Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 127 out of 127 for Smc5

<< First < Previous | Next > Last >>

0.017s

Type

Details

Score

Protein Domain

IPR026846 | Nse2(Mms21)

Type:

Family

Description:

This entry consists of the E3 SUMO-protein ligase Nse2 (also known as Mms21). Nse2 is an E3 SUMO-protein ligase component of the SMC5-SMC6 complex [, ]. Nse2 acts as an E3 ligase targeting several proteins for sumoylation and is required for efficient DNA repair and maintenance of genome stability [, , , ]. Nse2 and SMC5 may also be required for sister chromatid cohesion during prometaphase and mitotic progression; this role is apparently independent of SMC6 []. Nse2 is necessary for normal cell cycle progression in Arabidopsis, where Nse2 mutation results in abnormal root development [].

•

Publication

15331764 | -

First Author:	Pebernard S
Year:	2004
Journal:	Mol Biol Cell
Title:	Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.
Volume:	15
Issue:	11
Pages:	4866-76

•

Publication

23843628 | J:210407

First Author:	Gómez R
Year:	2013
Journal:	J Cell Sci
Title:	Dynamic localization of SMC5/6 complex proteins during mammalian meiosis and mitosis suggests functions in distinct chromosome processes.
Volume:	126
Issue:	Pt 18
Pages:	4239-52

•

Protein

Q3UZJ7

Organism:	Mus musculus/domesticus
Length:	451
Fragment?:	true

•

Protein

Q3TPG9

Organism:	Mus musculus/domesticus
Length:	353
Fragment?:	true

•

Protein

Q3US85

Organism:	Mus musculus/domesticus
Length:	284
Fragment?:	true

•

Protein

Q3TMK9

Organism:	Mus musculus/domesticus
Length:	171
Fragment?:	true

•

Protein

Q3U763

Organism:	Mus musculus/domesticus
Length:	337
Fragment?:	true

•

Publication

15752197 | -

First Author:	Hu B
Year:	2005
Journal:	Mol Microbiol
Title:	Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex.
Volume:	55
Issue:	6
Pages:	1735-50

•

Publication

20571088 | -

First Author:	Bermúdez-López M
Year:	2010
Journal:	Nucleic Acids Res
Title:	The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages.
Volume:	38
Issue:	19
Pages:	6502-12

•

Publication

32546830 | -

First Author:	Vondrova L
Year:	2020
Journal:	Sci Rep
Title:	A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6.
Volume:	10
Issue:	1
Pages:	9694

•

Publication

12966087 | -

First Author:	McDonald WH
Year:	2003
Journal:	J Biol Chem
Title:	Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.
Volume:	278
Issue:	46
Pages:	45460-7

•

Publication

11864377 | -

First Author:	Harvey SH
Year:	2002
Journal:	Genome Biol
Title:	Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases.
Volume:	3
Issue:	2
Pages:	REVIEWS3003

•

Protein Domain

IPR029225 | Nse4_Nse3-bd

Type:

Domain

Description:

This entry represents the Nse3/MAGE () binding domain found in NSE4/EID family proteins [, ]. Proteins in the NSE4/EID (Non-structural maintenance of chromosomes element 4/EP300-interacting inhibitor of differentiation 3) family are components of the Smc5/6 complex that is involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components [, , ]. In human, it acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. It may function as a coinhibitor of other CREBBP/EP300-dependent transcription factors []. Interestingly, there is a single NSE4 gene in most eukaryotes up to non-placental mammals while there are several NSE4/EID copies in placental mammals []. In humans, there are two NSE4 proteins, NSE4a and NSE4b/EID3. They contain both N and C-terminal kleisin domains. Their N-terminal domain binds to SMC6 neck and bridges it to the SMC5 head []and to the Nse3 (another SMC5-6 complex subunit) pocket [], which seems to increased the stability of the ATP-free SMC5/6 complex.

•

Protein Domain

IPR027786 | Nse4/EID

Type:

Family

Description:

Proteins in the NSE4/EID (Non-structural maintenance of chromosomes element 4/EP300-interacting inhibitor of differentiation 3) family are components of the Smc5/6 complex that is involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components [, , ]. In human, it acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. It may function as a coinhibitor of other CREBBP/EP300-dependent transcription factors []. Interestingly, there is a single NSE4 gene in most eukaryotes up to non-placental mammals while there are several NSE4/EID copies in placental mammals []. In humans, there are two NSE4 proteins, NSE4a and NSE4b/EID3. They contain both N and C-terminal kleisin domains. Their N-terminal domain binds to SMC6 neck and bridges it to the SMC5 head []and to the Nse3 (another SMC5-6 complex subunit) pocket [], which seems to increased the stability of the ATP-free SMC5/6 complex.

•

Publication

21364888 | -

First Author:	Hudson JJ
Year:	2011
Journal:	PLoS One
Title:	Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families.
Volume:	6
Issue:	2
Pages:	e17270

•

Protein

Q3UNU2

Organism:	Mus musculus/domesticus
Length:	723
Fragment?:	true

•

Publication

15987788 | -

First Author:	Båvner A
Year:	2005
Journal:	Nucleic Acids Res
Title:	EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation.
Volume:	33
Issue:	11
Pages:	3561-9

•

Publication

22536443 | -

First Author:	Guerineau M
Year:	2012
Journal:	PLoS One
Title:	Analysis of the Nse3/MAGE-binding domain of the Nse4/EID family proteins.
Volume:	7
Issue:	4
Pages:	e35813

•

Protein

Q9CW03

Organism:	Mus musculus/domesticus
Length:	1217
Fragment?:	false

•

Protein

Q8CG47

Organism:	Mus musculus/domesticus
Length:	1286
Fragment?:	false

•

Protein

Q6P5E5

Organism:	Mus musculus/domesticus
Length:	1216
Fragment?:	false

•

Protein

Q6P7V9

Organism:	Mus musculus/domesticus
Length:	1216
Fragment?:	false

•

Protein

E9Q2X6

Organism:	Mus musculus/domesticus
Length:	1261
Fragment?:	false

•

Protein

Q1HL32

Organism:	Mus musculus/domesticus
Length:	1217
Fragment?:	false

•

Protein

Q91VT1

Organism:	Mus musculus/domesticus
Length:	247
Fragment?:	false

•

Protein

A0A2I3BS18

Organism:	Mus musculus/domesticus
Length:	273
Fragment?:	false

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do;jsessionid=4578BD150C98227A68C86F95254E5E08?searchTerm=Smc5&searchBag=&searchOffset=100

MouseMine

Search our database by keyword

Examples

Search results 101 to 127 out of 127 for Smc5

Categories

Hits by Pathway

Hits by Strain

Hits by Category