|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 901 to 989 out of 989 for Lrrk2

<< First    < Previous  |  Next >    Last >>
0.033s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Allele
Tg(tetO-LRRK2)C77Cai | MGI:4420821
Name: transgene insertion C77, Huaibin Cai
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
•
•
•
•
•
Allele
Tg(tetO-LRRK2)C7874Cai | MGI:4420758
Name: transgene insertion C7874, Huaibin Cai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
•
•
•
•
•
Allele
Tg(Lrrk2-EGFP)KJ162Gsat | MGI:4847209
Name: transgene insertion KJ162, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
•
•
•
•
•
Strain
MGI:4942385 | FVB/N-Tg(LRRK2*G2019S)1Cjli/J
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Allele
Tg(LRRK2*G2019S)2AMjff | MGI:5502368
Name: transgene insertion 2A, The Michael J Fox Foundation
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Strain
MGI:7737636 | C57BL/6J-Lrrk2<em1Yue>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(LRRK2*G2019S)1Cjli/?
Background: FVB/N-Tg(LRRK2*G2019S)1Cjli/J
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Publication
31148170 | J:277683
First Author: Marte A
Year: 2019
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites.
Volume: 150
Issue: 3
Pages: 264-281
•
•
•
•
•
Publication
22342962 | J:184728
 
First Author: Gillardon F
Year: 2012
Journal: Neuroscience
Title: Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.
Volume: 208
Pages: 41-8
•
•
•
•
•
Publication
21494637 | J:171645
First Author: Ramonet D
Year: 2011
Journal: PLoS One
Title: Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
Volume: 6
Issue: 4
Pages: e18568
•
•
•
•
•
Publication
26192625 | J:222393
 
First Author: Tagliaferro P
Year: 2015
Journal: Neurobiol Dis
Title: An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease.
Volume: 82
Pages: 359-371
•
•
•
•
•
Publication
25654763 | -
 
First Author: Liu Y
Year: 2015
Journal: Cell Death Dis
Title: F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.
Volume: 6
Pages: e1630
•
•
•
•
•
Protein Domain
IPR045627 | FBXL18_LRR
Type: Domain
Description: In general, F-box proteins share a F-box motif and also have either WD40 repeat domains, LRR domains or various other domains. F-box proteins recruit specific substrates for ubiquitination via different protein-protein interaction domains, such as WD40 repeats and leucine rich repeats (LRRs) [, ]. This entry represents the leucine-rich repeats (LRR) domain of F-box/LRR repeat protein 18 (FBXL18). This protein is a component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF-Fbxl18 complex has been shown to ubiquitinate Fbxl7 and LRRK2 and promote their degradation through the proteasome pathway [, ].
•
•
•
•
•
Publication
37029193 | J:351295
First Author: Skiteva O
Year: 2023
Journal: NPJ Parkinsons Dis
Title: Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice.
Volume: 9
Issue: 1
Pages: 56
•
•
•
•
•
Strain
MGI:3847894 | FVB/N-Tg(LRRK2)1Cjli/J
Attribute String: coisogenic, transgenic
•
•
•
•
•
Strain
MGI:5293637 | B6.Cg-Tg(tetO-LRRK2)C7874Cai/J
Attribute String: congenic, transgenic, mutant strain
•
•
•
•
•
Strain
MGI:4421046 | STOCK Tg(teto-LRRK2)C7874Cai/J
Attribute String: transgenic, mutant strain
•
•
•
•
•
Allele
Tg(Lrrk2)6Yue | MGI:4437427
Name: transgene insertion 6, Zhenyu Yue
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Strain
MGI:4437451 | B6.Cg-Tg(Lrrk2)6Yue/J
Attribute String: congenic, mutant strain, transgenic
•
•
•
•
•
Allele
Tg(Lrrk2*G2019S)2Yue | MGI:4437428
Name: transgene insertion 2, Zhenyu Yue
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Strain
MGI:5008581 | FVB-Tg(LRRK2)WT1Mjfa
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Strain
MGI:4460777 | B6.FVB-Tg(LRRK2)WT1Mjfa/J
Attribute String: congenic, mutant strain, transgenic
•
•
•
•
•
Strain
MGI:4460781 | B6.FVB-Tg(LRRK2*G2019S)1Mjfa/J
Attribute String: congenic, mutant strain, transgenic
•
•
•
•
•
Strain
MGI:5008580 | FVB-Tg(LRRK2*G2019S)1Mjfa
Attribute String: transgenic, mutant strain, coisogenic
•
•
•
•
•
Strain
MGI:5004001 | STOCK Tg(Lrrk2-EGFP)KJ162Gsat/Mmucd
Attribute String: mutant stock, transgenic
•
•
•
•
•
Allele
Tg(PDGFB-LRRK2*G2019S)340Djmo | MGI:4950671
Name: transgene insertion 340, Darren Moore
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Strain
MGI:4950691 | B6;C3-Tg(PDGFB-LRRK2*G2019S)340Djmo/J
Attribute String: transgenic, mutant strain
•
•
•
•
•
Allele
Tg(PDGFB-LRRK2*R1441C)574Djmo | MGI:4950673
Name: transgene insertion 574, Darren Moore
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Strain
MGI:4950692 | B6;C3-Tg(PDGFB-LRRK2*R1441C)574Djmo/J
Attribute String: mutant stock, transgenic
•
•
•
•
•
Strain
MGI:5502369 | C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Publication
36671436 | J:347452
 
First Author: Yao N
Year: 2022
Journal: Biomolecules
Title: Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice.
Volume: 13
Issue: 1
•
•
•
•
•
Publication
35152441 | J:351293
First Author: Skiteva O
Year: 2022
Journal: J Neurochem
Title: LRRK2-G2019S mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons.
Volume: 161
Issue: 2
Pages: 158-172
•
•
•
•
•
Strain
MGI:5560147 | FVB/N-Tg(PDGFB-LRRK2*G2019S)32Hlw
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Lrrk2)6Yue/?
Background: involves: C3H * C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(LRRK2*G2019S)1Mjfa/Tg(LRRK2*G2019S)1Mjfa
Background: involves: FVB/NTac
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(LRRK2)WT1Mjfa/?
Background: FVB-Tg(LRRK2)WT1Mjfa
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(LRRK2*G2019S)1Mjfa/?
Background: FVB-Tg(LRRK2*G2019S)1Mjfa
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(PDGFB-LRRK2*G2019S)340Djmo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(PDGFB-LRRK2*R1441C)574Djmo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(LRRK2)1Cjli/?
Background: FVB-Tg(LRRK2)1Cjli
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(LRRK2)1Cjli/?
Background: FVB/N-Tg(LRRK2)1Cjli/J
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(PDGFB-LRRK2*G2019S)32Hlw/?
Background: FVB/N-Tg(PDGFB-LRRK2*G2019S)32Hlw
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(LRRK2*G2019S)2AMjff/?
Background: C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Publication
25104559 | J:218328
First Author: Wen Z
Year: 2014
Journal: Neurobiol Aging
Title: CDK5-mediated phosphorylation and autophagy of RKIP regulate neuronal death in Parkinson's disease.
Volume: 35
Issue: 12
Pages: 2870-2880
•
•
•
•
•
Allele
Tg(LRRK2*R1441G)3IMjff | MGI:5466850
Name: transgene insertion 3I, The Michael J Fox Foundation
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Strain
MGI:5800409 | FVB/N-Tg(PDGFB-LRRK2*R1441C)31Hlw
Attribute String: transgenic, mutant strain, coisogenic
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(PDGFB-LRRK2*R1441C)31Hlw/?
Background: FVB/N-Tg(PDGFB-LRRK2*R1441C)31Hlw
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Allele
Khdrbs2<Tg(LRRK2*R1441G)135Cjli> | MGI:3847811
Name: KH domain containing, RNA binding, signal transduction associated 2; transgene insertion 135, Chenjian Li
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
•
•
•
•
•
Strain
MGI:4437457 | B6.Cg-Tg(Lrrk2*G2019S)2Yue/J
Attribute String: transgenic, congenic, mutant strain
•
•
•
•
•
Publication
26310625 | J:226415
First Author: Zhou ZD
Year: 2015
Journal: Hum Mol Genet
Title: F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy.
Volume: 24
Issue: 22
Pages: 6314-30
•
•
•
•
•
Publication
34108219 | J:350971
 
First Author: Cornblath EJ
Year: 2021
Journal: Sci Adv
Title: Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor.
Volume: 7
Issue: 24
•
•
•
•
•
Strain
MGI:5502378 | C57BL/6J-Tg(LRRK2*R1441G)3IMjff/J
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2)C77Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2*)D10Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Lrrk2*G2019S)2Yue/?
Background: involves: C3H * C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Publication
21603132 | J:232312
 
First Author: Li T
Year: 2011
Journal: Parkinsons Dis
Title: Models for LRRK2-Linked Parkinsonism.
Volume: 2011
Pages: 942412
•
•
•
•
•
Strain
MGI:3848711 | FVB-Khdrbs2<Tg(LRRK2*R1441G)135Cjli>
Attribute String: coisogenic, transgenic
•
•
•
•
•
Strain
MGI:3847896 | FVB/N-Khdrbs2<Tg(LRRK2*R1441G)135Cjli>/J
Attribute String: transgenic, coisogenic
•
•
•
•
•
Publication
23721786 | J:201542
 
First Author: Dranka BP
Year: 2013
Journal: Neurosci Lett
Title: Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse.
Volume: 549
Pages: 57-62
•
•
•
•
•
Publication
25263790 | J:218447
 
First Author: Dranka BP
Year: 2014
Journal: Neurosci Lett
Title: A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Volume: 583
Pages: 159-64
•
•
•
•
•
Publication
18518923 | J:151155
First Author: Delic S
Year: 2008
Journal: Genes Brain Behav
Title: Genetic mouse models for behavioral analysis through transgenic RNAi technology.
Volume: 7
Issue: 7
Pages: 821-30
•
•
•
•
•
Genotype
Genotype
Symbol: Khdrbs2/Khdrbs2<+>
Background: FVB-Khdrbs2
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2)C77Cai/? Tg(tetO-SNCA*A53T)E2Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2*)D10Cai/? Tg(tetO-SNCA*A53T)E2Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2)C7874Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2)C7874Cai/? Tg(tetO-SNCA*A53T)E2Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Khdrbs2/Khdrbs2<+>
Background: FVB/N-Khdrbs2/J
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Publication
25471590 | J:218853
First Author: Cao M
Year: 2014
Journal: J Neurosci
Title: Upregulation of Parkin in endophilin mutant mice.
Volume: 34
Issue: 49
Pages: 16544-9
•
•
•
•
•
Publication
38091401 | J:349290
First Author: Pal P
Year: 2023
Journal: Sci Adv
Title: Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.
Volume: 9
Issue: 50
Pages: eadj1205
•
•
•
•
•
Publication
20547124 | J:163293
First Author: Dawson TM
Year: 2010
Journal: Neuron
Title: Genetic animal models of Parkinson's disease.
Volume: 66
Issue: 5
Pages: 646-61
•
•
•
•
•
Protein
Q3U4A0
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
•
•
•
•
•
Protein
A4VCH8
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: true
•
•
•
•
•
Protein
Q14BU8
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: true
•
•
•
•
•
Protein
F8VQK6
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
•
•
•
•
•
Protein
E9PYR1
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: false
•
•
•
•
•
Publication
10581972 | -
First Author: Craig KL
Year: 1999
Journal: Prog Biophys Mol Biol
Title: The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction.
Volume: 72
Issue: 3
Pages: 299-328
•
•
•
•
•
Publication
35345836 | J:322799
 
First Author: Liu XZ
Year: 2021
Journal: Front Mol Neurosci
Title: F-Actin Dysplasia Involved in Organ of Corti Deformity in Gjb2 Knockdown Mouse Model.
Volume: 14
Pages: 808553
•
•
•
•
•
Publication
33727250 | J:334026
 
First Author: Dhekne HS
Year: 2021
Journal: Life Sci Alliance
Title: LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.
Volume: 4
Issue: 5
•
•
•
•
•
Publication
25562633 | J:219336
 
First Author: Miyajima T
Year: 2015
Journal: Neurosci Lett
Title: The mouse/human cross-species heterodimer of leucine-rich repeat kinase 2: possible significance in the transgenic model mouse of Parkinson's disease.
Volume: 588
Pages: 142-6
•
•
•
•
•
Publication
26744328 | J:229469
First Author: Liu J
Year: 2016
Journal: Hum Mol Genet
Title: Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.
Volume: 25
Issue: 4
Pages: 672-80
•
•
•
•
•
Publication
29550548 | J:264773
 
First Author: Kritzinger A
Year: 2018
Journal: Neurobiol Aging
Title: Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum.
Volume: 66
Pages: 97-111
•
•
•
•
•
Publication
33367571 | J:305193
First Author: Nirujogi RS
Year: 2021
Journal: Biochem J
Title: Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites.
Volume: 478
Issue: 2
Pages: 299-326
•
•
•
•
•
Publication
9346238 | -
First Author: Skowyra D
Year: 1997
Journal: Cell
Title: F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
Volume: 91
Issue: 2
Pages: 209-19
•
•
•
•
•
Publication
31449520 | J:279444
First Author: Giguère N
Year: 2019
Journal: PLoS Genet
Title: Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout.
Volume: 15
Issue: 8
Pages: e1008352
•
•
•
•
•
Publication
23013868 | J:324569
 
First Author: Sekigawa A
Year: 2012
Journal: Mol Brain
Title: Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.
Volume: 5
Pages: 34
•
•
•
•
•
Protein
Q3UHC2
Organism: Mus musculus/domesticus
Length: 2014  
Fragment?: false
•
•
•
•
•
Protein
Q5S006
Organism: Mus musculus/domesticus
Length: 2527  
Fragment?: false
•
•
•
•
•
Publication
30659012 | J:276927
First Author: Goodwin LO
Year: 2019
Journal: Genome Res
Title: Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.
Volume: 29
Issue: 3
Pages: 494-505
•
•
•
•
•
Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom