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Search results 4201 to 4300 out of 7122 for App

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:3611188 | B6.Cg-Tg(PDGFB-APPSweIndArc)48Lms
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:3611187 | B6.Cg-Tg(PDGFB-APPSweIndArc)6Lms
Attribute String: transgenic, mutant strain, congenic
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Allele
Tg(tetO-APPSwInd)102Dbo | MGI:3708167
Name: transgene insertion 102, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Allele
Tg(PDGFB-APPInd)H6Lms | MGI:3717672
Name: transgene insertion H6, Lennart Mucke
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Thy1-APP)4Vln | MGI:3717568
Name: transgene insertion 4, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Thy1-APPSw)1Vln | MGI:3717574
Name: transgene insertion 1, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Thy1-App*R609D*K612E)4Vln | MGI:3720070
Name: transgene insertion 4, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Thy1-App*R609D*K612E)6Vln | MGI:3720071
Name: transgene insertion 6, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Thy1-App*R609D*K612E)2Vln | MGI:3720072
Name: transgene insertion 2, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:4366743 | C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:4838017 | C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:4412388 | C57BL/6-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz
Attribute String: coisogenic, mutant strain, transgenic
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Publication
28197095 | J:276720
 
First Author: Brendel M
Year: 2017
Journal: Front Aging Neurosci
Title: Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis.
Volume: 9
Pages: 8
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Publication
36906584 | J:339796
First Author: Ballweg A
Year: 2023
Journal: J Neuroinflammation
Title: [(18)F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data.
Volume: 20
Issue: 1
Pages: 68
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Publication
15922048 | J:98909
First Author: Woolley ML
Year: 2005
Journal: Behav Brain Res
Title: Age-related impairments in operant DMTP performance in the PS2APP mouse, a transgenic mouse model of Alzheimer's disease.
Volume: 161
Issue: 2
Pages: 220-8
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Publication
17008022 | J:116044
First Author: Güntert A
Year: 2006
Journal: Neuroscience
Title: High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain.
Volume: 143
Issue: 2
Pages: 461-75
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Strain
MGI:6438657 | B6.Cg-Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tac
Attribute String: mutant strain, congenic, transgenic
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Publication
25456500 | J:223074
First Author: Šišková Z
Year: 2014
Journal: Neuron
Title: Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease.
Volume: 84
Issue: 5
Pages: 1023-33
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Strain
MGI:6332196 | B6.Cg-Tg(ACTB-APP*V717F)1Colm/ArcApb
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:4839904 | B6.Cg-Tg(Prnp-PSEN2*N141I)30Jgr Tg(Thy1-APPSwe)71Jgr
Attribute String: congenic, mutant strain, transgenic
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Publication
17251422 | J:117779
First Author: Lopez-Lopez C
Year: 2007
Journal: J Neurosci
Title: Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease.
Volume: 27
Issue: 4
Pages: 824-31
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Publication
11403971 | J:108749
First Author: Wirths O
Year: 2001
Journal: Neurosci Lett
Title: Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Volume: 306
Issue: 1-2
Pages: 116-20
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Publication
21531045 | J:188209
First Author: Petiet A
Year: 2012
Journal: Neurobiol Aging
Title: Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice.
Volume: 33
Issue: 8
Pages: 1533-44
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Publication
15207260 | J:91228
First Author: Delatour B
Year: 2004
Journal: Neurobiol Dis
Title: Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model.
Volume: 16
Issue: 1
Pages: 41-7
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Publication
24927710 | J:284912
First Author: Trujillo-Estrada L
Year: 2014
Journal: J Alzheimers Dis
Title: Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.
Volume: 42
Issue: 2
Pages: 521-41
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Publication
19661615 | J:274986
First Author: Moreno-Gonzalez I
Year: 2009
Journal: J Alzheimers Dis
Title: Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice.
Volume: 18
Issue: 4
Pages: 755-76
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Publication
30249297 | J:277619
First Author: Nguyen TV
Year: 2018
Journal: Acta Neuropathol Commun
Title: Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.
Volume: 6
Issue: 1
Pages: 100
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Publication
21403389 | J:280595
First Author: Havas D
Year: 2011
Journal: J Alzheimers Dis
Title: A longitudinal study of behavioral deficits in an AβPP transgenic mouse model of Alzheimer's disease.
Volume: 25
Issue: 2
Pages: 231-43
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Publication
26620558 | J:276292
First Author: Spencer B
Year: 2016
Journal: J Biol Chem
Title: Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease.
Volume: 291
Issue: 4
Pages: 1905-20
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Publication
35165441 | J:326161
First Author: Yang AC
Year: 2022
Journal: Nature
Title: A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.
Volume: 603
Issue: 7903
Pages: 885-892
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Publication
17328871 | J:121462
 
First Author: Willis M
Year: 2007
Journal: Brain Res
Title: Localization and expression of substance P in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations.
Volume: 1143
Pages: 199-207
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Publication
22574282 | J:281406
First Author: Faizi M
Year: 2012
Journal: Brain Behav
Title: Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function.
Volume: 2
Issue: 2
Pages: 142-54
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Publication
23643485 | J:211728
First Author: Löffler T
Year: 2013
Journal: Neurobiol Aging
Title: Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice.
Volume: 34
Issue: 10
Pages: 2379-88
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Publication
23555933 | J:200158
First Author: Lipsanen A
Year: 2013
Journal: PLoS One
Title: Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion.
Volume: 8
Issue: 3
Pages: e60235
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Publication
25406061 | J:217691
First Author: Roth DM
Year: 2014
Journal: PLoS Biol
Title: Modulation of the maladaptive stress response to manage diseases of protein folding.
Volume: 12
Issue: 11
Pages: e1001998
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Publication
23545424 | J:211739
First Author: Knowles JK
Year: 2013
Journal: Neurobiol Aging
Title: Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.
Volume: 34
Issue: 8
Pages: 2052-63
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Strain
MGI:5754858 | B6J.129P2-Del(16Hspa13-App)3Yah
Attribute String: chromosome aberration, congenic, deletion, mutant strain, targeted mutation
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Strain
MGI:5519051 | B6;129P2-Del(16Hspa13-App)3Yah/Orl
Attribute String: chromosome aberration, deletion, mutant stock, targeted mutation
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Strain
MGI:5754852 | B6J.129P2-Dp(16Hspa13-App)2Yah
Attribute String: congenic, chromosome aberration, duplication, mutant strain, targeted mutation, trisomy
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Strain
MGI:5519061 | B6;129P2-Dp(16Hspa13-App)2Yah/Orl
Attribute String: targeted mutation, mutant stock, deletion, chromosome aberration
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Allele
Tg(PDGFB-APPInd)F17Plhn | MGI:5550581
Name: transgene insertion F17, Pyung-Lim Han
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
27836896 | J:239408
First Author: Merlini M
Year: 2017
Journal: Am J Physiol Heart Circ Physiol
Title: Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer's disease.
Volume: 312
Issue: 2
Pages: H232-H238
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Publication
30890928 | J:276312
 
First Author: Ni R
Year: 2019
Journal: Front Aging Neurosci
Title: fMRI Reveals Mitigation of Cerebrovascular Dysfunction by Bradykinin Receptors 1 and 2 Inhibitor Noscapine in a Mouse Model of Cerebral Amyloidosis.
Volume: 11
Pages: 27
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Publication
26834622 | J:244747
 
First Author: Ielacqua GD
Year: 2015
Journal: Front Aging Neurosci
Title: Magnetic Resonance Q Mapping Reveals a Decrease in Microvessel Density in the arcAβ Mouse Model of Cerebral Amyloidosis.
Volume: 7
Pages: 241
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Publication
23840405 | J:203724
First Author: Klohs J
Year: 2013
Journal: PLoS One
Title: Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging.
Volume: 8
Issue: 6
Pages: e66097
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Allele
Dp(16App-Runx1)5Yah | MGI:5789045
Name: duplication, Chr 16, Yann Herault 5
Allele Type: Targeted
Attribute String: Not Specified
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Allele
App<tm1.1Wevn> | MGI:5903308
 
Name: amyloid beta precursor protein; targeted mutation 1.1, William Van Nostrand
Allele Type: Targeted
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Strain
MGI:6369609 | B6(SJL)-Apoe<em2(APOE*)Adiuj> App<em1Adiuj>/J
Attribute String: endonuclease-mediated mutation, mutant strain
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Strain
MGI:6441012 | B6.Cg-App<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(tetO-APPSwInd, KRT14-EGFP)#Dbo | MGI:7541105
Name: transgene insertion, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(Prnp-APPSwInd,KRT14-EGFP)3Dbo | MGI:7541068
Name: transgene insertion 3, David Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(Prnp-APPSwe,Prnp-PSEN1dE9)D943Dbo | MGI:7541098
Name: transgene insertion D943, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
App<tm1.1(APP)Mdk> | MGI:7565473
Name: amyloid beta precursor protein; targeted mutation 1.1, Michael D Koob
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
App<em1Aduci> | MGI:7645709
Name: amyloid beta precursor protein; endonuclease-mediated mutation 1, Frank LaFerla
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Genotype
Genotype
Symbol: Tg(App)1874Kha/?
Background: FVB/N-Tg(App)1874Kha
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APP-App*R609D*K612E)7Vln/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(THY1-APP)1Somm/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APP)6209Kha/? Tg(SOD1)76Dpr/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PRNP-APPSwe)6Dwst/?
Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: C3H/HeJ * C57BL/6J)
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-App*,-Apbb1)25Spim/?
Background: C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(ACTB-APP*V717F)1Colm/?
Background: involves: C57BL/6 * DBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-PSEN2*N141I)30Jgr/? Tg(Thy1-APPSwe)71Jgr/?
Background: B6.Cg-Tg(Prnp-PSEN2*N141I)30Jgr Tg(Thy1-APPSwe)71Jgr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dp(16Hspa13-App)2Yah/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App
Background: involves: 129
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Eno2-APP*Ind,-PSEN1*P267S)#Kakiz/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dp(16Hspa13-App)2Yah/?
Background: B6J.129P2-Dp(16Hspa13-App)2Yah
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16Hspa13-App)3Yah/+
Background: B6J.129P2-Del(16Hspa13-App)3Yah
Zygosity: ht
Has Mutant Allele: true
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Publication
37298502 | J:348455
 
First Author: Choi Y
Year: 2023
Journal: Int J Mol Sci
Title: Capacitive Electrode-Based Electric Field Treatments on Redox-Toxic Iron Deposits in Transgenic AD Mouse Models: The Electroceutical Targeting of Alzheimer's Disease Feasibility Study.
Volume: 24
Issue: 11
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Publication
7592716 | J:29538
First Author: von Koch CS
Year: 1995
Journal: J Biol Chem
Title: The mouse APLP2 gene. Chromosomal localization and promoter characterization.
Volume: 270
Issue: 43
Pages: 25475-80
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Publication
36442651 | J:352444
 
First Author: Li YZ
Year: 2023
Journal: Neuropharmacology
Title: Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization.
Volume: 224
Pages: 109334
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Publication
27470171 | J:236530
First Author: Höfling C
Year: 2016
Journal: Aging Cell
Title: Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies.
Volume: 15
Issue: 5
Pages: 953-63
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Publication
19664757 | J:281363
First Author: España J
Year: 2010
Journal: Biol Psychiatry
Title: Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.
Volume: 67
Issue: 6
Pages: 513-21
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Publication
14645205 | J:87691
First Author: Jankowsky JL
Year: 2004
Journal: Hum Mol Genet
Title: Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Volume: 13
Issue: 2
Pages: 159-70
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HT Experiment
GSE141509 | A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
12486146 | J:129689
First Author: Buttini M
Year: 2002
Journal: J Neurosci
Title: Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
Volume: 22
Issue: 24
Pages: 10539-48
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Publication
23236499 | J:195677
First Author: Chen Y
Year: 2012
Journal: PLoS One
Title: Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease.
Volume: 7
Issue: 12
Pages: e51432
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Publication
36950017 | J:345220
 
First Author: Zhou X
Year: 2023
Journal: Front Pharmacol
Title: Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis.
Volume: 14
Pages: 1082602
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Publication
36968493 | J:345227
 
First Author: Hu YT
Year: 2023
Journal: Front Neurosci
Title: Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer's disease and the potential role of local estrogens.
Volume: 17
Pages: 1117584
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Publication
26635562 | J:289580
 
First Author: Huang HJ
Year: 2015
Journal: Front Behav Neurosci
Title: Administration of NaHS Attenuates Footshock-Induced Pathologies and Emotional and Cognitive Dysfunction in Triple Transgenic Alzheimer's Mice.
Volume: 9
Pages: 312
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Publication
26582141 | J:290046
 
First Author: Hou X
Year: 2015
Journal: Front Aging Neurosci
Title: Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease.
Volume: 7
Pages: 207
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Publication
31062249 | J:348502
First Author: Ting LL
Year: 2019
Journal: Mol Neurobiol
Title: Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer's Disease Model Cells.
Volume: 56
Issue: 11
Pages: 7572-7582
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Publication
18694898 | J:140396
First Author: Stokin GB
Year: 2008
Journal: Hum Mol Genet
Title: Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.
Volume: 17
Issue: 22
Pages: 3474-86
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Publication
27524794 | J:236982
First Author: Tiwari SS
Year: 2016
Journal: Brain
Title: Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss.
Volume: 139
Issue: Pt 10
Pages: 2751-2765
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Publication
28647555 | J:260246
 
First Author: García-Cerro S
Year: 2017
Journal: Neurobiol Dis
Title: Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.
Volume: 106
Pages: 76-88
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Publication
31043483 | J:277174
First Author: Jiang Y
Year: 2019
Journal: J Neurosci
Title: Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99).
Volume: 39
Issue: 27
Pages: 5255-5268
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Allele
Pin1<tm1Tuc> | MGI:2177943
Name: peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1; targeted mutation 1, Takafumi Uchida
Allele Type: Targeted
Attribute String: Null/knockout
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Transgene
MGI:2450858 | Tg(APP)6209Kha
Type: transgene
Organism: mouse, laboratory
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Allele
Sorl1<tm1Tew> | MGI:3604352
Name: sortilin-related receptor, LDLR class A repeats-containing; targeted mutation 1, Thomas E Willnow
Allele Type: Targeted
Attribute String: Null/knockout
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Transgene
MGI:3720040 | Tg(CAG-APP)0304Shoj
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:4356191 | Tg(Prnp*A116V*M128V)1309Jama
Type: transgene
Organism: mouse, laboratory
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Allele
Tg(Thy1-APPDutch)#Jckr | MGI:4438890
Name: transgene insertion, Mathias Jucker
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Thy1-APPSw)10Jiri | MGI:4843212
Name: transgene insertion 10, Jill C Richardson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Transgene
MGI:5803806 | Tg(tetO/Prnp-APP*Swe*Lon)9191Krz
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:6294490 | Tg(Myh6*/tetO-Hspb8*K141N)#Atsa
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: App/App<+>
Background: involves: C57BL/6 * CBA * CD-1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-App/APPswe)E1-2Dbo/?
Background: B6.C3-Tg(Prnp-App/APPswe)E1-2Dbo
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-APP)0304Shoj/?
Background: involves: C3H * C57BL/6N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Ldlr/Ldlr<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prnp/Prnp Tg(Prnp*A116V*M128V)1309Jama/?
Background: involves: 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tnfrsf1a/Tnfrsf1a Tg(Thy1-APP)3Somm/?
Background: involves: C57BL/6 * C57BL/6J * DBA/2
Zygosity: cx
Has Mutant Allele: true
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