Type |
Details |
Score |
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Pathway |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling. |
|
•
•
•
•
•
|
Publication |
First Author: |
Hadari YR |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. |
Volume: |
18 |
Issue: |
7 |
Pages: |
3966-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wong A |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. |
Volume: |
99 |
Issue: |
10 |
Pages: |
6684-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gotoh N |
Year: |
2008 |
Journal: |
Cancer Sci |
Title: |
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins. |
Volume: |
99 |
Issue: |
7 |
Pages: |
1319-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Degoutin J |
Year: |
2007 |
Journal: |
FEBS Lett |
Title: |
ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. |
Volume: |
581 |
Issue: |
4 |
Pages: |
727-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Y |
Year: |
2003 |
Journal: |
Biol Chem |
Title: |
EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. |
Volume: |
384 |
Issue: |
8 |
Pages: |
1215-26 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (Fgfr1) is mediated by alternative splicing of the juxtamembrane domain. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ong SH |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. |
Volume: |
20 |
Issue: |
3 |
Pages: |
979-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Melillo RM |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. |
Volume: |
21 |
Issue: |
13 |
Pages: |
4177-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim YP |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling. |
Volume: |
274 |
Issue: |
27 |
Pages: |
19025-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cross MJ |
Year: |
2002 |
Journal: |
Mol Biol Cell |
Title: |
The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells. |
Volume: |
13 |
Issue: |
8 |
Pages: |
2881-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burgar HR |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (Fgfr1) is mediated by alternative splicing of the juxtamembrane domain. |
Volume: |
277 |
Issue: |
6 |
Pages: |
4018-23 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
249
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
209
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
821
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
508
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Dhalluin C |
Year: |
2000 |
Journal: |
Mol Cell |
Title: |
Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors. |
Volume: |
6 |
Issue: |
4 |
Pages: |
921-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koshiba S |
Year: |
2010 |
Journal: |
J Struct Funct Genomics |
Title: |
Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2. |
Volume: |
11 |
Issue: |
2 |
Pages: |
125-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sain N |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Understanding the molecular basis of substrate binding specificity of PTB domains. |
Volume: |
6 |
|
Pages: |
31418 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
FRS2 (also called Suc1-associated neurotrophic factor (SNT)-induced tyrosine-phosphorylated target) proteins are membrane-anchored adaptor proteins. They are composed of an N-terminal myristoylation site followed by a phosphotyrosine binding (PTB) domain, which has a PH-like fold, and a C-terminal effector domain containing multiple tyrosine and serine/threonine phosphorylation site. The FRS2/SNT proteins show increased tyrosine phosphorylation by activated receptors, such as fibroblast growth factor receptor (FGFR) and TrkA, recruit SH2 domain containing proteins such as Grb2, and mediate signals from activated receptors to a variety of downstream pathways. The PTB domains of the SNT proteins directly interact with the canonical NPXpY motif of TrkA in a phosphorylation dependent manner, they directly bind to the juxtamembrane region of FGFR in a phosphorylation-independent manner [, ]. This domain can also be found in FRS3 []. PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lacking tyrosine residues altogether. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains. This domain is part of the IRS-like subgroup [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Dabrowski A |
Year: |
2015 |
Journal: |
Development |
Title: |
Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis. |
Volume: |
142 |
Issue: |
10 |
Pages: |
1818-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brewer JR |
Year: |
2015 |
Journal: |
Genes Dev |
Title: |
Fgfr1 regulates development through the combinatorial use of signaling proteins. |
Volume: |
29 |
Issue: |
17 |
Pages: |
1863-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manchado E |
Year: |
2016 |
Journal: |
Nature |
Title: |
A combinatorial strategy for treating KRAS-mutant lung cancer. |
Volume: |
534 |
Issue: |
7609 |
Pages: |
647-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hryciw T |
Year: |
2010 |
Journal: |
J Neurochem |
Title: |
The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons. |
Volume: |
112 |
Issue: |
4 |
Pages: |
924-39 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1319
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
217
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
492
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Uhlik MT |
Year: |
2005 |
Journal: |
J Mol Biol |
Title: |
Structural and evolutionary division of phosphotyrosine binding (PTB) domains. |
Volume: |
345 |
Issue: |
1 |
Pages: |
1-20 |
|
•
•
•
•
•
|