|  Help  |  About  |  Contact Us

Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 219 for Itgb4

Category restricted to Publication (x)

<< First    < Previous  |  Next >    Last >>
0.043s

Categories

Category: Publication
Type Details Score
Publication      
First Author: Yuan L
Year: 2022
Journal: J Allergy Clin Immunol
Title: Airway epithelial ITGB4 deficiency induces airway remodeling in a mouse model.
Publication
First Author: Liu C
Year: 2018
Journal: J Leukoc Biol
Title: ITGB4 is essential for containing HDM-induced airway inflammation and airway hyperresponsiveness.
Volume: 103
Issue: 5
Pages: 897-908
Publication
First Author: Tang S
Year: 2020
Journal: J Cell Mol Med
Title: Airway epithelial ITGB4 deficiency in early life mediates pulmonary spontaneous inflammation and enhanced allergic immune response.
Volume: 24
Issue: 5
Pages: 2761-2771
Publication
First Author: Van der Zee CE
Year: 2008
Journal: J Neurosci
Title: Conditional deletion of the Itgb4 integrin gene in Schwann cells leads to delayed peripheral nerve regeneration.
Volume: 28
Issue: 44
Pages: 11292-303
Publication
First Author: Du X
Year: 2022
Journal: Int J Biol Sci
Title: ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells.
Volume: 18
Issue: 1
Pages: 349-359
Publication
First Author: Han L
Year: 2018
Journal: J Neuroinflammation
Title: ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior.
Volume: 15
Issue: 1
Pages: 246
Publication
First Author: Roberts JE
Year: 2009
Journal: Reprod Sci
Title: Integrin beta-4 signaling plays a key role in mouse embryogenesis.
Volume: 16
Issue: 3
Pages: 286-93
Publication
First Author: Nikolopoulos SN
Year: 2005
Journal: Mol Cell Biol
Title: Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration.
Volume: 25
Issue: 14
Pages: 6090-102
Publication
First Author: Nikolopoulos SN
Year: 2004
Journal: Cancer Cell
Title: Integrin beta4 signaling promotes tumor angiogenesis.
Volume: 6
Issue: 5
Pages: 471-83
Publication
First Author: Guo W
Year: 2006
Journal: Cell
Title: Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.
Volume: 126
Issue: 3
Pages: 489-502
Publication  
First Author: Liu H
Year: 2022
Journal: Int J Mol Sci
Title: Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.
Volume: 23
Issue: 20
Publication
First Author: Raymond K
Year: 2007
Journal: Mol Biol Cell
Title: Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function.
Volume: 18
Issue: 11
Pages: 4210-21
Publication
First Author: Yoshioka T
Year: 2013
Journal: J Clin Invest
Title: β4 Integrin signaling induces expansion of prostate tumor progenitors.
Volume: 123
Issue: 2
Pages: 682-99
Publication
First Author: Heller BA
Year: 2014
Journal: J Cell Biol
Title: Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system.
Volume: 204
Issue: 7
Pages: 1219-36
Publication
First Author: Kennel SJ
Year: 1993
Journal: Gene
Title: Sequence of a cDNA encoding the beta 4 subunit of murine integrin.
Volume: 130
Issue: 2
Pages: 209-16
Publication
First Author: Walker MR
Year: 2020
Journal: Dev Biol
Title: Alveolar progenitor cells in the mammary gland are dependent on the β4 integrin.
Volume: 457
Issue: 1
Pages: 13-19
Publication
First Author: Tan ML
Year: 2022
Journal: Int J Biol Sci
Title: Integrin-β4 regulates the dynamic changes of phenotypic characteristics in association with epithelial-mesenchymal transition (EMT) and RhoA activity in airway epithelial cells during injury and repair.
Volume: 18
Issue: 3
Pages: 1254-1270
Publication
First Author: Frei R
Year: 1999
Journal: Glia
Title: Myelin formation by Schwann cells in the absence of beta4 integrin.
Volume: 27
Issue: 3
Pages: 269-74
Publication
First Author: van der Neut R
Year: 1996
Journal: Nat Genet
Title: Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice.
Volume: 13
Issue: 3
Pages: 366-9
Publication  
First Author: Kennel SJ
Year: 1992
Journal: J Cell Sci
Title: The beta 4 subunit of the integrin family is displayed on a restricted subset of endothelium in mice.
Volume: 101 ( Pt 1)
Pages: 145-50
Publication
First Author: Gómez M
Year: 1992
Journal: Exp Cell Res
Title: Expression of alpha 6 beta 4 integrin increases during malignant conversion of mouse epidermal keratinocytes: association of beta 4 subunit to the cytokeratin fraction.
Volume: 201
Issue: 2
Pages: 250-61
Publication  
First Author: Sánchez-Aparicio P
Year: 1997
Journal: J Cell Sci
Title: The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin beta 4 subunit.
Volume: 110 ( Pt 2)
Pages: 169-78
Publication
First Author: Seltmann K
Year: 2015
Journal: J Invest Dermatol
Title: Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover.
Volume: 135
Issue: 6
Pages: 1609-1620
Publication
First Author: Sachs N
Year: 2012
Journal: J Clin Invest
Title: Blood pressure influences end-stage renal disease of Cd151 knockout mice.
Volume: 122
Issue: 1
Pages: 348-58
Publication
First Author: Habtezion A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon.
Volume: 108
Issue: 4
Pages: 1445-50
Publication
First Author: Raymond K
Year: 2005
Journal: J Cell Sci
Title: Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.
Volume: 118
Issue: Pt 5
Pages: 1045-60
Publication
First Author: Welser JV
Year: 2017
Journal: J Neuroinflammation
Title: Endothelial α6β4 integrin protects during experimental autoimmune encephalomyelitis-induced neuroinflammation by maintaining vascular integrity and tight junction protein expression.
Volume: 14
Issue: 1
Pages: 217
Publication  
First Author: Viquez OM
Year: 2017
Journal: Matrix Biol
Title: Integrin alpha6 maintains the structural integrity of the kidney collecting system.
Volume: 57-58
Pages: 244-257
Publication
First Author: Jackson SJ
Year: 2013
Journal: Development
Title: Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation.
Volume: 140
Issue: 9
Pages: 1882-91
Publication
First Author: Niu G
Year: 2015
Journal: FASEB J
Title: Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin β4.
Volume: 29
Issue: 1
Pages: 131-40
Publication
First Author: Zent R
Year: 2001
Journal: Dev Biol
Title: Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development.
Volume: 238
Issue: 2
Pages: 289-302
Publication
First Author: Kennel SJ
Year: 1989
Journal: J Biol Chem
Title: Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily.
Volume: 264
Issue: 26
Pages: 15515-21
Publication
First Author: Wadsworth S
Year: 1992
Journal: J Immunol
Title: Developmentally regulated expression of the beta 4 integrin on immature mouse thymocytes.
Volume: 149
Issue: 2
Pages: 421-8
Publication
First Author: Vidal F
Year: 1995
Journal: Nat Genet
Title: Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia.
Volume: 10
Issue: 2
Pages: 229-34
Publication
First Author: Hierck BP
Year: 1996
Journal: Dev Dyn
Title: Expression of the beta 4 integrin subunit in the mouse heart during embryonic development: retinoic acid advances beta 4 expression.
Volume: 207
Issue: 1
Pages: 89-103
Publication  
First Author: Yajima-Himuro S
Year: 2014
Journal: Sci Rep
Title: The junctional epithelium originates from the odontogenic epithelium of an erupted tooth.
Volume: 4
Pages: 4867
Publication
First Author: Miyazaki A
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Integrin α6β4 and TRPV1 channel coordinately regulate directional keratinocyte migration.
Volume: 458
Issue: 1
Pages: 161-7
Publication
First Author: Chapman HA
Year: 2011
Journal: J Clin Invest
Title: Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice.
Volume: 121
Issue: 7
Pages: 2855-62
Publication
First Author: Chen Y
Year: 2018
Journal: J Cell Physiol
Title: The depletion of MARVELD1 leads to murine placenta accreta via integrin β4-dependent trophoblast cell invasion.
Volume: 233
Issue: 3
Pages: 2257-2269
Publication
First Author: Huang HS
Year: 2012
Journal: Virology
Title: Use of an in vivo animal model for assessing the role of integrin α(6)β(4) and syndecan-1 in early steps in papillomavirus infection.
Volume: 433
Issue: 2
Pages: 395-400
Publication
First Author: Liadaki K
Year: 2012
Journal: J Histochem Cytochem
Title: β4 integrin marks interstitial myogenic progenitor cells in adult murine skeletal muscle.
Volume: 60
Issue: 1
Pages: 31-44
Publication
First Author: Fuchs E
Year: 1997
Journal: Curr Opin Genet Dev
Title: Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins.
Volume: 7
Issue: 5
Pages: 672-82
Publication
First Author: Sigle RO
Year: 2004
Journal: J Cell Sci
Title: Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5.
Volume: 117
Issue: Pt 19
Pages: 4481-94
Publication
First Author: Carroll DK
Year: 2006
Journal: Nat Cell Biol
Title: p63 regulates an adhesion programme and cell survival in epithelial cells.
Volume: 8
Issue: 6
Pages: 551-61
Publication
First Author: Chang C
Year: 2013
Journal: Mol Cell Biol
Title: Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin β4.
Volume: 33
Issue: 19
Pages: 3795-804
Publication
First Author: Hierck BP
Year: 1993
Journal: Cell Adhes Commun
Title: Variants of the alpha 6 beta 1 laminin receptor in early murine development: distribution, molecular cloning and chromosomal localization of the mouse integrin alpha 6 subunit.
Volume: 1
Issue: 1
Pages: 33-53
Publication
First Author: Chen T
Year: 2012
Journal: Nature
Title: An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.
Volume: 485
Issue: 7396
Pages: 104-8
Publication
First Author: Klinowska TC
Year: 2001
Journal: Dev Biol
Title: Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits.
Volume: 233
Issue: 2
Pages: 449-67
Publication
First Author: Poitelon Y
Year: 2018
Journal: J Neurochem
Title: A dual role for Integrin α6β4 in modulating hereditary neuropathy with liability to pressure palsies.
Volume: 145
Issue: 3
Pages: 245-257
Publication
First Author: Raveh E
Year: 2005
Journal: Dev Dyn
Title: Runx3 is involved in hair shape determination.
Volume: 233
Issue: 4
Pages: 1478-87
Publication
First Author: Foote HP
Year: 2013
Journal: PLoS One
Title: FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes.
Volume: 8
Issue: 8
Pages: e71491
Publication  
First Author: Sonnenberg A
Year: 1990
Journal: J Cell Sci
Title: The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes: tissue distribution and biochemical properties.
Volume: 96 ( Pt 2)
Pages: 207-17
Publication
First Author: Thorsteinsdóttir S
Year: 1995
Journal: Dev Dyn
Title: Expression patterns of laminin receptor splice variants alpha 6A beta 1 and alpha 6B beta 1 suggest different roles in mouse development.
Volume: 204
Issue: 3
Pages: 240-58
Publication  
First Author: Falk M
Year: 1996
Journal: J Cell Sci
Title: Integrin alpha 6B beta 1 is involved in kidney tubulogenesis in vitro.
Volume: 109 ( Pt 12)
Pages: 2801-10
Publication
First Author: Alt A
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Differential regulation of alpha6beta4 integrin by PKC isoforms in murine skin keratinocytes.
Volume: 314
Issue: 1
Pages: 17-23
Publication
First Author: Yi R
Year: 2008
Journal: Nature
Title: A skin microRNA promotes differentiation by repressing 'stemness'.
Volume: 452
Issue: 7184
Pages: 225-9
Publication
First Author: Müller U
Year: 1997
Journal: Cell
Title: Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis.
Volume: 88
Issue: 5
Pages: 603-13
Publication  
First Author: DiPersio CM
Year: 2000
Journal: J Cell Sci
Title: alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development.
Volume: 113 ( Pt 17)
Pages: 3051-62
Publication
First Author: DiPersio CM
Year: 1997
Journal: J Cell Biol
Title: alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.
Volume: 137
Issue: 3
Pages: 729-42
Publication
First Author: Dacci P
Year: 2010
Journal: Glia
Title: Foot pad skin biopsy in mouse models of hereditary neuropathy.
Volume: 58
Issue: 16
Pages: 2005-16
Publication
First Author: Amici SA
Year: 2006
Journal: J Neurosci
Title: Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.
Volume: 26
Issue: 4
Pages: 1179-89
Publication
First Author: Yazlovitskaya EM
Year: 2015
Journal: Mol Biol Cell
Title: Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt.
Volume: 26
Issue: 10
Pages: 1857-74
Publication
First Author: Löffek S
Year: 2014
Journal: PLoS One
Title: Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling.
Volume: 9
Issue: 2
Pages: e87263
Publication
First Author: Larkins CE
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Spatiotemporal dynamics of androgen signaling underlie sexual differentiation and congenital malformations of the urethra and vagina.
Volume: 113
Issue: 47
Pages: E7510-E7517
Publication
First Author: Li Y
Year: 2020
Journal: EMBO Rep
Title: Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.
Volume: 21
Issue: 5
Pages: e48566
Publication
First Author: Ge Y
Year: 2017
Journal: Cell
Title: Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.
Volume: 169
Issue: 4
Pages: 636-650.e14
Publication
First Author: Ellis SJ
Year: 2019
Journal: Nature
Title: Distinct modes of cell competition shape mammalian tissue morphogenesis.
Volume: 569
Issue: 7757
Pages: 497-502
Publication
First Author: Georges-Labouesse E
Year: 1998
Journal: Curr Biol
Title: Essential role of alpha 6 integrins in cortical and retinal lamination.
Volume: 8
Issue: 17
Pages: 983-6
Publication  
First Author: van der Neut R
Year: 1999
Journal: J Cell Sci
Title: Partial rescue of epithelial phenotype in integrin beta4 null mice by a keratin-5 promoter driven human integrin beta4 transgene.
Volume: 112 ( Pt 22)
Pages: 3911-22
Publication
First Author: Kuster JE
Year: 1997
Journal: Mamm Genome
Title: IAP insertion in the murine LamB3 gene results in junctional epidermolysis bullosa.
Volume: 8
Issue: 9
Pages: 673-81
Publication
First Author: Lee P
Year: 2017
Journal: EMBO J
Title: Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis.
Volume: 36
Issue: 13
Pages: 1963-1980
Publication
First Author: Davies D
Year: 2002
Journal: J Comp Neurol
Title: Differential expression of alpha 3 and alpha 6 integrins in the developing mouse inner ear.
Volume: 445
Issue: 2
Pages: 122-32
Publication
First Author: Staquicini FI
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells.
Volume: 106
Issue: 8
Pages: 2903-8
Publication
First Author: Ruiz P
Year: 1995
Journal: Eur J Immunol
Title: Alpha 6 integrins participate in pro-T cell homing to the thymus.
Volume: 25
Issue: 7
Pages: 2034-41
Publication
First Author: Collo G
Year: 1995
Journal: Cell Adhes Commun
Title: Gradient of integrin alpha 6A distribution in the myocardium during early heart development.
Volume: 3
Issue: 2
Pages: 101-13
Publication
First Author: Salmivirta K
Year: 1996
Journal: Dev Dyn
Title: Integrin subunit expression associated with epithelial-mesenchymal interactions during murine tooth development.
Volume: 205
Issue: 2
Pages: 104-13
Publication
First Author: Borradori L
Year: 1999
Journal: J Invest Dermatol
Title: Structure and function of hemidesmosomes: more than simple adhesion complexes.
Volume: 112
Issue: 4
Pages: 411-8
Publication
First Author: Sumigray K
Year: 2014
Journal: PLoS One
Title: Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption.
Volume: 9
Issue: 7
Pages: e101824
Publication  
First Author: Ramovs V
Year: 2017
Journal: Matrix Biol
Title: The opposing roles of laminin-binding integrins in cancer.
Volume: 57-58
Pages: 213-243
Publication
First Author: Williams SE
Year: 2014
Journal: Nat Cell Biol
Title: Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN.
Volume: 16
Issue: 8
Pages: 758-69
Publication
First Author: Song H
Year: 2023
Journal: Dev Dyn
Title: Expression dynamics of lymphoid enhancer-binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis.
Volume: 252
Issue: 4
Pages: 527-535
Publication
First Author: Ruzinova MB
Year: 2003
Journal: Cancer Cell
Title: Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors.
Volume: 4
Issue: 4
Pages: 277-89
Publication
First Author: Grisanti L
Year: 2013
Journal: J Invest Dermatol
Title: Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis.
Volume: 133
Issue: 10
Pages: 2332-2339
Publication
First Author: Miao Q
Year: 2019
Journal: Nat Commun
Title: SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair.
Volume: 10
Issue: 1
Pages: 4042
Publication
First Author: Gladden AB
Year: 2010
Journal: Dev Cell
Title: The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.
Volume: 19
Issue: 5
Pages: 727-39
Publication
First Author: Li J
Year: 2015
Journal: Dev Biol
Title: Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development.
Volume: 407
Issue: 2
Pages: 313-20
Publication
First Author: Raveh E
Year: 2006
Journal: Mech Dev
Title: Dynamic expression of Runx1 in skin affects hair structure.
Volume: 123
Issue: 11
Pages: 842-50
Publication
First Author: Devenport D
Year: 2011
Journal: Nat Cell Biol
Title: Mitotic internalization of planar cell polarity proteins preserves tissue polarity.
Volume: 13
Issue: 8
Pages: 893-902
Publication
First Author: Ichijo R
Year: 2017
Journal: Genes Cells
Title: Essential roles of Tbx3 in embryonic skin development during epidermal stratification.
Volume: 22
Issue: 3
Pages: 284-292
Publication
First Author: Kashimata M
Year: 1997
Journal: Dev Dyn
Title: Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit.
Volume: 208
Issue: 2
Pages: 149-61
Publication
First Author: Barbour W
Year: 2004
Journal: Curr Eye Res
Title: Expression patterns of beta1-related alpha integrin subunits in murine lens during embryonic development and wound healing.
Volume: 29
Issue: 1
Pages: 1-10
Publication
First Author: Hoefert JE
Year: 2018
Journal: J Cell Biol
Title: The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis.
Volume: 217
Issue: 6
Pages: 2185-2204
Publication
First Author: Imanishi H
Year: 2014
Journal: Med Mol Morphol
Title: Spatial and temporal control of laminin-332 and -511 expressions during hair morphogenesis.
Volume: 47
Issue: 1
Pages: 38-42
Publication
First Author: Lee S
Year: 2013
Journal: Dev Biol
Title: Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells.
Volume: 383
Issue: 2
Pages: 201-13
Publication
First Author: Previtali SC
Year: 2003
Journal: J Neurosci
Title: Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles.
Volume: 23
Issue: 13
Pages: 5520-30
Publication    
First Author: Seldin L
Year: 2016
Journal: Elife
Title: NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.
Volume: 5
Publication
First Author: Mokkapati S
Year: 2008
Journal: J Invest Dermatol
Title: Basement membranes in skin are differently affected by lack of nidogen 1 and 2.
Volume: 128
Issue: 9
Pages: 2259-67
Publication
First Author: Böse K
Year: 2006
Journal: J Biol Chem
Title: Loss of nidogen-1 and -2 results in syndactyly and changes in limb development.
Volume: 281
Issue: 51
Pages: 39620-9
Publication
First Author: Sennett R
Year: 2015
Journal: Dev Cell
Title: An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin.
Volume: 34
Issue: 5
Pages: 577-91
Publication
First Author: Matilainen T
Year: 2007
Journal: Int J Dev Biol
Title: Analysis of Netrin 1 receptors during inner ear development.
Volume: 51
Issue: 5
Pages: 409-13