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Search results 201 to 300 out of 324 for Wnk4

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Type Details Score
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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UniProt Feature
UniProt Feature
Begin: 1
Description: Serine/threonine-protein kinase WNK4
Type: chain
End: 1222
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UniProt Feature
UniProt Feature
Begin: 371
Description: Phosphoserine; by WNK1 and WNK4
Type: modified residue
End: 371
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Publication
23665031 | J:198926
First Author: Wu G
Year: 2013
Journal: FEBS Lett
Title: Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
Volume: 587
Issue: 12
Pages: 1717-22
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Allele
Wnk4<em1Cjc> | MGI:6414871
 
Name: WNK lysine deficient protein kinase 4; endonuclease-mediated mutation 1, Chih-Jen Cheng
Allele Type: Endonuclease-mediated
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Protein
Q80UE6
Organism: Mus musculus/domesticus
Length: 1222  
Fragment?: false
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Protein
E9Q470
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: false
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Protein
E9PZ38
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
F6Z709
Organism: Mus musculus/domesticus
Length: 30  
Fragment?: true
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Publication
25805816 | J:220829
First Author: Lin DH
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK).
Volume: 112
Issue: 14
Pages: 4495-500
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Allele
Wnk4<em2Smoc> | MGI:7293179
Name: WNK lysine deficient protein kinase 4; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
17651736 | -
First Author: Tatum R
Year: 2007
Journal: FEBS Lett
Title: WNK4 phosphorylates ser(206) of claudin-7 and promotes paracellular Cl(-) permeability.
Volume: 581
Issue: 20
Pages: 3887-91
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Strain
MGI:6771266 | C57BL/6-Wnk4<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
23387299 | -
First Author: Ohta A
Year: 2013
Journal: Biochem J
Title: The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
Volume: 451
Issue: 1
Pages: 111-22
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Allele
Wnk4<em1Smoc> | MGI:7293178
Name: WNK lysine deficient protein kinase 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6771265 | C57BL/6-Wnk4<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(CLCNKB-WNK4)1Suc | MGI:3652731
Name: transgene insertion 1, Shinichi Uchida
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:3652732 | C57BL/6-Tg(CLCNKB-WNK4)1Suc
Attribute String: coisogenic, mutant strain, transgenic
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Publication
30146013 | J:283921
First Author: López-Cayuqueo KI
Year: 2018
Journal: Kidney Int
Title: A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis.
Volume: 94
Issue: 3
Pages: 514-523
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Allele
Tg(Wnk4)#Rpl | MGI:5525134
Name: transgene insertion, Richard P Lifton
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Wnk4*Q562E)#Rpl | MGI:5525135
Name: transgene insertion, Richard P Lifton
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
Background: involves: C3H * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
Background: involves: C3H * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Slc12a3/Slc12a3 Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
Background: involves: C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:1924363 | Klhl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0031086 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033644 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033626 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033551 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033622 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033332 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1924363 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034139 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032657 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033310 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033464 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034157 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032366 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021552 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032202 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3653659
Assay Type: Northern blot
Annotation Date: 2006-09-06
Strength: Present
Sex: Male
Emaps: EMAPS:3592628
Stage: TS28
Assay Id: MGI:3653660
Age: postnatal
Specimen Label: wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3653659
Assay Type: Northern blot
Annotation Date: 2006-09-06
Strength: Present
Sex: Male
Emaps: EMAPS:3592628
Stage: TS28
Assay Id: MGI:3653660
Age: postnatal
Specimen Label: db/db
Detected: true
Specimen Num: 2
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Publication
22266938 | -
First Author: Boyden LM
Year: 2012
Journal: Nature
Title: Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
Volume: 482
Issue: 7383
Pages: 98-102
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Protein Domain
IPR030578 | KLHL3
Type: Family
Description: Kelch-like protein 3 (KLHL3) is a substrate adaptor protein in the CUL3-KLHL3 E3 ubiquitin ligase complex. It targets WNK4 kinase 1 for ubiquitination and degradation, which in turn regulates electrolyte homeostasis []. Mutations in the KLHL3 gene cause cause pseudohypoaldosteronism type II (PHAII), which is a rare Mendelian syndrome featuring hypertension and hyperkalemia resulting from constitutive renal salt reabsorption and impaired K(+) secretion [, ]. The CUL3-KLHL3 E3 ligase complex may regulate blood pressure via its ability to interact with and ubiquitylate WNK isoforms [, ].The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ].
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Publication
23383144 | J:195911
First Author: Sato A
Year: 2013
Journal: PLoS One
Title: WNK signaling is involved in neural development via Lhx8/Awh expression.
Volume: 8
Issue: 1
Pages: e55301
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Publication
17392271 | J:123388
First Author: Lee BH
Year: 2007
Journal: J Biol Chem
Title: Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway.
Volume: 282
Issue: 25
Pages: 17985-96
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Publication
28052936 | J:244278
 
First Author: Sasaki E
Year: 2017
Journal: Mol Cell Biol
Title: KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.
Volume: 37
Issue: 7
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Publication
24610784 | J:209614
First Author: Richards J
Year: 2014
Journal: J Biol Chem
Title: A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells.
Volume: 289
Issue: 17
Pages: 11791-806
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Publication
35064051 | J:333768
First Author: Maeoka Y
Year: 2022
Journal: J Am Soc Nephrol
Title: Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice.
Volume: 33
Issue: 3
Pages: 584-600
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Publication
30301860 | J:292543
First Author: Cornelius RJ
Year: 2018
Journal: J Am Soc Nephrol
Title: Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway.
Volume: 29
Issue: 11
Pages: 2627-2640
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Publication
28052988 | J:287780
First Author: Cuevas CA
Year: 2017
Journal: J Am Soc Nephrol
Title: Potassium Sensing by Renal Distal Tubules Requires Kir4.1.
Volume: 28
Issue: 6
Pages: 1814-1825
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Publication
28289184 | J:290403
First Author: Al-Qusairi L
Year: 2017
Journal: J Am Soc Nephrol
Title: Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion.
Volume: 28
Issue: 8
Pages: 2431-2442
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Publication
23213404 | J:181538
First Author: Oi K
Year: 2012
Journal: Biol Open
Title: A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo.
Volume: 1
Issue: 2
Pages: 120-7
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Publication
32956652 | J:334240
First Author: Anderegg MA
Year: 2021
Journal: Kidney Int
Title: The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney.
Volume: 99
Issue: 2
Pages: 350-363
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Publication
21963515 | J:177276
First Author: Hoorn EJ
Year: 2011
Journal: Nat Med
Title: The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension.
Volume: 17
Issue: 10
Pages: 1304-9
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Publication
26490675 | J:226618
First Author: Araki Y
Year: 2015
Journal: Biol Open
Title: Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene.
Volume: 4
Issue: 11
Pages: 1509-17
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Publication
20921400 | J:165537
First Author: Hadchouel J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.
Volume: 107
Issue: 42
Pages: 18109-14
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Publication
25761881 | J:280737
First Author: Feng X
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Aldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway.
Volume: 308
Issue: 10
Pages: F1119-27
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Publication
30148674 | J:284284
First Author: Lin CM
Year: 2019
Journal: FASEB J
Title: Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain.
Volume: 33
Issue: 1
Pages: 1051-1061
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Publication
12522152 | J:335663
First Author: Choate KA
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.
Volume: 100
Issue: 2
Pages: 663-8
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Publication
16275913 | J:172996
First Author: Rinehart J
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.
Volume: 102
Issue: 46
Pages: 16777-82
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Publication
30718414 | J:272870
First Author: Ishizawa K
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling.
Volume: 116
Issue: 8
Pages: 3155-3160
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Publication
29263298 | J:287902
 
First Author: Ferdaus MZ
Year: 2017
Journal: JCI Insight
Title: Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.
Volume: 2
Issue: 24
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Publication
33498219 | J:303924
 
First Author: Chan CH
Year: 2021
Journal: Int J Mol Sci
Title: MST3 Involvement in Na+ and K+ Homeostasis with Increasing Dietary Potassium Intake.
Volume: 22
Issue: 3
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Publication
32790646 | J:315643
First Author: Louis-Dit-Picard H
Year: 2020
Journal: J Clin Invest
Title: Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Volume: 130
Issue: 12
Pages: 6379-6394
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Publication
29848507 | J:318503
First Author: Bazúa-Valenti S
Year: 2018
Journal: J Am Soc Nephrol
Title: The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway.
Volume: 29
Issue: 7
Pages: 1838-1848
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Publication
23427142 | J:197267
First Author: Mederle K
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse.
Volume: 304
Issue: 9
Pages: F1198-209
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Publication
22718890 | J:188424
First Author: Ko B
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: A new model of the distal convoluted tubule.
Volume: 303
Issue: 5
Pages: F700-10
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Publication
21549840 | J:177947
First Author: Tseng LA
Year: 2011
Journal: Mol Cell Neurosci
Title: Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis.
Volume: 47
Issue: 4
Pages: 254-64
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