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Search results 501 to 578 out of 578 for Pink1

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Hits by Pathway

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Type Details Score
Publication
27334109 | J:237872
First Author: Szargel R
Year: 2016
Journal: Hum Mol Genet
Title: The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway.
Volume: 25
Issue: 16
Pages: 3476-3490
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Publication
29991771 | -
First Author: Okatsu K
Year: 2018
Journal: Sci Rep
Title: Structural insights into ubiquitin phosphorylation by PINK1.
Volume: 8
Issue: 1
Pages: 10382
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Protein Domain
IPR040110 | PINK1_STKc
Type: Domain
Description: PINK1 is a mitochondrial serine/threonine kinase that acts as a sensor of mitochondrial damage []. It phosphorylates ubiquitin (Ub) and the Ub-like domain (UBL) of the E3 Ub ligase parkin at Ser65. The phosphorylation of Ub and the parkin UBL facilitates the transition from the autoinhibition state to the catalytically active state in parkin []. Upon mitochondrial damage, PINK1 accumulates on the outer mitochondrial membrane (OMM), where it may recruit and activate Parkin []. PINK1 has also been shown to phosphorylate Miro, a component of the primary motor/adaptor complex that anchors kinesin to the mitochondrial surface. The phosphorylation of Miro activates proteasomal degradation of Miro in a Parkin-dependent manner []. PINK1 contains an N-terminal mitochondrial targeting sequence (MTS), a transmembrane domain (TM), a highly conserved serine/threonine kinase domain, and a C-terminal auto-regulatory domain. Mutations of the PINK1 and Parkin genes have been linked to familial Parkinson's disease (PD) [].
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Publication
16595633 | -
First Author: Eyal A
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.
Volume: 103
Issue: 15
Pages: 5917-22
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Publication
17982729 | -
First Author: Szargel R
Year: 2008
Journal: Cell Mol Life Sci
Title: Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.
Volume: 65
Issue: 1
Pages: 80-8
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Publication
17467279 | -
First Author: Humbert J
Year: 2007
Journal: Neurobiol Dis
Title: Parkin and synphilin-1 isoform expression changes in Lewy body diseases.
Volume: 26
Issue: 3
Pages: 681-7
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Publication
24064336 | J:205004
First Author: Casadei N
Year: 2014
Journal: Hum Mol Genet
Title: Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.
Volume: 23
Issue: 3
Pages: 767-81
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Protein Domain
IPR040133 | SNCAIP
Type: Family
Description: Synphilin-1 interacts with and is ubiquitylated by the E3 ubiquitin ligase SIAH. It also interacs with PINK1 and is recruited to the mitochondria where promotes PINK1-dependent mitophagy. Synphilin-1, SIAH-1 and PINK1 seem to constitute a new mitophagy pathway [].Synphilin-1 is an alpha-synuclein-interacting protein that promotes the formation of inclusion bodies []. Alternative splicing gives rise to at least eight synphilin-1 isoforms []. Among them, synphilin-1A is an aggregation-prone protein that causes neuronal toxicity []. Synphilin-1A has been linked to Parkinson's disease [].
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HT Experiment
E-GEOD-60413 | Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
Series Id: GSE60413
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
Q9D3Y6
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
Q99ME3
Organism: Mus musculus/domesticus
Length: 962  
Fragment?: false
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Protein
E9Q4E2
Organism: Mus musculus/domesticus
Length: 915  
Fragment?: false
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Protein
Q3V1N2
Organism: Mus musculus/domesticus
Length: 914  
Fragment?: false
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Protein
Q9D3W0
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: false
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Protein
J3QP58
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
Q4KMM4
Organism: Mus musculus/domesticus
Length: 965  
Fragment?: false
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Protein
Q8C4I8
Organism: Mus musculus/domesticus
Length: 869  
Fragment?: false
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Protein
Q3TVI3
Organism: Mus musculus/domesticus
Length: 965  
Fragment?: false
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Protein
J3QNK1
Organism: Mus musculus/domesticus
Length: 855  
Fragment?: false
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Protein
Q8BRF4
Organism: Mus musculus/domesticus
Length: 687  
Fragment?: true
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Protein
G5E848
Organism: Mus musculus/domesticus
Length: 965  
Fragment?: false
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Protein
Q99MQ3
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
A2AM78
Organism: Mus musculus/domesticus
Length: 550  
Fragment?: false
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Protein
Q3U258
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q5DU52
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: true
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Protein
Q6IS31
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: true
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Publication
24898855 | J:219122
 
First Author: Yun J
Year: 2014
Journal: Elife
Title: MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.
Volume: 3
Pages: e01958
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Publication
24768297 | J:215278
First Author: Liang H
Year: 2014
Journal: Cell Metab
Title: PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism.
Volume: 19
Issue: 5
Pages: 836-48
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Publication
31577952 | J:337054
First Author: Sarraf SA
Year: 2019
Journal: Cell Rep
Title: PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis.
Volume: 29
Issue: 1
Pages: 225-235.e5
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Publication
24813611 | J:214396
First Author: Fang EF
Year: 2014
Journal: Cell
Title: Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.
Volume: 157
Issue: 4
Pages: 882-896
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Publication
29514094 | J:271638
First Author: Carneiro FRG
Year: 2018
Journal: Cell Rep
Title: An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages.
Volume: 22
Issue: 10
Pages: 2654-2666
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Publication
33406421 | J:304271
First Author: Murakami K
Year: 2021
Journal: Cell Rep
Title: OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.
Volume: 34
Issue: 1
Pages: 108579
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Publication
30584104 | J:269909
First Author: Baranov SV
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Mitochondria modulate programmed neuritic retraction.
Volume: 116
Issue: 2
Pages: 650-659
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Publication
26785495 | J:229454
First Author: Gong G
Year: 2015
Journal: Science
Title: Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice.
Volume: 350
Issue: 6265
Pages: aad2459
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Publication
38081847 | J:344427
First Author: Zhu Q
Year: 2023
Journal: Nat Commun
Title: GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
Volume: 14
Issue: 1
Pages: 8187
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Publication
25533483 | J:219342
First Author: Dhungel N
Year: 2015
Journal: Neuron
Title: Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.
Volume: 85
Issue: 1
Pages: 76-87
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Publication
20604804 | J:169629
First Author: Okatsu K
Year: 2010
Journal: Genes Cells
Title: p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria.
Volume: 15
Issue: 8
Pages: 887-900
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Publication
32054064 | J:298493
 
First Author: Torii S
Year: 2020
Journal: Int J Mol Sci
Title: Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson's Disease and Its Substrate-Involved Mouse Experimental Models.
Volume: 21
Issue: 4
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Publication
25779963 | J:222286
 
First Author: Khang R
Year: 2015
Journal: Neuroscience
Title: Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice.
Volume: 294
Pages: 182-92
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Publication
35008897 | J:317690
 
First Author: Mucha O
Year: 2021
Journal: Int J Mol Sci
Title: Dysregulated Autophagy and Mitophagy in a Mouse Model of Duchenne Muscular Dystrophy Remain Unchanged Following Heme Oxygenase-1 Knockout.
Volume: 23
Issue: 1
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Publication
32816243 | J:311336
First Author: Ochi S
Year: 2020
Journal: Mol Neurobiol
Title: Identifying Blood Transcriptome Biomarkers of Alzheimer's Disease Using Transgenic Mice.
Volume: 57
Issue: 12
Pages: 4941-4951
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Publication
25060553 | J:259323
First Author: Rossin F
Year: 2015
Journal: Cell Death Differ
Title: Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis.
Volume: 22
Issue: 3
Pages: 408-18
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Publication
25229693 | J:234221
First Author: Roe ND
Year: 2015
Journal: Biochim Biophys Acta
Title: Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy.
Volume: 1852
Issue: 2
Pages: 290-8
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Publication
27110594 | J:290250
First Author: Hull TD
Year: 2016
Journal: JCI Insight
Title: Heme oxygenase-1 regulates mitochondrial quality control in the heart.
Volume: 1
Issue: 2
Pages: e85817
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Publication
30217996 | J:279229
First Author: Dongil P
Year: 2018
Journal: Sci Rep
Title: Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver.
Volume: 8
Issue: 1
Pages: 13810
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Publication
29561660 | J:263895
First Author: Peker N
Year: 2018
Journal: Am J Physiol Cell Physiol
Title: Loss of Parkin impairs mitochondrial function and leads to muscle atrophy.
Volume: 315
Issue: 2
Pages: C164-C185
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Publication
32444656 | J:293825
First Author: Shires SE
Year: 2020
Journal: Sci Rep
Title: Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia.
Volume: 10
Issue: 1
Pages: 8499
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Publication
26916519 | J:339115
 
First Author: Roy A
Year: 2016
Journal: Sci Rep
Title: BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease.
Volume: 6
Pages: 22067
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Publication
20639397 | J:163635
First Author: Irrcher I
Year: 2010
Journal: Hum Mol Genet
Title: Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
Volume: 19
Issue: 19
Pages: 3734-46
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Publication
29388469 | J:261374
First Author: Narala VR
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice.
Volume: 314
Issue: 5
Pages: L860-L870
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Publication
36878048 | J:340680
 
First Author: Zhou G
Year: 2023
Journal: Int Immunopharmacol
Title: Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction.
Volume: 117
Pages: 109614
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Publication
26807733 | J:249089
First Author: Lu W
Year: 2016
Journal: PLoS One
Title: Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis.
Volume: 11
Issue: 1
Pages: e0147792
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Publication
33459343 | J:305195
First Author: Malik AU
Year: 2021
Journal: Biochem J
Title: Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
Volume: 478
Issue: 3
Pages: 553-578
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Publication
33890401 | J:345478
First Author: Luo H
Year: 2021
Journal: Acta Physiol (Oxf)
Title: Pharmacological inhibition of USP30 activates tissue-specific mitophagy.
Volume: 232
Issue: 3
Pages: e13666
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Publication
38132101 | J:344428
 
First Author: Liu T
Year: 2023
Journal: Cells
Title: Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion.
Volume: 12
Issue: 24
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Publication
30404819 | J:341592
 
First Author: McWilliams TG
Year: 2018
Journal: Open Biol
Title: Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
Volume: 8
Issue: 11
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Publication
24794857 | J:213877
First Author: Dusonchet J
Year: 2014
Journal: Hum Mol Genet
Title: A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Volume: 23
Issue: 18
Pages: 4887-905
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Publication
21355049 | J:219079
First Author: Shi G
Year: 2011
Journal: Hum Mol Genet
Title: Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease.
Volume: 20
Issue: 10
Pages: 1966-74
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Publication
23804577 | J:213893
First Author: Quadri M
Year: 2013
Journal: Hum Mutat
Title: Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism.
Volume: 34
Issue: 9
Pages: 1208-15
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Publication
25655803 | J:230976
First Author: Coughlin L
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve.
Volume: 56
Issue: 3
Pages: 1437-46
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Publication
27593930 | J:236385
First Author: Bernardini JP
Year: 2017
Journal: Oncogene
Title: Parkin and mitophagy in cancer.
Volume: 36
Issue: 10
Pages: 1315-1327
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Publication
28007983 | J:239549
First Author: Aguirre JD
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.
Volume: 114
Issue: 2
Pages: 298-303
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Publication
28673964 | J:247454
First Author: Zhang C
Year: 2017
Journal: J Biol Chem
Title: Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.
Volume: 292
Issue: 36
Pages: 15105-15120
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Publication
28973175 | J:253503
First Author: Moller A
Year: 2017
Journal: Hum Mol Genet
Title: Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.
Volume: 26
Issue: 23
Pages: 4668-4679
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Publication
28615325 | J:255665
First Author: Zhang X
Year: 2017
Journal: FASEB J
Title: Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis.
Volume: 31
Issue: 10
Pages: 4382-4395
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Publication
25591737 | J:260867
First Author: Bertolin G
Year: 2015
Journal: Cell Death Differ
Title: Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10.
Volume: 22
Issue: 10
Pages: 1563-76
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Publication
32332095 | J:297142
First Author: Verma M
Year: 2020
Journal: J Biol Chem
Title: Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2-associated athanogene 6 (BAG6).
Volume: 295
Issue: 23
Pages: 7865-7876
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Publication
35367811 | J:337807
 
First Author: Liu Z
Year: 2022
Journal: Redox Biol
Title: XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury.
Volume: 52
Pages: 102305
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Publication
36632468 | J:332611
First Author: Xu WN
Year: 2023
Journal: Int J Biol Sci
Title: Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
Volume: 19
Issue: 2
Pages: 571-592
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Publication
36950017 | J:345220
 
First Author: Zhou X
Year: 2023
Journal: Front Pharmacol
Title: Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis.
Volume: 14
Pages: 1082602
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Publication
31306119 | J:303311
First Author: Simonovitch S
Year: 2019
Journal: J Alzheimers Dis
Title: The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo.
Volume: 70
Issue: 3
Pages: 861-875
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Publication
33685483 | J:320471
First Author: Roca-Agujetas V
Year: 2021
Journal: Mol Neurodegener
Title: Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease.
Volume: 16
Issue: 1
Pages: 15
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Publication
31519688 | J:280891
First Author: Yazdani HO
Year: 2019
Journal: Cancer Res
Title: Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth.
Volume: 79
Issue: 21
Pages: 5626-5639
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Publication
28504722 | J:248081
First Author: Chi HC
Year: 2017
Journal: Oncogene
Title: Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover.
Volume: 36
Issue: 37
Pages: 5274-5284
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Publication
26471730 | J:227761
First Author: Lai YC
Year: 2015
Journal: EMBO J
Title: Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.
Volume: 34
Issue: 22
Pages: 2840-61
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Publication
39397581 | J:359799
First Author: Lee HS
Year: 2024
Journal: Thyroid
Title: Mitophagy Defects Exacerbate Inflammation and Aberrant Proliferation in Lymphocytic Thyroiditis.
Volume: 34
Issue: 11
Pages: 1401-1413
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Publication
30290714 | J:308566
First Author: Araya J
Year: 2019
Journal: Autophagy
Title: PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Volume: 15
Issue: 3
Pages: 510-526
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Publication
31066324 | J:346539
First Author: Livingston MJ
Year: 2019
Journal: Autophagy
Title: Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.
Volume: 15
Issue: 12
Pages: 2142-2162
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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