|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 148 out of 148 for Mdc1

<< First    < Previous  |  Next >    Last >>
0.029s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Interaction Experiment
Description: MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks.
Publication
First Author: Wu L
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks.
Volume: 105
Issue: 32
Pages: 11200-5
Allele
Name: mediator of DNA damage checkpoint 1; gene trap OST441263, Lexicon Genetics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
Publication
First Author: Luo S
Year: 2012
Journal: FEBS Lett
Title: Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1.
Volume: 586
Issue: 4
Pages: 344-9
Protein Domain
Type: Domain
Description: This is the N-terminal forkhead-associated (FHA) domain found in Drosophila mutator 2 (MU2) protein. FHA domains are generally phosphothreonine (pThr) specific-binding domains and are present in DNA repair and checkpoint proteins. However, phosphothreonine binding is not conserved in the MU2 active site pocket due to the absence of three key residues needed for pThr binding. Dimerization, is conserved between FHA domains of Drosophila MU2 and human MDC1 albeit through different interfaces. The MU2 FHA domain dimerizes via the β-sheet 2, the MDC1 FHA domain dimerizes via the opposite β-sheet 1 [].
Strain
Attribute String: coisogenic, mutant strain, gene trap
Genotype
Symbol: Mdc1/Mdc1
Background: involves: 129S5/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Lilley CE
Year: 2010
Journal: EMBO J
Title: A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses.
Volume: 29
Issue: 5
Pages: 943-55
Publication
First Author: Peng Y
Year: 2019
Journal: Nat Commun
Title: The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors.
Volume: 10
Issue: 1
Pages: 1224
Publication  
First Author: Chukrallah LG
Year: 2022
Journal: J Cell Sci
Title: ADAD2 regulates heterochromatin in meiotic and post-meiotic male germ cells via translation of MDC1.
Volume: 135
Issue: 4
Publication
First Author: Hartlerode AJ
Year: 2012
Journal: PLoS One
Title: Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks.
Volume: 7
Issue: 11
Pages: e49211
Publication
First Author: Xu C
Year: 2008
Journal: J Mol Biol
Title: Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites.
Volume: 381
Issue: 2
Pages: 361-72
Publication
First Author: Zhang J
Year: 2019
Journal: Cancer Discov
Title: PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.
Volume: 9
Issue: 9
Pages: 1306-1323
Publication
First Author: Vyas R
Year: 2013
Journal: Cell Death Differ
Title: RNF4 is required for DNA double-strand break repair in vivo.
Volume: 20
Issue: 3
Pages: 490-502
Publication
First Author: Jiang H
Year: 2018
Journal: PLoS Genet
Title: MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice.
Volume: 14
Issue: 5
Pages: e1007300
Publication
First Author: Lu D
Year: 2015
Journal: Mol Cell Biol
Title: Nuclear GIT2 is an ATM substrate and promotes DNA repair.
Volume: 35
Issue: 7
Pages: 1081-96
Publication
First Author: Townsend PA
Year: 2005
Journal: J Cell Sci
Title: STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage.
Volume: 118
Issue: Pt 8
Pages: 1629-39
Publication
First Author: Burrage J
Year: 2012
Journal: J Cell Sci
Title: The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells.
Volume: 125
Issue: Pt 22
Pages: 5524-34
Publication
First Author: Francia S
Year: 2016
Journal: J Cell Sci
Title: DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.
Volume: 129
Issue: 7
Pages: 1468-76
Publication
First Author: Yu L
Year: 2021
Journal: PLoS Pathog
Title: Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining.
Volume: 17
Issue: 8
Pages: e1009812
Publication
First Author: Rybanska-Spaeder I
Year: 2014
Journal: PLoS One
Title: 53BP1 mediates the fusion of mammalian telomeres rendered dysfunctional by DNA-PKcs loss or inhibition.
Volume: 9
Issue: 9
Pages: e108731