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Search results 401 to 486 out of 486 for Aqp3

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Type Details Score
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
27059301 | J:233702
First Author: Su Z
Year: 2016
Journal: FEBS Lett
Title: LncRNA H19 functions as a competing endogenous RNA to regulate AQP3 expression by sponging miR-874 in the intestinal barrier.
Volume: 590
Issue: 9
Pages: 1354-64
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Publication
22397925 | J:185468
First Author: Nilsson L
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Disruption of cyclooxygenase-2 prevents downregulation of cortical AQP2 and AQP3 in response to bilateral ureteral obstruction in the mouse.
Volume: 302
Issue: 11
Pages: F1430-9
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Publication
12239222 | -
First Author: Roudier N
Year: 2002
Journal: J Biol Chem
Title: AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL.
Volume: 277
Issue: 48
Pages: 45854-9
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Allele
Aqp3<em1Smoc> | MGI:7288314
Name: aquaporin 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6474787 | C57BL/6-Aqp3<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Aqp3<tm1Ask> | MGI:2150021
Name: aquaporin 3; targeted mutation 1, Alan S Verkman
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Aqp3/Aqp3
Background: involves: C57BL/6J * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aqp3/Aqp3
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aqp3/Aqp3 Aqp4/Aqp4
Background: involves: C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aqp3/Aqp3 Aqp4/Aqp4
Background: involves: C57BL/6J * CD-1
Zygosity: cx
Has Mutant Allele: true
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Publication
7517548 | -
First Author: Ishibashi K
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells.
Volume: 91
Issue: 14
Pages: 6269-73
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Protein Domain
IPR023275 | Aquaporin_3
Type: Family
Description: Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol []. In higher eukaryotes these proteins play diverse roles in the maintenance of water homeostasis, indicating that membrane water permeability can be regulated independently of solute permeability. In microorganisms however, many of which do not contain aquaporins, they do not appear to play such a broad role. Instead, they assist specific microbial lifestyles within the environment, e.g. they confer protection against freeze-thaw stress and may help maintain water permeability at low temperatures []. The regulation of aquaporins is complex, including transcriptional, post-translational, protein-trafficking and channel-gating mechanisms that are frequently distinct for each family member.Structural studies show that aquaporins are present in the membrane as tetramers, though each monomer contains its own channel [, , ]. The monomer has an overall "hourglass"structure made up of three structural elements: an external vestibule, an internal vestibule, and an extended pore which connects the two vestibules. Substrate selectivity is conferred by two mechanisms. Firstly, the diameter of the pore physically limits the size of molecules that can pass through the channel. Secondly, specific amino acids within the molecule regulate the preference for hydrophobic or hydrophilic substrates.Aquaporins are classified into two subgroups: the aquaporins (also known as orthodox aquaporins), which transport only water, and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water [, ].Aquaporin-3 (AQP3) forms a water-specific channel that renders the kidney medullary collecting duct highly permeability to water. It may function as a water and urea exit mechanism in antidiuresis in collecting duct cells, and is also slightly permeable to urea and glycerol. It may also play an important role in gastrointestinal tract water transport and in glycerol metabolism. It is widely expressed in epithelial cells of kidney (collecting ducts []) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Expression studies have shown that cells transfected with AQP3 cDNA react strongly with anti-GIL antibodies []. These studies hence report the first cases of human AQP3 deficiency and offer the molecular basis of a new blood group system, GIL, believed to be encoded by AQP3 [].
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Publication
26837049 | J:233327
First Author: Watanabe S
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Aquaporin-9 facilitates membrane transport of hydrogen peroxide in mammalian cells.
Volume: 471
Issue: 1
Pages: 191-7
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HT Experiment
GSE131196 | SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE139587 | SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms (scRNA-seq: batch2)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
9806845 | J:51114
First Author: Koyama N
Year: 1998
Journal: Genomics
Title: Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene.
Volume: 54
Issue: 1
Pages: 169-72
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Publication
17636116 | J:123305
First Author: Liu Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence.
Volume: 104
Issue: 30
Pages: 12560-4
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Publication
35086002 | J:323041
 
First Author: Zhang B
Year: 2022
Journal: Redox Biol
Title: Aquaporin-9 facilitates liver regeneration following hepatectomy.
Volume: 50
Pages: 102246
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Publication
9486146 | J:46296
First Author: Chou CL
Year: 1998
Journal: Am J Physiol
Title: Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice.
Volume: 274
Issue: 2 Pt 1
Pages: C549-54
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Publication
31241990 | J:283972
First Author: Mendoza LD
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice.
Volume: 317
Issue: 3
Pages: F547-F559
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Publication
18241265 | J:169519
First Author: Mirza R
Year: 2008
Journal: Br J Dermatol
Title: Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice.
Volume: 158
Issue: 4
Pages: 679-84
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Publication
24784577 | J:217140
First Author: Cano-Peñalver JL
Year: 2014
Journal: FASEB J
Title: Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption.
Volume: 28
Issue: 8
Pages: 3645-59
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Publication
11773623 | J:130418
First Author: Nejsum LN
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Functional requirement of aquaporin-5 in plasma membranes of sweat glands.
Volume: 99
Issue: 1
Pages: 511-6
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Publication
26377795 | J:323064
First Author: Nam BY
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Double transduction of a Cre/LoxP lentiviral vector: a simple method to generate kidney cell-specific knockdown mice.
Volume: 309
Issue: 12
Pages: F1060-9
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Publication
17913837 | J:127547
First Author: Cai Q
Year: 2007
Journal: Am J Physiol Renal Physiol
Title: Vasopressin receptor subtype 2 activation increases cell proliferation in the renal medulla of AQP1 null mice.
Volume: 293
Issue: 6
Pages: F1858-64
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Publication
23087172 | J:192627
First Author: Soh YM
Year: 2012
Journal: Endocrinology
Title: Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice.
Volume: 153
Issue: 12
Pages: 6054-64
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Publication
22622456 | J:186840
First Author: Evans LC
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice.
Volume: 303
Issue: 4
Pages: F494-502
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Publication
16434568 | J:110648
First Author: Yang B
Year: 2006
Journal: Am J Physiol Renal Physiol
Title: Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion.
Volume: 291
Issue: 2
Pages: F465-72
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Publication
24005472 | J:202994
First Author: Zhou L
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Increased susceptibility of db/db mice to rosiglitazone-induced plasma volume expansion: role of dysregulation of renal water transporters.
Volume: 305
Issue: 10
Pages: F1491-7
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Publication
10644652 | J:60783
First Author: Verkman AS
Year: 2000
Journal: Am J Physiol Renal Physiol
Title: Structure and function of aquaporin water channels.
Volume: 278
Issue: 1
Pages: F13-28
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Publication
9714739 | J:49128
First Author: Ishibashi K
Year: 1998
Journal: Biochim Biophys Acta
Title: Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping.
Volume: 1399
Issue: 1
Pages: 62-6
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Publication
9822113 | J:51165
First Author: Verkman AS
Year: 1998
Journal: Am J Med Sci
Title: Role of aquaporin water channels in kidney and lung.
Volume: 316
Issue: 5
Pages: 310-20
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Publication
18548108 | J:139893
First Author: Hara-Chikuma M
Year: 2008
Journal: J Invest Dermatol
Title: Roles of aquaporin-3 in the epidermis.
Volume: 128
Issue: 9
Pages: 2145-51
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Publication
19357255 | J:164625
First Author: van Balkom BW
Year: 2009
Journal: J Am Soc Nephrol
Title: LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation.
Volume: 20
Issue: 5
Pages: 990-1001
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Publication
23593143 | J:200038
First Author: Bell CE
Year: 2013
Journal: PLoS One
Title: p38 MAPK regulates cavitation and tight junction function in the mouse blastocyst.
Volume: 8
Issue: 4
Pages: e59528
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Publication
24236206 | J:209312
First Author: Qin H
Year: 2013
Journal: PLoS One
Title: The caveolin-1 scaffolding domain peptide decreases phosphatidylglycerol levels and inhibits calcium-induced differentiation in mouse keratinocytes.
Volume: 8
Issue: 11
Pages: e80946
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Publication
30862673 | J:277895
First Author: Sonntag Y
Year: 2019
Journal: J Biol Chem
Title: Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors.
Volume: 294
Issue: 18
Pages: 7377-7387
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Publication
31649296 | J:284633
First Author: Soler DC
Year: 2019
Journal: Sci Rep
Title: An uncharacterized region within the N-terminus of mouse TMC1 precludes trafficking to plasma membrane in a heterologous cell line.
Volume: 9
Issue: 1
Pages: 15263
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Protein
Q8R2N1
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Publication
9514918 | -
First Author: Ishibashi K
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.
Volume: 244
Issue: 1
Pages: 268-74
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Publication
12594337 | -
First Author: Carbrey JM
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver.
Volume: 100
Issue: 5
Pages: 2945-50
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Publication
30420639 | -
First Author: Gotfryd K
Year: 2018
Journal: Nat Commun
Title: Human adipose glycerol flux is regulated by a pH gate in AQP10.
Volume: 9
Issue: 1
Pages: 4749
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Protein Domain
IPR015685 | Aquaporin_9
Type: Family
Description: Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol []. In higher eukaryotes these proteins play diverse roles in the maintenance of water homeostasis, indicating that membrane water permeability can be regulated independently of solute permeability. In microorganisms however, many of which do not contain aquaporins, they do not appear to play such a broad role. Instead, they assist specific microbial lifestyles within the environment, e.g. they confer protection against freeze-thaw stress and may help maintain water permeability at low temperatures []. The regulation of aquaporins is complex, including transcriptional, post-translational, protein-trafficking and channel-gating mechanisms that are frequently distinct for each family member.Structural studies show that aquaporins are present in the membrane as tetramers, though each monomer contains its own channel [, , ]. The monomer has an overall "hourglass"structure made up of three structural elements: an external vestibule, an internal vestibule, and an extended pore which connects the two vestibules. Substrate selectivity is conferred by two mechanisms. Firstly, the diameter of the pore physically limits the size of molecules that can pass through the channel. Secondly, specific amino acids within the molecule regulate the preference for hydrophobic or hydrophilic substrates.Aquaporins are classified into two subgroups: the aquaporins (also known as orthodox aquaporins), which transport only water, and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water [, ].Aquaporin-9 was identified from human leukocytes by homology cloning []. AQP9 has unusually broad solute permeability. It is expressed in hepatocyte plasma membranes and also in lung, small intestine and spleen cells []. Expression of AQP9 in liver was induced up to 20-fold in rats fasted for 24 to 96 hours, and the AQP9 level gradually declined after re-feeding []. AQP9 shares greater sequence identity with AQP3 and AQP7 than with other members of the family, suggesting that these 3 proteins belong to a subfamily.
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Publication
21880835 | J:180040
First Author: Nørregaard R
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: COX-2 disruption leads to increased central vasopressin stores and impaired urine concentrating ability in mice.
Volume: 301
Issue: 6
Pages: F1303-13
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Publication
18434389 | J:148646
First Author: Wang W
Year: 2008
Journal: Am J Physiol Renal Physiol
Title: Role of AQP1 in endotoxemia-induced acute kidney injury.
Volume: 294
Issue: 6
Pages: F1473-80
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Publication
15713911 | J:98932
First Author: Morris RG
Year: 2005
Journal: Am J Physiol Renal Physiol
Title: Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout mice.
Volume: 289
Issue: 1
Pages: F194-9
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Publication
23359673 | J:208102
First Author: Kortenoeven ML
Year: 2013
Journal: J Physiol
Title: Genetic ablation of aquaporin-2 in the mouse connecting tubules results in defective renal water handling.
Volume: 591
Issue: 8
Pages: 2205-19
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Publication
18718702 | J:173745
First Author: Rubenwolf PC
Year: 2009
Journal: Eur Urol
Title: Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro.
Volume: 56
Issue: 6
Pages: 1013-23
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Publication
9124401 | J:38826
First Author: Ishibashi K
Year: 1997
Journal: Am J Physiol
Title: Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts.
Volume: 272
Issue: 2 Pt 2
Pages: F235-41
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Publication
9950948 | J:53124
First Author: Frøkiaer J
Year: 1999
Journal: Am J Physiol
Title: Low aquaporin-2 levels in polyuric DI +/+ severe mice with constitutively high cAMP-phosphodiesterase activity.
Volume: 276
Issue: 2 Pt 2
Pages: F179-90
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Publication
17576812 | J:125011
First Author: Matsumura K
Year: 2007
Journal: Mol Cell Biol
Title: Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.
Volume: 27
Issue: 17
Pages: 6026-37
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Publication
15377788 | -
First Author: Harries WE
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: The channel architecture of aquaporin 0 at a 2.2-A resolution.
Volume: 101
Issue: 39
Pages: 14045-50
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Publication
15340377 | -
First Author: King LS
Year: 2004
Journal: Nat Rev Mol Cell Biol
Title: From structure to disease: the evolving tale of aquaporin biology.
Volume: 5
Issue: 9
Pages: 687-98
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Publication
16406529 | -
First Author: Tanghe A
Year: 2006
Journal: Trends Microbiol
Title: Why do microorganisms have aquaporins?
Volume: 14
Issue: 2
Pages: 78-85
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Publication
14691544 | -
First Author: Savage DF
Year: 2003
Journal: PLoS Biol
Title: Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z.
Volume: 1
Issue: 3
Pages: E72
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Publication
16650285 | -
 
First Author: Gorelick DA
Year: 2006
Journal: BMC Biochem
Title: Aquaporin-11: a channel protein lacking apparent transport function expressed in brain.
Volume: 7
Pages: 14
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Publication
10872456 | -
 
First Author: Borgnia M
Year: 1999
Journal: Annu Rev Biochem
Title: Cellular and molecular biology of the aquaporin water channels.
Volume: 68
Pages: 425-58
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Protein
Q9JJJ3
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q4FK77
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
E9Q8P3
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
D3YYD6
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
Q8R1T7
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Publication
11780053 | -
First Author: Sui H
Year: 2001
Journal: Nature
Title: Structural basis of water-specific transport through the AQP1 water channel.
Volume: 414
Issue: 6866
Pages: 872-8
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