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Search results 4201 to 4300 out of 5063 for Pole

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0.037s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Nr3c2/Nr3c2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cfc1/Cfc1
Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hand2/Hand2
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dll1/Dll1
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ovol2/Ovol2
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Megf8/Megf8
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
21862448 | J:198109
First Author: Oeschger FM
Year: 2012
Journal: Cereb Cortex
Title: Gene expression analysis of the embryonic subplate.
Volume: 22
Issue: 6
Pages: 1343-59
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Protein Coding Gene
MGI:1918348 | Cep170
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924066 | Sdccag8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108360 | Enah
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926176 | Gas2l1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104745 | Sez6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915061 | Poldip2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3652048 | Gas2l2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891826 | Tubd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2151064 | Strn3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923661 | Ift43
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924145 | Bicd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1261910 | Pibf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1859293 | Atxn10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915958 | Rabl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347073 | Nubp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2137414 | Kifc5b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1333757 | Strn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2147298 | Cep120
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2179288 | Rttn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1921662 | Gle1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2139083 | Cep152
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349669 | Spo11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2140340 | Akna
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923061 | Saxo1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918244 | Agbl4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922422 | Ccdc146
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99700 | Cenpc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098597 | Ift81
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922945 | Rilpl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1101760 | Bicd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2142346 | Strn4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103234 | Herc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1196431 | D7Ertd443e
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107428 | Cfap20
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920670 | Ccsap
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2442521 | Cep295
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384878 | Cep164
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914241 | Khdc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99694 | Rasgrf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919757 | Dzip1l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891258 | Parp3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1277953 | Rp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97309 | Nefh
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1270862 | Axin2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914243 | Smarcd3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107785 | Mesp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70188
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
P46718
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Protein
Q3U9G9
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
Q78PY7
Organism: Mus musculus/domesticus
Length: 910  
Fragment?: false
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Protein
Q8BRT1
Organism: Mus musculus/domesticus
Length: 1286  
Fragment?: false
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Protein
Q3TYG6
Organism: Mus musculus/domesticus
Length: 1002  
Fragment?: false
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Protein
Q08EB6
Organism: Mus musculus/domesticus
Length: 1287  
Fragment?: false
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Protein
Q3UZI3
Organism: Mus musculus/domesticus
Length: 910  
Fragment?: false
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Protein
Q3UF57
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
Q3TW51
Organism: Mus musculus/domesticus
Length: 910  
Fragment?: false
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Protein
A2RRR3
Organism: Mus musculus/domesticus
Length: 1089  
Fragment?: false
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Protein
B9EJA4
Organism: Mus musculus/domesticus
Length: 1308  
Fragment?: false
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Protein
F7DCH5
Organism: Mus musculus/domesticus
Length: 1307  
Fragment?: false
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Protein
F6TW36
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
F6YU21
Organism: Mus musculus/domesticus
Length: 1022  
Fragment?: true
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Protein
E9Q8N5
Organism: Mus musculus/domesticus
Length: 1286  
Fragment?: false
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Protein
Q3TRW3
Organism: Mus musculus/domesticus
Length: 910  
Fragment?: false
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Protein
A0A0R4J0N5
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Protein
A0A087WQS9
Organism: Mus musculus/domesticus
Length: 1113  
Fragment?: true
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Protein
Q3UZA5
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
Q08EB5
Organism: Mus musculus/domesticus
Length: 1304  
Fragment?: false
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Publication
19948484 | -
First Author: Chikashige Y
Year: 2009
Journal: J Cell Biol
Title: Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation.
Volume: 187
Issue: 3
Pages: 413-27
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Publication
18252797 | -
First Author: Krapp A
Year: 2008
Journal: J Cell Sci
Title: Homoeostasis between the GTPase Spg1p and its GAP in the regulation of cytokinesis in S. pombe.
Volume: 121
Issue: Pt 5
Pages: 601-8
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Publication
16431930 | -
First Author: Cooper JA
Year: 2006
Journal: J Cell Biol
Title: Checkpoint control of mitotic exit--do budding yeast mind the GAP?
Volume: 172
Issue: 3
Pages: 331-3
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Publication
9203579 | -
First Author: Schmidt S
Year: 1997
Journal: Genes Dev
Title: The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe.
Volume: 11
Issue: 12
Pages: 1519-34
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Protein Domain
IPR017231 | Small_GTPase_Tem1/Spg1
Type: Family
Description: Small GTPases form an independent superfamily within the larger class of regulatory GTP hydrolases. This superfamily contains proteins that control a vast number of important processes and possess a common, structurally preserved GTP-binding domain [, ]. Sequence comparisons of small G proteins from various species have revealed that they are conserved in primary structures at the level of 30-55% similarity [].Crystallographic analysis of various small G proteins revealed the presence of a 20kDa catalytic domain that is unique for the whole superfamily [, ]. The domain is built of five alpha helices (A1-A5), six β-strands (B1-B6) and five polypeptide loops (G1-G5). A structural comparison of the GTP- and GDP-bound form, allows one to distinguish two functional loop regions: switch I and switch II that surround the gamma-phosphate group of the nucleotide. The G1 loop (also called the P-loop) that connects the B1 strand and the A1 helix is responsible for the binding of the phosphate groups. The G3 loop provides residues for Mg2 and phosphate binding and is located at the N terminus of the A2 helix. The G1 and G3 loops are sequentially similar to Walker A and Walker B boxes that are found in other nucleotide binding motifs. The G2 loop connects the A1 helix and the B2 strand and contains a conserved Thr residue responsible for Mg2 binding. The guanine base is recognised by the G4 and G5 loops. The consensus sequence NKXD of the G4 loop contains Lys and Asp residues directly interacting with the nucleotide. Part of the G5 loop located between B6 and A5 acts as a recognition site for the guanine base [].The small GTPase superfamily can be divided into at least 8 different families, including:Arf small GTPases. GTP-binding proteins involved in protein trafficking by modulating vesicle budding and uncoating within the Golgi apparatus.Ran small GTPases. GTP-binding proteins involved in nucleocytoplasmic transport. Required for the import of proteins into the nucleus and also for RNA export.Rab small GTPases. GTP-binding proteins involved in vesicular traffic.Rho small GTPases. GTP-binding proteins that control cytoskeleton reorganisation.Ras small GTPases. GTP-binding proteins involved in signalling pathways.Sar1 small GTPases. Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).Mitochondrial Rho (Miro). Small GTPase domain found in mitochondrial proteins involved in mitochondrial trafficking.Roc small GTPases domain. Small GTPase domain always found associated with the COR domain.This entry includes Tem1 from budding yeasts and Spg1 from fission yeasts. They are GTPases involved in the regulation of the cell cycle. In Schizosaccharomyces pombe, Spg1 is required for the localisation of Cdc7 (part of the septation initiation network) to the spindle pole body (SPB) []. It is regulated negatively by a GTPase-activating protein (GAP) comprising two subunits - Byr4 and Cdc16. In anaphase B, Spg1 is localised on the new SPB []. In Saccharomyces cerevisiae, Tem1 is associated with the mitotic exit network (MEN). It is involved in termination of M phase of the cell cycle [].
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Publication
15902260 | J:98580
First Author: Youngren KK
Year: 2005
Journal: Nature
Title: The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.
Volume: 435
Issue: 7040
Pages: 360-4
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Publication
16638812 | J:108928
First Author: Christodoulou A
Year: 2006
Journal: J Cell Sci
Title: Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication.
Volume: 119
Issue: Pt 10
Pages: 2035-47
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Publication
16098829 | J:129786
First Author: Furukawa N
Year: 2005
Journal: Cell Metab
Title: Role of Rho-kinase in regulation of insulin action and glucose homeostasis.
Volume: 2
Issue: 2
Pages: 119-29
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Publication
2654938 | J:16692
First Author: Kaestner KH
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes.
Volume: 86
Issue: 9
Pages: 3150-4
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Publication
1730609 | J:1657
First Author: Nagamatsu S
Year: 1992
Journal: J Biol Chem
Title: Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization.
Volume: 267
Issue: 1
Pages: 467-72
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Publication
14615604 | J:87746
First Author: Bandyopadhyay G
Year: 2004
Journal: Mol Endocrinol
Title: Protein kinase C-lambda knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport.
Volume: 18
Issue: 2
Pages: 373-83
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Publication
8772201 | J:35061
First Author: Nakagawa O
Year: 1996
Journal: FEBS Lett
Title: ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.
Volume: 392
Issue: 2
Pages: 189-93
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Publication
18718479 | J:225274
First Author: Zhou Z
Year: 2009
Journal: Neuropharmacology
Title: A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function.
Volume: 56
Issue: 1
Pages: 81-9
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Publication
23172836 | J:209475
First Author: Saito T
Year: 2013
Journal: Circulation
Title: Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility.
Volume: 127
Issue: 1
Pages: 104-14
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Publication
2190533 | J:34513
First Author: Reed BC
Year: 1990
Journal: Arch Biochem Biophys
Title: 3T3-L1 adipocyte glucose transporter (HepG2 class): sequence and regulation of protein and mRNA expression by insulin, differentiation, and glucose starvation.
Volume: 279
Issue: 2
Pages: 261-74
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Publication
22641098 | J:186835
First Author: Nguyen HT
Year: 2012
Journal: Lab Invest
Title: Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice.
Volume: 92
Issue: 8
Pages: 1203-12
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Publication
28012647 | J:273990
 
First Author: Baumer Y
Year: 2017
Journal: Atherosclerosis
Title: CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis.
Volume: 256
Pages: 105-114
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Publication
10995754 | J:66414
First Author: Chi MM
Year: 2000
Journal: J Biol Chem
Title: Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst.
Volume: 275
Issue: 51
Pages: 40252-7
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Publication
34198548 | J:308910
 
First Author: Penny HL
Year: 2021
Journal: Int J Mol Sci
Title: Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma.
Volume: 22
Issue: 12
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Publication
32627870 | J:312128
First Author: Li B
Year: 2020
Journal: FASEB J
Title: Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation.
Volume: 34
Issue: 8
Pages: 11058-11067
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Publication
28396402 | J:242133
First Author: Bobo-Jiménez V
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: APC/CCdh1-Rock2 pathway controls dendritic integrity and memory.
Volume: 114
Issue: 17
Pages: 4513-4518
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Publication
31914704 | J:299726
First Author: Wei L
Year: 2020
Journal: FASEB J
Title: ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice.
Volume: 34
Issue: 1
Pages: 474-493
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Publication
27886408 | J:319616
First Author: Kasahara DI
Year: 2017
Journal: Clin Exp Allergy
Title: Role of ROCK2 in CD4+ cells in allergic airways responses in mice.
Volume: 47
Issue: 2
Pages: 224-235
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Publication
18414683 | J:135152
First Author: Noma K
Year: 2008
Journal: J Clin Invest
Title: ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
Volume: 118
Issue: 5
Pages: 1632-44
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Publication
17213475 | J:121238
First Author: Ganguly A
Year: 2007
Journal: Am J Physiol Endocrinol Metab
Title: Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction.
Volume: 292
Issue: 5
Pages: E1241-55
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Publication
16098146 | J:106856
First Author: Thumkeo D
Year: 2005
Journal: Genes Cells
Title: ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo.
Volume: 10
Issue: 8
Pages: 825-34
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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