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Search results 601 to 700 out of 2034 for Bcr

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Type Details Score
Publication
10518561 | -
First Author: Ohya K
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.
Volume: 96
Issue: 21
Pages: 11976-81
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Publication
15611091 | J:97253
First Author: Sekine Y
Year: 2005
Journal: J Biol Chem
Title: Physical and functional interactions between STAP-2/BKS and STAT5.
Volume: 280
Issue: 9
Pages: 8188-96
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Protein Domain
IPR036481 | Bcr-Abl_oncoprot_oligo_sf
Type: Homologous_superfamily
Description: This entry represents the oligomerisation domain of the breakpoint cluster region oncoprotein Bcr, and the Bcr/Abl (Abelson-leukemia-virus) fusion protein created by a reciprocal (9;22) fusion []. Brc displays serine/threonine protein kinase activity (), acting as a GTPase-activating protein for RAC1 and CDC42. Brc promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them []. The Bcr/Abl fusion protein loses some of the regulatory function of Bcr with regards to small Rho-like GTPases with negative consequences on cell motility, in particular on the capacity to adhere to endothelial cells [].The Bcr, Bcr/Abl oncoprotein oligomerisation domain consists of a short N-terminal helix (alpha-1), a flexible loop and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two helices to assume a parallel orientation. The monomeric domains associate into a dimer through the formation of an antiparallel coiled coil between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second monomer. Two dimers then associate into a tetramer. The oligomerisation domain is essential for the oncogenicity of the Bcr-Abl protein [].
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Protein Domain
IPR015123 | Bcr-Abl_oncoprot_oligo
Type: Domain
Description: This entry represents the oligomerisation domain of the breakpoint cluster region oncoprotein Bcr, and the Bcr/Abl (Abelson-leukemia-virus) fusion protein created by a reciprocal (9;22) fusion []. Brc displays serine/threonine protein kinase activity (), acting as a GTPase-activating protein for RAC1 and CDC42. Brc promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them []. The Bcr/Abl fusion protein loses some of the regulatory function of Bcr with regards to small Rho-like GTPases with negative consequences on cell motility, in particular on the capacity to adhere to endothelial cells [].The Bcr, Bcr/Abl oncoprotein oligomerisation domain consists of a short N-terminal helix (alpha-1), a flexible loop and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two helices to assume a parallel orientation. The monomeric domains associate into a dimer through the formation of an antiparallel coiled coil between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second monomer. Two dimers then associate into a tetramer. The oligomerisation domain is essential for the oncogenicity of the Bcr-Abl protein [].
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Protein Domain
IPR035748 | Lyn_SH3
Type: Domain
Description: Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR []. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5 []. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
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Protein Coding Gene
MGI:88140 | Bcl3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96892 | Lyn
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25759025 | J:219919
First Author: Geng H
Year: 2015
Journal: Cancer Cell
Title: Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.
Volume: 27
Issue: 3
Pages: 409-25
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Protein Coding Gene
MGI:2183438 | Ell2
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tcrb/Tcrb Tcrd/Tcrd
Background: B6.129P2-Tcrb Tcrd/J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atp11c/?
Background: involves: C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sh3kbp1/Sh3kbp1 Cd79a/Cd79a<+>
Background: involves: BALB/c * C57BL/6 * NZB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd19/Cd19<+> Ell2/Ell2
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Card11/Card11
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
12771181 | J:120692
First Author: Sohn HW
Year: 2003
Journal: J Exp Med
Title: Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.
Volume: 197
Issue: 11
Pages: 1511-24
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Publication
10811867 | J:110720
First Author: Petro JB
Year: 2000
Journal: J Exp Med
Title: Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement.
Volume: 191
Issue: 10
Pages: 1745-54
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Publication
28039360 | J:240887
First Author: Lentucci C
Year: 2017
Journal: J Biol Chem
Title: Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development.
Volume: 292
Issue: 7
Pages: 2754-2772
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Publication
16860757 | J:113407
First Author: Patterson HC
Year: 2006
Journal: Immunity
Title: The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain.
Volume: 25
Issue: 1
Pages: 55-65
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Publication
20696394 | J:245273
First Author: Radaev S
Year: 2010
Journal: Structure
Title: Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor.
Volume: 18
Issue: 8
Pages: 934-43
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Publication
9705962 | J:53975
First Author: Wienands J
Year: 1998
Journal: J Exp Med
Title: SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation.
Volume: 188
Issue: 4
Pages: 791-5
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Publication
18438409 | J:136292
First Author: Wilker PR
Year: 2008
Journal: Nat Immunol
Title: Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation.
Volume: 9
Issue: 6
Pages: 603-12
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Publication
15477350 | J:93951
First Author: Zhu M
Year: 2004
Journal: J Exp Med
Title: Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
Volume: 200
Issue: 8
Pages: 991-1000
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Publication
9252121 | J:42037
First Author: Chan VW
Year: 1997
Journal: Immunity
Title: Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
Volume: 7
Issue: 1
Pages: 69-81
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Publication
15304502 | J:119327
First Author: Shao Y
Year: 2004
Journal: J Biol Chem
Title: Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl.
Volume: 279
Issue: 42
Pages: 43646-53
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Publication
23499492 | J:195115
First Author: Mattila PK
Year: 2013
Journal: Immunity
Title: The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.
Volume: 38
Issue: 3
Pages: 461-74
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Publication
12833156 | J:84669
First Author: Yamazaki T
Year: 2003
Journal: Nat Immunol
Title: Contribution of BCAP to maintenance of mature B cells through c-Rel.
Volume: 4
Issue: 8
Pages: 780-6
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Publication
16301747 | J:118843
First Author: Shinohara H
Year: 2005
Journal: J Exp Med
Title: PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
Volume: 202
Issue: 10
Pages: 1423-31
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Publication
9763612 | J:72477
First Author: Liu Q
Year: 1998
Journal: J Exp Med
Title: The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.
Volume: 188
Issue: 7
Pages: 1333-42
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Publication
17890318 | J:125556
First Author: Togayachi A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation.
Volume: 104
Issue: 40
Pages: 15829-34
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Publication
10229183 | J:88257
First Author: Garrett-Sinha LA
Year: 1999
Journal: Immunity
Title: PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction.
Volume: 10
Issue: 4
Pages: 399-408
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Publication
21727189 | J:177613
First Author: Nakano-Yokomizo T
Year: 2011
Journal: J Exp Med
Title: The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
Volume: 208
Issue: 8
Pages: 1661-71
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Publication
34376664 | J:314345
First Author: Ricker E
Year: 2021
Journal: Nat Commun
Title: Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice.
Volume: 12
Issue: 1
Pages: 4813
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Publication
11371362 | J:69477
First Author: Cariappa A
Year: 2001
Journal: Immunity
Title: The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21.
Volume: 14
Issue: 5
Pages: 603-15
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Publication
12626529 | J:126271
First Author: Mizuno T
Year: 2003
Journal: J Immunol
Title: Cutting edge: CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-kappa B.
Volume: 170
Issue: 6
Pages: 2806-10
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Publication
19109164 | J:142896
First Author: Sharma S
Year: 2009
Journal: J Immunol
Title: Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells.
Volume: 182
Issue: 1
Pages: 329-39
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Publication
22994860 | J:191267
First Author: Blair D
Year: 2012
Journal: Biochem J
Title: Protein kinase Cβ is critical for the metabolic switch to glycolysis following B-cell antigen receptor engagement.
Volume: 448
Issue: 1
Pages: 165-9
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Publication
16818796 | J:135036
First Author: Lartigue A
Year: 2006
Journal: J Immunol
Title: Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus.
Volume: 177
Issue: 2
Pages: 1349-54
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Publication
26852110 | J:308047
 
First Author: Wang X
Year: 2016
Journal: Mol Immunol
Title: Pre-existing CD19-independent GL7(-) Breg cells are expanded during inflammation and in mice with lupus-like disease.
Volume: 71
Pages: 54-63
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Publication
37714151 | J:352780
First Author: Raso F
Year: 2023
Journal: Immunity
Title: Antigen receptor signaling and cell death resistance controls intestinal humoral response zonation.
Volume: 56
Issue: 10
Pages: 2373-2387.e8
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Publication
18692443 | J:140403
First Author: Bradshaw S
Year: 2008
Journal: Clin Immunol
Title: A role for Fli-1 in B cell proliferation: implications for SLE pathogenesis.
Volume: 129
Issue: 1
Pages: 19-30
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Publication
16054613 | J:100560
First Author: Mattsson N
Year: 2005
Journal: Cell Immunol
Title: Expansion of CD22lo B cells in the spleen of autoimmune-prone flaky skin mice.
Volume: 234
Issue: 2
Pages: 124-32
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Publication
26187411 | J:263564
First Author: Di Niro R
Year: 2015
Journal: Immunity
Title: Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.
Volume: 43
Issue: 1
Pages: 120-31
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Publication
30765568 | J:271722
First Author: Graf R
Year: 2019
Journal: Science
Title: BCR-dependent lineage plasticity in mature B cells.
Volume: 363
Issue: 6428
Pages: 748-753
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Publication
16286018 | J:113283
First Author: Bergtold A
Year: 2005
Journal: Immunity
Title: Cell surface recycling of internalized antigen permits dendritic cell priming of B cells.
Volume: 23
Issue: 5
Pages: 503-14
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Publication
37115935 | J:335729
First Author: Rivera CE
Year: 2023
Journal: Sci Adv
Title: Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells.
Volume: 9
Issue: 17
Pages: eade8928
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Publication
32610078 | J:292416
First Author: New JS
Year: 2020
Journal: Immunity
Title: Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development.
Volume: 53
Issue: 1
Pages: 172-186.e6
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Publication
16111632 | J:100532
First Author: Takahashi Y
Year: 2005
Journal: Immunity
Title: Novel role of the Ras cascade in memory B cell response.
Volume: 23
Issue: 2
Pages: 127-38
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Publication
32522835 | J:294822
First Author: Geng Y
Year: 2020
Journal: J Immunol
Title: HMGB1-Neutralizing IgM Antibody Is a Normal Component of Blood Plasma.
Volume: 205
Issue: 2
Pages: 407-413
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Publication
28552327 | J:242566
First Author: Lionakis MS
Year: 2017
Journal: Cancer Cell
Title: Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma.
Volume: 31
Issue: 6
Pages: 833-843.e5
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Publication
12563258 | J:96704
First Author: Suzuki H
Year: 2003
Journal: Nat Immunol
Title: PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction.
Volume: 4
Issue: 3
Pages: 280-6
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Publication
21464221 | J:177319
First Author: Bhattacharyya S
Year: 2011
Journal: J Exp Med
Title: NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.
Volume: 208
Issue: 4
Pages: 823-39
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Publication
29521626 | J:264188
   
First Author: Noviski M
Year: 2018
Journal: Elife
Title: IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.
Volume: 7
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Publication
22078222 | J:178833
First Author: O'Neill SK
Year: 2011
Journal: Immunity
Title: Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.
Volume: 35
Issue: 5
Pages: 746-56
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Publication
10981970 | J:64152
First Author: Bolland S
Year: 2000
Journal: Immunity
Title: Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis.
Volume: 13
Issue: 2
Pages: 277-85
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Publication
29996101 | J:270861
First Author: Domeier PP
Year: 2018
Journal: Cell Rep
Title: B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells.
Volume: 24
Issue: 2
Pages: 406-418
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Publication
31433298 | J:278686
   
First Author: Kreuk LS
Year: 2019
Journal: Elife
Title: B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota.
Volume: 8
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Publication
21530328 | J:172608
First Author: Matsumoto M
Year: 2011
Journal: Immunity
Title: The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production.
Volume: 34
Issue: 5
Pages: 703-14
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Publication
23223530 | J:193187
First Author: Yasui T
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.
Volume: 109
Issue: 51
Pages: 21022-7
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Publication
33207194 | J:304765
First Author: Ramezani-Rad P
Year: 2020
Journal: Cell Rep
Title: Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells.
Volume: 33
Issue: 7
Pages: 108403
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Publication
29562201 | J:272419
First Author: Li X
Year: 2018
Journal: Immunity
Title: Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.
Volume: 48
Issue: 3
Pages: 530-541.e6
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Publication
21604259 | J:176828
First Author: Eschbach C
Year: 2011
Journal: Eur J Immunol
Title: Efficient generation of B lymphocytes by recognition of self-antigens.
Volume: 41
Issue: 8
Pages: 2397-403
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Publication
17082570 | J:140502
First Author: Otero DC
Year: 2006
Journal: J Immunol
Title: Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3.
Volume: 177
Issue: 10
Pages: 6593-7
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Publication
39092178 | J:353087
First Author: Tsai PJ
Year: 2024
Journal: iScience
Title: PTEN acts as a crucial inflammatory checkpoint controlling TLR9/IL-6 axis in B cells.
Volume: 27
Issue: 7
Pages: 110388
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Publication
32983140 | J:305737
 
First Author: Märklin M
Year: 2020
Journal: Front Immunol
Title: Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia.
Volume: 11
Pages: 1995
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Publication
19877015 | J:155459
First Author: Richards SM
Year: 2009
Journal: Eur J Immunol
Title: BCR-induced superoxide negatively regulates B-cell proliferation and T-cell-independent type 2 Ab responses.
Volume: 39
Issue: 12
Pages: 3395-403
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Publication
27875245 | J:239088
First Author: Villa M
Year: 2017
Journal: EMBO J
Title: Aryl hydrocarbon receptor is required for optimal B-cell proliferation.
Volume: 36
Issue: 1
Pages: 116-128
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Publication
23453634 | J:194830
First Author: Schweighoffer E
Year: 2013
Journal: Immunity
Title: The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.
Volume: 38
Issue: 3
Pages: 475-88
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Publication
25642821 | J:259148
First Author: McHeyzer-Williams LJ
Year: 2015
Journal: Nat Immunol
Title: Class-switched memory B cells remodel BCRs within secondary germinal centers.
Volume: 16
Issue: 3
Pages: 296-305
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Publication
33119032 | J:307785
 
First Author: Müller-Winkler J
Year: 2021
Journal: J Exp Med
Title: Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival.
Volume: 218
Issue: 2
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Publication
18955699 | J:144071
First Author: Khiem D
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A p38 MAPK-MEF2C pathway regulates B-cell proliferation.
Volume: 105
Issue: 44
Pages: 17067-72
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Publication
18191593 | J:131150
First Author: Arana E
Year: 2008
Journal: Immunity
Title: Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.
Volume: 28
Issue: 1
Pages: 88-99
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Publication
28356391 | J:241854
First Author: Schweighoffer E
Year: 2017
Journal: J Exp Med
Title: TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
Volume: 214
Issue: 5
Pages: 1269-1280
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Publication
15941910 | J:119378
First Author: Vigorito E
Year: 2005
Journal: Blood
Title: Vav proteins regulate peripheral B-cell survival.
Volume: 106
Issue: 7
Pages: 2391-8
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Publication
31591571 | J:282532
First Author: Schwickert TA
Year: 2019
Journal: Nat Immunol
Title: Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.
Volume: 20
Issue: 11
Pages: 1517-1529
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Publication
30021765 | J:264511
First Author: Pore D
Year: 2018
Journal: J Immunol
Title: Cutting Edge: Deletion of Ezrin in B Cells of Lyn-Deficient Mice Downregulates Lupus Pathology.
Volume: 201
Issue: 5
Pages: 1353-1358
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Publication
27889108 | J:259745
First Author: Skrzypczynska KM
Year: 2016
Journal: Immunity
Title: Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells.
Volume: 45
Issue: 6
Pages: 1232-1244
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Publication
23776171 | J:205452
First Author: Guo B
Year: 2013
Journal: J Immunol
Title: IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation.
Volume: 191
Issue: 2
Pages: 670-7
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Publication
23749435 | J:201329
First Author: Chatterjee P
Year: 2013
Journal: Eur J Immunol
Title: Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.
Volume: 43
Issue: 9
Pages: 2441-2450
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Publication
9323135 | J:79299
First Author: Lam KP
Year: 1997
Journal: Cell
Title: In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.
Volume: 90
Issue: 6
Pages: 1073-83
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Publication
18059271 | J:130478
First Author: Depoil D
Year: 2008
Journal: Nat Immunol
Title: CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.
Volume: 9
Issue: 1
Pages: 63-72
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Publication
23267023 | J:192603
First Author: Choi SC
Year: 2013
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