: |
30 |
Issue: |
6 |
Pages: |
1067-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Westman BJ |
Year: |
2010 |
Journal: |
Mol Cell |
Title: |
A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58. |
Volume: |
39 |
Issue: |
4 |
Pages: |
618-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Bacco A |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
The SUMO-specific protease SENP5 is required for cell division. |
Volume: |
26 |
Issue: |
12 |
Pages: |
4489-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zunino R |
Year: |
2007 |
Journal: |
J Cell Sci |
Title: |
The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. |
Volume: |
120 |
Issue: |
Pt 7 |
Pages: |
1178-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zunino R |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis. |
Volume: |
284 |
Issue: |
26 |
Pages: |
17783-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim EY |
Year: |
2015 |
Journal: |
J Mol Cell Cardiol |
Title: |
SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy. |
Volume: |
78 |
|
Pages: |
154-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Federzoni EA |
Year: |
2015 |
Journal: |
Leuk Res Rep |
Title: |
Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. |
Volume: |
4 |
Issue: |
1 |
Pages: |
32-5 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
SENP5 peptidase (sentrin-specific peptidase 5, MEROPS identifier C48.008) is a deSUMOylating peptidase localized predominantly to the nucleolus. SENP5 releases the tag proteins SUMO-2 and -3 from conjugates, preferentially acting as an isopeptidase rather than an endopeptidase []. Simultaneous depletion of SENP3 and SENP5 results in enhanced SUMOylation of proteins such as RPL37A and GNL2, which are involved in the processing of pre-rRNA [], PELP1 and LAS1L, which are involved in the release of mature ribosomal particles [], and Nop58, which is a component of small nucleolar ribonucleoprotein (snoRNP) and SUMOlyation is required for binding of Nop58 to snoRNA to maintain nucleolar retention []. SENP5 depletion also affects mitotic progression, and cells arrest at the G2/M transition []. SENP5 is also involved in mitochondrial fusion and fission, because SUMOylated dynamin-1-like protein (Drp1), which is a mitochondrial fission factor, is a target for SENP5 []. DeSUMOylation of Drp1 is a contributory factor to cardiomyopathy []. During the G2/M transition stage of mitosis, SENP5 transiently locates to the mitochondrion []. SENP5 is also required for neutrophil differentiation, and the SNP5 gene is repressed in clinical acute myeloid leukemia []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
749
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
607
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
210
|
Fragment?: |
true |
|
•
•
•
•
•
|