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Search results 201 to 212 out of 212 for Cxcr6

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0.017s

Type

Details

Score

Protein

D9YM45

Organism:	Mus musculus/domesticus
Length:	119
Fragment?:	false

•

Protein

I7HIQ2

Organism:	Mus musculus/domesticus
Length:	233
Fragment?:	true

•

Protein

A2CFE9

Organism:	Mus musculus/domesticus
Length:	246
Fragment?:	false

•

Publication

15128827 | -

First Author:	Abel S
Year:	2004
Journal:	J Immunol
Title:	The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Volume:	172
Issue:	10
Pages:	6362-72

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Protein Domain

IPR026296 | CXCL16

Type:

Family

Description:

Chemokines are proteins that have important physiological and pathophysiological roles in a wide range of acute and chronic inflammatory processes []. Chemokines exert their biological effects by binding to cell surface receptors. Their sequences are similar and are characterised by a 4-cysteine motif: the family can be divided according to whether the first 2Cys residues are adjacent (the C-C family), separated by an intervening residue (the C-x-C family), have only one of the first two Cys residues (C chemokines), or contain both cysteines, separated by threeintervening residues (C-x3-C chemokines). This entry represents a novel chemokine, chemokine (C-X-C motif) ligand 16 (CXCL16), has been identified that is a member of the C-X-C family [, ], it is also called SR-PSOX. Despite possessing the CXC motif, however, it is distantly related to the other family members and has greatest sequence similarity to members of the C-C family []. CXCL16 also differs in structure from the other family members (all of which are secreted proteins) and contains a TM domain linked to the chemokine domain by a heavily glycosylated mucin stalk. This structure is similar to that of the CX3C chemokine ligand 1 (CX3C chemokine fractalkine), the only other known chemokine with a TM domain. CXCL16 has been found to be expressed in the spleen, lymph nodes, Peyer's patches and thymus. In non-lymphoid tissues, CXCL16 is found in the lung, small intestine, kidney, heart and liver []. The chemokine appears to be expressed as a membrane-bound cell surface ligand on antigen presenting cells (APCs), such as B cells and macrophages []. CXCL16 can also be shed from the cell surface in an active, soluble form [, ]. These two forms may have different functions. Expression of CXCL16 is upregulated by exposure to inflammatory stimuli.CXCL16 induces a strong chemotactic response. It induces calcium mobilisation and binds to chemokine receptor CXCR6 and HIV-coreceptor Bonzo [, ]. It also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis []. Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha [].

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Publication

25683115 | J:309413

First Author:	Chalabi-Dchar M
Year:	2015
Journal:	Gastroenterology
Title:	Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16.
Volume:	148
Issue:	7
Pages:	1452-65

•

Publication

11544102 | -

First Author:	Horuk R
Year:	2001
Journal:	Cytokine Growth Factor Rev
Title:	Chemokine receptors.
Volume:	12
Issue:	4
Pages:	313-35

•

Publication

9689100 | J:49070

First Author:	Ma Q
Year:	1998
Journal:	Proc Natl Acad Sci U S A
Title:	Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume:	95
Issue:	16
Pages:	9448-53

•

Publication

10601351 | -

First Author:	Charbonnier AS
Year:	1999
Journal:	J Exp Med
Title:	Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume:	190
Issue:	12
Pages:	1755-68

•

Publication

9500790 | -

First Author:	Sallusto F
Year:	1998
Journal:	J Exp Med
Title:	Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume:	187
Issue:	6
Pages:	875-83

•

Publication

7592998 | -

First Author:	Strieter RM
Year:	1995
Journal:	J Biol Chem
Title:	The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume:	270
Issue:	45
Pages:	27348-57

•

Publication

10714678 | -

First Author:	Zlotnik A
Year:	2000
Journal:	Immunity
Title:	Chemokines: a new classification system and their role in immunity.
Volume:	12
Issue:	2
Pages:	121-7

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