| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Allele |
| Name: |
serine and arginine-rich splicing factor 4; targeted mutation 1c, Wellcome Trust Sanger Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ninomiya K |
| Year: |
2011 |
| Journal: |
J Cell Biol |
| Title: |
Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor. |
| Volume: |
195 |
| Issue: |
1 |
| Pages: |
27-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Du K |
| Year: |
1997 |
| Journal: |
Gene |
| Title: |
Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. |
| Volume: |
204 |
| Issue: |
1-2 |
| Pages: |
243-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2011 |
| Journal: |
Gene |
| Title: |
An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia. |
| Volume: |
485 |
| Issue: |
2 |
| Pages: |
130-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ankö ML |
| Year: |
2010 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells. |
| Volume: |
17 |
| Issue: |
8 |
| Pages: |
962-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zahler AM |
| Year: |
1993 |
| Journal: |
Mol Cell Biol |
| Title: |
Human SR proteins and isolation of a cDNA encoding SRp75. |
| Volume: |
13 |
| Issue: |
7 |
| Pages: |
4023-8 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This is the RNA recognition motif 1 (RRM1) in serine/arginine (SR) proteins serine/arginine-rich splicing factor 4 (SRSF4 or SRp75 or SFRS4) and serine/arginine-rich splicing factor 5 (SRSF5 or SRp40 or SFRS5 or HRS), and related proteins. SRSF4 plays an important role in both constitutive and alternative, splicing of many pre-mRNAs [, ]. It can shuttle between the nucleus and cytoplasm. SRSF5 regulates both alternative splicing and basal splicing []. It is the only SR protein efficiently selected from nuclear extracts (NE) by the splicing enhancer (ESE) and essential for enhancer activation. Members in this family contain two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), followed by a C-terminal RS domains rich in serine-arginine dipeptides []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
269
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
489
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
491
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
124
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
270
 |
| Fragment?: |
false |
|
•
•
•
•
•
|