Type |
Details |
Score |
Publication |
First Author: |
Martin J |
Year: |
2016 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. |
Volume: |
310 |
Issue: |
7 |
Pages: |
G497-509 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weis VG |
Year: |
2016 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. |
Volume: |
2 |
Issue: |
2 |
Pages: |
131-157 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schatton D |
Year: |
2017 |
Journal: |
J Cell Biol |
Title: |
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. |
Volume: |
216 |
Issue: |
3 |
Pages: |
675-693 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alsina D |
Year: |
2020 |
Journal: |
EMBO Mol Med |
Title: |
FBXL4 deficiency increases mitochondrial removal by autophagy. |
Volume: |
12 |
Issue: |
7 |
Pages: |
e11659 |
|
•
•
•
•
•
|
Publication |
First Author: |
Journiac N |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly. |
Volume: |
31 |
Issue: |
2 |
Pages: |
107506 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chae SA |
Year: |
2022 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism. |
Volume: |
323 |
Issue: |
5 |
Pages: |
R728-R738 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meng TG |
Year: |
2023 |
Journal: |
Adv Sci (Weinh) |
Title: |
NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. |
Volume: |
10 |
Issue: |
27 |
Pages: |
e2301940 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kohr MJ |
Year: |
2011 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Characterization of potential S-nitrosylation sites in the myocardium. |
Volume: |
300 |
Issue: |
4 |
Pages: |
H1327-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poché RA |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. |
Volume: |
14 |
Issue: |
7 |
Pages: |
1684-1697 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wertz K |
Year: |
2000 |
Journal: |
Mech Dev |
Title: |
Large-scale screen for genes involved in gonad development. |
Volume: |
98 |
Issue: |
1-2 |
Pages: |
51-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Da Cruz S |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Proteomic analysis of the mouse liver mitochondrial inner membrane. |
Volume: |
278 |
Issue: |
42 |
Pages: |
41566-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Werner HB |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. |
Volume: |
27 |
Issue: |
29 |
Pages: |
7717-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory DNA Panel Mapping Resource |
Year: |
1999 |
Journal: |
Database Release |
Title: |
JAX Interspecific Backcross BSS and BSB Public Mapping Data |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mootha VK |
Year: |
2003 |
Journal: |
Cell |
Title: |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
Volume: |
115 |
Issue: |
5 |
Pages: |
629-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pagliarini DJ |
Year: |
2008 |
Journal: |
Cell |
Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
Volume: |
134 |
Issue: |
1 |
Pages: |
112-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Rat to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
Strain |
Attribute String: |
congenic, gene trap, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang E |
Year: |
2019 |
Journal: |
Cell Metab |
Title: |
Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells. |
Volume: |
29 |
Issue: |
1 |
Pages: |
64-77.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu NN |
Year: |
2023 |
Journal: |
Exp Mol Med |
Title: |
Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis. |
Volume: |
55 |
Issue: |
1 |
Pages: |
269-280 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chaudhuri AD |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression. |
Volume: |
291 |
Issue: |
12 |
Pages: |
6483-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yan C |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
CFTR Deletion in Mouse Testis Induces VDAC1 Mediated Inflammatory Pathway Critical for Spermatogenesis. |
Volume: |
11 |
Issue: |
8 |
Pages: |
e0158994 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6507611 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-01-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6850045 |
Age: |
postnatal adult |
Image: |
4C |
Note: |
Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells. |
Specimen Label: |
4C |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6507611 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-01-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2965528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6850045 |
Age: |
postnatal adult |
Image: |
4C |
Note: |
Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells. |
Specimen Label: |
4C |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion JF127, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
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•
•
•
•
•
|
Publication |
First Author: |
Anflous-Pharayra K |
Year: |
2011 |
Journal: |
Biochim Biophys Acta |
Title: |
VDAC3 has differing mitochondrial functions in two types of striated muscles. |
Volume: |
1807 |
Issue: |
1 |
Pages: |
150-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hinsch KD |
Year: |
2001 |
Journal: |
Biochim Biophys Acta |
Title: |
VDAC2 (porin-2) expression pattern and localization in the bovine testis. |
Volume: |
1518 |
Issue: |
3 |
Pages: |
329-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Angelini A |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. |
Volume: |
37 |
Issue: |
1 |
Pages: |
109767 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee J |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer. |
Volume: |
11 |
Issue: |
1 |
Pages: |
4181 |
|
•
•
•
•
•
|
Publication |
First Author: |
Majumder S |
Year: |
2012 |
Journal: |
Cell Cycle |
Title: |
VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes. |
Volume: |
11 |
Issue: |
19 |
Pages: |
3666-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Majumder S |
Year: |
2013 |
Journal: |
Cell Cycle |
Title: |
VDAC3 and Mps1 negatively regulate ciliogenesis. |
Volume: |
12 |
Issue: |
5 |
Pages: |
849-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sampson MJ |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Immotile sperm and infertility in mice lacking mitochondrial voltage-dependent anion channel type 3. |
Volume: |
276 |
Issue: |
42 |
Pages: |
39206-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Checchetto V |
Year: |
2014 |
Journal: |
Cell Physiol Biochem |
Title: |
Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance. |
Volume: |
34 |
Issue: |
3 |
Pages: |
842-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng EH |
Year: |
2003 |
Journal: |
Science |
Title: |
VDAC2 inhibits BAK activation and mitochondrial apoptosis. |
Volume: |
301 |
Issue: |
5632 |
Pages: |
513-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roy SS |
Year: |
2009 |
Journal: |
EMBO Rep |
Title: |
VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria. |
Volume: |
10 |
Issue: |
12 |
Pages: |
1341-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Veresov VG |
Year: |
2014 |
Journal: |
Cell Signal |
Title: |
Structural insights into proapoptotic signaling mediated by MTCH2, VDAC2, TOM40 and TOM22. |
Volume: |
26 |
Issue: |
2 |
Pages: |
370-82 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes VDAC3 from animals. Recombinant VDAC3 shows a channel activity with a very small conductance []. VDAC3 is involved in the transport of ADP across the mitochondrial outer membrane in the cardiac muscle (oxidative muscle) but not in the gastrocnemius muscle (mixed muscle) []. VDAC3 is also a centrosomal protein that interacts with the centrosomal protein kinase Mps1 []. VDAC3 and Mps1 negatively regulate ciliogenesis; they promote ciliary disassembly during cell cycle entry and suppress cilia assembly in proliferating cells []. Mice lacking VDAC3 suffered from immotile sperm and infertility [].Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) []and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic β-strands barrel with an N-terminal α-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ]. |
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Protein Domain |
Type: |
Family |
Description: |
VDAC2 is a voltage dependent anion channel that mediates the flow of metabolites and ions across the outer mitochondrial membrane. It may play a role in mitochondrial apoptosis through its involvement in the mitochondrial recruitment of BAK, a protein belonging to the BCL-2 protein family [, , ].Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) []and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic β-strands barrel with an N-terminal α-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ]. |
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Publication |
First Author: |
Liu C |
Year: |
2016 |
Journal: |
Aging Cell |
Title: |
The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment. |
Volume: |
15 |
Issue: |
1 |
Pages: |
167-76 |
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Publication |
First Author: |
Fazal L |
Year: |
2017 |
Journal: |
Circ Res |
Title: |
Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death. |
Volume: |
120 |
Issue: |
4 |
Pages: |
645-657 |
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Publication |
First Author: |
Kielar C |
Year: |
2009 |
Journal: |
Hum Mol Genet |
Title: |
Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease. |
Volume: |
18 |
Issue: |
21 |
Pages: |
4066-80 |
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Publication |
First Author: |
Yang X |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Gene co-expression network analysis provides novel insights into myostatin regulation at three different mouse developmental timepoints. |
Volume: |
10 |
Issue: |
2 |
Pages: |
e0117607 |
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Publication |
First Author: |
Behar V |
Year: |
2018 |
Journal: |
J Invest Dermatol |
Title: |
A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses. |
Volume: |
138 |
Issue: |
12 |
Pages: |
2635-2643 |
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Publication |
First Author: |
Ha BG |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
Depletion of Mitochondrial Components from Extracellular Vesicles Secreted from Astrocytes in a Mouse Model of Fragile X Syndrome. |
Volume: |
22 |
Issue: |
1 |
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Publication |
First Author: |
Huang H |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake. |
Volume: |
288 |
Issue: |
27 |
Pages: |
19870-81 |
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Publication |
First Author: |
Blachly-Dyson E |
Year: |
1994 |
Journal: |
Genomics |
Title: |
Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. |
Volume: |
20 |
Issue: |
1 |
Pages: |
62-7 |
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Publication |
First Author: |
Gonzalez S |
Year: |
2016 |
Journal: |
J Clin Invest |
Title: |
Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. |
Volume: |
126 |
Issue: |
3 |
Pages: |
1023-38 |
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Publication |
First Author: |
Budelier MM |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. |
Volume: |
292 |
Issue: |
22 |
Pages: |
9294-9304 |
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Publication |
First Author: |
Naghdi S |
Year: |
2016 |
Journal: |
Biochim Biophys Acta |
Title: |
VDAC2-specific cellular functions and the underlying structure. |
Volume: |
1863 |
Issue: |
10 |
Pages: |
2503-14 |
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Publication |
First Author: |
Niemann J |
Year: |
2019 |
Journal: |
Cell Calcium |
Title: |
Cytosolic and mitochondrial Ca2+ concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. |
Volume: |
82 |
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Pages: |
102055 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
201
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
75
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
75
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
246
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
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Fragment?: |
false |
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