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Search results 101 to 106 out of 106 for Ftsj1

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0.018s

Type

Details

Score

Allele

Ftsj1<tm1Tomik> | MGI:7341380

Name:	FtsJ RNA 2'-O-methyltransferase 1; targeted mutation 1, Kazuhito Tomizawa
Allele Type:	Targeted
Attribute String:	Null/knockout

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DO Term

DOID:0112034 | non-syndromic X-linked intellectual disability 9

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Genotype

Symbol:	Ftsj1/?
Background:	Not Specified
Zygosity:	ot
Has Mutant Allele:	true

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Publication

22912484 | -

First Author:	Guy MP
Year:	2012
Journal:	RNA
Title:	Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
Volume:	18
Issue:	10
Pages:	1921-33

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Protein Domain

IPR028590 | RNA_methyltr_E_TRM7

Type:

Family

Description:

This entry represents the tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferases, including Trm7 from Saccharomyces cerevisiae. Trm7 methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of tRNA(Phe), tRNA(Trp) and tRNA(Leu(UAA)) []. It requires Trm732 for methylation of the cytidine at position 32 and Rtt10/Trm734 for methylation of the nucleotides at position 34 in substrate tRNAs [].This entry also includes FTSJ1 from human. FTSJ1 is a homologue of yeast Trm7 and may play a role in the regulation of translation. Mutations in FTSJ1 cause the mental retardation, X-linked 44 (MRX44), which is a disorder characterised by significantly below average general intellectual functioning associated with impairments in adaptive behaviour and manifested during the developmental period [].

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Publication

11927565 | -

First Author:	Pintard L
Year:	2002
Journal:	EMBO J
Title:	Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop.
Volume:	21
Issue:	7
Pages:	1811-20

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