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Search results 101 to 174 out of 174 for Sart3

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0.025s
Type Details Score
GXD Expression  
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Pattern: Ubiquitous
Stage: TS15
Assay Id: MGI:6835789
Age: embryonic day 9.5
Note: There is higher expression in areas with more rapid proliferation and differentiation processes.
Specimen Label: S2C
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Pattern: Ubiquitous
Stage: TS15
Assay Id: MGI:6835789
Age: embryonic day 9.5
Note: There is higher expression in areas with more rapid proliferation and differentiation processes.
Specimen Label: S2D
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6835789
Age: embryonic day 8.5
Note: Expression is in the outer regions.
Specimen Label: S2A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6835789
Age: embryonic day 8.5
Note: Expression is in the outer regions.
Specimen Label: S2B
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6835789
Age: embryonic day 9.5
Specimen Label: S2H
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6835789
Age: embryonic day 9.5
Specimen Label: S2G
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3615955
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1679727
Stage: TS27
Assay Id: MGI:3618080
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3615955
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3618080
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
GXD Expression  
Probe: MGI:3615955
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3618080
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
GXD Expression  
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160465
Pattern: Not Specified
Stage: TS05
Assay Id: MGI:6835793
Age: embryonic day 3.5
Note: Expression is nuclear.
Specimen Label: S3
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615955
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3267921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3618080
Age: embryonic day 13.5
Image: E13.5
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: E13.5
Specimen Num: 1
GXD Expression  
Probe: MGI:3615955
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3618080
Age: embryonic day 13.5
Image: E13.5
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: E13.5
Specimen Num: 1
GXD Expression    
Probe: MGI:3615955
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757727
Stage: TS27
Assay Id: MGI:3618080
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Not Specified
Stage: TS02
Assay Id: MGI:6835793
Age: embryonic day 1.0
Specimen Label: not shown 2-cell
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3800315
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6835789
Age: embryonic day 9.5
Note: Expression is in the anterior and posterior neuropore.
Specimen Label: S2C
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3800315
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6835789
Age: embryonic day 9.5
Note: Expression is in the anterior and posterior neuropore.
Specimen Label: S2D
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6835788
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3800315
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6835789
Age: embryonic day 9.5
Note: Expression is in the anterior neuropore.
Specimen Label: S2E
Detected: true
Specimen Num: 5
Publication
First Author: Liu Y
Year: 2011
Journal: Blood
Title: TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC.
Volume: 117
Issue: 21
Pages: 5643-51
Publication
First Author: Whitmill A
Year: 2017
Journal: Stem Cells
Title: Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2.
Volume: 35
Issue: 7
Pages: 1674-1686
Publication  
First Author: McKee AE
Year: 2005
Journal: BMC Dev Biol
Title: A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume: 5
Pages: 14
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein
Organism: Mus musculus/domesticus
Length: 962  
Fragment?: false
Publication
First Author: Harada K
Year: 2001
Journal: Int J Cancer
Title: Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation.
Volume: 93
Issue: 5
Pages: 623-8
Protein
Organism: Mus musculus/domesticus
Length: 401  
Fragment?: false
Publication
First Author: Matz A
Year: 2015
Journal: Cell Death Differ
Title: Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.
Volume: 22
Issue: 4
Pages: 626-42
Publication
First Author: Yang D
Year: 1999
Journal: Cancer Res
Title: Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients.
Volume: 59
Issue: 16
Pages: 4056-63
Publication
First Author: Liu Y
Year: 2002
Journal: J Biol Chem
Title: HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110.
Volume: 277
Issue: 26
Pages: 23854-63
Publication
First Author: Medenbach J
Year: 2004
Journal: Mol Cell Biol
Title: Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling.
Volume: 24
Issue: 17
Pages: 7392-401
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of SART3 (also known as Tip110), which is an RNA-binding protein expressed in the nucleus of the majority of proliferating cells, including normal cells and malignant cells, but not in normal tissues except for the testes and fetal liver []. It is involved in the regulation of mRNA splicing probably via its complex formation with RNPS1 (an RNA-binding protein with a serine-rich domain), a pre-mRNA-splicing factor []. SART3 has also been identified as a nuclear Tat-interacting protein that regulates Tat transactivation activity through direct interaction and functions as an important cellular factor for HIV-1 gene expression and viral replication []. In addition, SART3 is required for U6 snRNP targeting to Cajal bodies []. It binds specifically and directly to the U6 snRNA, interacts transiently with the U6 and U4/U6 snRNPs, and promotes the reassembly of U4/U6 snRNPs after splicing in vitro [].SART3 contains an N-terminal HAT (half-a-tetratricopeptide repeat)-rich domain, a nuclearlocalization signal (NLS) domain, and two C-terminal RNA recognition motifs (RRMs).
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of SART3 (also known as Tip110), which is an RNA-binding protein expressed in the nucleus of the majority of proliferating cells, including normal cells and malignant cells, but not in normal tissues except for the testes and fetal liver []. It is involved in the regulation of mRNA splicing probably via its complex formation with RNPS1 (an RNA-binding protein with a serine-rich domain), a pre-mRNA-splicing factor []. SART3 has also been identified as a nuclear Tat-interacting protein that regulates Tat transactivation activity through direct interaction and functions as an important cellular factor for HIV-1 gene expression and viral replication []. In addition, SART3 is required for U6 snRNP targeting to Cajal bodies []. It binds specifically and directly to the U6 snRNA, interacts transiently with the U6 and U4/U6 snRNPs, and promotes the reassembly of U4/U6 snRNPs after splicing in vitro [].SART3 contains a HAT (N-terminal half-a-tetratricopeptide repeat)-rich domain, a nuclearlocalization signal (NLS) domain, and two C-terminal RNA recognition motifs (RRMs).
Publication
First Author: Jiao J
Year: 2009
Journal: Biochim Biophys Acta
Title: Abnormal regulation of TSG101 in mice with spongiform neurodegeneration.
Volume: 1792
Issue: 10
Pages: 1027-35
Publication
First Author: Pratelli R
Year: 2012
Journal: Plant Physiol
Title: The ubiquitin E3 ligase LOSS OF GDU2 is required for GLUTAMINE DUMPER1-induced amino acid secretion in Arabidopsis.
Volume: 158
Issue: 4
Pages: 1628-42
Publication
First Author: Pérez-Oliva AB
Year: 2009
Journal: J Biol Chem
Title: Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas.
Volume: 284
Issue: 46
Pages: 31714-25
Publication
First Author: Kim BY
Year: 2007
Journal: Mol Biol Cell
Title: Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.
Volume: 18
Issue: 4
Pages: 1129-42
Publication  
First Author: Chhangani D
Year: 2013
Journal: Sci Rep
Title: Mahogunin ring finger-1 (MGRN1) suppresses chaperone-associated misfolded protein aggregation and toxicity.
Volume: 3
Pages: 1972
Publication
First Author: Mukherjee R
Year: 2017
Journal: Traffic
Title: MGRN1-mediated ubiquitination of α-tubulin regulates microtubule dynamics and intracellular transport.
Volume: 18
Issue: 12
Pages: 791-807
Protein
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
Protein Domain
Type: Domain
Description: This entry represent the C3HC5-type RING-HC finger found in MGRN1/RNF157 and related proteins. It is distinguished from typical C3HC4 RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.MGRN1 is a cytosolic E3 ubiquitin-protein ligase that inhibits signalling through the G protein-coupled melanocortin receptors-1 (MC1R), -2 (MC2R) and -4 (MC4R) via ubiquitylation-dependent and -independent processes []. It suppresses chaperone-associated misfolded protein aggregation and toxicity []. MGRN1 interacts with cytosolic prion proteins (PrPs) that are linked with neurodegeneration[]. It also interacts with expanded polyglutamine proteins, and suppresses misfolded polyglutamine aggregation and cytotoxicity. Moreover, MGRN1 inhibits melanocortin receptor signaling by competition with Galphas, suggesting a novel pathway for melanocortin signaling from the cell surface to the nucleus []. Furthermore, MGRN1 interacts with and ubiquitylates TSG101, a key component of the endosomal sorting complex required for transport (ESCRT)-I, and regulates endosomal trafficking. A null mutation in the gene encoding MGRN1 causes spongiform neurodegeneration, suggesting a link between dysregulation of endosomal trafficking and spongiform neurodegeneration [, ].RNF157 is a cytoplasmic E3 ubiquitin ligase predominantly expressed in brain. In cultured neurons, it promotes neuronal survival in an E3 ligase-dependent manner. In contrast, it supports growth and maintenance of dendrites independent of its E3 ligase activity. RNF157 interacts with and ubiquitinates the adaptor protein APBB1 (amyloid beta precursor protein-binding, family B, member 1 or Fe65), which regulates neuronal survival, but not dendritic growth downstream of RNF157. The nuclear localization of APBB1 together with its interaction partner RNA-binding protein SART3 (squamous cell carcinoma antigen recognized by T cells 3 or Tip110) is crucial to trigger apoptosis []. Both MGRN1 and RNF157 contain a modified C3HC5-type RING-HC finger, and a functionally uncharacterized region, known as domain associated with RING2 (DAR2), N-terminal to the RING finger.In Arabidopsis, LOG2 is a predicted E3 ubiquitin ligase that interact with GDU1 and is involved in the regulation of amino acid export from plant cells [].
Protein Domain
Type: Family
Description: This entry represents a group of confirmed and predicted E3 ubiquitin ligases, including MGRN1/RNF157 from humans and LOG2/LUL1-4 from Arabidopsis.MGRN1 is a cytosolic E3 ubiquitin-protein ligase that inhibits signalling through the G protein-coupled melanocortin receptors-1 (MC1R), -2 (MC2R) and -4 (MC4R) via ubiquitylation-dependent and -independent processes []. It suppresses chaperone-associated misfolded protein aggregation and toxicity []. MGRN1 interacts with cytosolic prion proteins (PrPs) that are linked with neurodegeneration[]. It also interacts with expanded polyglutamine proteins, and suppresses misfolded polyglutamine aggregation and cytotoxicity. Moreover, MGRN1 inhibits melanocortin receptor signaling by competition with Galphas, suggesting a novel pathway for melanocortin signaling from the cell surface to the nucleus []. Furthermore, MGRN1 interacts with and ubiquitylates TSG101, a key component of the endosomal sorting complex required for transport (ESCRT)-I, and regulates endosomal trafficking. A null mutation in the gene encoding MGRN1 causes spongiform neurodegeneration, suggesting a link between dysregulation of endosomal trafficking and spongiform neurodegeneration [, ].RNF157 is a cytoplasmic E3 ubiquitin ligase predominantly expressed in brain. In cultured neurons, it promotes neuronal survival in an E3 ligase-dependent manner. In contrast, it supports growth and maintenance of dendrites independent of its E3 ligase activity. RNF157 interacts with and ubiquitinates the adaptor protein APBB1 (amyloid beta precursor protein-binding, family B, member 1 or Fe65), which regulates neuronal survival, but not dendritic growth downstream of RNF157. The nuclear localization of APBB1 together with its interaction partner RNA-binding protein SART3 (squamous cell carcinoma antigen recognized by T cells 3 or Tip110) is crucial to trigger apoptosis []. Both MGRN1 and RNF157 contain a modified C3HC5-type RING-HC finger, and a functionally uncharacterized region, known as domain associated with RING2 (DAR2), N-terminal to the RING finger.In Arabidopsis, LOG2 is a predicted E3 ubiquitin ligase that interact with GDU1 and is involved in the regulation of amino acid export from plant cells [].
Protein
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 685  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 506  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 506  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 659  
Fragment?: false