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Search results 901 to 1000 out of 1024 for Ace2

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Type Details Score
Protein
F6QCP8
Organism: Mus musculus/domesticus
Length: 1016  
Fragment?: true
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Protein
Q7TSV8
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: true
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Protein
Q8K233
Organism: Mus musculus/domesticus
Length: 1015  
Fragment?: true
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Protein
Q5XK22
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: true
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Protein
Q61265
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein
Q3TU20
Organism: Mus musculus/domesticus
Length: 1312  
Fragment?: false
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Publication
9629165 | -
 
First Author: Isaac RE
Year: 1998
Journal: Ann N Y Acad Sci
Title: Toward a role for angiotensin-converting enzyme in insects.
Volume: 839
Pages: 288-92
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Publication
1851160 | -
First Author: Wei L
Year: 1991
Journal: J Biol Chem
Title: The two homologous domains of human angiotensin I-converting enzyme are both catalytically active.
Volume: 266
Issue: 14
Pages: 9002-8
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Publication
12633854 | -
First Author: Kim HM
Year: 2003
Journal: FEBS Lett
Title: Crystal structure of Drosophila angiotensin I-converting enzyme bound to captopril and lisinopril.
Volume: 538
Issue: 1-3
Pages: 65-70
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Publication
17439247 | -
First Author: Corradi HR
Year: 2007
Journal: Biochemistry
Title: The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380.
Volume: 46
Issue: 18
Pages: 5473-8
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Publication
18457420 | -
First Author: Watermeyer JM
Year: 2008
Journal: Biochemistry
Title: Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme.
Volume: 47
Issue: 22
Pages: 5942-50
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Protein Domain
IPR001548 | Peptidase_M2
Type: Family
Description: This group of metallopeptidases belong to the MEROPS peptidase family M2 (clan MA(E)). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA. The catalytic residues and zinc ligands have been identified, the zinc ion being ligated to two His residues within the motif HEXXH, showing that the enzyme belongs to the glu-zincin sub-group of metalloproteases [].Peptidyl-dipeptidase A (angiotensin-converting enzyme or ACE, ) is a mammalian enzyme responsible for cleavage of dipeptides from the C-termini of proteins, notably converting decapeptide angiotensin I to the octapeptide angiotensin II []. The enzyme exists in two differentially transcribed forms, the most common of which is from lung endothelium; this contains two homologous domains that have arisen by gene duplication []. The testis-specific form contains only the C-terminal domain, arising from a duplicated promoter region present in intron 12 of the gene []. Both enzymatic forms are membrane proteins that are anchored by means of a C-terminal transmembrane domain. Both domains of the endothelial enzyme are active, but have differing kinetic constants [, ]. ACE is well-known as a key part of the renin-angiotensin system that regulates blood pressure and ACE inhibitors are important for the treatment of hypertension [, ].An ACE homologue, ACE2 (MEROPS identifier M02.006), has been identified in humans that differs from ACE; it preferentially removes carboxy-terminal hydrophobic or basic amino acids and appears to be important in cardiac function [, ]. ACE3 is a non-peptidase homologue included in this entry which lacks Glu378 in the HEXXH motif.A number of insect enzymes have been shown to be similar to peptidyl-dipeptidase A, these containing a single catalytic domain [, ].
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Publication
32075877 | -
First Author: Wrapp D
Year: 2020
Journal: Science
Title: Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Volume: 367
Issue: 6483
Pages: 1260-1263
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Publication
32132184 | -
First Author: Yan R
Year: 2020
Journal: Science
Title: Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.
Volume: 367
Issue: 6485
Pages: 1444-1448
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Publication
26868298 | J:283999
First Author: Zumla A
Year: 2016
Journal: Nat Rev Drug Discov
Title: Coronaviruses - drug discovery and therapeutic options.
Volume: 15
Issue: 5
Pages: 327-47
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Publication
37307197 | J:338419
First Author: Castanheira FVS
Year: 2023
Journal: Blood Adv
Title: Intravital imaging of three different microvascular beds in SARS-CoV-2-infected mice.
Volume: 7
Issue: 15
Pages: 4170-4181
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Publication
32225175 | -
First Author: Shang J
Year: 2020
Journal: Nature
Title: Structural basis of receptor recognition by SARS-CoV-2.
Volume: 581
Issue: 7807
Pages: 221-224
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Publication
26184451 | J:284000
 
First Author: Gretebeck LM
Year: 2015
Journal: Curr Opin Virol
Title: Animal models for SARS and MERS coronaviruses.
Volume: 13
Pages: 123-9
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Strain
MGI:7261387 | C(Cg)-Tmprss2<em2.1(TMPRSS2)Synbl> Ace2<em2.1(ACE2)Synbl>/J
Attribute String: endonuclease-mediated mutation, mutant strain
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Strain
MGI:7261379 | C57BL/6J-Tmprss2<em1(TMPRSS2)Synbl> Ace2<em1(ACE2)Synbl>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
28371822 | J:261072
First Author: Sato T
Year: 2017
Journal: Cardiovasc Res
Title: ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.
Volume: 113
Issue: 7
Pages: 760-769
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Publication
24814023 | J:212910
 
First Author: Zheng J
Year: 2014
Journal: Neuroscience
Title: Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction.
Volume: 273
Pages: 39-51
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Publication
37310920 | J:341033
First Author: Strine MS
Year: 2023
Journal: PLoS Biol
Title: DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.
Volume: 21
Issue: 6
Pages: e3002097
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Publication
32726802 | J:292665
     
First Author: Yang J
Year: 2020
Journal: Nature
Title: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.
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Publication
31189595 | J:277411
First Author: Wang W
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.
Volume: 116
Issue: 26
Pages: 13006-13015
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Publication
28559246 | J:249550
First Author: Brar GS
Year: 2017
Journal: Diabetes
Title: Neprilysin Is Required for Angiotensin-(1-7)'s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1-2).
Volume: 66
Issue: 8
Pages: 2201-2212
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Publication
22921883 | J:286379
First Author: Guimarães GG
Year: 2012
Journal: Peptides
Title: Exercise induces renin-angiotensin system unbalance and high collagen expression in the heart of Mas-deficient mice.
Volume: 38
Issue: 1
Pages: 54-61
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Publication
27496559 | J:286381
 
First Author: Ali Q
Year: 2016
Journal: J Renin Angiotensin Aldosterone Syst
Title: Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury.
Volume: 17
Issue: 3
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Publication
34047808 | J:312269
First Author: Liao MC
Year: 2021
Journal: Diabetologia
Title: AT2R deficiency in mice accelerates podocyte dysfunction in diabetic progeny in a sex-dependent manner.
Volume: 64
Issue: 9
Pages: 2108-2121
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Publication
24599018 | J:286416
First Author: Iwanami J
Year: 2014
Journal: Hypertens Res
Title: Role of angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis in the hypotensive effect of azilsartan.
Volume: 37
Issue: 7
Pages: 616-20
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Publication
30634441 | J:286354
 
First Author: Sato T
Year: 2019
Journal: Int J Mol Sci
Title: Loss of Apelin Augments Angiotensin II-Induced Cardiac Dysfunction and Pathological Remodeling.
Volume: 20
Issue: 2
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Publication
26886190 | J:286447
First Author: Tanno T
Year: 2016
Journal: J Cardiovasc Pharmacol
Title: Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression.
Volume: 67
Issue: 6
Pages: 503-9
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Publication
30369568 | J:286430
First Author: Ichikawa H
Year: 2018
Journal: Int Heart J
Title: Blood Pressure-Independent Effect of Olmesartan on Albuminuria in Mice Overexpressing Renin.
Volume: 59
Issue: 6
Pages: 1445-1453
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Publication
22205225 | J:182441
First Author: Lo CS
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice.
Volume: 302
Issue: 7
Pages: F840-52
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Publication
23552863 | J:197243
First Author: Shi Y
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice.
Volume: 304
Issue: 11
Pages: F1335-46
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Publication
38483537 | J:348940
 
First Author: Chen M
Year: 2024
Journal: J Clin Invest
Title: Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants.
Volume: 134
Issue: 8
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Publication
37552656 | J:339697
First Author: Weiss CM
Year: 2023
Journal: PLoS One
Title: N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2.
Volume: 18
Issue: 8
Pages: e0289139
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Publication
35483427 | J:331822
First Author: Solopov PA
Year: 2022
Journal: Am J Pathol
Title: Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression and Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1-Induced Acute Lung Injury in K18-hACE2 Transgenic Mice.
Volume: 192
Issue: 7
Pages: 990-1000
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Publication
35584773 | J:334864
First Author: Suryawanshi RK
Year: 2022
Journal: Nature
Title: Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.
Volume: 607
Issue: 7918
Pages: 351-355
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Publication
35062015 | J:334870
First Author: Halfmann PJ
Year: 2022
Journal: Nature
Title: SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.
Volume: 603
Issue: 7902
Pages: 687-692
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Publication
32723427 | J:291888
     
First Author: Moreau GB
Year: 2020
Journal: Am J Trop Med Hyg
Title: Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection.
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Publication
38101297 | J:343779
 
First Author: Hu B
Year: 2023
Journal: EBioMedicine
Title: Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA.2/5 subvariants in the upper and lower respiratory tract.
Volume: 99
Pages: 104916
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Publication
35476528 | J:335952
First Author: Hong J
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants.
Volume: 119
Issue: 18
Pages: e2201433119
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Publication
35780162 | J:335964
First Author: Case JB
Year: 2022
Journal: Nat Commun
Title: Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains.
Volume: 13
Issue: 1
Pages: 3824
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Publication
34927793 | J:335925
First Author: Wagner TR
Year: 2022
Journal: EMBO Rep
Title: Biparatopic nanobodies protect mice from lethal challenge with SARS-CoV-2 variants of concern.
Volume: 23
Issue: 2
Pages: e53865
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Publication
34214142 | J:336007
First Author: Rawle DJ
Year: 2021
Journal: PLoS Pathog
Title: ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions.
Volume: 17
Issue: 7
Pages: e1009723
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Publication
35058437 | J:335924
First Author: El-Shennawy L
Year: 2022
Journal: Nat Commun
Title: Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2.
Volume: 13
Issue: 1
Pages: 405
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Publication
34634927 | J:336021
First Author: van Oosten L
Year: 2021
Journal: mBio
Title: Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 Variants.
Volume: 12
Issue: 5
Pages: e0181321
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Publication
32841215 | J:294084
     
First Author: Golden JW
Year: 2020
Journal: JCI Insight
Title: Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease.
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Publication
36091051 | J:335974
 
First Author: Barbier M
Year: 2022
Journal: Front Immunol
Title: Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2.
Volume: 13
Pages: 948431
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Publication
35547740 | J:335942
 
First Author: Casasnovas JM
Year: 2022
Journal: Front Immunol
Title: Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron.
Volume: 13
Pages: 863831
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Publication
35546150 | J:335944
First Author: Lu T
Year: 2022
Journal: Nat Commun
Title: Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19.
Volume: 13
Issue: 1
Pages: 2576
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Publication
34929007 | J:335919
First Author: Chaouat AE
Year: 2021
Journal: PLoS Pathog
Title: SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection.
Volume: 17
Issue: 12
Pages: e1010175
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Publication
36311758 | J:331639
 
First Author: Lennol MP
Year: 2022
Journal: Front Immunol
Title: Serum angiotensin-converting enzyme 2 as a potential biomarker for SARS-CoV-2 infection and vaccine efficacy.
Volume: 13
Pages: 1001951
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Publication
35344983 | J:336214
First Author: Shapira T
Year: 2022
Journal: Nature
Title: A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic.
Volume: 605
Issue: 7909
Pages: 340-348
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Publication
37729215 | J:340771
First Author: Lende SSF
Year: 2023
Journal: PLoS One
Title: Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster.
Volume: 18
Issue: 9
Pages: e0291131
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Publication
38365933 | J:349961
First Author: Willett JDS
Year: 2024
Journal: Commun Biol
Title: SARS-CoV-2 rapidly evolves lineage-specific phenotypic differences when passaged repeatedly in immune-naïve mice.
Volume: 7
Issue: 1
Pages: 191
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Publication
37648855 | J:349981
First Author: Addetia A
Year: 2023
Journal: Nature
Title: Neutralization, effector function and immune imprinting of Omicron variants.
Volume: 621
Issue: 7979
Pages: 592-601
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Publication
34161386 | J:309634
First Author: Chan CEZ
Year: 2021
Journal: PLoS One
Title: The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody.
Volume: 16
Issue: 6
Pages: e0253487
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Publication
24014829 | J:286424
First Author: Xia H
Year: 2013
Journal: Circ Res
Title: Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension.
Volume: 113
Issue: 9
Pages: 1087-1096
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Publication
23155428 | J:195465
First Author: Feng Y
Year: 2012
Journal: PLoS One
Title: Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy.
Volume: 7
Issue: 11
Pages: e48910
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Publication
34098567 | J:307753
First Author: Xu J
Year: 2021
Journal: Nature
Title: Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.
Volume: 595
Issue: 7866
Pages: 278-282
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Publication
34747367 | J:319449
 
First Author: Kamle S
Year: 2021
Journal: JCI Insight
Title: Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19.
Volume: 6
Issue: 21
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Publication
36564389 | J:333743
First Author: Guo X
Year: 2022
Journal: Nat Commun
Title: Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2.
Volume: 13
Issue: 1
Pages: 7907
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Publication
20660625 | J:169343
First Author: Bindom SM
Year: 2010
Journal: Diabetes
Title: Angiotensin I-converting enzyme type 2 (ACE2) gene therapy improves glycemic control in diabetic mice.
Volume: 59
Issue: 10
Pages: 2540-8
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Publication
23646149 | J:200870
First Author: Chodavarapu H
Year: 2013
Journal: PLoS One
Title: Rosiglitazone treatment of type 2 diabetic db/db mice attenuates urinary albumin and angiotensin converting enzyme 2 excretion.
Volume: 8
Issue: 4
Pages: e62833
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Publication
24756098 | J:286374
First Author: Somineni HK
Year: 2014
Journal: J Endocrinol
Title: Daily exercise training protects against albuminuria and angiotensin converting enzyme 2 shedding in db/db diabetic mice.
Volume: 221
Issue: 2
Pages: 235-51
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Publication
33139569 | J:299936
First Author: Li W
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection.
Volume: 117
Issue: 47
Pages: 29832-29838
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Publication
37452066 | J:339219
First Author: Yang K
Year: 2023
Journal: Signal Transduct Target Ther
Title: SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells.
Volume: 8
Issue: 1
Pages: 276
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Publication
16889841 | J:286420
First Author: Faber F
Year: 2006
Journal: Regul Pept
Title: Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice.
Volume: 136
Issue: 1-3
Pages: 130-7
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Publication
31390839 | J:286352
 
First Author: Suh SH
Year: 2019
Journal: Int J Mol Sci
Title: Olmesartan Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome by Suppressing Tubular Expression of TGFβ.
Volume: 20
Issue: 15
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Publication
32144368 | J:286364
First Author: Choi HS
Year: 2020
Journal: Sci Rep
Title: Angiotensin-[1-7] attenuates kidney injury in experimental Alport syndrome.
Volume: 10
Issue: 1
Pages: 4225
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Publication
25777062 | J:220732
First Author: Bae EH
Year: 2015
Journal: Am J Pathol
Title: Characterization of the intrarenal renin-angiotensin system in experimental alport syndrome.
Volume: 185
Issue: 5
Pages: 1423-35
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Publication
27178803 | J:234019
First Author: Dominguez JM 2nd
Year: 2016
Journal: Am J Pathol
Title: Adeno-Associated Virus Overexpression of Angiotensin-Converting Enzyme-2 Reverses Diabetic Retinopathy in Type 1 Diabetes in Mice.
Volume: 186
Issue: 6
Pages: 1688-700
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Publication
19420084 | J:286406
First Author: Rockx B
Year: 2009
Journal: J Virol
Title: Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection.
Volume: 83
Issue: 14
Pages: 7062-74
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Publication
32200014 | J:286442
     
First Author: Xie W
Year: 2020
Journal: World Neurosurg
Title: OIP5-AS1 attenuates microangiopathy in diabetic mouse by regulating miR-200b/ACE2.
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Publication
26216430 | J:286484
First Author: Ribeiro AA
Year: 2015
Journal: J Renin Angiotensin Aldosterone Syst
Title: Characterization of the renal renin-angiotensin system in transgenic mice that express rat tonin.
Volume: 16
Issue: 4
Pages: 947-55
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Publication
32707445 | J:291894
 
First Author: Yang R
Year: 2020
Journal: EBioMedicine
Title: Lack of antibody-mediated cross-protection between SARS-CoV-2 and SARS-CoV infections.
Volume: 58
Pages: 102890
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Publication
32669391 | J:297449
First Author: Obukhov AG
Year: 2020
Journal: Diabetes
Title: SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes.
Volume: 69
Issue: 9
Pages: 1875-1886
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Publication
32985513 | J:296250
First Author: Brooke GN
Year: 2020
Journal: Sci Rep
Title: Structural and functional modelling of SARS-CoV-2 entry in animal models.
Volume: 10
Issue: 1
Pages: 15917
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Publication
32878480 | J:302109
First Author: Myti D
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Elevated FiO2 increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium.
Volume: 319
Issue: 4
Pages: L670-L674
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Publication
33284134 | J:302826
 
First Author: Li S
Year: 2021
Journal: JCI Insight
Title: Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2-induced systemic toxicity.
Volume: 6
Issue: 2
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Publication
33205194 | J:302245
First Author: Chadchan SB
Year: 2021
Journal: Biol Reprod
Title: The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization†.
Volume: 104
Issue: 2
Pages: 336-343
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Publication
- | J:324917
     
First Author: Case JB
Year: 2022
Journal: bioRxiv
Title: Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-COV-2 Omicron lineage strains.
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Publication
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First Author: Bolkhovitina EL
Year: 2022
Journal: bioRxiv
Title: The SARS-CoV-2 receptor-binding domain facilitates neutrophil transepithelial migration and nanoparticle uptake in the mice airways.
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Strain
MGI:7261381 | C57BL/6J-Fcgrt<em1(FCGRT)Synbl> Tmprss2<em1(TMPRSS2)Synbl> Ace2<em1(ACE2)Synbl>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
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First Author: Scaglione A
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Journal: Front Immunol
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Publication
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Title: The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells.
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Title: In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury.
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Publication
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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