MEF-2 (also known as MyEF-2) is a sequence-specific single-stranded DNA (ssDNA) binding protein that binds specifically to ssDNA derived from the proximal (MB1) element of the myelin basic protein (MBP) promoter and represses transcription of the MBP gene [, ]. MEF-2 contains two RNA recognition motifs (RRMs). MEF-2 is also a binding partner of RUNX1 during erythropoiesis, which is bound in undifferentiated cells and lost upon differentiation [].
