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Search results 101 to 145 out of 145 for Pnpla1

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:6500822
Assay Type: Western blot
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Stage: TS26
Assay Id: MGI:7461580
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:7461526
Assay Type: Western blot
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Stage: TS26
Assay Id: MGI:7461581
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7461526
Assay Type: Western blot
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Stage: TS26
Assay Id: MGI:7461581
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:7461526
Assay Type: Western blot
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Stage: TS26
Assay Id: MGI:7461581
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:7461526
Assay Type: Western blot
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Stage: TS26
Assay Id: MGI:7461581
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:7461589
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461611
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461590
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461612
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461591
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461613
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461592
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461614
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461593
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461615
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461594
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461616
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461595
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461617
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461596
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461618
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461597
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461619
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461598
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461620
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461599
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461621
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461600
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461622
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461601
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461623
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461602
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461624
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461603
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461625
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461604
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461626
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461605
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461627
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7461606
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Stage: TS26
Assay Id: MGI:7461628
Age: embryonic day 18.5
Specimen Label: Pnpla1 tm1a
Detected: true
Specimen Num: 2
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Allele
Pnpla1<tm1a(KOMP)Wtsi> | MGI:5085354
Name: patatin-like phospholipase domain containing 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Genotype
Genotype
Symbol: Pnpla1/Pnpla1
Background: B6NTac;B6N-A Pnpla1/Ics
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060719 | autosomal recessive congenital ichthyosis 10
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Publication
26083785 | -
First Author: Xie M
Year: 2015
Journal: PLoS Genet
Title: The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans.
Volume: 11
Issue: 6
Pages: e1005284
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Publication
19052547 | -
First Author: Narbonne P
Year: 2009
Journal: Nature
Title: Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival.
Volume: 457
Issue: 7226
Pages: 210-4
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Publication
20176933 | -
First Author: Zhang SO
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.
Volume: 107
Issue: 10
Pages: 4640-5
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Publication
24120942 | -
First Author: Noble T
Year: 2013
Journal: Cell Metab
Title: An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat.
Volume: 18
Issue: 5
Pages: 672-84
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Publication
25202121 | -
First Author: Lee JH
Year: 2014
Journal: Mol Cell Biol
Title: Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans.
Volume: 34
Issue: 22
Pages: 4165-76
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Publication
26098762 | -
First Author: Xie M
Year: 2015
Journal: PLoS One
Title: AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae.
Volume: 10
Issue: 6
Pages: e0130480
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Protein Domain
IPR033562 | PLPL
Type: Family
Description: This entry includes patatin-like phospholipase domain-containing proteins 1-5 (PNPLA1-5) from humans and Atgl-1 from Caenorhabditis elegans. They are a group of lipid hydrolases. Atgl-1 may play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion [, , , , , ]. In humans PNPLA1 has a role in the formation of the epidermal lipid barrier; mutations in this gene are associated with the skin disorder known as ichthyosis []. PNPLA1 acts as an omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation [, ]. It catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramid [].Human PNPLA2 catalyses the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets []. PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities [].
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Publication
30361410 | J:269318
First Author: Kien B
Year: 2018
Journal: J Lipid Res
Title: ABHD5 stimulates PNPLA1-mediated ω-O-acylceramide biosynthesis essential for a functional skin permeability barrier.
Volume: 59
Issue: 12
Pages: 2360-2367
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Publication
15550674 | J:289460
First Author: Zimmermann R
Year: 2004
Journal: Science
Title: Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Volume: 306
Issue: 5700
Pages: 1383-6
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Protein
Q3V1D5
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: false
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Protein
Q32LZ8
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
E9PZA4
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: true
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Protein
E9Q323
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
B2KF06
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: false
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Protein
H3BIT5
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: false
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Publication
15364929 | -
First Author: Jenkins CM
Year: 2004
Journal: J Biol Chem
Title: Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.
Volume: 279
Issue: 47
Pages: 48968-75
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Protein
Q8BJ56
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
Q91WW7
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
E9QNZ9
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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