This entry represents the tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferases, including Trm7 from Saccharomyces cerevisiae. Trm7 methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of tRNA(Phe), tRNA(Trp) and tRNA(Leu(UAA)) []. It requires Trm732 for methylation of the cytidine at position 32 and Rtt10/Trm734 for methylation of the nucleotides at position 34 in substrate tRNAs [].This entry also includes FTSJ1 from human. FTSJ1 is a homologue of yeast Trm7 and may play a role in the regulation of translation. Mutations in FTSJ1 cause the mental retardation, X-linked 44 (MRX44), which is a disorder characterised by significantly below average general intellectual functioning associated with impairments in adaptive behaviour and manifested during the developmental period [].
