Type |
Details |
Score |
HT Experiment |
Series Id: |
E-GEOD-55831 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7580780 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1758520 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:7580782 |
Age: |
embryonic day 12.5 |
|
Note: |
Expressed in the ventricular zone in the dorsal spinal cord, with enrichment in regions lateral to the Ptf1a domain. |
Specimen Label: |
S2B' |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7580780 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616617 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7580782 |
Age: |
embryonic day 10.5 |
|
Note: |
Expressed in the ventricular zone in the dorsal spinal cord, with enrichment in regions lateral to the Ptf1a domain. |
Specimen Label: |
S2A' |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7580780 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616615 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:7580782 |
Age: |
embryonic day 9.5 |
|
Note: |
Expressed in the ventricular zone in the dorsal spinal cord, with enrichment in regions lateral to the Ptf1a domain. |
Specimen Label: |
S2E |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7580780 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616617 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7580782 |
Age: |
embryonic day 10.5 |
|
Note: |
Expressed in the ventricular zone in the dorsal spinal cord, with enrichment in regions lateral to the Ptf1a domain. |
Specimen Label: |
S2F |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6695356 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706615 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:6695727 |
Age: |
embryonic day 9.5 |
Image: |
S3A/D Pdx-1 |
Note: |
Expression coincide with that of Ptf1a in vast majority of pancreatic epithelial cells from E9.5 to E10.5. |
Specimen Label: |
S3A/D Pdx-1 |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7580780 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1715219 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:7580782 |
Age: |
embryonic day 11.5 |
|
Note: |
Expressed in the ventricular zone in the dorsal spinal cord, with enrichment in regions lateral to the Ptf1a domain. |
Specimen Label: |
S2G |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Z |
Year: |
2008 |
Journal: |
PLoS Biol |
Title: |
Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish. |
Volume: |
6 |
Issue: |
11 |
Pages: |
e293 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6695356 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706717 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:6695727 |
Age: |
embryonic day 10.5 |
Image: |
5B Pdx-1 |
Note: |
Expression in pancreatic progenitor cells of dorsal pancreatic bud at E10.5 coinciding with Ptf1a and Ngn3 in scattered cells throughout pancreatic epithelium. |
Specimen Label: |
5B Pdx-1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6695359 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-04-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706717 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:6695730 |
Age: |
embryonic day 10.5 |
Image: |
5B Ngn3 |
Note: |
Expression in pancreatic progenitor cells of dorsal pancreatic bud at E10.5 coinciding with Ptf1a and Pdx1 in scattered cells throughout pancreatic epithelium. |
Specimen Label: |
5B Ngn3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6194277 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-08-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1707420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:7520313 |
Age: |
embryonic day 12.5 |
Image: |
3B/C |
Note: |
Expression was predominantly localized in the ventricular zone. Overlapping Ptf1a and Olig2 expression in GABAergic precursors was observed in the intermediary region of the ventricular zone. |
Specimen Label: |
3B/C |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
MP Term |
|
•
•
•
•
•
|
Allele |
Name: |
pancreas specific transcription factor, 1a; targeted mutation 2, Raymond MacDonald |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Allele |
Name: |
pancreas specific transcription factor, 1a; targeted mutation 3.1, Mark A Magnuson |
Allele Type: |
Targeted |
Attribute String: |
Epitope tag, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
pancreas specific transcription factor, 1a; targeted mutation 3.1, Mark A Magnuson |
Allele Type: |
Targeted |
Attribute String: |
RMCE-ready, Transactivator |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6194277 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2018-08-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778721 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6194375 |
Age: |
embryonic day 12.5 |
Image: |
3A,G |
Note: |
Triple labeling indicated that some Olig2-positive cells express Ptf1a (marker for GABAergic neuron progenitors) and other Olig2-positive cells express Lhx1 and Lhx5 (which mark postmitotic GABAergic neurons). The results indicate that Olig2 is expressed in both mitotic and postmitotic cells. |
Specimen Label: |
3A,G |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. |
Volume: |
71 |
Issue: |
19 |
Pages: |
6106-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jayasena CS |
Year: |
2012 |
Journal: |
J Cell Biol |
Title: |
Rbms3 functions in craniofacial development by posttranscriptionally modulating TGF-β signaling. |
Volume: |
199 |
Issue: |
3 |
Pages: |
453-66 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the RNA recognition motif 2 (RRM2) of RBMS3 (RNA-binding motif, single-stranded-interacting protein 3). RBMS3 contains two RNA binding motifs and is closely related to the structure of the c-myc gene single-strand binding proteins (MSSPs). RBMS3 has been shown to exhibit tumour suppressor function via regulation of c-Myc and to bind/stabilize RNA in vitro []. It may posttranscriptionally regulate the transforming growth factor beta receptor pathway []. RBMS3 regulates the expression of Ptf1a (pancreas transcription factor 1 alpha subunit) []. |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ptf1a/Ptf1a |
Background: |
involves: 129S6/SvEvTac |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5560706 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-05-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1707420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:5561118 |
Age: |
embryonic day 12.5 |
Image: |
4B, A/B inlay, B/C inlay |
Note: |
Expression was detected in ventricular layer. The signal overlaps with the caudal two thirds of Ptf1a (A/B inlay) and Mash1 (Ascl1 - B/C inlay). There was a gap in the expression domain (bracket) that is positive for Ptf1a and Mash1 (Ascl1). |
Specimen Label: |
4B, A/B inlay, B/C inlay |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5560706 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-05-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1707420 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:5561118 |
Age: |
embryonic day 12.5 |
Image: |
4B', A'/B' inlay, B'/C' inlay |
Note: |
Expression was detected in the ventricular layer. The signal overlaps with the caudal two thirds of Ptf1a (A/B inlay) and Mash1 (Ascl1 - B/C inlay). There was a gap in the expression domain (bracket) that is positive for Ptf1a and Mash1 (Ascl1). |
Specimen Label: |
4B', A'/B' inlay, B'/C' inlay |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Allele |
Name: |
cerebelless; transgene insertion 7-2, Mikio Hoshino |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
achaete-scute family bHLH transcription factor 1; targeted mutation 1, Francois Guillemot |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ascl1/Ascl1 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cbll/Cbll |
Background: |
involves: C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
ladybird homeobox 1; endonuclease-mediated mutation 1, Megan J Wilson |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
T cell leukemia, homeobox 3; targeted mutation 1, Stanley J Korsmeyer |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tlx1/Tlx1 Tlx3/Tlx3 |
Background: |
involves: 129S2/SvPas * 129X1/SvJ |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ascl1/Ascl1 Neurog2/Neurog2 |
Background: |
involves: 129 * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ptf1a/Ptf1a<+> Cbll/? |
Background: |
involves: C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ptf1a/Ptf1a |
Background: |
involves: 129 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tlx3/Tlx3 |
Background: |
involves: 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pax3/Pax3<+> Rbpj/Rbpj |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Schinzel F |
Year: |
2021 |
Journal: |
J Comp Neurol |
Title: |
The Lbx1 lineage differentially contributes to inhibitory cell types of the dorsal cochlear nucleus, a cerebellum-like structure, and the cerebellum. |
Volume: |
529 |
Issue: |
11 |
Pages: |
3032-3045 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pierreux CE |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas. |
Volume: |
347 |
Issue: |
1 |
Pages: |
216-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Irhimeh MR |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Identification of novel diabetes impaired miRNA-transcription factor co-regulatory networks in bone marrow-derived Lin-/VEGF-R2+ endothelial progenitor cells. |
Volume: |
13 |
Issue: |
7 |
Pages: |
e0200194 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanotel J |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj downstream target that suppresses glutamatergic and promotes GABAergic neuronal fate in the dorsal neural tube. |
Volume: |
386 |
Issue: |
2 |
Pages: |
340-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobberup S |
Year: |
2010 |
Journal: |
Mech Dev |
Title: |
Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10. |
Volume: |
127 |
Issue: |
3-4 |
Pages: |
220-34 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Lbx1/Lbx1 |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
achaete-scute family bHLH transcription factor 1; targeted mutation 1, David J Anderson |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ascl1/Ascl1 |
Background: |
involves: 129 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
431
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
355
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
541
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Allele |
Name: |
recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1, Tasuku Honjo |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|