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Search results 201 to 300 out of 302 for Vdac1

0.037s
Type Details Score
Publication
First Author: Martin J
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.
Volume: 310
Issue: 7
Pages: G497-509
Publication
First Author: Weis VG
Year: 2016
Journal: Cell Mol Gastroenterol Hepatol
Title: Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum.
Volume: 2
Issue: 2
Pages: 131-157
Publication
First Author: Schatton D
Year: 2017
Journal: J Cell Biol
Title: CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Volume: 216
Issue: 3
Pages: 675-693
Publication
First Author: Alsina D
Year: 2020
Journal: EMBO Mol Med
Title: FBXL4 deficiency increases mitochondrial removal by autophagy.
Volume: 12
Issue: 7
Pages: e11659
Publication
First Author: Journiac N
Year: 2020
Journal: Cell Rep
Title: Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.
Volume: 31
Issue: 2
Pages: 107506
Publication
First Author: Chae SA
Year: 2022
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism.
Volume: 323
Issue: 5
Pages: R728-R738
Publication
First Author: Meng TG
Year: 2023
Journal: Adv Sci (Weinh)
Title: NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition.
Volume: 10
Issue: 27
Pages: e2301940
Publication
First Author: Kohr MJ
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Characterization of potential S-nitrosylation sites in the myocardium.
Volume: 300
Issue: 4
Pages: H1327-35
Publication
First Author: Poché RA
Year: 2016
Journal: Cell Rep
Title: RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina.
Volume: 14
Issue: 7
Pages: 1684-1697
Publication
First Author: Wertz K
Year: 2000
Journal: Mech Dev
Title: Large-scale screen for genes involved in gonad development.
Volume: 98
Issue: 1-2
Pages: 51-70
Publication
First Author: Da Cruz S
Year: 2003
Journal: J Biol Chem
Title: Proteomic analysis of the mouse liver mitochondrial inner membrane.
Volume: 278
Issue: 42
Pages: 41566-71
Publication
First Author: Werner HB
Year: 2007
Journal: J Neurosci
Title: Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
Volume: 27
Issue: 29
Pages: 7717-30
Publication      
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
Publication
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
Publication
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Strain
Attribute String: congenic, gene trap, mutant strain
Publication
First Author: Zhang E
Year: 2019
Journal: Cell Metab
Title: Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells.
Volume: 29
Issue: 1
Pages: 64-77.e6
Publication
First Author: Wu NN
Year: 2023
Journal: Exp Mol Med
Title: Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis.
Volume: 55
Issue: 1
Pages: 269-280
Publication
First Author: Chaudhuri AD
Year: 2016
Journal: J Biol Chem
Title: MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression.
Volume: 291
Issue: 12
Pages: 6483-93
Publication
First Author: Yan C
Year: 2016
Journal: PLoS One
Title: CFTR Deletion in Mouse Testis Induces VDAC1 Mediated Inflammatory Pathway Critical for Spermatogenesis.
Volume: 11
Issue: 8
Pages: e0158994
Interaction Experiment
Description: TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control.
GXD Expression
Probe: MGI:6507611
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-07
Strength: Present
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6850045
Age: postnatal adult
Image: 4C
Note: Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells.
Specimen Label: 4C
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6507611
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-07
Strength: Present
Sex: Male
Emaps: EMAPS:2965528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6850045
Age: postnatal adult
Image: 4C
Note: Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells.
Specimen Label: 4C
Detected: true
Specimen Num: 2
Allele
Name: transgene insertion JF127, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: mutant stock, transgenic
Publication
First Author: Anflous-Pharayra K
Year: 2011
Journal: Biochim Biophys Acta
Title: VDAC3 has differing mitochondrial functions in two types of striated muscles.
Volume: 1807
Issue: 1
Pages: 150-6
Publication
First Author: Hinsch KD
Year: 2001
Journal: Biochim Biophys Acta
Title: VDAC2 (porin-2) expression pattern and localization in the bovine testis.
Volume: 1518
Issue: 3
Pages: 329-33
Publication
First Author: Angelini A
Year: 2021
Journal: Cell Rep
Title: PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes.
Volume: 37
Issue: 1
Pages: 109767
Publication
First Author: Lee J
Year: 2021
Journal: Sci Rep
Title: Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer.
Volume: 11
Issue: 1
Pages: 4181
Publication
First Author: Majumder S
Year: 2012
Journal: Cell Cycle
Title: VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes.
Volume: 11
Issue: 19
Pages: 3666-78
Publication
First Author: Majumder S
Year: 2013
Journal: Cell Cycle
Title: VDAC3 and Mps1 negatively regulate ciliogenesis.
Volume: 12
Issue: 5
Pages: 849-58
Publication
First Author: Sampson MJ
Year: 2001
Journal: J Biol Chem
Title: Immotile sperm and infertility in mice lacking mitochondrial voltage-dependent anion channel type 3.
Volume: 276
Issue: 42
Pages: 39206-12
Publication
First Author: Checchetto V
Year: 2014
Journal: Cell Physiol Biochem
Title: Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance.
Volume: 34
Issue: 3
Pages: 842-53
Publication
First Author: Cheng EH
Year: 2003
Journal: Science
Title: VDAC2 inhibits BAK activation and mitochondrial apoptosis.
Volume: 301
Issue: 5632
Pages: 513-7
Publication
First Author: Roy SS
Year: 2009
Journal: EMBO Rep
Title: VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria.
Volume: 10
Issue: 12
Pages: 1341-7
Publication
First Author: Veresov VG
Year: 2014
Journal: Cell Signal
Title: Structural insights into proapoptotic signaling mediated by MTCH2, VDAC2, TOM40 and TOM22.
Volume: 26
Issue: 2
Pages: 370-82
Protein Domain
Type: Family
Description: This entry includes VDAC3 from animals. Recombinant VDAC3 shows a channel activity with a very small conductance []. VDAC3 is involved in the transport of ADP across the mitochondrial outer membrane in the cardiac muscle (oxidative muscle) but not in the gastrocnemius muscle (mixed muscle) []. VDAC3 is also a centrosomal protein that interacts with the centrosomal protein kinase Mps1 []. VDAC3 and Mps1 negatively regulate ciliogenesis; they promote ciliary disassembly during cell cycle entry and suppress cilia assembly in proliferating cells []. Mice lacking VDAC3 suffered from immotile sperm and infertility [].Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) []and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic β-strands barrel with an N-terminal α-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ].
Protein Domain
Type: Family
Description: VDAC2 is a voltage dependent anion channel that mediates the flow of metabolites and ions across the outer mitochondrial membrane. It may play a role in mitochondrial apoptosis through its involvement in the mitochondrial recruitment of BAK, a protein belonging to the BCL-2 protein family [, , ].Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) []and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic β-strands barrel with an N-terminal α-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ].
Publication
First Author: Liu C
Year: 2016
Journal: Aging Cell
Title: The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment.
Volume: 15
Issue: 1
Pages: 167-76
Publication
First Author: Fazal L
Year: 2017
Journal: Circ Res
Title: Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.
Volume: 120
Issue: 4
Pages: 645-657
Publication
First Author: Kielar C
Year: 2009
Journal: Hum Mol Genet
Title: Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease.
Volume: 18
Issue: 21
Pages: 4066-80
Publication
First Author: Yang X
Year: 2015
Journal: PLoS One
Title: Gene co-expression network analysis provides novel insights into myostatin regulation at three different mouse developmental timepoints.
Volume: 10
Issue: 2
Pages: e0117607
Publication
First Author: Behar V
Year: 2018
Journal: J Invest Dermatol
Title: A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses.
Volume: 138
Issue: 12
Pages: 2635-2643
Publication  
First Author: Ha BG
Year: 2021
Journal: Int J Mol Sci
Title: Depletion of Mitochondrial Components from Extracellular Vesicles Secreted from Astrocytes in a Mouse Model of Fragile X Syndrome.
Volume: 22
Issue: 1
Publication
First Author: Huang H
Year: 2013
Journal: J Biol Chem
Title: An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.
Volume: 288
Issue: 27
Pages: 19870-81
Publication
First Author: Blachly-Dyson E
Year: 1994
Journal: Genomics
Title: Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms.
Volume: 20
Issue: 1
Pages: 62-7
Publication
First Author: Gonzalez S
Year: 2016
Journal: J Clin Invest
Title: Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies.
Volume: 126
Issue: 3
Pages: 1023-38
Publication
First Author: Budelier MM
Year: 2017
Journal: J Biol Chem
Title: Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.
Volume: 292
Issue: 22
Pages: 9294-9304
Publication
First Author: Naghdi S
Year: 2016
Journal: Biochim Biophys Acta
Title: VDAC2-specific cellular functions and the underlying structure.
Volume: 1863
Issue: 10
Pages: 2503-14
Publication  
First Author: Niemann J
Year: 2019
Journal: Cell Calcium
Title: Cytosolic and mitochondrial Ca2+ concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation.
Volume: 82
Pages: 102055
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false