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Search results 5001 to 5100 out of 7122 for App

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Hits by Strain

Type Details Score
Publication
22472085 | J:283615
 
First Author: Ferretti MT
Year: 2012
Journal: J Neuroinflammation
Title: Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology.
Volume: 9
Pages: 62
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Allele
Gt(ROSA)26Sor<em1(CAG-APPIbe)Jjan> | MGI:7277689
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Joanna L Jankowsky
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Strain
MGI:7645718 | B6(Cg)-App<em1Aduci>/J
Attribute String: mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Psen1/Psen1 Tg(Thy1-APPLon)2Vln/? Tg(Thy1-cre)1Vln/?
Background: involves: FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-App*R609D*K612E)4Vln/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-App*R609D*K612E)6Vln/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
Background: involves: FVB
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
Background: involves: FVB
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-App*R609D*K612E)2Vln/?
Background: involves: C57BL * CBA/J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe<+> Tg(APPV717I)1130Kha/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Tg(APPV717I)1130Kha/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPV717I)1130Kha/? Tg(SOD1)76Dpr/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APP)6209Kha/? Tg(Pgk1-FGF2)15Cofn/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PRNP-APPSweInd)8Dwst/? Tg(PSEN1*L286V)1274Citr/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dab1/Dab1 Tg(APPSWE)2576Kha/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pld2/Pld2<+> Tg(APPSWE)2576Kha/?
Background: involves: 129X1/SvJ * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pld2/Pld2 Tg(APPSWE)2576Kha/?
Background: involves: 129X1/SvJ * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: C57BL/6 * DBA/2 * SJL * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hprt1/Hprt1<+> Tg(PSEN1)5Dbo/?
Background: involves: 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Tg(PDGFB-PSEN1)1Jhd/?
Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(tetO-APPSwInd)Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Protein Coding Gene
MGI:1346036 | Pin1
Type: protein_coding_gene
Organism: mouse, laboratory
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Transgene
MGI:2152038 | Tg(APPV717F)109Ili
Type: transgene
Organism: mouse, laboratory
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Allele
Tg(tetO-CDK5R1/GFP)337Lht | MGI:3653679
Name: transgene insertion 337, Li-Huei Tsai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence, Reporter
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Transgene
MGI:3717495 | Tg(Thy1-APPLon)2Vln
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3721991 | Tg(Thy1-APPSwDutIowa)BWevn
Type: transgene
Organism: mouse, laboratory
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Allele
Tg(CMV-IgkvaD11)BCat | MGI:3721910
Name: transgene insertion B, Antonio Cattaneo
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(DMD-APP*)7Neve | MGI:3720652
Name: transgene insertion 7, Rachel L Neve
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Prnp-Abca1)EHol | MGI:3800823
Name: transgene insertion E, David M Holtzman
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Transgene
MGI:3800822 | Tg(Prnp-Abca1)EHol
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:4420230 | Tg(Thy1-APPSweArc)BLngn
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:4438880 | Tg(Thy1-APPDutch)#Jckr
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:4843218 | Tg(Thy1-APPSw)10Jiri
Type: transgene
Organism: mouse, laboratory
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Allele
Pitrm1<tm1a(KOMP)Wtsi> | MGI:5085349
Name: pitrilysin metallepetidase 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Transgene
MGI:5295153 | Tg(tetO-APPSwInd)Dbo
Type: transgene
Organism: mouse, laboratory
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Allele
Psap<tm4.1Ggb> | MGI:5510529
 
Name: prosaposin; targeted mutation 4.1, Gregory A Grabowski
Allele Type: Targeted
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Transgene
MGI:5553462 | Tg(Prnp-APPSweArc)#Rmni
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:6324680 | Tg(Thy1-APP*Swe*Ind)fAccu
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Zbtb20/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APP)3Somm/?
Background: B6.Cg-Tg(Thy1-APP)3Somm
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-Abca1)EHol/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPDutch)#Jckr/?
Background: involves: C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw)10Jiri/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Gfap-TGFB1)64Lms/? Zbtb20/?
Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPswe,PSEN1dE9)85Dbo/?
Background: B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
Background: involves: C3HeB/FeJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cfh/Cfh
Background: B6.129-Cfh
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sorl1/Sorl1
Background: involves: 129 * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat
Background: involves: 129 * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pitrm1/Pitrm1<+>
Background: C57BL/6N-Pitrm1/Wtsi
Zygosity: ht
Has Mutant Allele: true
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Publication
21153684 | J:183201
First Author: Mishra M
Year: 2011
Journal: Mol Cell Biochem
Title: Characterizing the novel protein p33MONOX.
Volume: 350
Issue: 1-2
Pages: 127-34
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Publication
17298186 | J:122019
First Author: Westmark CJ
Year: 2007
Journal: PLoS Biol
Title: FMRP mediates mGluR5-dependent translation of amyloid precursor protein.
Volume: 5
Issue: 3
Pages: e52
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Publication
9774383 | J:54419
First Author: Buxbaum JD
Year: 1998
Journal: J Biol Chem
Title: Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor.
Volume: 273
Issue: 43
Pages: 27765-7
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Publication
31315045 | J:288512
First Author: Wang ZH
Year: 2019
Journal: Cell Rep
Title: Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.
Volume: 28
Issue: 3
Pages: 655-669.e5
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Publication
9856475 | J:111807
First Author: Naruse S
Year: 1998
Journal: Neuron
Title: Effects of PS1 deficiency on membrane protein trafficking in neurons.
Volume: 21
Issue: 5
Pages: 1213-21
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Publication
35383160 | J:332304
First Author: von Ziegler LM
Year: 2022
Journal: Nat Commun
Title: Multiomic profiling of the acute stress response in the mouse hippocampus.
Volume: 13
Issue: 1
Pages: 1824
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Publication
25242217 | J:217895
First Author: Liu CC
Year: 2014
Journal: Neuron
Title: Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease.
Volume: 84
Issue: 1
Pages: 63-77
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Publication
26786779 | J:236127
First Author: Moskovitz J
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Methionine sulfoxide reductase A affects β-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease.
Volume: 310
Issue: 6
Pages: E388-93
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Publication
19501042 | J:151423
First Author: Hook VY
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein.
Volume: 386
Issue: 2
Pages: 284-8
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Publication
27693425 | J:244954
First Author: Pan H
Year: 2016
Journal: Stem Cell Reports
Title: Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein.
Volume: 7
Issue: 4
Pages: 707-718
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Publication
12646573 | J:83641
First Author: Chen F
Year: 2003
Journal: J Biol Chem
Title: Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Volume: 278
Issue: 22
Pages: 19974-9
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Publication
16203860 | J:102611
First Author: Yu WH
Year: 2005
Journal: J Cell Biol
Title: Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
Volume: 171
Issue: 1
Pages: 87-98
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Publication
26895626 | J:285078
 
First Author: Schönherr C
Year: 2016
Journal: Mol Neurodegener
Title: Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site.
Volume: 11
Pages: 19
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Publication
12815056 | J:85205
First Author: Li J
Year: 2003
Journal: J Biol Chem
Title: Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.
Volume: 278
Issue: 35
Pages: 33445-9
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Publication
19148186 | J:164195
First Author: Lourenço FC
Year: 2009
Journal: Cell Death Differ
Title: Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production.
Volume: 16
Issue: 5
Pages: 655-63
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Publication
20053918 | J:157639
First Author: Harris JA
Year: 2010
Journal: J Neurosci
Title: Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.
Volume: 30
Issue: 1
Pages: 372-81
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Publication
23748076 | J:201534
 
First Author: Fan LF
Year: 2013
Journal: Neurosci Lett
Title: Caspr interaction with Amyloid Precursor Protein reduces amyloid-β generation in vitro.
Volume: 548
Pages: 255-60
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Publication
29641978 | J:268595
 
First Author: Tang Y
Year: 2018
Journal: Exp Neurol
Title: Estrogen-related receptor alpha is involved in Alzheimer's disease-like pathology.
Volume: 305
Pages: 89-96
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Publication
36734880 | J:338578
First Author: de Sousa DMB
Year: 2023
Journal: Aging (Albany NY)
Title: Immune-mediated platelet depletion augments Alzheimer's disease neuropathological hallmarks in APP-PS1 mice.
Volume: 15
Issue: 3
Pages: 630-649
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Publication
23933749 | J:203865
First Author: Ma T
Year: 2013
Journal: Nat Neurosci
Title: Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
Volume: 16
Issue: 9
Pages: 1299-305
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Publication
22230888 | J:182316
First Author: Poirier R
Year: 2012
Journal: Neurosci Lett
Title: Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency.
Volume: 509
Issue: 2
Pages: 101-4
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Publication
28114405 | J:247965
First Author: Kastanenka KV
Year: 2017
Journal: PLoS One
Title: Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease.
Volume: 12
Issue: 1
Pages: e0170275
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Publication
17029828 | J:113200
First Author: Garcia-Alloza M
Year: 2006
Journal: Neurobiol Dis
Title: Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.
Volume: 24
Issue: 3
Pages: 516-24
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Publication
31308530 | J:281638
First Author: Esteve P
Year: 2019
Journal: Nat Neurosci
Title: Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis.
Volume: 22
Issue: 8
Pages: 1258-1268
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Publication
29937276 | J:269650
First Author: Readhead B
Year: 2018
Journal: Neuron
Title: Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.
Volume: 99
Issue: 1
Pages: 64-82.e7
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Publication
20826464 | J:182823
First Author: Jonas MC
Year: 2010
Journal: J Cell Sci
Title: AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability.
Volume: 123
Issue: Pt 19
Pages: 3378-88
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Publication
16891409 | J:114926
First Author: Shukkur EA
Year: 2006
Journal: Hum Mol Genet
Title: Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome.
Volume: 15
Issue: 18
Pages: 2752-62
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Publication
38536818 | J:349703
First Author: Kim R
Year: 2024
Journal: Cell Rep
Title: Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.
Volume: 43
Issue: 4
Pages: 114009
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Publication
33707583 | J:304829
First Author: Tosh JL
Year: 2021
Journal: Sci Rep
Title: Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models.
Volume: 11
Issue: 1
Pages: 5736
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Publication
17558301 | J:123688
First Author: Matsuyama S
Year: 2007
Journal: Neuroreport
Title: Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice.
Volume: 18
Issue: 10
Pages: 1083-7
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Publication
23131567 | J:193753
First Author: Yoon SH
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1.
Volume: 429
Issue: 3-4
Pages: 204-9
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Publication
35579602 | J:332590
 
First Author: Ahmad T
Year: 2022
Journal: J Cell Biol
Title: Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3.
Volume: 221
Issue: 7
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Publication
28279219 | J:302088
First Author: Guix FX
Year: 2017
Journal: Mol Neurodegener
Title: Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.
Volume: 12
Issue: 1
Pages: 25
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Publication
17301176 | J:118332
First Author: Marcello E
Year: 2007
Journal: J Neurosci
Title: Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity.
Volume: 27
Issue: 7
Pages: 1682-91
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Publication
11719200 | J:73169
First Author: Annaert WG
Year: 2001
Journal: Neuron
Title: Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
Volume: 32
Issue: 4
Pages: 579-89
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Publication
12354302 | J:79007
First Author: Li J
Year: 2002
Journal: J Neurochem
Title: SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production.
Volume: 82
Issue: 6
Pages: 1540-8
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Publication
12297508 | J:80170
First Author: Lee SF
Year: 2002
Journal: J Biol Chem
Title: Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
Volume: 277
Issue: 47
Pages: 45013-9
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Publication
9173930 | J:39869
First Author: Yehiely F
Year: 1997
Journal: Neurobiol Dis
Title: Identification of candidate proteins binding to prion protein.
Volume: 3
Issue: 4
Pages: 339-55
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Publication
11083918 | J:197522
First Author: Lau KF
Year: 2000
Journal: Mol Cell Neurosci
Title: X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains.
Volume: 16
Issue: 5
Pages: 557-65
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Publication
23115192 | J:322696
First Author: Zhang H
Year: 2012
Journal: J Neurosci
Title: Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration.
Volume: 32
Issue: 44
Pages: 15565-76
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Publication
8198393 | J:19589
 
First Author: Price DL
Year: 1994
Journal: Annu Rev Med
Title: Cellular and molecular biology of Alzheimer's disease and animal models.
Volume: 45
Pages: 435-46
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Publication
8786110 | J:31587
First Author: Zhong S
Year: 1996
Journal: Genomics
Title: Characterization of the genomic structure of the mouse APLP1 gene.
Volume: 32
Issue: 1
Pages: 159-62
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Publication
15457210 | J:93305
First Author: Arancio O
Year: 2004
Journal: EMBO J
Title: RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
Volume: 23
Issue: 20
Pages: 4096-105
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Publication
9221907 | J:109179
First Author: Czech C
Year: 1997
Journal: Brain Res Mol Brain Res
Title: Proteolytical processing of mutated human amyloid precursor protein in transgenic mice.
Volume: 47
Issue: 1-2
Pages: 108-16
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Publication
16096062 | J:115198
First Author: Shah S
Year: 2005
Journal: Cell
Title: Nicastrin functions as a gamma-secretase-substrate receptor.
Volume: 122
Issue: 3
Pages: 435-47
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Publication
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Title: SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
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Year: 2010
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Title: EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APP.
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First Author: Azkona G
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Title: Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.
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First Author: Matos MF
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Title: Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing.
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Title: A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.
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