Zinc finger FYVE domain-containing protein 26 (ZFYVE26, also known as SPG15) is a phosphatidylinositol 3-phosphate-binding protein recruited to the midbody during cytokinesis and required for the abcission step in cytokinesis (cleaving of the midbody in two) []. It may also be required for efficient homologous recombination DNA double-strand break repair [].Mutations in ZFYVE26 cause spastic paraplegia 15, autosomal recessive (SPG15), which is a form of spastic paraplegia, a neurodegenerative disorder characterised by a slow, gradual, progressive weakness and spasticity of the lower limbs [, ].
