Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1620420 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 12.5 |
|
Note: |
There is fibrin deposition in this mutant. |
Specimen Label: |
Not shown |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6449861 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-14 |
Strength: |
Trace |
Sex: |
Not Specified |
Emaps: |
EMAPS:2823927 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:6450008 |
Age: |
postnatal newborn |
|
Note: |
Some traces of fibrin deposition were evident in the glomeruli and tubuli. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1929028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6693254 |
Age: |
postnatal adult |
Image: |
UC Davis_1882044 |
|
Specimen Label: |
UC Davis_1882044 |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668825 |
Pattern: |
Not Specified |
Stage: |
TS25 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 17.5 |
Image: |
1i |
Note: |
There is fibrin deposition. |
Specimen Label: |
1i |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668825 |
Pattern: |
Not Specified |
Stage: |
TS25 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 17.5 |
|
Note: |
There is fibrin deposition in this mutant. |
Specimen Label: |
Not shown FVII+/+/PC-/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668825 |
Pattern: |
Not Specified |
Stage: |
TS25 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 17.5 |
|
Note: |
There is fibrin deposition in this mutant. |
Specimen Label: |
Not shown FVII+/-/PC-/- |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668825 |
|
Stage: |
TS25 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 17.5 |
|
Note: |
There are no fibrin deposits in wild type embryos. |
Specimen Label: |
Not shown wild type |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668825 |
|
Stage: |
TS25 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 17.5 |
|
Note: |
There are no fibrin deposits in this mutant embryo. |
Specimen Label: |
Not shown FVII-/-/PC-+/+ |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 12.5 |
|
Note: |
Fibrin deposits are in the neural canal. |
Specimen Label: |
Not shown |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689420 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 12.5 |
Image: |
3a |
|
Specimen Label: |
3a |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689425 |
Pattern: |
Not Specified |
Stage: |
TS25 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 17.5 |
|
Note: |
There is fibrin deposition in this mutant. |
Specimen Label: |
Not shown FVII+/+/PC-/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689425 |
Pattern: |
Not Specified |
Stage: |
TS25 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 17.5 |
|
Note: |
There is fibrin deposition in this mutant. |
Specimen Label: |
Not shown FVII+/-/PC-/- |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689425 |
|
Stage: |
TS25 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 17.5 |
|
Note: |
There are no fibrin deposits in wild type embryos. |
Specimen Label: |
Not shown wild type |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689425 |
|
Stage: |
TS25 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 17.5 |
|
Note: |
There are no fibrin deposits in this mutant embryo. |
Specimen Label: |
Not shown FVII-/-/PC-+/+ |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4839927 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2010-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689422 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4840018 |
Age: |
embryonic day 14.5 |
|
Note: |
Fibron deposition in the brain is less than in the liver. |
Specimen Label: |
Not shown FVII+/-/PC-/- |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6449861 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-14 |
Strength: |
Trace |
Sex: |
Not Specified |
Emaps: |
EMAPS:2778227 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:6450008 |
Age: |
postnatal newborn |
|
Note: |
Some traces of fibrin deposition were evident in the glomeruli and tubuli. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Archibald AL |
Year: |
1998 |
Journal: |
Anim Genet |
Title: |
RFLP and linkage analysis of the porcine fibrinogen loci--FGA, FGB and FGG. |
Volume: |
29 |
Issue: |
6 |
Pages: |
471-2 |
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Allele |
Name: |
fibrinogen beta chain; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Publication |
First Author: |
Kay AB |
Year: |
1974 |
Journal: |
Br J Haematol |
Title: |
The identification of fibrinopeptide B as a chemotactic agent derived from human fibrinogen. |
Volume: |
27 |
Issue: |
4 |
Pages: |
669-77 |
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Publication |
First Author: |
Duga S |
Year: |
2000 |
Journal: |
Blood |
Title: |
Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion. |
Volume: |
95 |
Issue: |
4 |
Pages: |
1336-41 |
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Publication |
First Author: |
Koopman J |
Year: |
1992 |
Journal: |
J Clin Invest |
Title: |
Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala----Thr. |
Volume: |
90 |
Issue: |
1 |
Pages: |
238-44 |
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Protein Domain |
Type: |
Family |
Description: |
Fibrinogens are cleaved by thrombin to yield fibrins, which polymerize to form the insoluble fibrin clot which blocks sites of vascular injury, preventing further blood loss. The clot is subsequently degraded by plasmin (fibrinolysis) []. There are three fibrinogens, alpha, beta and gamma []. Thrombin activates fibrinogen to release a fibrinopeptide []. The newly exposed N terminus forms an Glu-Lys isopeptide bond, which is stabilized by factor XIIIA []. Fibrinogen is also required for successful pregnancy, and in knockout mice fatal uterine bleeding occurs around the tenth day of gestation [].This entry represents the beta chain of fibrinogen (FGB). Cleavage by thrombin releases fibrinopeptidase B, a chemotactic agent []. Mutations in the FGB gene can lead to congenital afibrinogenemia, which can cause a hemphilia [], or congenital dysfibrinogenemia, frequently asymptomatic []. |
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Publication |
First Author: |
Suh TT |
Year: |
1995 |
Journal: |
Genes Dev |
Title: |
Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. |
Volume: |
9 |
Issue: |
16 |
Pages: |
2020-33 |
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Publication |
First Author: |
Lebedeva IV |
Year: |
1979 |
Journal: |
Zdravookhr Ross Fed |
Title: |
[Economic effectiveness of dispensary care in textile enterprises]. |
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Issue: |
4 |
Pages: |
14-6 |
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Publication |
First Author: |
Lord ST |
Year: |
1990 |
Journal: |
J Biol Chem |
Title: |
Analysis of fibrinogen A alpha-fusion proteins. Mutants which inhibit thrombin equivalently are not equally good substrates. |
Volume: |
265 |
Issue: |
2 |
Pages: |
838-43 |
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Publication |
First Author: |
Kirschbaum NE |
Year: |
1990 |
Journal: |
J Biol Chem |
Title: |
A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule. |
Volume: |
265 |
Issue: |
23 |
Pages: |
13669-76 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
481
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
481
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Fragment?: |
false |
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