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Search results 501 to 600 out of 638 for Synj2

0.042s
Type Details Score
Publication  
First Author: Necchi D
Year: 2008
Journal: Brain Res
Title: Axonal abnormalities in cerebellar Purkinje cells of the Ts65Dn mouse.
Volume: 1238
Pages: 181-8
Publication
First Author: Alldred MJ
Year: 2023
Journal: FASEB J
Title: Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation.
Volume: 37
Issue: 6
Pages: e22944
Publication
First Author: Sansevero G
Year: 2016
Journal: Exp Neurol
Title: Experience-dependent reduction of soluble β-amyloid oligomers and rescue of cognitive abilities in middle-age Ts65Dn mice, a model of Down syndrome.
Volume: 283
Issue: Pt A
Pages: 49-56
Publication  
First Author: Sarver DC
Year: 2023
Journal: Mol Metab
Title: Dysregulated systemic metabolism in a Down syndrome mouse model.
Volume: 68
Pages: 101666
Publication  
First Author: Catuara-Solarz S
Year: 2015
Journal: Front Behav Neurosci
Title: Principal Component Analysis of the Effects of Environmental Enrichment and (-)-epigallocatechin-3-gallate on Age-Associated Learning Deficits in a Mouse Model of Down Syndrome.
Volume: 9
Pages: 330
Publication
First Author: Rueda N
Year: 2005
Journal: Neurosci Lett
Title: Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome.
Volume: 380
Issue: 1-2
Pages: 197-201
Publication  
First Author: Mitra A
Year: 2012
Journal: Brain Res
Title: Developmentally altered inhibition in Ts65Dn, a mouse model of Down syndrome.
Volume: 1440
Pages: 1-8
Publication  
First Author: Giacomini A
Year: 2015
Journal: Neurobiol Dis
Title: Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.
Volume: 82
Pages: 385-396
Publication
First Author: Fernandez F
Year: 2009
Journal: J Neurochem
Title: Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome.
Volume: 110
Issue: 1
Pages: 157-69
Publication  
First Author: Begenisic T
Year: 2015
Journal: Neurobiol Dis
Title: Early environmental therapy rescues brain development in a mouse model of Down syndrome.
Volume: 82
Pages: 409-419
Publication
First Author: Fortress AM
Year: 2015
Journal: J Neurosci
Title: Designer receptors enhance memory in a mouse model of Down syndrome.
Volume: 35
Issue: 4
Pages: 1343-53
Publication
First Author: Deidda G
Year: 2015
Journal: Nat Med
Title: Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.
Volume: 21
Issue: 4
Pages: 318-26
Publication  
First Author: Altafaj X
Year: 2013
Journal: Neurobiol Dis
Title: Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome.
Volume: 52
Pages: 117-27
Publication
First Author: Trazzi S
Year: 2011
Journal: Hum Mol Genet
Title: APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.
Volume: 20
Issue: 8
Pages: 1560-73
Publication
First Author: Fowler TW
Year: 2012
Journal: PLoS One
Title: Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment.
Volume: 7
Issue: 8
Pages: e42967
Publication
First Author: Starbuck JM
Year: 2021
Journal: Sci Rep
Title: Green tea extracts containing epigallocatechin-3-gallate modulate facial development in Down syndrome.
Volume: 11
Issue: 1
Pages: 4715
Publication
First Author: Han F
Year: 2009
Journal: Int J Exp Pathol
Title: Otitis media in a mouse model for Down syndrome.
Volume: 90
Issue: 5
Pages: 480-8
Publication
First Author: Huang W
Year: 2000
Journal: Neuroreport
Title: Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment.
Volume: 11
Issue: 3
Pages: 445-8
Publication
First Author: Faizi M
Year: 2011
Journal: Neurobiol Dis
Title: Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.
Volume: 43
Issue: 2
Pages: 397-413
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: involves: C3H/HeSnJ * C57BL/6JEi * DBA/2J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: involves: C3H/HeJ * C57BL/6 * DBA/2J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: involves: DBA/2J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: involves: C3H * C57BL/6 * DBA/2J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: involves: C3H/HeJ * C57BL/6JEi * DBA/2J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: B6EiC3Sn a/A-Ts(17<16>)65Dn/J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Rcan1/Rcan1<+> Ts(17<16>)65Dn/?
Background: involves: 129S4/SvJae * C3H/HeSn * C57BL/6 * C57BL/6Ei * DBA/2J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: B6EiC3Sn.BLiA-Ts(17<16>)65Dn/DnJ
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: involves: C3H/HeJ * C57BL/6J * DBA/2J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Del(16App-Runx1)5Yah/? Ts(17<16>)65Dn/?
Background: involves: BALB/c * C3H * C57BL/6 * DBA/2J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: involves: C3H/HeH * C3H/HeSn * C57BL/6Ei * C57BL/6J * DBA/2J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: involves: BALB/c * C3H/He * C57BL/6JEiJ * DBA/2J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Ts(17<16>)65Dn/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Wang X
Year: 2013
Journal: Nat Med
Title: Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Volume: 19
Issue: 4
Pages: 473-80
Publication  
First Author: Blazek JD
Year: 2015
Journal: Mech Dev
Title: Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner.
Volume: 136
Pages: 133-42
Publication  
First Author: Hawley LE
Year: 2023
Journal: Neurobiol Dis
Title: Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model.
Volume: 190
Pages: 106359
Publication
First Author: Blazek JD
Year: 2015
Journal: Hum Mol Genet
Title: Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a.
Volume: 24
Issue: 20
Pages: 5687-96
Publication
First Author: McElyea SD
Year: 2016
Journal: Hum Mol Genet
Title: Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome.
Volume: 25
Issue: 22
Pages: 4856-4869
Publication  
First Author: García-Cerro S
Year: 2017
Journal: Neurobiol Dis
Title: Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.
Volume: 106
Pages: 76-88
Strain
Attribute String: mutant strain, chromosome aberration, trisomy
Publication
First Author: Hill CA
Year: 2009
Journal: Am J Med Genet A
Title: Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic "Down syndrome" mice.
Volume: 149A
Issue: 10
Pages: 2158-65
Publication  
First Author: Polk RC
Year: 2015
Journal: BMC Dev Biol
Title: The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.
Volume: 15
Pages: 30
Publication
First Author: Baek KH
Year: 2009
Journal: Nature
Title: Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.
Volume: 459
Issue: 7250
Pages: 1126-30
Publication
First Author: Klein SL
Year: 1996
Journal: Physiol Behav
Title: Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice.
Volume: 60
Issue: 4
Pages: 1159-64
Publication
First Author: Toiber D
Year: 2010
Journal: Neurobiol Dis
Title: Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.
Volume: 40
Issue: 1
Pages: 348-59
Publication
First Author: Duchon A
Year: 2011
Journal: Mamm Genome
Title: Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.
Volume: 22
Issue: 11-12
Pages: 674-84
Publication
First Author: Tlili A
Year: 2013
Journal: Mol Genet Metab
Title: DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.
Volume: 110
Issue: 3
Pages: 371-7
Publication
First Author: Blazek JD
Year: 2011
Journal: Bone
Title: Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice.
Volume: 48
Issue: 2
Pages: 275-80
Publication
First Author: Singh N
Year: 2015
Journal: Dis Model Mech
Title: Acute upregulation of hedgehog signaling in mice causes differential effects on cranial morphology.
Volume: 8
Issue: 3
Pages: 271-9
Publication
First Author: Herault Y
Year: 2017
Journal: Dis Model Mech
Title: Rodent models in Down syndrome research: impact and future opportunities.
Volume: 10
Issue: 10
Pages: 1165-1186
Publication
First Author: Harashima C
Year: 2006
Journal: Cell Mol Neurobiol
Title: Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model.
Volume: 26
Issue: 4-6
Pages: 719-34
Publication
First Author: Villar AJ
Year: 2005
Journal: Mamm Genome
Title: Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.
Volume: 16
Issue: 2
Pages: 79-90
Publication
First Author: Colas D
Year: 2008
Journal: Neurobiol Dis
Title: Sleep and EEG features in genetic models of Down syndrome.
Volume: 30
Issue: 1
Pages: 1-7
Publication  
First Author: Moyer AJ
Year: 2023
Journal: Dis Model Mech
Title: Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome.
Volume: 16
Issue: 4
Publication
First Author: Belichenko PV
Year: 2004
Journal: J Comp Neurol
Title: Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.
Volume: 480
Issue: 3
Pages: 281-98
Publication
First Author: Illouz T
Year: 2024
Journal: Sci Rep
Title: Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks.
Volume: 14
Issue: 1
Pages: 15944
Publication
First Author: Victorino DB
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome.
Volume: 61
Issue: 5
Pages: 25
Publication
First Author: Fulton SL
Year: 2022
Journal: Nat Commun
Title: Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.
Volume: 13
Issue: 1
Pages: 6384
Publication  
First Author: Glass TJ
Year: 2024
Journal: Front Neurol
Title: Altered tongue muscle contractile properties coincide with altered swallow function in the adult Ts65Dn mouse model of down syndrome.
Volume: 15
Pages: 1384572
Publication  
First Author: Navarro-Romero A
Year: 2019
Journal: Neurobiol Dis
Title: Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.
Volume: 125
Pages: 92-106
Publication  
First Author: Dutka T
Year: 2015
Journal: Mech Dev
Title: Chronic up-regulation of the SHH pathway normalizes some developmental effects of trisomy in Ts65Dn mice.
Volume: 135
Pages: 68-80
Publication
First Author: Belichenko PV
Year: 2007
Journal: J Comp Neurol
Title: Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.
Volume: 504
Issue: 4
Pages: 329-45
Publication  
First Author: Jiang Y
Year: 2016
Journal: Neurobiol Aging
Title: Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.
Volume: 39
Pages: 90-8
Publication
First Author: Olson LE
Year: 2007
Journal: Hum Mol Genet
Title: Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.
Volume: 16
Issue: 7
Pages: 774-82
Publication
First Author: Belichenko PV
Year: 2016
Journal: PLoS One
Title: An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.
Volume: 11
Issue: 3
Pages: e0152471
Publication
First Author: Xu JC
Year: 2013
Journal: EMBO J
Title: Usp16: key controller of stem cells in Down syndrome.
Volume: 32
Issue: 21
Pages: 2788-9
Publication
First Author: Sago H
Year: 2000
Journal: Pediatr Res
Title: Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome.
Volume: 48
Issue: 5
Pages: 606-13
Publication  
First Author: Hijazi M
Year: 2013
Journal: Exp Neurol
Title: Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.
Volume: 239
Pages: 229-34
Publication
First Author: Noll C
Year: 2009
Journal: PLoS One
Title: DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
Volume: 4
Issue: 10
Pages: e7540
Publication
First Author: Kirsammer G
Year: 2008
Journal: Blood
Title: Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome.
Volume: 111
Issue: 2
Pages: 767-75
Publication
First Author: Jiang Y
Year: 2019
Journal: J Neurosci
Title: Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99).
Volume: 39
Issue: 27
Pages: 5255-5268
Publication
First Author: Yang A
Year: 2011
Journal: Cancer Res
Title: Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome.
Volume: 71
Issue: 10
Pages: 3573-81
Publication
First Author: William CM
Year: 2017
Journal: J Neurosci
Title: Activity-Dependent Dysfunction in Visual and Olfactory Sensory Systems in Mouse Models of Down Syndrome.
Volume: 37
Issue: 41
Pages: 9880-9888
Publication
First Author: Colombi I
Year: 2024
Journal: iScience
Title: Heterogeneous subpopulations of GABA(A)R-responding neurons coexist across neuronal network scales and developmental stages in health and disease.
Volume: 27
Issue: 4
Pages: 109438
Publication  
First Author: Kida E
Year: 2013
Journal: Exp Neurol
Title: Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn.
Volume: 240
Pages: 178-89
Publication
First Author: Richtsmeier JT
Year: 2002
Journal: Am J Med Genet
Title: Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome.
Volume: 107
Issue: 4
Pages: 317-24
Publication
First Author: Starbuck JM
Year: 2014
Journal: Am J Med Genet A
Title: Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice.
Volume: 164A
Issue: 8
Pages: 1981-1990
Publication
First Author: Aldridge K
Year: 2007
Journal: Am J Med Genet A
Title: Differential effects of trisomy on brain shape and volume in related aneuploid mouse models.
Volume: 143A
Issue: 10
Pages: 1060-70
Publication
First Author: Salehi A
Year: 2009
Journal: Sci Transl Med
Title: Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.
Volume: 1
Issue: 7
Pages: 7ra17
Publication  
First Author: Aziz NM
Year: 2018
Journal: Dis Model Mech
Title: Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome.
Volume: 11
Issue: 6
Publication
First Author: Sussan TE
Year: 2008
Journal: Nature
Title: Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome.
Volume: 451
Issue: 7174
Pages: 73-5
Publication
First Author: Blank M
Year: 2011
Journal: J Neurosci
Title: The Down syndrome critical region regulates retinogeniculate refinement.
Volume: 31
Issue: 15
Pages: 5764-76
Publication
First Author: Roper RJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice.
Volume: 103
Issue: 5
Pages: 1452-6
Publication      
First Author: Wang X
Year: 2024
Journal: Alzheimers Dement
Title: Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down syndrome.
Publication      
First Author: Rastogi M
Year: 2024
Journal: Neuron
Title: Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains.
Publication
First Author: Olson LE
Year: 2004
Journal: Science
Title: A chromosome 21 critical region does not cause specific Down syndrome phenotypes.
Volume: 306
Issue: 5696
Pages: 687-90
Publication
First Author: Adams AD
Year: 2024
Journal: Am J Obstet Gynecol
Title: Embryonic statistical analyses reveal 2 growth phenotypes in mouse models of Down syndrome.
Volume: 230
Issue: 2
Pages: 258.e1-258.e11
Publication
First Author: Siegel AE
Year: 2023
Journal: J Neurosci Res
Title: Visual discrimination and inhibitory control deficits in mouse models of Down syndrome: A pilot study using rodent touchscreen technology.
Volume: 101
Issue: 4
Pages: 492-507
Publication      
First Author: Sierra C
Year: 2024
Journal: Mol Psychiatry
Title: The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity, and memory deficits in Down syndrome.
Publication
First Author: Adams AD
Year: 2021
Journal: Am J Obstet Gynecol
Title: Novel insights from fetal and placental phenotyping in 3 mouse models of Down syndrome.
Volume: 225
Issue: 3
Pages: 296.e1-296.e13
Publication  
First Author: Heller HC
Year: 2014
Journal: Neurobiol Learn Mem
Title: Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors.
Volume: 116
Pages: 162-71
Publication
First Author: Chen XQ
Year: 2024
Journal: Ann Neurol
Title: γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.
Volume: 96
Issue: 2
Pages: 390-404
Publication  
First Author: Ravaioli F
Year: 2024
Journal: Front Aging Neurosci
Title: Increased hippocampal epigenetic age in the Ts65Dn mouse model of Down Syndrome.
Volume: 16
Pages: 1401109
Publication
First Author: Siddiqui A
Year: 2008
Journal: Genes Brain Behav
Title: Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.
Volume: 7
Issue: 7
Pages: 810-20
Publication  
First Author: Guedj F
Year: 2016
Journal: Sci Rep
Title: An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.
Volume: 6
Pages: 32353
Publication  
First Author: Nguyen TL
Year: 2018
Journal: Dis Model Mech
Title: Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.
Volume: 11
Issue: 9
Publication
First Author: Lane AA
Year: 2014
Journal: Nat Genet
Title: Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.
Volume: 46
Issue: 6
Pages: 618-23
Publication
First Author: Singh N
Year: 2016
Journal: Dev Dyn
Title: Chronic up-regulation of sonic hedgehog has little effect on postnatal craniofacial morphology of euploid and trisomic mice.
Volume: 245
Issue: 2
Pages: 114-22
Publication
First Author: Olson LE
Year: 2004
Journal: Dev Dyn
Title: Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.
Volume: 230
Issue: 3
Pages: 581-9
Publication  
First Author: Kleschevnikov AM
Year: 2017
Journal: Neurobiol Dis
Title: Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
Volume: 103
Pages: 1-10
Publication  
First Author: Ash JA
Year: 2014
Journal: Neurobiol Dis
Title: Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice.
Volume: 70
Pages: 32-42