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Search results 101 to 188 out of 188 for Ncstn

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Type Details Score
Publication
23852374 | J:228608
First Author: Evangelou K
Year: 2013
Journal: Cell Death Differ
Title: The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.
Volume: 20
Issue: 11
Pages: 1485-97
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Publication
12815056 | J:85205
First Author: Li J
Year: 2003
Journal: J Biol Chem
Title: Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.
Volume: 278
Issue: 35
Pages: 33445-9
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Publication
15035625 | J:89109
First Author: Crystal AS
Year: 2004
Journal: Biochemistry
Title: Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
Volume: 43
Issue: 12
Pages: 3555-63
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Publication
22086926 | J:277862
First Author: Michaki V
Year: 2012
Journal: J Biol Chem
Title: Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.
Volume: 287
Issue: 2
Pages: 1100-11
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Publication
17913918 | J:125592
First Author: Li T
Year: 2007
Journal: J Neurosci
Title: Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.
Volume: 27
Issue: 40
Pages: 10849-59
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Publication
20674680 | J:164909
First Author: Sanjo N
Year: 2010
Journal: Neurosci Lett
Title: Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase.
Volume: 483
Issue: 1
Pages: 53-6
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Publication
19725872 | J:200386
First Author: Maeda T
Year: 2009
Journal: FEBS J
Title: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein.
Volume: 276
Issue: 20
Pages: 5832-40
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Publication
15379903 | J:93286
First Author: Ilaya NT
Year: 2004
Journal: J Neurochem
Title: Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle.
Volume: 91
Issue: 1
Pages: 230-7
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Publication
19494151 | J:149506
First Author: Tabuchi K
Year: 2009
Journal: J Neurosci
Title: Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.
Volume: 29
Issue: 22
Pages: 7290-301
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Publication
22547652 | J:185137
First Author: Billiard F
Year: 2012
Journal: J Exp Med
Title: Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
Volume: 209
Issue: 5
Pages: 1011-28
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Publication
12388777 | J:79991
First Author: Rozmahel R
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Volume: 99
Issue: 22
Pages: 14452-7
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Publication
16371134 | J:111897
First Author: Shiraishi H
Year: 2006
Journal: Genes Cells
Title: Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
Volume: 11
Issue: 1
Pages: 83-93
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Publication
21600962 | J:177751
First Author: Marutani T
Year: 2011
Journal: Biochim Biophys Acta
Title: ER-stress-inducible Herp, facilitates the degradation of immature nicastrin.
Volume: 1810
Issue: 8
Pages: 790-8
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Publication
25592972 | J:229208
First Author: Kizuka Y
Year: 2015
Journal: EMBO Mol Med
Title: An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
Volume: 7
Issue: 2
Pages: 175-89
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Publication
15634781 | J:95769
First Author: Ma G
Year: 2005
Journal: J Neurosci
Title: APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development.
Volume: 25
Issue: 1
Pages: 192-8
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Publication
17222949 | J:137701
First Author: Zhang H
Year: 2008
Journal: Neurobiol Aging
Title: Presenilins regulate the cellular level of the tumor suppressor PTEN.
Volume: 29
Issue: 5
Pages: 653-60
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Publication
20130175 | J:157933
First Author: Zhao G
Year: 2010
Journal: J Neurosci
Title: Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.
Volume: 30
Issue: 5
Pages: 1648-56
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Publication
15474363 | J:93093
First Author: Hébert SS
Year: 2004
Journal: Neurobiol Dis
Title: Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.
Volume: 17
Issue: 2
Pages: 260-72
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Publication
21562564 | J:172442
First Author: Klinakis A
Year: 2011
Journal: Nature
Title: A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.
Volume: 473
Issue: 7346
Pages: 230-3
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Publication
23359070 | J:196407
First Author: Lobry C
Year: 2013
Journal: J Exp Med
Title: Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
Volume: 210
Issue: 2
Pages: 301-19
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Publication
12646573 | J:83641
First Author: Chen F
Year: 2003
Journal: J Biol Chem
Title: Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Volume: 278
Issue: 22
Pages: 19974-9
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Publication
11943765 | J:76858
First Author: Leem JY
Year: 2002
Journal: J Biol Chem
Title: Presenilin 1 is required for maturation and cell surface accumulation of nicastrin.
Volume: 277
Issue: 21
Pages: 19236-40
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Publication
21597003 | J:177000
First Author: Barthet G
Year: 2011
Journal: FASEB J
Title: Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.
Volume: 25
Issue: 9
Pages: 2937-46
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Publication
16641999 | J:108398
First Author: Chen F
Year: 2006
Journal: Nature
Title: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Volume: 440
Issue: 7088
Pages: 1208-12
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Publication
19457123 | J:150744
First Author: Sevalle J
Year: 2009
Journal: J Neurochem
Title: Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
Volume: 110
Issue: 1
Pages: 275-83
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Publication
23585889 | J:206895
First Author: Stemmer N
Year: 2013
Journal: PLoS One
Title: Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.
Volume: 8
Issue: 4
Pages: e61299
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Publication
15274632 | J:320147
First Author: Fraering PC
Year: 2004
Journal: Biochemistry
Title: Purification and characterization of the human gamma-secretase complex.
Volume: 43
Issue: 30
Pages: 9774-89
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Publication
14717705 | J:97674
First Author: Culvenor JG
Year: 2004
Journal: Eur J Biochem
Title: Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
Volume: 271
Issue: 2
Pages: 375-85
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Publication
18456655 | J:138527
First Author: Vetrivel KS
Year: 2008
Journal: J Biol Chem
Title: Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
Volume: 283
Issue: 28
Pages: 19489-98
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Publication
10206645 | J:54336
First Author: De Strooper B
Year: 1999
Journal: Nature
Title: A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Volume: 398
Issue: 6727
Pages: 518-22
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Publication
15886206 | J:100835
First Author: Vetrivel KS
Year: 2005
Journal: J Biol Chem
Title: Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Volume: 280
Issue: 27
Pages: 25892-900
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Publication
21187406 | J:169417
First Author: Valkova C
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits.
Volume: 108
Issue: 2
Pages: 621-5
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Publication
10920231 | J:63697
First Author: Underhill DA
Year: 2000
Journal: Mamm Genome
Title: Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation.
Volume: 11
Issue: 8
Pages: 633-8
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Publication
24145027 | J:209333
First Author: Almenar-Queralt A
Year: 2013
Journal: J Biol Chem
Title: Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.
Volume: 288
Issue: 49
Pages: 35222-36
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Publication
31467060 | J:282009
First Author: Lio CJ
Year: 2019
Journal: Blood
Title: Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies.
Volume: 134
Issue: 18
Pages: 1487-1497
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Publication
30704515 | J:273177
First Author: Gerber H
Year: 2019
Journal: Acta Neuropathol Commun
Title: The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.
Volume: 7
Issue: 1
Pages: 13
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Publication
9933565 | J:52853
First Author: Underhill DA
Year: 1999
Journal: Genomics
Title: Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1.
Volume: 55
Issue: 2
Pages: 185-93
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Publication
27256505 | J:236499
 
First Author: Liu L
Year: 2016
Journal: Neuroscience
Title: Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.
Volume: 330
Pages: 236-46
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Publication
11709546 | J:72911
First Author: Murdoch JN
Year: 2001
Journal: Hum Mol Genet
Title: Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.
Volume: 10
Issue: 22
Pages: 2593-601
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Publication
11431695 | J:70272
First Author: Kibar Z
Year: 2001
Journal: Nat Genet
Title: Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.
Volume: 28
Issue: 3
Pages: 251-5
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Publication
11401431 | J:68343
First Author: Doudney K
Year: 2001
Journal: Genomics
Title: Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23.
Volume: 72
Issue: 2
Pages: 180-92
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Publication
25533675 | J:219292
First Author: Kobayashi T
Year: 2015
Journal: Nat Rev Cancer
Title: Modelling bladder cancer in mice: opportunities and challenges.
Volume: 15
Issue: 1
Pages: 42-54
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Publication
25741723 | J:219929
First Author: Xia D
Year: 2015
Journal: Neuron
Title: Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Volume: 85
Issue: 5
Pages: 967-81
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Publication
34990407 | J:321806
 
First Author: Dave JM
Year: 2022
Journal: J Clin Invest
Title: JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.
Volume: 132
Issue: 5
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Publication
30260951 | J:266159
First Author: Hara T
Year: 2018
Journal: PLoS Genet
Title: Rer1-mediated quality control system is required for neural stem cell maintenance during cerebral cortex development.
Volume: 14
Issue: 9
Pages: e1007647
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Publication
25438880 | J:221387
First Author: Liu L
Year: 2015
Journal: J Neurochem
Title: Pre-synaptic localization of the γ-secretase-inhibiting protein p24α2 in the mammalian brain.
Volume: 133
Issue: 3
Pages: 422-31
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Publication
30692224 | J:273599
First Author: Cheng S
Year: 2019
Journal: J Neurosci
Title: Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors.
Volume: 39
Issue: 12
Pages: 2195-2207
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Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GO Term
GO:0070765 | gamma-secretase complex
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Publication
22728099 | J:192517
 
First Author: Marques SC
Year: 2012
Journal: Neuroscience
Title: Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice.
Volume: 220
Pages: 256-66
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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