|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 701 to 800 out of 952 for C9

<< First    < Previous  |  Next >    Last >>
0.038s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
21383175 | J:170090
First Author: Xu B
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Axial Hox9 activity establishes the posterior field in the developing forelimb.
Volume: 108
Issue: 12
Pages: 4888-91
•
•
•
•
•
Publication
31747609 | J:299212
First Author: Coughlan E
Year: 2019
Journal: Cell Rep
Title: A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization.
Volume: 29
Issue: 8
Pages: 2408-2421.e4
•
•
•
•
•
Publication
11335109 | J:69781
First Author: Ikeya M
Year: 2001
Journal: Mech Dev
Title: Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression.
Volume: 103
Issue: 1-2
Pages: 27-33
•
•
•
•
•
Publication
16624538 | J:109284
First Author: Lorente M
Year: 2006
Journal: Mech Dev
Title: Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.
Volume: 123
Issue: 4
Pages: 312-20
•
•
•
•
•
Publication
25255084 | J:228776
First Author: Muto A
Year: 2014
Journal: PLoS Genet
Title: Nipbl and mediator cooperatively regulate gene expression to control limb development.
Volume: 10
Issue: 9
Pages: e1004671
•
•
•
•
•
Publication
14973489 | J:89076
First Author: Luo L
Year: 2004
Journal: Nature
Title: The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions.
Volume: 427
Issue: 6976
Pages: 749-53
•
•
•
•
•
Publication
1358803 | J:2660
First Author: Hameister H
Year: 1992
Journal: Genomics
Title: Gene order and genetic distance of 13 loci spanning murine chromosome 15.
Volume: 14
Issue: 2
Pages: 417-22
•
•
•
•
•
Publication
7768176 | J:23135
First Author: Burke AC
Year: 1995
Journal: Development
Title: Hox genes and the evolution of vertebrate axial morphology.
Volume: 121
Issue: 2
Pages: 333-46
•
•
•
•
•
Publication
536693 | J:6274
 
First Author: Johnson DR
Year: 1979
Journal: J Embryol Exp Morphol
Title: Crinkly-tail, a mild skeletal mutant in the mouse.
Volume: 53
Pages: 327-33
•
•
•
•
•
Publication
17520166 | J:121991
First Author: Katayama K
Year: 2007
Journal: Mamm Genome
Title: Characterization of chromosomal inversion of the mouse hairy ears (Eh) mutation associated with cleft palate.
Volume: 18
Issue: 4
Pages: 246-54
•
•
•
•
•
Publication
26367869 | J:243182
First Author: Wang H
Year: 2015
Journal: PLoS One
Title: Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.
Volume: 10
Issue: 9
Pages: e0137797
•
•
•
•
•
Publication
23359544 | J:195163
First Author: Lacombe J
Year: 2013
Journal: PLoS Genet
Title: Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons.
Volume: 9
Issue: 1
Pages: e1003184
•
•
•
•
•
Publication
16790475 | J:119016
First Author: Liu JP
Year: 2006
Journal: Development
Title: The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord.
Volume: 133
Issue: 15
Pages: 2865-74
•
•
•
•
•
Publication
9639506 | J:48502
First Author: Yagi H
Year: 1998
Journal: Blood
Title: Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice.
Volume: 92
Issue: 1
Pages: 108-17
•
•
•
•
•
Publication
9291463 | J:42706
First Author: McGrath KE
Year: 1997
Journal: Mol Reprod Dev
Title: Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation.
Volume: 48
Issue: 2
Pages: 145-53
•
•
•
•
•
Publication
2783549 | J:9554
First Author: Kwon BS
Year: 1989
Journal: Biochem Biophys Res Commun
Title: The structure of the mouse lymphocyte pore-forming protein perforin.
Volume: 158
Issue: 1
Pages: 1-10
•
•
•
•
•
Publication
2303785 | J:10315
First Author: Trapani JA
Year: 1990
Journal: J Exp Med
Title: Genomic organization of the mouse pore-forming protein (perforin) gene and localization to chromosome 10. Similarities to and differences from C9.
Volume: 171
Issue: 2
Pages: 545-57
•
•
•
•
•
Publication
3261391 | J:9295
First Author: Shinkai Y
Year: 1988
Journal: Nature
Title: Homology of perforin to the ninth component of complement (C9).
Volume: 334
Issue: 6182
Pages: 525-7
•
•
•
•
•
Publication
16301611 | J:122201
First Author: Longhi MP
Year: 2005
Journal: J Immunol
Title: Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner.
Volume: 175
Issue: 11
Pages: 7098-102
•
•
•
•
•
Publication
21572031 | J:175481
First Author: Ramos TN
Year: 2011
Journal: J Immunol
Title: Cutting edge: the membrane attack complex of complement is required for the development of murine experimental cerebral malaria.
Volume: 186
Issue: 12
Pages: 6657-60
•
•
•
•
•
Publication
18166159 | J:133451
First Author: González-Arenas A
Year: 2008
Journal: Biochim Biophys Acta
Title: Regulation of LPA receptor function by estrogens.
Volume: 1783
Issue: 2
Pages: 253-62
•
•
•
•
•
Publication
29176862 | -
First Author: Koschmieder J
Year: 2017
Journal: PLoS One
Title: Plant-type phytoene desaturase: Functional evaluation of structural implications.
Volume: 12
Issue: 11
Pages: e0187628
•
•
•
•
•
Protein Domain
IPR014102 | Phytoene_desaturase
Type: Family
Description: This entry represents phytoene desaturase (PDS) from plants and cyanobacteria (blue-green algae). It is an essential carotenoid biosynthetic enzyme. It converts phytoene into zeta-carotene via the intermediary of phytofluene by the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene with a concomitant isomerization of two neighbouring double bonds at the C9 and C9' positions from trans to cis [, ].This entry does not include plant chloroplast transit peptides and the entry does not contain zeta-carotene desaturase, which is a closely related family in the same pathway.
•
•
•
•
•
Publication
1358459 | J:3235
First Author: Scott MP
Year: 1992
Journal: Cell
Title: Vertebrate homeobox gene nomenclature.
Volume: 71
Issue: 4
Pages: 551-3
•
•
•
•
•
Publication
33257809 | J:308865
First Author: Higashijima Y
Year: 2020
Journal: Commun Biol
Title: Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.
Volume: 3
Issue: 1
Pages: 725
•
•
•
•
•
Publication
27894818 | J:238549
First Author: Warrier S
Year: 2017
Journal: Dev Biol
Title: Supt20 is required for development of the axial skeleton.
Volume: 421
Issue: 2
Pages: 245-257
•
•
•
•
•
Publication
12441290 | J:80020
First Author: Marcil A
Year: 2003
Journal: Development
Title: Pitx1 and Pitx2 are required for development of hindlimb buds.
Volume: 130
Issue: 1
Pages: 45-55
•
•
•
•
•
Publication
15042701 | J:89197
First Author: Patterson LT
Year: 2004
Journal: Dev Dyn
Title: Atlas of Hox gene expression in the developing kidney.
Volume: 229
Issue: 4
Pages: 771-9
•
•
•
•
•
Publication
19204410 | J:149067
First Author: Grier DG
Year: 2009
Journal: Neonatology
Title: Quantification of Hox and surfactant protein-B transcription during murine lung development.
Volume: 96
Issue: 1
Pages: 50-60
•
•
•
•
•
Publication
19998061 | J:160194
First Author: Shaw L
Year: 2010
Journal: In Vitro Cell Dev Biol Anim
Title: Gene expression profiling of the developing mouse kidney and embryo.
Volume: 46
Issue: 2
Pages: 155-65
•
•
•
•
•
Publication
16944957 | -
First Author: Ghesquière B
Year: 2006
Journal: J Proteome Res
Title: Proteome-wide characterization of N-glycosylation events by diagonal chromatography.
Volume: 5
Issue: 9
Pages: 2438-47
•
•
•
•
•
Protein
Q8BGT4
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
•
•
•
•
•
Protein
Q8K1T7
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
•
•
•
•
•
Publication
9914519 | -
First Author: Bartley GE
Year: 1999
Journal: Eur J Biochem
Title: Two Arabidopsis thaliana carotene desaturases, phytoene desaturase and zeta-carotene desaturase, expressed in Escherichia coli, catalyze a poly-cis pathway to yield pro-lycopene.
Volume: 259
Issue: 1-2
Pages: 396-403
•
•
•
•
•
Publication
19931914 | -
First Author: Kuijpers TW
Year: 2010
Journal: Mol Immunol
Title: Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease.
Volume: 47
Issue: 4
Pages: 671-7
•
•
•
•
•
Publication
21454577 | -
First Author: Lovelace LL
Year: 2011
Journal: J Biol Chem
Title: Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.
Volume: 286
Issue: 20
Pages: 17585-92
•
•
•
•
•
Protein Domain
IPR003884 | FacI_MAC
Type: Domain
Description: This domain is found in complement component proteins, complement component factor 1 and agrin. Complement components C5b, C6, C7 C8 and C9 are the constituents of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Its assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. Factor I is responsible for cleaving alpha chains of C4B and C3B in the presence of the cofactors C4-binding protein and factor H respectively. Agrin is a component of the basal lamina that causes the aggregation of acetylcholine receptors and acetylcholine-esterase on the surface of muscle fibres of the neuromuscular junction.
•
•
•
•
•
Protein Domain
IPR037565 | Complement_C8_alpha
Type: Family
Description: This entry represents the alpha chain of complement component C8. C8 is a complex of three chains, alpha, beta and gamma []. C8 is a component of the membrane attack complex (MAC) which forms pores in the membranes of cells of invading organisms. MAC forms when C5 is cleaved into C5a and C5b, and C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 [, ]. C8 alpha is synthesized as a precursor and activation occurs by cleavage at paired basic residues by kallikrein-related peptidase 4 []. The tertiary structure of C8 alpha has been solved and shows the following domains (N- to C-terminal): first TSP type-1, LDL-receptor class A, MACPF, EGF-like, and second TSP type-1 []. This domain architecture is shared with the beta chain of C8.
•
•
•
•
•
Protein Domain
IPR037564 | Complement_C7
Type: Family
Description: This entry represents complement component C7, a subunit of the membrane attack complex (MAC) which forms pores in the membranes of cells of invading organisms. C7 anchors the MAC to the membrane. MAC forms when C5 is cleaved into C5a and C5b, and C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 []. The structure of C7 has been solved and C7 contains a several domains, which from N to C terminus are: TSP type-1, LDL-receptor class A, MACPF, EGF-like, another TSP type-1 and two sushi domains []. Variants of C7 are associated with immunodeficiency diseases and susceptibility to infection such as meningococcal disease caused by Neisseria meningitidis [].
•
•
•
•
•
Protein Domain
IPR037566 | Complement_C8_beta
Type: Family
Description: This entry represents the beta chain of complement component C8. C8 is a complex of three chains, alpha, beta and gamma []. C8 is a component of the membrane attack complex (MAC) which forms pores in the membranes of cells of invading organisms. MAC forms when C5 is cleaved into C5a and C5b, and C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 [, ]. C8 beta is synthesized as a precursor and activation occurs by cleavage by kallikrein-related peptidase 4 []. The tertiary structure of C8 beta has been solved and shows the following domains (N- to C-terminal): first TSP type-1, LDL-receptor class A, MACPF, EGF-like, second TSP type-1 []. This domain architecture is shared with the alpha chain of C8.
•
•
•
•
•
Protein
P58019
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: false
•
•
•
•
•
Protein
O55186
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
•
•
•
•
•
Protein
A2BI31
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
•
•
•
•
•
Protein
Q920G6
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
•
•
•
•
•
Publication
7440581 | -
First Author: Steckel EW
Year: 1980
Journal: J Biol Chem
Title: The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure.
Volume: 255
Issue: 24
Pages: 11997-2005
•
•
•
•
•
Publication
15389820 | -
First Author: Matsumura M
Year: 2005
Journal: Prostate
Title: Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries.
Volume: 62
Issue: 1
Pages: 1-13
•
•
•
•
•
Publication
22832194 | -
First Author: Hadders MA
Year: 2012
Journal: Cell Rep
Title: Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.
Volume: 1
Issue: 3
Pages: 200-7
•
•
•
•
•
Publication
10946279 | J:64057
First Author: Qian YM
Year: 2000
Journal: J Immunol
Title: Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59.
Volume: 165
Issue: 5
Pages: 2528-34
•
•
•
•
•
Publication
11865066 | J:74983
First Author: Rosenberg ME
Year: 2002
Journal: Mol Cell Biol
Title: Apolipoprotein J/clusterin prevents a progressive glomerulopathy of aging.
Volume: 22
Issue: 6
Pages: 1893-902
•
•
•
•
•
Publication
10070158 | J:53985
First Author: Mount DB
Year: 1999
Journal: Am J Physiol
Title: Isoforms of the Na-K-2Cl cotransporter in murine TAL I. Molecular characterization and intrarenal localization.
Volume: 276
Issue: 3 Pt 2
Pages: F347-58
•
•
•
•
•
Publication
33022226 | J:300537
First Author: Nguyen L
Year: 2020
Journal: Neuron
Title: Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.
Volume: 108
Issue: 4
Pages: 784-796.e3
•
•
•
•
•
Publication
16859686 | J:144682
First Author: Kaminski HJ
Year: 2006
Journal: Exp Neurol
Title: Deficiency of decay accelerating factor and CD59 leads to crisis in experimental myasthenia.
Volume: 202
Issue: 2
Pages: 287-93
•
•
•
•
•
Publication
34953854 | J:318766
First Author: Belyaeva OV
Year: 2022
Journal: J Biol Chem
Title: Dehydrogenase reductase 9 (SDR9C4) and related homologs recognize a broad spectrum of lipid mediator oxylipins as substrates.
Volume: 298
Issue: 1
Pages: 101527
•
•
•
•
•
Publication
28159992 | J:241787
First Author: Augereau C
Year: 2016
Journal: Hum Mol Genet
Title: Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells.
Volume: 25
Issue: 22
Pages: 5017-5026
•
•
•
•
•
Publication
29895552 | J:291005
First Author: Wang X
Year: 2018
Journal: J Am Soc Nephrol
Title: Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily.
Volume: 29
Issue: 8
Pages: 2053-2059
•
•
•
•
•
Publication
16339572 | J:122254
First Author: Alexander JJ
Year: 2005
Journal: J Immunol
Title: Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis.
Volume: 175
Issue: 12
Pages: 8312-9
•
•
•
•
•
Publication
16951374 | J:138043
First Author: Turnberg D
Year: 2006
Journal: J Immunol
Title: Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice.
Volume: 177
Issue: 6
Pages: 4094-102
•
•
•
•
•
Publication
15931394 | J:99198
First Author: Cheung W
Year: 2005
Journal: J Clin Invest
Title: Role of leptin and melanocortin signaling in uremia-associated cachexia.
Volume: 115
Issue: 6
Pages: 1659-65
•
•
•
•
•
Publication
20212283 | J:170437
First Author: Wu G
Year: 2010
Journal: Circulation
Title: Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice.
Volume: 121
Issue: 11
Pages: 1338-46
•
•
•
•
•
Publication
17586095 | J:123553
First Author: Bykov I
Year: 2007
Journal: Clin Immunol
Title: Effect of chronic ethanol consumption on the expression of complement components and acute-phase proteins in liver.
Volume: 124
Issue: 2
Pages: 213-20
•
•
•
•
•
Publication
29292077 | J:258110
 
First Author: Xu B
Year: 2018
Journal: Neuroscience
Title: Proteomic Profiling of Brain and Testis Reveals the Diverse Changes in Ribosomal Proteins in fmr1 Knockout Mice.
Volume: 371
Pages: 469-483
•
•
•
•
•
Publication
15331407 | J:92414
First Author: Turnberg D
Year: 2004
Journal: Am J Pathol
Title: CD59a deficiency exacerbates ischemia-reperfusion injury in mice.
Volume: 165
Issue: 3
Pages: 825-32
•
•
•
•
•
Publication
16565498 | J:108204
First Author: Lin T
Year: 2006
Journal: Am J Pathol
Title: Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.
Volume: 168
Issue: 4
Pages: 1241-8
•
•
•
•
•
Publication
19109183 | J:142888
First Author: Ziporen L
Year: 2009
Journal: J Immunol
Title: Programmed necrotic cell death induced by complement involves a Bid-dependent pathway.
Volume: 182
Issue: 1
Pages: 515-21
•
•
•
•
•
Publication
47885 | J:23999
First Author: Kolb WP
Year: 1975
Journal: J Exp Med
Title: The membrane attack mechanism of complement. Isolation and subunit composition of the C5b-9 complex.
Volume: 141
Issue: 4
Pages: 724-35
•
•
•
•
•
Publication
1381503 | J:2264
First Author: Petranka JG
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
Volume: 89
Issue: 17
Pages: 7876-9
•
•
•
•
•
Publication
8738959 | J:33129
First Author: Birk OS
Year: 1996
Journal: J Autoimmun
Title: NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells.
Volume: 9
Issue: 2
Pages: 159-66
•
•
•
•
•
Publication
9553129 | J:47130
First Author: Zhao XJ
Year: 1998
Journal: J Biol Chem
Title: Identity of the residues responsible for the species-restricted complement inhibitory function of human CD59.
Volume: 273
Issue: 17
Pages: 10665-71
•
•
•
•
•
Publication
10070159 | J:53837
First Author: Plata C
Year: 1999
Journal: Am J Physiol
Title: Isoforms of the Na-K-2Cl cotransporter in murine TAL II. Functional characterization and activation by cAMP.
Volume: 276
Issue: 3 Pt 2
Pages: F359-66
•
•
•
•
•
Publication
22217416 | J:191176
First Author: Lee M
Year: 2012
Journal: Neurobiol Aging
Title: Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex.
Volume: 33
Issue: 10
Pages: 2237-46
•
•
•
•
•
Publication
30150298 | J:267977
 
First Author: Fomin V
Year: 2018
Journal: Mol Cell Biol
Title: The C9ORF72 Gene, Implicated in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, Encodes a Protein That Functions in Control of Endothelin and Glutamate Signaling.
Volume: 38
Issue: 22
•
•
•
•
•
Publication
30714990 | J:295266
First Author: Smith-Jackson K
Year: 2019
Journal: J Clin Invest
Title: Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice.
Volume: 129
Issue: 3
Pages: 1061-1075
•
•
•
•
•
Publication
22819676 | J:187603
First Author: Zhu H
Year: 2012
Journal: Dev Biol
Title: Ndrg2 regulates vertebral specification in differentiating somites.
Volume: 369
Issue: 2
Pages: 308-18
•
•
•
•
•
Publication
37167859 | J:338694
 
First Author: Kumar S
Year: 2023
Journal: Differentiation
Title: Sf3b4 regulates chromatin remodeler splicing and Hox expression.
Volume: 131
Pages: 59-73
•
•
•
•
•
Publication
28190640 | J:256105
First Author: Mendelsohn AI
Year: 2017
Journal: Neuron
Title: Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.
Volume: 93
Issue: 4
Pages: 792-805.e4
•
•
•
•
•
Publication
22701719 | J:225113
First Author: Zhang Y
Year: 2012
Journal: PLoS One
Title: Reduction of Hox gene expression by histone H1 depletion.
Volume: 7
Issue: 6
Pages: e38829
•
•
•
•
•
Publication
22972626 | J:187969
First Author: Pazin DE
Year: 2012
Journal: Dev Dyn
Title: Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.
Volume: 241
Issue: 11
Pages: 1816-26
•
•
•
•
•
Publication
17535249 | J:127131
First Author: Ueda T
Year: 2007
Journal: Genes Cells
Title: Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.
Volume: 12
Issue: 5
Pages: 581-92
•
•
•
•
•
Publication
21256124 | J:170604
First Author: Zhang Z
Year: 2011
Journal: Dev Biol
Title: The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning.
Volume: 351
Issue: 2
Pages: 254-65
•
•
•
•
•
Publication
29379870 | J:262472
 
First Author: Edmond M
Year: 2017
Journal: eNeuro
Title: Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs.
Volume: 4
Issue: 6
•
•
•
•
•
Publication
32479258 | J:290220
   
First Author: Sato T
Year: 2020
Journal: Elife
Title: Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.
Volume: 9
•
•
•
•
•
Publication
11471050 | J:70846
First Author: Qin X
Year: 2001
Journal: Mamm Genome
Title: Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b.
Volume: 12
Issue: 8
Pages: 582-9
•
•
•
•
•
Publication
17145993 | J:128656
First Author: Schepers A
Year: 2006
Journal: Circulation
Title: Inhibition of complement component C3 reduces vein graft atherosclerosis in apolipoprotein E3-Leiden transgenic mice.
Volume: 114
Issue: 25
Pages: 2831-8
•
•
•
•
•
Publication
14764738 | J:88060
First Author: Lin F
Year: 2004
Journal: J Immunol
Title: Respective roles of decay-accelerating factor and CD59 in circumventing glomerular injury in acute nephrotoxic serum nephritis.
Volume: 172
Issue: 4
Pages: 2636-42
•
•
•
•
•
Publication
15086460 | J:128408
First Author: Mühlfeld AS
Year: 2004
Journal: Kidney Int
Title: Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis.
Volume: 65
Issue: 4
Pages: 1214-23
•
•
•
•
•
Publication
22190594 | J:191511
First Author: Nishiguchi KM
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: C9-R95X polymorphism in patients with neovascular age-related macular degeneration.
Volume: 53
Issue: 1
Pages: 508-12
•
•
•
•
•
Publication
2607149 | J:24637
First Author: Ong GL
Year: 1989
Journal: J Immunol Methods
Title: Mouse strains with typical mammalian levels of complement activity.
Volume: 125
Issue: 1-2
Pages: 147-58
•
•
•
•
•
Publication
2181376 | J:31723
First Author: Moscinski LC
Year: 1990
Journal: Oncogene
Title: Identification of a series of differentiation-associated gene sequences from GM-CSF stimulated bone marrow.
Volume: 5
Issue: 1
Pages: 31-7
•
•
•
•
•
Publication
- | J:15885
 
First Author: Womack JE
Year: 1991
Journal: Cytogenet Cell Genet
Title: Assignment of 47 additional comparative anchor loci to the bovine synteny map
Volume: 58
Pages: 2132 (Abstr.)
•
•
•
•
•
Protein Domain
IPR020863 | MACPF_CS
Type: Conserved_site
Description: The membrane attack complex/perforin (MACPF) domain is conserved in bacteria, fungi, mammals and plants. It was originally identified and named as being common to five complement components (C6, C7, C8-alpha, C8-beta, and C9) and perforin. These molecules perform critical functions in innate and adaptive immunity. The MAC family proteins and perforin are known to participate in lytic pore formation. In response to pathogen infection, a sequential and highly specific interaction between the constituent elements occurs to form transmembrane channels which are known as the membrane-attack complex (MAC).Only a few other MACPF proteins have been characterised and several are thought to form pores for invasion or protection [, , ]. Examples are proteins from malarial parasites [], the cytolytic toxins from sea anemones [], and proteins that provide plant immunity [, ]. Functionally uncharacterised MACPF proteins are also evident in pathogenic bacteria such as Chlamydia spp []and Photorhabdus luminescens (Xenorhabdus luminescens) [].The MACPF domain is commonly found to be associated with other N- and C-terminal domains, such as TSP1 (see ), LDLRA (see ), EGF-like (see ),Sushi/CCP/SCR (see ), FIMAC or C2 (see ). They probably control or target MACPF function [, ]. The MACPF domain oligomerizes, undergoes conformational change, and is required for lytic activity.The MACPF domain consists of a central kinked four-stranded antiparallel beta sheet surrounded by alpha helices and beta strands, forming two structural segments. Overall, the MACPF domain hasa thin L-shaped appearance. MACPF domains exhibit limited sequence similarity but contain a signature [YW]-G-[TS]-H-[FY]-x(6)-G-G motif [, , ].Some proteins known to contain a MACPF domain are listed below:Vertebrate complement proteins C6 to C9. Complement factors C6 to C9 assemble to form a scaffold, the membrane attack complex (MAC), that permits C9 polymerisation into pores that lyse Gram-negative pathogens [, ].Vertebrate perforin. It is delivered by natural killer cells and cytotoxic T lymphocytes and forms oligomeric pores (12 to 18 monomers) in the plasma membrane of either virus-infected or transformed cells.Arabidopsis thaliana (Mouse-ear cress) constitutively activated cell death 1 (CAD1) protein. It is likely to act as a mediator that recognises plant signals for pathogen infection [].Arabidopsis thaliana (Mouse-ear cress) necrotic spotted lesions 1 (NSL1) protein [].Venomous sea anemone Phyllodiscus semoni (Night anemone) toxins PsTX-60A and PsTX-60B [].Venomous sea anemone Actineria villosa (Okinawan sea anemone) toxin AvTX-60A [].Plasmodium sporozoite microneme protein essential for cell traversal 2 (SPECT2). It is essential for the membrane-wounding activity of the sporozoite and is involved in its traversal of the sinusoidal cell layer prior to hepatocyte-infection [].P. luminescens Plu-MACPF. Although nonlytic, it was shown to bind to cell membranes [].Chlamydial putative uncharacterised protein CT153 [].
•
•
•
•
•
Protein Domain
IPR020864 | MACPF
Type: Domain
Description: The membrane attack complex/perforin (MACPF) domain is conserved in bacteria, fungi, mammals and plants. It was originally identified and named as being common to five complement components (C6, C7, C8-alpha, C8-beta, and C9) and perforin. These molecules perform critical functions in innate and adaptive immunity. The MAC family proteins and perforin are known to participate in lytic pore formation. In response to pathogen infection, a sequential and highly specific interaction between the constituent elements occurs to form transmembrane channels which are known as the membrane-attack complex (MAC).Only a few other MACPF proteins have been characterised and several are thought to form pores for invasion or protection [, , ]. Examples are proteins from malarial parasites [], the cytolytic toxins from sea anemones [], and proteins that provide plant immunity [, ]. Functionally uncharacterised MACPF proteins are also evident in pathogenic bacteria such as Chlamydia spp []and Photorhabdus luminescens (Xenorhabdus luminescens) [].The MACPF domain is commonly found to be associated with other N- and C-terminal domains, such as TSP1 (see ), LDLRA (see ), EGF-like (see ),Sushi/CCP/SCR (see ), FIMAC or C2 (see ). They probably control or target MACPF function [, ]. The MACPF domain oligomerizes, undergoes conformational change, and is required for lytic activity.The MACPF domain consists of a central kinked four-stranded antiparallel beta sheet surrounded by alpha helices and beta strands, forming two structural segments. Overall, the MACPF domain has a thin L-shaped appearance. MACPF domainsexhibit limited sequence similarity but contain a signature [YW]-G-[TS]-H-[FY]-x(6)-G-G motif [, , ].Some proteins known to contain a MACPF domain are listed below:Vertebrate complement proteins C6 to C9. Complement factors C6 to C9 assemble to form a scaffold, the membrane attack complex (MAC), that permits C9 polymerisation into pores that lyse Gram-negative pathogens [, ].Vertebrate perforin. It is delivered by natural killer cells and cytotoxic T lymphocytes and forms oligomeric pores (12 to 18 monomers) in the plasma membrane of either virus-infected or transformed cells.Arabidopsis thaliana (Mouse-ear cress) constitutively activated cell death 1 (CAD1) protein. It is likely to act as a mediator that recognises plant signals for pathogen infection [].Arabidopsis thaliana (Mouse-ear cress) necrotic spotted lesions 1 (NSL1) protein [].Venomous sea anemone Phyllodiscus semoni (Night anemone) toxins PsTX-60A and PsTX-60B [].Venomous sea anemone Actineria villosa (Okinawan sea anemone) toxin AvTX-60A [].Plasmodium sporozoite microneme protein essential for cell traversal 2 (SPECT2). It is essential for the membrane-wounding activity of the sporozoite and is involved in its traversal of the sinusoidal cell layer prior to hepatocyte-infection [].P. luminescens Plu-MACPF. Although nonlytic, it was shown to bind to cell membranes [].Chlamydial putative uncharacterised protein CT153 [].
•
•
•
•
•
Publication
17872444 | -
First Author: Hadders MA
Year: 2007
Journal: Science
Title: Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.
Volume: 317
Issue: 5844
Pages: 1552-4
•
•
•
•
•
Publication
16900325 | -
First Author: Noutoshi Y
Year: 2006
Journal: Plant Mol Biol
Title: Loss of Necrotic Spotted Lesions 1 associates with cell death and defense responses in Arabidopsis thaliana.
Volume: 62
Issue: 1-2
Pages: 29-42
•
•
•
•
•
Publication
18440555 | -
First Author: Slade DJ
Year: 2008
Journal: J Mol Biol
Title: Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.
Volume: 379
Issue: 2
Pages: 331-42
•
•
•
•
•
Publication
15659064 | -
First Author: Ishino T
Year: 2005
Journal: Cell Microbiol
Title: A Plasmodium sporozoite protein with a membrane attack complex domain is required for breaching the liver sinusoidal cell layer prior to hepatocyte infection.
Volume: 7
Issue: 2
Pages: 199-208
•
•
•
•
•
Publication
17368498 | -
First Author: Satoh H
Year: 2007
Journal: Toxicon
Title: Characterization of PsTX-60B, a new membrane-attack complex/perforin (MACPF) family toxin, from the venomous sea anemone Phyllodiscus semoni.
Volume: 49
Issue: 8
Pages: 1208-10
•
•
•
•
•
Publication
15799997 | -
First Author: Morita-Yamamuro C
Year: 2005
Journal: Plant Cell Physiol
Title: The Arabidopsis gene CAD1 controls programmed cell death in the plant immune system and encodes a protein containing a MACPF domain.
Volume: 46
Issue: 6
Pages: 902-12
•
•
•
•
•
Publication
10608922 | -
First Author: Ponting CP
Year: 1999
Journal: Curr Biol
Title: Chlamydial homologues of the MACPF (MAC/perforin) domain.
Volume: 9
Issue: 24
Pages: R911-3
•
•
•
•
•
Publication
19419965 | -
First Author: Phelan MM
Year: 2009
Journal: J Biol Chem
Title: Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement.
Volume: 284
Issue: 29
Pages: 19637-49
•
•
•
•
•
Publication
17692377 | -
First Author: Lovelace LL
Year: 2008
Journal: Mol Immunol
Title: Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.
Volume: 45
Issue: 3
Pages: 750-6
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom