Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606213 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 8.5 |
Image: |
5A |
Note: |
Expression was detected in the definitive endoderm. |
Specimen Label: |
5A |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606213 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 8.5 |
Image: |
5C |
|
Specimen Label: |
5C |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606215 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 9.5 |
Image: |
6A |
|
Specimen Label: |
6A |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606215 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 9.5 |
Image: |
6C |
|
Specimen Label: |
6C |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606217 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 10.5 |
Image: |
7H |
|
Specimen Label: |
7H |
Detected: |
true |
Specimen Num: |
28 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7706009 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-08-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606215 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7706021 |
Age: |
embryonic day 9.5 |
Image: |
1b |
|
Specimen Label: |
1b |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7856980 |
Assay Type: |
RNA in situ |
Annotation Date: |
2025-02-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1667017 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7857174 |
Age: |
embryonic day 10.5 |
|
Note: |
Expression notably absent from surrounding mesenchyme. |
Specimen Label: |
S2A |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3718603 |
Assay Type: |
RNA in situ |
Annotation Date: |
2007-08-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1625012 |
Pattern: |
Not Specified |
Stage: |
TS12 |
Assay Id: |
MGI:3718640 |
Age: |
embryonic day 8.25 |
Image: |
4M |
|
Specimen Label: |
4M |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1625013 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 8.5 |
Image: |
5A |
|
Specimen Label: |
5A |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619117 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 10.5 |
Image: |
7H |
|
Specimen Label: |
7H |
Detected: |
false |
Specimen Num: |
28 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615434 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-29 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3618173 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615434 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-29 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3618173 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672320 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 12.5 |
Image: |
8D |
Note: |
Expression was detected in the salivary glands. |
Specimen Label: |
8D |
Detected: |
true |
Specimen Num: |
33 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1657715 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 9.5 |
Image: |
6D |
|
Specimen Label: |
6D |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1657717 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 10.5 |
Image: |
7A |
|
Specimen Label: |
7A |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1657717 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 10.5 |
Image: |
7C |
|
Specimen Label: |
7C |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5486197 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1657717 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5486214 |
Age: |
embryonic day 10.5 |
Image: |
7D |
|
Specimen Label: |
7D |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6514298 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-04-01 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3801319 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6514312 |
Age: |
embryonic day 11.5 |
Image: |
3D/D' |
|
Specimen Label: |
3D/D' |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
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Spruce T |
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2022 |
Journal: |
PLoS Biol |
Title: |
The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians. |
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20 |
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4 |
Pages: |
e3001615 |
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•
•
•
•
•
|
Publication |
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2010 |
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Genesis |
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Ectoderm, endoderm, and the evolution of heterodont dentitions. |
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6 |
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•
•
•
•
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2017 |
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•
•
•
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2016 |
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Grainyhead-like 2 downstream targets act to suppress epithelial-to-mesenchymal transition during neural tube closure. |
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143 |
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7 |
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1192-204 |
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•
•
•
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2020 |
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Dis Model Mech |
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Dis Model Mech |
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•
•
•
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•
•
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•
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Mouse Genome Informatics Scientific Curators |
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MGC Data curation in Mouse Genome Informatics |
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MGI and IMPC |
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Database Release |
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Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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Database Release |
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PLoS Biol |
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•
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Mouse Genome Informatics Scientific Curators |
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Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Nomenclature Committee Use |
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Proc Natl Acad Sci U S A |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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Database Download |
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Mouse Gene Trap Data Load from dbGSS |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
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Mouse Genome Informatics Scientific Curators |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
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The RNA-binding protein ESRP1 promotes human colorectal cancer progression. |
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•
•
•
•
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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•
•
•
•
•
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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•
•
•
•
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Publication |
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Warzecha CC |
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5 |
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546-62 |
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•
•
•
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Interaction Experiment |
Description: |
The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells. |
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•
•
•
•
•
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Publication |
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Fagoonee S |
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PLoS One |
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The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells. |
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e72300 |
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DO Term |
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•
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Publication |
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RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer. |
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3 |
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490-7 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the RNA recognition motif 1 (RRM1) of epithelial splicing regulatory protein 1 (ESRP1). ESRP1 has been identified as an epithelial cell type-specific regulator of fibroblast growth factor receptor 2 (FGFR2) splicing []. It is required for expression of epithelial FGFR2-IIIb and the regulation of CD44, CTNND1 (p120-Catenin) and ENAH (hMena) splicing. It enhances epithelial-specific exons of CD44 and ENAH, silences mesenchymal exons of CTNND1, or both within FGFR2 []. ESRP1 has been shown to function as a tumour suppressor in colon cancer cells, due to its ability to bind to the 5' UTR of several cancer-related genes and regulate their translation []. However, high ESRP1 expression has been linked to colorectal cancer progression []. ESRP1 contains three RNA recognition motifs (RRMs). |
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HT Experiment |
Series Id: |
GSE64357 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Publication |
First Author: |
Zhang H |
Year: |
2019 |
Journal: |
Genes Dev |
Title: |
CD44 splice isoform switching determines breast cancer stem cell state. |
Volume: |
33 |
Issue: |
3-4 |
Pages: |
166-179 |
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Publication |
First Author: |
Caetano da Silva C |
Year: |
2024 |
Journal: |
Commun Biol |
Title: |
Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. |
Volume: |
7 |
Issue: |
1 |
Pages: |
1040 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
680
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
659
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
681
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Fragment?: |
false |
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Publication |
First Author: |
Joo JH |
Year: |
2013 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Transcriptomic analysis of PNN- and ESRP1-regulated alternative pre-mRNA splicing in human corneal epithelial cells. |
Volume: |
54 |
Issue: |
1 |
Pages: |
697-707 |
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Publication |
First Author: |
Supplee JG |
Year: |
2024 |
Journal: |
J Biol Chem |
Title: |
ACLY alternative splicing correlates with cancer phenotypes. |
Volume: |
300 |
Issue: |
7 |
Pages: |
107418 |
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