|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 4801 to 4900 out of 7122 for App

<< First    < Previous  |  Next >    Last >>
0.037s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
23528227 | J:211741
First Author: Geekiyanage H
Year: 2013
Journal: Neurobiol Aging
Title: Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.
Volume: 34
Issue: 8
Pages: 2037-51
•
•
•
•
•
Publication
27644077 | J:239563
 
First Author: Pacheco-Quinto J
Year: 2016
Journal: Neurobiol Aging
Title: Major amyloid-β-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.
Volume: 48
Pages: 83-92
•
•
•
•
•
Publication
21676499 | J:188203
First Author: Wykes R
Year: 2012
Journal: Neurobiol Aging
Title: Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice.
Volume: 33
Issue: 8
Pages: 1609-23
•
•
•
•
•
Publication
21887366 | J:176146
First Author: Fenili D
Year: 2011
Journal: PLoS One
Title: Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.
Volume: 6
Issue: 8
Pages: e24032
•
•
•
•
•
Publication
29122977 | J:256420
First Author: Mohamed A
Year: 2018
Journal: J Lipid Res
Title: Aβ inhibits SREBP-2 activation through Akt inhibition.
Volume: 59
Issue: 1
Pages: 1-13
•
•
•
•
•
Publication
26076358 | J:237810
First Author: Colby-Milley J
Year: 2015
Journal: PLoS One
Title: Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological Stages.
Volume: 10
Issue: 6
Pages: e0130177
•
•
•
•
•
Publication
28242605 | J:241517
First Author: Chen ZL
Year: 2017
Journal: Blood
Title: Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice.
Volume: 129
Issue: 18
Pages: 2547-2556
•
•
•
•
•
Publication
21443906 | J:171684
First Author: Walker JM
Year: 2011
Journal: Behav Brain Res
Title: Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease.
Volume: 222
Issue: 1
Pages: 169-75
•
•
•
•
•
Strain
MGI:3719451 | B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax
Attribute String: congenic, mutant strain, transgenic
•
•
•
•
•
Publication
10860782 | J:129723
First Author: Bronfman FC
Year: 2000
Journal: Neurobiol Dis
Title: Acetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein london mutant transgenic mice.
Volume: 7
Issue: 3
Pages: 152-68
•
•
•
•
•
Publication
25164658 | J:223271
First Author: Jacobsen H
Year: 2014
Journal: J Neurosci
Title: Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.
Volume: 34
Issue: 35
Pages: 11621-30
•
•
•
•
•
Publication
21593432 | J:175580
First Author: Rat D
Year: 2011
Journal: FASEB J
Title: Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice.
Volume: 25
Issue: 9
Pages: 3208-18
•
•
•
•
•
Publication
29059594 | J:258053
 
First Author: Hoeijmakers L
Year: 2018
Journal: Neurobiol Aging
Title: The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis.
Volume: 61
Pages: 112-123
•
•
•
•
•
Publication
25484285 | J:219296
 
First Author: Hanson JE
Year: 2015
Journal: Neurobiol Dis
Title: Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease.
Volume: 74
Pages: 254-62
•
•
•
•
•
Publication
27466196 | J:238571
First Author: Kanatsu K
Year: 2016
Journal: Hum Mol Genet
Title: Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.
Volume: 25
Issue: 18
Pages: 3988-3997
•
•
•
•
•
Strain
MGI:5550585 | C57BL/6-Tg(PDGFB-APPInd)F17Plhn
Attribute String: mutant strain, coisogenic, transgenic
•
•
•
•
•
Strain
MGI:5903439 | B6.129S6(FVB)-App<tm1.1Wevn>
Attribute String: congenic, mutant strain, targeted mutation
•
•
•
•
•
Strain
MGI:5903309 | B6.129S6(FVB)-App<tm1.1Wevn>/Mmjax
Attribute String: congenic, mutant strain, targeted mutation
•
•
•
•
•
Strain
MGI:7541069 | B6C3-Tg(Prnp-APPSwInd,KRT14-EGFP)3Dbo/Mmjax
Attribute String: mutant strain, transgenic
•
•
•
•
•
Strain
MGI:7565474 | B6J.B6N-App<tm1.1(APP)Mdk>/J
Attribute String: congenic, mutant strain, targeted mutation
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APPV717I)1130Kha/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APPSWE)2123Kha/?
Background: FVB/N-Tg(APPSWE)2123Kha
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Thy1-APPSw)1Vln/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Thy1-APP)4Vln/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Thy1-APPLon)2Vln/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Thy1-APP)4Vln/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APPV717F)109Ili/?
Background: involves: C57BL/6 * DBA/2 * Swiss Webster
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APP)8.9Btla/Tg(APP)8.9Btla
Background: involves: 129S2/SvPas
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APPV717I)1130Kha/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APPV717I)1130Kha/?
Background: (CAST/Ei x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APPV717I)1130Kha/?
Background: (DBA/2 X FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APPV717I)1130Kha/?
Background: FVB/N-Tg(APPV717I)1130Kha
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APPV717I)1130Kha/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(APPV717I)1130Kha/?
Background: involves: CAST/Ei * FVB/N
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(PRNP-APPSweInd)8Dwst/? Tg(PSEN1)1098Citr/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Apoe/Apoe Tg(Eno2-APP*751)10Cord/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: C3H/HeJ * C57BL/6
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Azdm2/Azdm2 Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: A/J * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Azdm2/Azdm2 Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: A/J * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Azdm3/Azdm3 Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: A/J * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Azdm3/Azdm3 Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: A/J * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Azdm4/Azdm4 Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: A/J * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Azdm4/Azdm4 Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: A/J * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Ccr2/Ccr2<+> Tg(APPSWE)2576Kha/?
Background: involves: 129S4/SvJae * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Hspa4/Hspa4 Tg(APPSWE)2576Kha/?
Background: involves: BALB/cJ * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(PDGFB-APPInd)F17Plhn/?
Background: C57BL/6-Tg(PDGFB-APPInd)F17Plhn
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: App/App
Background: B6.129S6(FVB)-App
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Apoe/Apoe Tg(APPSWE)2576Kha/?
Background: involves: C57BL/6 * C57BL/6N * SJL
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(tetO-APPSwInd)107Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Publication
16279840 | J:109829
First Author: Jankowsky JL
Year: 2005
Journal: PLoS Med
Title: Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.
Volume: 2
Issue: 12
Pages: e355
•
•
•
•
•
Publication
27569580 | J:258151
 
First Author: Melnikova T
Year: 2016
Journal: Neurobiol Dis
Title: Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease.
Volume: 96
Pages: 171-185
•
•
•
•
•
Publication
9753324 | J:49850
First Author: Butz S
Year: 1998
Journal: Cell
Title: A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.
Volume: 94
Issue: 6
Pages: 773-82
•
•
•
•
•
Publication
20378958 | -
First Author: Mitchell JC
Year: 2010
Journal: J Alzheimers Dis
Title: Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.
Volume: 20
Issue: 1
Pages: 31-6
•
•
•
•
•
Publication
12970358 | -
First Author: Lee JH
Year: 2003
Journal: J Biol Chem
Title: The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.
Volume: 278
Issue: 47
Pages: 47025-9
•
•
•
•
•
Publication
20531236 | -
First Author: Lau KF
Year: 2010
Journal: Neuroreport
Title: An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.
Volume: 21
Issue: 11
Pages: 761-6
•
•
•
•
•
Publication
9952408 | -
First Author: Borg JP
Year: 1999
Journal: J Neurosci
Title: Molecular analysis of the X11-mLin-2/CASK complex in brain.
Volume: 19
Issue: 4
Pages: 1307-16
•
•
•
•
•
Protein Domain
IPR030530 | Apba1
Type: Family
Description: Amyloid beta A4 precursor protein-binding family A member 1, also known as Mint1 or X11alpha, is a neuronal adaptor protein that binds to the intracellular domain of the amyloid precursor protein (APP) []. It belongs to the X11/Mint family of adaptor proteins []. It has been shown to modulate processing of APP and accumulation of Abeta (hallmark pathologies of Alzheimer's disease), making it a potential therapeutic target for Alzheimer's disease []. It may also affect Alzheimer's disease pathogenesis through its interaction with transcription factor FSBP (fibrinogen silencer binding protein), forming a complex that represses glycogen synthase kinase-3beta (GSK3beta) transcription. GSK3beta is a candidate kinase for the phosphorylation of tau in Alzheimer's disease [].X11alpha participates in a brain-specific heterotrimeric complex containing two other PDZ domain proteins, Lin-2/CASK and mLin-7, involved in synaptic vesicle exocytosis and synaptic junctions []. Additional proteins can bind, forming a neuronal multiprotein complex predicted to be involved in receptor localisation []. The X11/Mint family members are multidomain proteins typically composed of a conserved PTB domain and two C-terminal PDZ domains. They are adaptor proteins that possess several functions, such as trafficking and transport, synaptic function and regulation of ion channel []. Two of the family members, X11alpha and X11beta, are expressed primarily in neurones [].
•
•
•
•
•
Protein Domain
IPR042524 | Presenilin_C
Type: Homologous_superfamily
Description: This superfamily represents the C-terminal region of aspartic peptidases belonging to the MEROPS peptidase family A22 (presenilin family), subfamily A22A, the type example being presenilin 1 from Homo sapiens (Human).Presenilins are polytopic transmembrane (TM) proteins, mutations in whichare associated with the occurrence of early-onset familial Alzheimer'sdisease, a rare form of the disease that results from a single-genemutation [, ]. Alzheimer's disease is associated with the formation of extracellular deposits of amyloid, which contain aggregates of the amyloid-beta peptide. The β-peptides are released from the Alzheimer's amyloid precursor protein (APP) by the action of two peptidase activities: "beta-secretase"cleaves at the N terminus of the peptide, and "gamma-secretase"cleaves at the C terminus. The gamma-secretase cleavage occurs in a transmembrane segment of APP. Presenilin, which exists in a complex with nicastrin, APH-1 and PEN-2, has been identified as gamma-secretase from its deficiency []and mutation of its active site residues [], but proteolytic activity has only been directly demonstrated on a peptide derived from APP [].Presenilin-1 is also known to process notch proteins []and syndecan-3 [].Presenilin has nine transmembrane regions with the active site aspartic acid residues located on TM6, within a Tyr-Asp motif, and TM7, within a Gly-Xaa-Gly-Asp motif []. The protein autoprocesses to form an amino-terminal fragment (TMs 1-6) and a C-terminal fragment (TMs 7-9) []. The tertiary structure of the human gamma-sectretase complex has been solved []. Nicastrin is extracellular, whereas presenilin-1, APH-1 and PEN-2 are all transmembrane proteins. The transmembrane regions of all three proteins form a horseshoe shape.
•
•
•
•
•
Publication
32595447 | J:311244
 
First Author: Loeffler T
Year: 2020
Journal: Front Neurosci
Title: Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value.
Volume: 14
Pages: 579
•
•
•
•
•
Publication
35573205 | J:328754
First Author: Takahashi F
Year: 2022
Journal: iScience
Title: Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1.
Volume: 25
Issue: 5
Pages: 104278
•
•
•
•
•
Publication
28602351 | J:324482
First Author: Keren-Shaul H
Year: 2017
Journal: Cell
Title: A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Volume: 169
Issue: 7
Pages: 1276-1290.e17
•
•
•
•
•
Publication
37328454 | J:355740
First Author: Cho E
Year: 2023
Journal: Nat Commun
Title: Ratiometric measurement of MAM Ca(2+) dynamics using a modified CalfluxVTN.
Volume: 14
Issue: 1
Pages: 3586
•
•
•
•
•
Publication
30046111 | J:265289
First Author: Da Mesquita S
Year: 2018
Journal: Nature
Title: Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease.
Volume: 560
Issue: 7717
Pages: 185-191
•
•
•
•
•
Publication
34262178 | J:335093
First Author: McAlpine CS
Year: 2021
Journal: Nature
Title: Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
Volume: 595
Issue: 7869
Pages: 701-706
•
•
•
•
•
Publication
30373880 | J:269026
First Author: Wang ZH
Year: 2018
Journal: J Exp Med
Title: Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
Volume: 215
Issue: 12
Pages: 3038-3056
•
•
•
•
•
Publication
36352225 | J:339995
First Author: Drieu A
Year: 2022
Journal: Nature
Title: Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid.
Volume: 611
Issue: 7936
Pages: 585-593
•
•
•
•
•
Publication
37541210 | J:339355
First Author: Yoo Y
Year: 2023
Journal: Cell Stem Cell
Title: A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease.
Volume: 30
Issue: 8
Pages: 1043-1053.e6
•
•
•
•
•
Publication
38734693 | J:348384
First Author: Kim B
Year: 2024
Journal: Nat Commun
Title: Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis.
Volume: 15
Issue: 1
Pages: 3996
•
•
•
•
•
Publication
17703189 | J:124925
First Author: Watts JC
Year: 2007
Journal: EMBO J
Title: The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.
Volume: 26
Issue: 17
Pages: 4038-50
•
•
•
•
•
Publication
20529957 | J:163294
First Author: Rothenberg C
Year: 2010
Journal: Hum Mol Genet
Title: Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.
Volume: 19
Issue: 16
Pages: 3219-32
•
•
•
•
•
Publication
29518356 | J:260524
First Author: Zhao Y
Year: 2018
Journal: Neuron
Title: TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Volume: 97
Issue: 5
Pages: 1023-1031.e7
•
•
•
•
•
Publication
14617772 | J:86701
First Author: Phinney AL
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: In vivo reduction of amyloid-beta by a mutant copper transporter.
Volume: 100
Issue: 24
Pages: 14193-8
•
•
•
•
•
Publication
15466405 | J:93658
First Author: Fagan AM
Year: 2004
Journal: Am J Pathol
Title: ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis.
Volume: 165
Issue: 4
Pages: 1413-22
•
•
•
•
•
Publication
16516482 | J:111271
First Author: Pacheco-Quinto J
Year: 2006
Journal: Neurobiol Dis
Title: Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels.
Volume: 22
Issue: 3
Pages: 651-6
•
•
•
•
•
Publication
18606155 | J:139872
 
First Author: Laporte V
Year: 2008
Journal: Brain Res
Title: CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Volume: 1231
Pages: 132-42
•
•
•
•
•
Strain
MGI:3611754 | B6.Cg-Fmr1<tm1Cgr> Tg(APPSWE)2576Kha/Cjw
Attribute String: congenic, mutant strain, targeted mutation, transgenic
•
•
•
•
•
Publication
16236385 | J:114480
First Author: Cao D
Year: 2006
Journal: Neurobiol Aging
Title: Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice.
Volume: 27
Issue: 11
Pages: 1632-43
•
•
•
•
•
Publication
12417655 | J:107567
First Author: Van Uden E
Year: 2002
Journal: J Neurosci
Title: Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.
Volume: 22
Issue: 21
Pages: 9298-304
•
•
•
•
•
Publication
24126163 | J:212601
First Author: Oh SB
Year: 2014
Journal: Neurobiol Aging
Title: Tissue plasminogen activator arrests Alzheimer's disease pathogenesis.
Volume: 35
Issue: 3
Pages: 511-9
•
•
•
•
•
Publication
20570249 | J:283280
First Author: Yang H
Year: 2010
Journal: Biol Psychiatry
Title: Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.
Volume: 68
Issue: 10
Pages: 922-9
•
•
•
•
•
Publication
17579710 | J:129325
First Author: Melov S
Year: 2007
Journal: PLoS One
Title: Mitochondrial oxidative stress causes hyperphosphorylation of tau.
Volume: 2
Issue: 6
Pages: e536
•
•
•
•
•
Publication
18786355 | J:149874
First Author: Wetzel MK
Year: 2008
Journal: Neuron
Title: p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease.
Volume: 59
Issue: 5
Pages: 708-21
•
•
•
•
•
Publication
19230830 | J:148203
 
First Author: Bitner RS
Year: 2009
Journal: Brain Res
Title: Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Volume: 1265
Pages: 65-74
•
•
•
•
•
Publication
18314463 | J:137558
First Author: Burgess BL
Year: 2008
Journal: J Lipid Res
Title: ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Volume: 49
Issue: 6
Pages: 1254-67
•
•
•
•
•
Publication
12145324 | J:78357
First Author: DeMattos RB
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
Volume: 99
Issue: 16
Pages: 10843-8
•
•
•
•
•
Strain
MGI:4839977 | STOCK Nos2<+> Tg(APPSWE)2576Kha Tg(Thy1-PSEN1*A246E)16-3Sqn/Mmnc
Attribute String: mutant stock, targeted mutation, transgenic
•
•
•
•
•
Publication
11404397 | J:239214
First Author: Dineley KT
Year: 2001
Journal: J Neurosci
Title: Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
Volume: 21
Issue: 12
Pages: 4125-33
•
•
•
•
•
Publication
28808140 | J:256411
First Author: Wijesekara N
Year: 2017
Journal: FASEB J
Title: Amyloid-β and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model.
Volume: 31
Issue: 12
Pages: 5409-5418
•
•
•
•
•
Publication
24899720 | J:211628
First Author: Caccamo A
Year: 2014
Journal: J Neurosci
Title: Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature.
Volume: 34
Issue: 23
Pages: 7988-98
•
•
•
•
•
Publication
20142765 | J:174831
First Author: Lin J
Year: 2010
Journal: J Neuropathol Exp Neurol
Title: Genetic ablation of luteinizing hormone receptor improves the amyloid pathology in a mouse model of Alzheimer disease.
Volume: 69
Issue: 3
Pages: 253-61
•
•
•
•
•
Strain
MGI:4839176 | STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc/Tac
Attribute String: transgenic, mutant stock
•
•
•
•
•
Publication
18026100 | J:130221
First Author: Mi W
Year: 2007
Journal: Nat Genet
Title: Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models.
Volume: 39
Issue: 12
Pages: 1440-2
•
•
•
•
•
Publication
24936619 | J:284792
First Author: Wang B
Year: 2014
Journal: J Neurosci Res
Title: Low-dose total-body carbon-ion irradiations induce early transcriptional alteration without late Alzheimer's disease-like pathogenesis and memory impairment in mice.
Volume: 92
Issue: 7
Pages: 915-26
•
•
•
•
•
Publication
20479943 | J:160835
First Author: Massaad CA
Year: 2010
Journal: PLoS One
Title: Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease.
Volume: 5
Issue: 5
Pages: e10561
•
•
•
•
•
Publication
22702220 | J:207659
First Author: Esteras N
Year: 2012
Journal: Eur J Neurosci
Title: Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer's disease [amyloid precursor protein/presenilin 1 (PS1)].
Volume: 36
Issue: 5
Pages: 2609-18
•
•
•
•
•
Publication
17341475 | J:123102
First Author: Ahmed Z
Year: 2007
Journal: J Histochem Cytochem
Title: Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry.
Volume: 55
Issue: 7
Pages: 687-700
•
•
•
•
•
Publication
17137722 | J:117957
First Author: Wilcock DM
Year: 2007
Journal: Neuroscience
Title: Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid.
Volume: 144
Issue: 3
Pages: 950-60
•
•
•
•
•
Publication
20451607 | J:164930
First Author: Braithwaite SP
Year: 2010
Journal: Neurobiol Dis
Title: Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.
Volume: 39
Issue: 3
Pages: 311-7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom