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Search results 601 to 669 out of 669 for Timeless

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Type Details Score
Allele
Timeless<Gt(EUCE00155f04)Hmgu> | MGI:4377111
 
Name: timeless circadian clock 1; gene trap EUCE00155f04, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Timeless<Gt(EUCE00104c09)Hmgu> | MGI:4382819
 
Name: timeless circadian clock 1; gene trap EUCE00104c09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Timeless<Gt(EUCE0023f06)Hmgu> | MGI:4387146
 
Name: timeless circadian clock 1; gene trap EUCE0023f06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Strain
MGI:5000106 | B6.129S6-Timeless<tm1Jt>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:4999620 | B6.129S6-Timeless<tm1Jt>/J
Attribute String: mutant strain, targeted mutation, congenic
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Allele
Tipin<Gt(411H3)Cmhd> | MGI:4961589
 
Name: timeless interacting protein; gene trap 411H3, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Tipin<Gt(400H10)Cmhd> | MGI:4962873
 
Name: timeless interacting protein; gene trap 400H10, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Timeless<Gt(IST13203E7)Tigm> | MGI:5154893
 
Name: timeless circadian clock 1; gene trap IST13203E7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST13262A12)Tigm> | MGI:5158610
 
Name: timeless interacting protein; gene trap IST13262A12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST13441H9)Tigm> | MGI:5169362
 
Name: timeless interacting protein; gene trap IST13441H9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST13636C2)Tigm> | MGI:5179147
 
Name: timeless interacting protein; gene trap IST13636C2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST13779C2)Tigm> | MGI:5185135
 
Name: timeless interacting protein; gene trap IST13779C2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Timeless<Gt(IST13907A10)Tigm> | MGI:5197046
 
Name: timeless circadian clock 1; gene trap IST13907A10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST13957F3)Tigm> | MGI:5197517
 
Name: timeless interacting protein; gene trap IST13957F3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST13996B5)Tigm> | MGI:5202324
 
Name: timeless interacting protein; gene trap IST13996B5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST14176A6)Tigm> | MGI:5214439
 
Name: timeless interacting protein; gene trap IST14176A6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST14228E1)Tigm> | MGI:5217652
 
Name: timeless interacting protein; gene trap IST14228E1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Timeless<Gt(IST14472C11)Tigm> | MGI:5232991
 
Name: timeless circadian clock 1; gene trap IST14472C11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Timeless<Gt(IST14509B9)Tigm> | MGI:5241276
 
Name: timeless circadian clock 1; gene trap IST14509B9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST14517D6)Tigm> | MGI:5242520
 
Name: timeless interacting protein; gene trap IST14517D6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST14592H7)Tigm> | MGI:5244564
 
Name: timeless interacting protein; gene trap IST14592H7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST14641C3)Tigm> | MGI:5247791
 
Name: timeless interacting protein; gene trap IST14641C3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST14785C5)Tigm> | MGI:5259851
 
Name: timeless interacting protein; gene trap IST14785C5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST14841F11)Tigm> | MGI:5260365
 
Name: timeless interacting protein; gene trap IST14841F11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Timeless<Gt(IST15026H8)Tigm> | MGI:5276539
 
Name: timeless circadian clock 1; gene trap IST15026H8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST15070G5)Tigm> | MGI:5278803
 
Name: timeless interacting protein; gene trap IST15070G5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Tipin<Gt(IST15076D8)Tigm> | MGI:5280140
 
Name: timeless interacting protein; gene trap IST15076D8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Timeless<tm1a(EUCOMM)Hmgu> | MGI:5286357
Name: timeless circadian clock 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Timeless<tm1e(EUCOMM)Hmgu> | MGI:5286284
Name: timeless circadian clock 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Timeless<tm1b(EUCOMM)Hmgu> | MGI:5692606
Name: timeless circadian clock 1; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:6392808 | C57BL/6J-Timeless<em1Ljp>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7767599 | C57BL/6JSmoc-Tipin<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7837600 | C57BL/6JCya-Timeless<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7839184 | C57BL/6JCya-Timeless<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Timeless/Timeless
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Publication
22052878 | J:196039
First Author: Howden R
Year: 2012
Journal: Am J Respir Cell Mol Biol
Title: Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in mice.
Volume: 46
Issue: 4
Pages: 470-8
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Strain
MGI:6122780 | C57BL/6N-A<tm1Brd> Timeless<tm1a(EUCOMM)Hmgu>/WtsiBiat
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:7381030 | C57BL/6N-Timeless<tm1b(EUCOMM)Hmgu>/WtsiOulu
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6261012 | C57BL/6N-Timeless<tm1b(EUCOMM)Hmgu>/Wtsi
Attribute String: coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Timeless/Timeless
Background: C57BL/6N-Timeless/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Timeless/Timeless<+>
Background: involves: 129S4/SvJae
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Timeless/Timeless<+>
Background: B6.129S6-Timeless
Zygosity: ht
Has Mutant Allele: true
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Publication
10428031 | -
First Author: Kume K
Year: 1999
Journal: Cell
Title: mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.
Volume: 98
Issue: 2
Pages: 193-205
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Protein Domain
IPR006906 | Timeless_N
Type: Domain
Description: This entry represents the N-terminal domain of the Timeless protein. The timeless gene in Drosophila melanogasteris involved in circadian rhythm control []. Drosophila contains two paralogs, dTIM and dTIM2, acting in clock/photoreception and chromosome integrity/photoreception respectively. The mammalian TIMELESS (TIM) protein, originally identified based on its similarity to Drosophila dTIM, interacts with the clock proteins dCRY and dPER and is essential for circadian rhythm generation and photo-entrainment in the fly []. However, phylogenetic sequence analysis has demonstrated that dTIM2 is likely to be the orthologue of mammalian TIM and other widely conserved TIM-like proteins in eukaryotes []. These proteins include Saccharomyces cerevisiae Tof1, Schizosaccharomyces pombe Swi1, and Caenorhabditis elegans TIM. These proteins are not involved in the core clock mechanism, but instead play important roles in chromosome integrity, efficient cell growth and/or development [, ], with the exception of dTIM-2, that has an additional function in retinal photoreception [].Saccharomyces cerevisiae Tof1 is a subunit of a replication-pausing checkpoint complex (Tof1-Mrc1-Csm3) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA [, ]. Schizosaccharomyces pombe Swi1 and Swi3 form the fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks []. In humans timeless forms a stable complex with its partner protein Tipin. The Timeless-Tipin complex has been reported to travel along with the replication fork during unperturbed DNA replication. Moreover, the Timeless-Tipin-Claspin complex contributes to full activation of the ATR-Chk1 signaling pathway through the recruitment of Chk1 to arrested replication forks for sufficient ATR-mediated phosphorylation. It also interacts with PARP-1, and this interaction is required for efficient homologous recombination repair [].
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Protein Domain
IPR007725 | TIMELESS_C
Type: Domain
Description: This entry represents the C-terminal domain found in the Timeless (TIM) proteins. This domain can be found in TIM homologues mostly from animals. This domain found in hTIM has been shown to bind to the PARP-1 catalytic domain [].The timeless gene in Drosophila melanogasteris involved in circadian rhythm control []. Drosophila contains two paralogs, dTIM and dTIM2, acting in clock/photoreception and chromosome integrity/photoreception respectively. The mammalian TIMELESS (TIM) protein, originally identified based on its similarity to Drosophila dTIM, interacts with the clock proteins dCRY and dPER and is essential for circadian rhythm generation and photo-entrainment in the fly []. However, phylogenetic sequence analysis has demonstrated that dTIM2 is likely to be the orthologue of mammalian TIM and other widely conserved TIM-like proteins in eukaryotes []. These proteins include Saccharomyces cerevisiae Tof1, Schizosaccharomyces pombe Swi1, and Caenorhabditis elegans TIM. These proteins are not involved in the core clock mechanism, but instead play important roles in chromosome integrity, efficient cell growth and/or development [, ], with the exception of dTIM-2, that has an additional function in retinal photoreception [].Saccharomyces cerevisiae Tof1 is a subunit of a replication-pausing checkpoint complex (Tof1-Mrc1-Csm3) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA [, ]. Schizosaccharomyces pombe Swi1 and Swi3 form the fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks []. In humans timeless forms a stable complex with its partner protein Tipin. The Timeless-Tipin complex has been reported to travel along with the replication fork during unperturbed DNA replication. Moreover, the Timeless-Tipin-Claspin complex contributes to full activation of the ATR-Chk1 signaling pathway through the recruitment of Chk1 to arrested replication forks for sufficient ATR-mediated phosphorylation. It also interacts with PARP-1, and this interaction is required for efficient homologous recombination repair [].
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Publication
10807566 | J:62075
First Author: Shearman LP
Year: 2000
Journal: Science
Title: Interacting molecular loops in the mammalian circadian clock.
Volume: 288
Issue: 5468
Pages: 1013-9
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Publication
14742714 | -
First Author: Mayer ML
Year: 2004
Journal: Mol Biol Cell
Title: Identification of protein complexes required for efficient sister chromatid cohesion.
Volume: 15
Issue: 4
Pages: 1736-45
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Publication
15755447 | -
First Author: Nedelcheva MN
Year: 2005
Journal: J Mol Biol
Title: Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.
Volume: 347
Issue: 3
Pages: 509-21
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Protein Domain
IPR040038 | TIPIN/Csm3/Swi3
Type: Family
Description: Proteins in this family contain a domain found in yeast chromosome segregation in meiosis protein 3. Proteins include:Chromosome segregation in meiosis protein 3, which is required for required for chromosome segregation during meiosis and DNA damage repair, forming a fork protection complex with TOF1 [, ].TIMELESS-interacting protein (also known as TIPIN), which is a nuclear protein that associates with the replicative helicase, and is required for efficient cell cycle arrest in response to DNA damage. It forms a checkpoint complex with TIMELESS []. Protein TIPIN homolog, which is the orthologue of TIPIN from Caenorhabditis elegans and Drosophila melanogaster.Swi1-interacting protein swi3, from Schizosaccharomyces pombe, which forms a fork protection complex with swi1 [].
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Protein
Q91WA1
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
A0A1L1SUJ5
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Protein
A0A1L1SUT4
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
A0A1L1STK1
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Publication
24427314 | J:211935
First Author: Dorval V
Year: 2014
Journal: PLoS One
Title: Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.
Volume: 9
Issue: 1
Pages: e85510
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Publication
20568244 | J:161796
First Author: Kumada T
Year: 2010
Journal: Dev Dyn
Title: Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development.
Volume: 239
Issue: 8
Pages: 2233-45
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Publication
19402751 | J:150484
First Author: Hennig S
Year: 2009
Journal: PLoS Biol
Title: Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2.
Volume: 7
Issue: 4
Pages: e94
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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