Adherens junction-associated protein 1 (AJAP1, also known as shrew-1) was first discovered as a transmembrane protein of adherent junctions in epithelial cells. Later, it was found to act as a tumour suppressor in gliomas. It may affect cell motility, migration, invasion and proliferation [, ]. Homologues are found only in chordates.
This is a domain found in the C terminus of adherens junction-associated protein 1 (AJAP1) and of PILR-associating neural protein (PANP). AJAP1 inhibits cell adhesion and migration []. PANP is a ligand for the immune inhibitory receptor paired immunoglobulin-like type 2 receptor alpha [].
