Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Kell blood group glycoprotein (KEL; MEROPS identifier M13.090) shares sequence homology with members of the M13 family of zinc-dependent metalloproteases and is part of the Kell blood group system (consists of KEL and XK) []. KEL and XK are antigens linked covalently at the surface of red blood cells []. KEL processes big endothelin-3 to generate endothelin-3 []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Clapéron A |
Year: |
2007 |
Journal: |
Brain Res |
Title: |
The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system. |
Volume: |
1147 |
|
Pages: |
12-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee S |
Year: |
1999 |
Journal: |
Blood |
Title: |
Proteolytic processing of big endothelin-3 by the kell blood group protein. |
Volume: |
94 |
Issue: |
4 |
Pages: |
1440-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kel JM |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis. |
Volume: |
185 |
Issue: |
6 |
Pages: |
3248-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kel JM |
Year: |
2008 |
Journal: |
Int Immunol |
Title: |
Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation. |
Volume: |
20 |
Issue: |
1 |
Pages: |
117-27 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
69
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
713
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
286
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu X |
Year: |
2009 |
Journal: |
Am J Hematol |
Title: |
Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel). |
Volume: |
84 |
Issue: |
8 |
Pages: |
492-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee S |
Year: |
2000 |
Journal: |
Immunogenetics |
Title: |
The mouse Kell blood group gene (Kel): cDNA sequence, genomic organization, expression, and enzymatic function. |
Volume: |
52 |
Issue: |
1-2 |
Pages: |
53-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rivera A |
Year: |
2013 |
Journal: |
Blood Cells Mol Dis |
Title: |
Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis. |
Volume: |
50 |
Issue: |
2 |
Pages: |
80-5 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu X |
Year: |
2014 |
Journal: |
Am J Pathol |
Title: |
Giant axon formation in mice lacking Kell, XK, or Kell and XK: animal models of McLeod neuroacanthocytosis syndrome. |
Volume: |
184 |
Issue: |
3 |
Pages: |
800-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osawa M |
Year: |
2004 |
Journal: |
Gene |
Title: |
Divergent evolution of the prolactin-inducible protein gene and related genes in the mouse genome. |
Volume: |
325 |
|
Pages: |
179-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maruyama T |
Year: |
2015 |
Journal: |
Nat Biotechnol |
Title: |
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. |
Volume: |
33 |
Issue: |
5 |
Pages: |
538-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
Year: |
1999 |
Journal: |
Database Release |
Title: |
JAX BSS Panel Mapping Data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bender K |
Year: |
1988 |
Journal: |
Hum Hered |
Title: |
Linkage relations of JK, CO, KEL and IGK with each other and with AHCY. |
Volume: |
38 |
Issue: |
1 |
Pages: |
12-7 |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
66 |
Description: |
Cleavage; by KEL |
Type: |
site |
End: |
67 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
117 |
Description: |
Cleavage; by KEL |
Type: |
site |
End: |
118 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
73 |
Description: |
Cleavage; by KEL |
Type: |
site |
End: |
74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Escamilla-Rivera V |
Year: |
2020 |
Journal: |
Blood |
Title: |
Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice. |
Volume: |
135 |
Issue: |
22 |
Pages: |
1983-1993 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stowell SR |
Year: |
2013 |
Journal: |
Blood |
Title: |
Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model. |
Volume: |
122 |
Issue: |
8 |
Pages: |
1494-504 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weber K |
Year: |
2002 |
Journal: |
GenBank Submission |
Title: |
Mus musuclus Kel blood group protein (Kel), Epithelial calcium Channel 1 (Ecac1), epithelial calcium channel 2 (Ecac2), and ephrin type A receptor (Mep) genes, complete cds; and T cell receptor beta chain (Tcr) gene, partial cds |
|
|
Pages: |
AF336378 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zahner SP |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Conditional deletion of TGF-βR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity. |
Volume: |
187 |
Issue: |
10 |
Pages: |
5069-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lukas D |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity. |
Volume: |
114 |
Issue: |
8 |
Pages: |
E1480-E1489 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mandić AD |
Year: |
2017 |
Journal: |
Mucosal Immunol |
Title: |
c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine. |
Volume: |
10 |
Issue: |
5 |
Pages: |
1211-1223 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion LX107, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Bain CC |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine. |
Volume: |
8 |
Issue: |
1 |
Pages: |
620 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Cang C |
Year: |
2015 |
Journal: |
Cell |
Title: |
TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function. |
Volume: |
162 |
Issue: |
5 |
Pages: |
1101-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mener A |
Year: |
2018 |
Journal: |
JCI Insight |
Title: |
Complement serves as a switch between CD4+ T cell-independent and -dependent RBC antibody responses. |
Volume: |
3 |
Issue: |
22 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lee S |
Year: |
1993 |
Journal: |
Blood |
Title: |
The human Kell blood group gene maps to chromosome 7q33 and its expression is restricted to erythroid cells. |
Volume: |
81 |
Issue: |
10 |
Pages: |
2804-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patel SR |
Year: |
2018 |
Journal: |
Front Immunol |
Title: |
Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion. |
Volume: |
9 |
|
Pages: |
2516 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2016 |
Journal: |
Blood |
Title: |
Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice. |
Volume: |
128 |
Issue: |
26 |
Pages: |
3159-3168 |
|
•
•
•
•
•
|
Publication |
First Author: |
Escamilla-Rivera V |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. |
Volume: |
12 |
|
Pages: |
704072 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mener A |
Year: |
2018 |
Journal: |
Front Immunol |
Title: |
Complement Component 3 Negatively Regulates Antibody Response by Modulation of Red Blood Cell Antigen. |
Volume: |
9 |
|
Pages: |
676 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee JY |
Year: |
2020 |
Journal: |
Front Immunol |
Title: |
Type 1 Interferon Gene Signature Promotes RBC Alloimmunization in a Lupus Mouse Model. |
Volume: |
11 |
|
Pages: |
584254 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|