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Search results 2601 to 2700 out of 7122 for App

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Type Details Score
Publication
32032729 | J:297609
 
First Author: Borreca A
Year: 2020
Journal: Neurobiol Dis
Title: Transient upregulation of translational efficiency in prodromal and early symptomatic Tg2576 mice contributes to Aβ pathology.
Volume: 139
Pages: 104787
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Publication
21295112 | J:170855
First Author: Ma K
Year: 2011
Journal: Neurosci Lett
Title: Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice.
Volume: 492
Issue: 1
Pages: 5-10
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Gene
4353 | MPO
Type: gene
Organism: human
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Allele
Tg(Thy1-APPSwe)71Jgr | MGI:4839764
Name: transgene insertion 71, J Richards
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Thy1-APPSweInd,-PSEN1*M146V*L286V)5Gpt | MGI:7307395
Name: transgene insertion 5, GemPharmatech Co., Ltd
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
App<em1Smoc> | MGI:7288307
Name: amyloid beta precursor protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Tg(CMV-APPSwe)3Wcx | MGI:7543606
Name: transgene insertion 3, Wen-Cheng Xiong
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Allele
Tg(Thy1-APPSwe,-MAPT*P301L,-PSEN1*M146V)17Gpt | MGI:7576549
Name: transgene insertion 17, GemPharmatech
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Del(16App-Runx1)5Yah/+
Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16App-Runx1)5Yah/+
Background: involves: C3H * C57BL/6N
Zygosity: ht
Has Mutant Allele: true
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Allele
Tg(PRNP-APPSweInd)8Dwst | MGI:3589475
Name: transgene insertion 8, David Westaway
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(tetO-APPSwInd)107Dbo | MGI:3708462
Name: transgene insertion 107, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Genotype
Genotype
Symbol: Vps35/Vps35<+> Tg(APPSWE)2576Kha/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-APPSweArc)#Rmni/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Publication
37496076 | J:338543
First Author: Farfara D
Year: 2023
Journal: J Neuroinflammation
Title: Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice.
Volume: 20
Issue: 1
Pages: 174
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Genotype
Genotype
Symbol: Tg(APP695)3Dbo/? Tg(PSEN1)5Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-ITM2B/APP695*42)A12Emcg/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-APPSwInd)107Dbo/?
Background: (FVB/NJ x B6.Cg-Tg(tetO-APPSwInd)107Dbo Tg(Camk2a-tTA)1Mmay)F1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
17135361 | J:129755
First Author: Liu Q
Year: 2007
Journal: FASEB J
Title: Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model.
Volume: 21
Issue: 1
Pages: 61-73
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Publication
16876915 | J:128080
First Author: Knobloch M
Year: 2007
Journal: Neurobiol Aging
Title: Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice.
Volume: 28
Issue: 9
Pages: 1297-306
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Publication
23667698 | J:200531
First Author: Takasugi N
Year: 2013
Journal: PLoS One
Title: FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.
Volume: 8
Issue: 5
Pages: e64050
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Protein
Q61482
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
Q3UDL6
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q60709
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q3TV12
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
Q3U775
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein Domain
IPR024329 | Amyloid_glyco_E2_domain
Type: Domain
Description: Amyloid-beta precursor protein (APP, or A4) is associated with Alzheimer's disease (AD), because one of its breakdown products, amyloid-beta (A-beta), aggregates to form amyloid or senile plaques [, , ]. Mutations in APP or in proteins that process APP have been linked with early-onset, familial AD. Individuals with Down's syndrome carry an extra copy of chromosome 21, which contains the APP gene, and almost invariably develop amyloid plaques and Alzheimer's symptoms.APP is important for the neurogenesis and neuronal regeneration, either through the intact protein, or through its many breakdown products [, ]. APP consists of a large N-terminal extracellular region containing heparin-binding and copper-binding sites, Kunitz domain, E2 domain, a short hydrophobic transmembrane domain, and a short C-terminal intracellular domain. The N-terminal region is similar in structure to cysteine-rich growth factors and appears to function as a cell surface receptor, contributing to neurite growth, neuronal adhesion, axonogenesis and cell mobility []. APP acts as a kinesin I membrane receptor to mediate the axonal transport of beta-secretase and presenilin 1. The N-terminal domain can regulate neurite outgrowth through its binding to heparin and collagen I and IV, which are components of the extracellular matrix. APP is also coupled to apoptosis-inducing pathways, and is involved in copper homeostasis/oxidative stress through copper ion reduction, where copper-metallated APP induces neuronal death [, ]. The C-terminal intracellular domain appears to be involved in transcription regulation through protein-protein interactions. APP can promote transcription activation through binding to APBB1/Tip60, and may bind to the adaptor protein FE65 to transactivate a wide variety of different promoters.APP can be processed by different sets of enzymes:In the non-amyloidogenic (non-plaque-forming) pathway, APP is cleaved by alpha-secretase to yield a soluble N-terminal sAPP-alpha (neuroprotective) and a membrane-bound CTF-alpha. CTF-alpha is broken-down by presenilin-containing gamma-secretase to yield soluble p3 and membrane-bound AICD (nuclear signalling). In the amyloidogenic pathway (plaque-forming), APP is broken down by beta-secretase to yield soluble sAPP-beta and membrane-bound CTF-beta. CTF-beta is broken down by gamma-secretase to yield soluble amyloid-beta and membrane-bound AICD. Amyloid-beta is required for neuronal function, but can aggregate to form amyloid plaques that seem to disrupt brain cells by clogging points of cell-cell contact.The E2 domain is the largest of the conserved domains in the amyloidogenic glycoproteins. The structure of E2 consists of two coiled-coil sub-structures connected through a continuous helix, and bears an unexpected resemblance to the spectrin family of protein structures. E2 can reversibly dimerise in solution, and the dimerisation occurs along the longest dimension of the molecule in an antiparallel orientation, which enables the N-terminal substructure of one monomer to pack against the C-terminal substructure of a second monomer. The high degree of conservation of residues at the putative dimer interface suggests that the E2 dimer observed in the crystal could be physiologically relevant. Heparin sulphate proteoglycans, the putative ligands for the precursor present in extracellular matrix, bind to E2 at a conserved and positively charged site near the dimer interface []. The E2 domain is also known as CAPPD (for central APP domain) [].
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Allele
Tg(DMD-APP*)18Neve | MGI:3720650
Name: transgene insertion 18, Rachel L Neve
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: App/App Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: C57BL/6 * DBA/2 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(EIF1AX-Aldh2*E487K)101Oht/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Publication
39528445 | J:358423
First Author: Li C
Year: 2024
Journal: Cell Death Dis
Title: GNG5 is a novel regulator of Aβ42 production in Alzheimer's disease.
Volume: 15
Issue: 11
Pages: 815
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Publication
38473822 | J:348938
 
First Author: Romero-Molina C
Year: 2024
Journal: Int J Mol Sci
Title: Autosomal Dominant Alzheimer's Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice.
Volume: 25
Issue: 5
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Publication
35236834 | J:342927
First Author: Zhao Y
Year: 2022
Journal: Nat Commun
Title: ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
Volume: 13
Issue: 1
Pages: 1121
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Genotype
Genotype
Symbol: Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APP)28Lpr/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Publication
10195200 | J:56016
First Author: Iadecola C
Year: 1999
Journal: Nat Neurosci
Title: SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein.
Volume: 2
Issue: 2
Pages: 157-61
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Publication
11520987 | J:100965
First Author: Lewis J
Year: 2001
Journal: Science
Title: Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
Volume: 293
Issue: 5534
Pages: 1487-91
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Genotype
Genotype
Symbol: Tg(Thy1-APPLon)2Vln/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APP695)3Dbo/? Tg(PSEN1dE9)S9Dbo/?
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Publication
17331621 | J:140920
First Author: Kobayashi D
Year: 2008
Journal: Neurobiol Aging
Title: BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.
Volume: 29
Issue: 6
Pages: 861-73
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Publication
13678674 | J:306029
First Author: Sheng JG
Year: 2003
Journal: Neurobiol Dis
Title: Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice.
Volume: 14
Issue: 1
Pages: 133-45
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Publication
25018730 | J:288957
 
First Author: Christensen DZ
Year: 2014
Journal: Front Aging Neurosci
Title: Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation.
Volume: 6
Pages: 139
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Publication
39110781 | J:353793
First Author: Han J
Year: 2024
Journal: Sci Transl Med
Title: Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas-based epigenome editing in Alzheimer's disease.
Volume: 16
Issue: 759
Pages: eadi4830
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Publication
28806762 | J:244104
First Author: Rocchi A
Year: 2017
Journal: PLoS Genet
Title: A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
Volume: 13
Issue: 8
Pages: e1006962
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Publication
36359919 | J:348209
 
First Author: Siddik MAB
Year: 2022
Journal: Cells
Title: Branched-Chain Amino Acids Are Linked with Alzheimer's Disease-Related Pathology and Cognitive Deficits.
Volume: 11
Issue: 21
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HT Experiment
GSE214244 | Single nucleus RNA-seq of brain regions showing high-low Abeta plaque pathology in a mouse model of Alzheimer's disease
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
18184372 | J:145588
 
First Author: Le Cudennec C
Year: 2008
Journal: Genes Brain Behav
Title: One-year longitudinal evaluation of sensorimotor functions in APP751SL transgenic mice.
Volume: 7 Suppl 1
Pages: 83-91
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Publication
17007963 | J:130697
First Author: Barrier L
Year: 2007
Journal: Neurobiol Aging
Title: Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease.
Volume: 28
Issue: 12
Pages: 1863-72
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Publication
15816856 | J:98306
First Author: Santiard-Baron D
Year: 2005
Journal: J Neurochem
Title: Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in beta-amyloid load.
Volume: 93
Issue: 2
Pages: 330-8
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Publication
20034479 | J:158786
 
First Author: Michelsen KA
Year: 2010
Journal: Brain Res
Title: Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease.
Volume: 1316
Pages: 139-44
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Publication
18295378 | J:152956
First Author: Hauptmann S
Year: 2009
Journal: Neurobiol Aging
Title: Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice.
Volume: 30
Issue: 10
Pages: 1574-86
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Publication
21793038 | J:284875
First Author: Rockenstein E
Year: 2011
Journal: J Neurosci Res
Title: Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease.
Volume: 89
Issue: 11
Pages: 1812-21
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Publication
33230162 | J:300222
First Author: Yang T
Year: 2020
Journal: Sci Rep
Title: Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies.
Volume: 10
Issue: 1
Pages: 20322
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Publication
27313503 | J:288959
 
First Author: Löffler T
Year: 2016
Journal: Front Neurosci
Title: Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice Is Associated with BBB Dysfunction.
Volume: 10
Pages: 232
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Publication
19741145 | J:204270
First Author: Yamada K
Year: 2009
Journal: J Neurosci
Title: Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta.
Volume: 29
Issue: 36
Pages: 11393-8
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Publication
22542680 | J:192436
 
First Author: Cai Y
Year: 2012
Journal: Neuroscience
Title: An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation.
Volume: 215
Pages: 160-73
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Genotype
Genotype
Symbol: Tg(APP695)3Dbo/? Tg(PSEN1)5Dbo/?
Background: B6.Cg-Tg(APP695)3Dbo Tg(PSEN1)5Dbo
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPLon)2Vln/? Tg(Thy1-BACE1)16Vln/?
Background: involves: C57BL/6 * DBA * FVB/N
Zygosity: cx
Has Mutant Allele: true
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GO Term
GO:1902945 | metalloendopeptidase activity involved in amyloid precursor protein catabolic process
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Publication
23833557 | J:202532
First Author: Lee JE
Year: 2013
Journal: Exp Neurobiol
Title: An update of animal models of Alzheimer disease with a reevaluation of plaque depositions.
Volume: 22
Issue: 2
Pages: 84-95
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Publication
34505007 | J:313520
First Author: Aguilar-Pineda JA
Year: 2021
Journal: iScience
Title: Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease.
Volume: 24
Issue: 9
Pages: 102993
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Publication
33846335 | J:311263
First Author: Kim K
Year: 2021
Journal: Nat Commun
Title: Therapeutic B-cell depletion reverses progression of Alzheimer's disease.
Volume: 12
Issue: 1
Pages: 2185
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Publication
35961653 | J:352637
First Author: Israel LL
Year: 2022
Journal: ACS Nano
Title: Signature Effects of Vector-Guided Systemic Nano Bioconjugate Delivery Across Blood-Brain Barrier of Normal, Alzheimer's, and Tumor Mouse Models.
Volume: 16
Issue: 8
Pages: 11815-11832
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Publication
37402372 | J:340719
First Author: Wu Y
Year: 2023
Journal: Neuron
Title: Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer's disease in mice.
Volume: 111
Issue: 18
Pages: 2847-2862.e10
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Publication
28802038 | J:242830
First Author: Ulland TK
Year: 2017
Journal: Cell
Title: TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Volume: 170
Issue: 4
Pages: 649-663.e13
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Publication
24853300 | J:230012
First Author: Kook SY
Year: 2014
Journal: Cell Death Differ
Title: Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model.
Volume: 21
Issue: 10
Pages: 1575-87
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Publication
37713312 | J:341732
First Author: Lin CJ
Year: 2023
Journal: Cell Rep
Title: Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice.
Volume: 42
Issue: 9
Pages: 113141
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Publication
39696597 | J:360170
First Author: Evans AK
Year: 2024
Journal: J Neuroinflammation
Title: Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer's disease.
Volume: 21
Issue: 1
Pages: 322
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Publication
36890231 | J:355378
First Author: Chen X
Year: 2023
Journal: Nature
Title: Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.
Volume: 615
Issue: 7953
Pages: 668-677
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Publication
30700530 | J:273604
First Author: de Pins B
Year: 2019
Journal: J Neurosci
Title: Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease.
Volume: 39
Issue: 13
Pages: 2441-2458
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Publication
32541832 | J:306642
First Author: Masuda T
Year: 2020
Journal: Nat Immunol
Title: Novel Hexb-based tools for studying microglia in the CNS.
Volume: 21
Issue: 7
Pages: 802-815
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Publication
26884167 | J:231007
First Author: Marsh SE
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function.
Volume: 113
Issue: 9
Pages: E1316-25
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Publication
30012602 | J:267741
First Author: Patel D
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory.
Volume: 115
Issue: 31
Pages: E7408-E7417
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Publication
36682514 | J:352196
 
First Author: Rangasamy SB
Year: 2023
Journal: Brain Behav Immun
Title: Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease.
Volume: 109
Pages: 204-218
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Publication
30894406 | J:284813
 
First Author: Pierrot N
Year: 2019
Journal: Life Sci Alliance
Title: Sex-regulated gene dosage effect of PPARα on synaptic plasticity.
Volume: 2
Issue: 2
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Publication
32315292 | J:301822
 
First Author: Patel D
Year: 2020
Journal: JCI Insight
Title: Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα.
Volume: 5
Issue: 10
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Publication
37437568 | J:339131
First Author: Paidi RK
Year: 2023
Journal: Cell Rep
Title: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice.
Volume: 42
Issue: 7
Pages: 112717
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Publication
37580742 | J:339360
First Author: Comerota MM
Year: 2023
Journal: Mol Neurodegener
Title: Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer's disease.
Volume: 18
Issue: 1
Pages: 56
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Publication
29967008 | J:265695
First Author: Chandra S
Year: 2018
Journal: J Neurosci
Title: Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα.
Volume: 38
Issue: 30
Pages: 6682-6699
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Publication
30578827 | J:277511
 
First Author: Chandra S
Year: 2019
Journal: Neurobiol Dis
Title: Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model.
Volume: 124
Pages: 379-395
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Publication
37198698 | J:346272
First Author: Suelves N
Year: 2023
Journal: Acta Neuropathol Commun
Title: Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology.
Volume: 11
Issue: 1
Pages: 82
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•
•
•
•
Publication
34622466 | J:318690
First Author: Sankowski R
Year: 2021
Journal: EMBO J
Title: Commensal microbiota divergently affect myeloid subsets in the mammalian central nervous system during homeostasis and disease.
Volume: 40
Issue: 23
Pages: e108605
•
•
•
•
•
Publication
39106304 | J:353874
First Author: Wei X
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: A therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice.
Volume: 121
Issue: 33
Pages: e2400420121
•
•
•
•
•
Publication
22307640 | J:182028
First Author: You H
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors.
Volume: 109
Issue: 5
Pages: 1737-42
•
•
•
•
•
Publication
37291385 | J:337758
First Author: Mendiola AS
Year: 2023
Journal: Nat Immunol
Title: Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.
Volume: 24
Issue: 7
Pages: 1173-1187
•
•
•
•
•
Publication
30352630 | J:279643
First Author: Müller MK
Year: 2018
Journal: Acta Neuropathol Commun
Title: NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice.
Volume: 6
Issue: 1
Pages: 110
•
•
•
•
•
Publication
31257024 | J:278330
First Author: Heckmann BL
Year: 2019
Journal: Cell
Title: LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.
Volume: 178
Issue: 3
Pages: 536-551.e14
•
•
•
•
•
Publication
35348636 | J:360156
First Author: Greve HJ
Year: 2023
Journal: Brain
Title: The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment.
Volume: 146
Issue: 3
Pages: 991-1005
•
•
•
•
•
Publication
38624088 | J:350434
First Author: Ahmed C
Year: 2024
Journal: Alzheimers Dement
Title: Peripheral HMGB1 is linked to O(3) pathology of disease-associated astrocytes and amyloid.
Volume: 20
Issue: 5
Pages: 3551-3566
•
•
•
•
•
Publication
19767128 | J:176716
First Author: Mijatovic J
Year: 2011
Journal: Neurobiol Aging
Title: Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals.
Volume: 32
Issue: 8
Pages: 1486-94
•
•
•
•
•
Publication
38159571 | J:348203
First Author: Millet A
Year: 2024
Journal: Immunity
Title: An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer's brains.
Volume: 57
Issue: 1
Pages: 153-170.e6
•
•
•
•
•
Publication
38301863 | J:348172
 
First Author: Eisenbaum M
Year: 2024
Journal: Exp Neurol
Title: Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain.
Volume: 374
Pages: 114702
•
•
•
•
•
Publication
33813349 | J:311279
 
First Author: Cacciottolo M
Year: 2021
Journal: Neurobiol Aging
Title: Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice.
Volume: 103
Pages: 42-51
•
•
•
•
•
Publication
33178186 | J:311287
 
First Author: Ma QL
Year: 2020
Journal: Front Immunol
Title: The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models.
Volume: 11
Pages: 558036
•
•
•
•
•
Publication
32758917 | J:299539
 
First Author: Ringland C
Year: 2020
Journal: Neurobiol Aging
Title: Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease.
Volume: 95
Pages: 56-68
•
•
•
•
•
Publication
28612048 | J:255879
 
First Author: Moser VA
Year: 2017
Journal: eNeuro
Title: Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice.
Volume: 4
Issue: 3
•
•
•
•
•
Publication
31461505 | J:284309
First Author: Hoffman JD
Year: 2019
Journal: PLoS One
Title: Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model.
Volume: 14
Issue: 8
Pages: e0221828
•
•
•
•
•




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