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Search results 301 to 357 out of 357 for Npm1

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0.021s

Type

Details

Score

Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

•

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

•

Publication

23435463 | J:196690

First Author:	Sportoletti P
Year:	2013
Journal:	Blood
Title:	The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.
Volume:	121
Issue:	17
Pages:	3447-58

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DO Term

DOID:0081089 | acute myeloid leukemia with mutated NPM1

•

Publication

30755706 | J:278202

First Author:	Sportoletti P
Year:	2019
Journal:	Leukemia
Title:	GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations.
Volume:	33
Issue:	7
Pages:	1827-1832

•

Allele

Npm1<em1Smoc> | MGI:7291369

Name:	nucleophosmin 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

•

Publication

24991885 | -

First Author:	Lührig S
Year:	2014
Journal:	Stem Cells Dev
Title:	Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells.
Volume:	23
Issue:	23
Pages:	2862-74

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GXD Expression

Probe:	MGI:5295858
Assay Type:	Immunohistochemistry
Annotation Date:	2011-11-14
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:1616417
Pattern:	Not Specified
Stage:	TS17
Assay Id:	MGI:5295632
Age:	embryonic day 10.5

Note:	Expression was largely in the cytoplasm of cells in the trunk neural tube. A very small portion of staining was present in the nucleus and some of it colocalizes with the nucleolar marker Npm1 (B23).
Specimen Label:	6J p53 L24 Bst/+
Detected:	true
Specimen Num:	4

•

Allele

Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno> | MGI:5502770

Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Genoway
Allele Type:	Targeted
Attribute String:	Conditional ready, Humanized sequence, Inserted expressed sequence

•

Allele

Npm1<tm1Trow> | MGI:6285874

Name:	nucleophosmin 1; targeted mutation 1, Jennifer Trowbridge
Allele Type:	Targeted
Attribute String:	Conditional ready, Humanized sequence

•

Strain

MGI:6285878 | C57BL/6-Npm1<tm1Trow>/J

Attribute String:

coisogenic, mutant strain, targeted mutation

•

Publication

25772360 | -

First Author:	Onikubo T
Year:	2015
Journal:	Cell Rep
Title:	Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition.

•

Protein Domain

IPR004301 | Nucleoplasmin

Type:

Family

Description:

The nucleoplasmin family includes nucleophosmin, nucleoplasmin and nucleoplasmin-like proteins. Nucleophosmin (also known as NPM1/B23) is a multifunctional protein that is involved in a number of cellular activities, such as ribosome maturatation and export, centrosome duplication, and response to stress stimuli []. Nucleoplasmin (NPM2) is a histone chaperone for histones H2A-H2B and is highly expressed in the oocyte and through the early stages of embryogenesis [].Mutations of the NPM1 gene has been linked to acute myeloid leukemia [].

•

Strain

MGI:6286133 | B6.Cg-Gt(ROSA)26Sor<tm3(CAG-flpo/ERT2)Alj> Npm1<tm1Trow>

Attribute String:

targeted mutation, mutant strain, congenic

•

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mx1-cre)1Cgn/?
Background:	involves: C57BL/6 * CBA
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Mx1-cre)1Cgn/?
Background:	involves: C57BL/6 * CBA
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Npm1/Npm1<+>
Background:	B6.Cg-Gt(ROSA)26Sor Npm1
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

16041368 | -

First Author:	Wang W
Year:	2005
Journal:	Nat Cell Biol
Title:	Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication.
Volume:	7
Issue:	8
Pages:	823-30

•

Publication

24952945 | -

First Author:	Arcovito A
Year:	2014
Journal:	J Biol Chem
Title:	Synergic role of nucleophosmin three-helix bundle and a flanking unstructured tail in the interaction with G-quadruplex DNA.
Volume:	289
Issue:	31
Pages:	21230-41

•

Protein Domain

IPR032569 | NPM1_C

Type:

Domain

Description:

This domain, approximately 50 residues in length, is mainly found in C-terminal region of nucleophosmin from animals []. Nucleophosmin (also known as NPM1/B23) is a multifunctional protein that is involved in a number of cellular activities, such as ribosome maturatation and export, centrosome duplication, and response to stress stimuli []. Although it shuttles rapidly between the nucleus and the cytoplasm, a large fraction of NPM1/B23 resides in the nucleoli []. Mutations of the NPM1 gene has been linked to acute myeloid leukemia []. This domain has a three-helix bundle which binds the G-quadruplex DNA at the interface between helices H1 and H2 through electrostatic interactions with the G-quadruplex phosphate backbone [, ].

•

Publication

22707729 | -

First Author:	Gallo A
Year:	2012
Journal:	J Biol Chem
Title:	Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter.
Volume:	287
Issue:	32
Pages:	26539-48

•

Publication

16794633 | -

First Author:	Grisendi S
Year:	2006
Journal:	Nat Rev Cancer
Title:	Nucleophosmin and cancer.
Volume:	6
Issue:	7
Pages:	493-505

•

Publication

31767858 | J:285814

First Author:	Papaioannou D
Year:	2019
Journal:	Nat Commun
Title:	The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.
Volume:	10
Issue:	1
Pages:	5351

•

Publication

37615668 | J:345635

First Author:	Zhou L
Year:	2023
Journal:	J Cell Biol
Title:	T cell proliferation requires ribosomal maturation in nucleolar condensates dependent on DCAF13.
Volume:	222
Issue:	10

•

Publication

28017614 | J:238414

First Author:	Li Z
Year:	2017
Journal:	Cancer Cell
Title:	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N⁶-Methyladenosine RNA Demethylase.
Volume:	31
Issue:	1
Pages:	127-141

•

Publication

19666870 | J:160805

First Author:	Cheng K
Year:	2010
Journal:	Blood
Title:	The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
Volume:	115
Issue:	16
Pages:	3341-5

•

Publication

22614325 | J:193069

First Author:	Mano H
Year:	2012
Journal:	Cancer Discov
Title:	ALKoma: a cancer subtype with a shared target.
Volume:	2
Issue:	6
Pages:	495-502

•

Publication

26836305 | J:230716

First Author:	Mitrea DM
Year:	2016
Journal:	Elife
Title:	Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.
Volume:	5

•

Publication

33523834 | J:327672

First Author:	Gueiderikh A
Year:	2021
Journal:	Sci Adv
Title:	Fanconi anemia A protein participates in nucleolar homeostasis maintenance and ribosome biogenesis.
Volume:	7
Issue:	1

•

Strain

MGI:6286135 | B6.Cg-Gt(ROSA)26Sor<tm3(CAG-flpo/ERT2)Alj> Npm1<tm1Trow> Dnmt3a<tm1Trow> Tg(Mx1-cre)1Cgn

Attribute String:

congenic, mutant strain, targeted mutation

•

Genotype

Symbol:	Dnmt3a/Dnmt3a<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Npm1/Npm1<+> Tg(Mx1-cre)1Cgn/?
Background:	B6.Cg-Gt(ROSA)26Sor Npm1 Dnmt3a Tg(Mx1-cre)1Cgn
Zygosity:	cn
Has Mutant Allele:	true

•

Protein

Q61937

Organism:	Mus musculus/domesticus
Length:	292
Fragment?:	false

•

Protein

Q5SQB0

Organism:	Mus musculus/domesticus
Length:	264
Fragment?:	false

•

Protein

Q5U438

Organism:	Mus musculus/domesticus
Length:	292
Fragment?:	false

•

Protein

Q3U536

Organism:	Mus musculus/domesticus
Length:	292
Fragment?:	false

•

Protein

Q5SQB7

Organism:	Mus musculus/domesticus
Length:	292
Fragment?:	false

•

Protein

Q80W85

Organism:	Mus musculus/domesticus
Length:	207
Fragment?:	false

•

Protein

Q9CPP0

Organism:	Mus musculus/domesticus
Length:	175
Fragment?:	false

•

Protein

Q3UDA7

Organism:	Mus musculus/domesticus
Length:	200
Fragment?:	true

•

Protein

Q3TAH3

Organism:	Mus musculus/domesticus
Length:	175
Fragment?:	false

•

Protein

Q8BSZ3

Organism:	Mus musculus/domesticus
Length:	226
Fragment?:	true

•

Protein

Q3UTE3

Organism:	Mus musculus/domesticus
Length:	167
Fragment?:	true

•

Protein

Q5SQB5

Organism:	Mus musculus/domesticus
Length:	285
Fragment?:	false

•

Protein

A0A2I3BR42

Organism:	Mus musculus/domesticus
Length:	168
Fragment?:	false

•

Protein

Q3SXW7

Organism:	Mus musculus/domesticus
Length:	207
Fragment?:	false

•

Protein

Q9DAY9

Organism:	Mus musculus/domesticus
Length:	257
Fragment?:	false

•

Publication

34880223 | J:318006

First Author:	Sönmez A
Year:	2021
Journal:	Cell Death Dis
Title:	Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.
Volume:	12
Issue:	12
Pages:	1139

•

Publication

35563782 | J:338852

First Author:	Ko CF
Year:	2022
Journal:	Cells
Title:	The Puf-A Protein Is Required for Primordial Germ Cell Development.
Volume:	11
Issue:	9

•

Publication

23327922 | J:195868

First Author:	Diffner E
Year:	2013
Journal:	Blood
Title:	Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.
Volume:	121
Issue:	12
Pages:	2289-300

•

Publication

16984370 | J:115913

First Author:	Naoe T
Year:	2006
Journal:	Cancer Sci
Title:	Nucleophosmin: a versatile molecule associated with hematological malignancies.
Volume:	97
Issue:	10
Pages:	963-9

•

Publication

16189272 | J:126614

First Author:	Piva R
Year:	2006
Journal:	Blood
Title:	Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas.
Volume:	107
Issue:	2
Pages:	689-97

•

Publication

28481984 | J:243430

First Author:	Farg MA
Year:	2017
Journal:	Hum Mol Genet
Title:	The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.
Volume:	26
Issue:	15
Pages:	2882-2896

•

Publication

28536276 | J:243198

First Author:	Tripodo C
Year:	2017
Journal:	Cancer Res
Title:	Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling.
Volume:	77
Issue:	13
Pages:	3685-3699

•

Publication

28916722 | J:248993

First Author:	Shinde MY
Year:	2017
Journal:	J Biol Chem
Title:	Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.
Volume:	292
Issue:	44
Pages:	18240-18255

•

Publication

33782403 | J:304846

First Author:	Zhu G
Year:	2021
Journal:	Nat Commun
Title:	HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.
Volume:	12
Issue:	1
Pages:	1956

•

Publication

34999733 | J:321220

First Author:	Cho HC
Year:	2022
Journal:	Oncogene
Title:	Puf-A promotes cancer progression by interacting with nucleophosmin in nucleolus.
Volume:	41
Issue:	8
Pages:	1155-1165

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

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