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Search results 1 to 100 out of 114 for Uxt

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Hits by Category

Hits by Strain

Type Details Score
Gene
8409 | UXT
Type: gene
Organism: human
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Gene
100487762 | uxt
Type: gene
Organism: frog, western clawed
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Gene
116406734 | uxt
Type: gene
Organism: frog, western clawed
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Gene
299313 | Uxt
Type: gene
Organism: rat
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Gene
480900 | UXT
Type: gene
Organism: dog, domestic
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Gene
465609 | UXT
Type: gene
Organism: chimpanzee
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Gene
525680 | UXT
Type: gene
Organism: cattle
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Gene
447933 | uxt
Type: gene
Organism: zebrafish
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Gene
712682 | UXT
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR003994 | UXT
Type: Family
Description: Ubiquitously expressed transcript protein UXT is involved in gene transcription regulation. It acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). It is an AR N terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation []. It is a protein which interacts with the N terminus of the Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21. DSCR1 interacts with calcineurin and is overexpressed in Down's syndrome patients. UXT, which is encoded in human Xp11, is a 157-amino acid protein present in both cytosol and nucleus of the cells []. The members of this family are related to prefoldin, which is part of a molecular chaperone system that promotes the correct folding of nascent polypeptide chains. Prefoldin interacts with the nascent chain to stabilise it prior to its folding within the central cavity of a chaperonin. Prefoldin is a hexamer consisting of two types of subunits, alpha and beta. Archaeal prefoldin contains one type of alpha and one type of beta subunit [], while eukaryotic prefoldin contains two different but related alpha subunits and four related beta subunits [].
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Protein Coding Gene
MGI:1277988 | Uxt
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9WTZ0
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
Q8K2X4
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Publication
10087202 | J:54401
First Author: Schroer A
Year: 1999
Journal: Genomics
Title: Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue.
Volume: 56
Issue: 3
Pages: 340-3
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Gene
100133957 | UXT-AS1
Type: gene
Organism: human
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Publication
29649254 | J:261955
First Author: Schafler ED
Year: 2018
Journal: PLoS One
Title: UXT is required for spermatogenesis in mice.
Volume: 13
Issue: 4
Pages: e0195747
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Publication
15264020 | -
First Author: Silveira HC
Year: 2004
Journal: Braz J Med Biol Res
Title: A calcineurin inhibitory protein overexpressed in Down's syndrome interacts with the product of a ubiquitously expressed transcript.
Volume: 37
Issue: 6
Pages: 785-9
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Publication
11854421 | -
First Author: Markus SM
Year: 2002
Journal: Mol Biol Cell
Title: Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus.
Volume: 13
Issue: 2
Pages: 670-82
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Publication
30774773 | J:298067
First Author: Wang Y
Year: 2019
Journal: Oncotarget
Title: Prostate-specific loss of UXT promotes cancer progression.
Volume: 10
Issue: 7
Pages: 707-716
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Publication
17635584 | J:166014
First Author: McGilvray R
Year: 2007
Journal: FEBS J
Title: UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation.
Volume: 274
Issue: 15
Pages: 3960-71
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Publication
12456645 | -
First Author: Martín-Benito J
Year: 2002
Journal: EMBO J
Title: Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT.
Volume: 21
Issue: 23
Pages: 6377-86
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Publication
11106732 | -
First Author: Siegert R
Year: 2000
Journal: Cell
Title: Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins.
Volume: 103
Issue: 4
Pages: 621-32
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Publication
21907703 | J:177522
First Author: Enunlu I
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Alfa-class prefoldin protein UXT is a novel interacting partner of Amyotrophic Lateral Sclerosis 2 (Als2) protein.
Volume: 413
Issue: 3
Pages: 471-5
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Publication
32744119 | J:303303
   
First Author: Pan M
Year: 2020
Journal: Autophagy
Title: Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation.
Pages: 1-16
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Publication
21307340 | J:183001
First Author: Huang Y
Year: 2011
Journal: Mol Biol Cell
Title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
Volume: 22
Issue: 8
Pages: 1389-97
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Gene
705529 | LOC705529
Type: gene
Organism: macaque, rhesus
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Gene
103693333 | LOC103693333
Type: gene
Organism: rat
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Protein Coding Gene
MGP_CAROLIEiJ_G0032972 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035602 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035579 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035572 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035290 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1277988 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036108 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034581 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035259 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035411 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035357 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035493 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035401 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034282 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034716 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031515 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034122 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:2314818
Assay Type: RNA in situ
Annotation Date: 2019-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6274345
Age: embryonic day 14.5
Specimen Label: Table S1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2314818
Assay Type: RNA in situ
Annotation Date: 2019-01-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6274345
Age: embryonic day 14.5
Specimen Label: Table S1
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585944
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585944
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585944
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585944
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585944
Age: embryonic day 16.0
Note: Expression was widespread.
Specimen Label: Embryo
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3585944
Age: embryonic day 18.0
Image: E18
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3585944
Age: postnatal day 0-1
Image: P0/1
Note: Expression was detected in the vitreal outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585944
Age: postnatal day 2-3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585944
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585944
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585944
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3585944
Age: embryonic day 16.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:3574228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585944
Age: postnatal adult
Note: Expression was detected in bipolar cells.
Specimen Label: Adult
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:2314818
Assay Type: RNA in situ
Annotation Date: 2019-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6274345
Age: embryonic day 14.5
Specimen Label: Table S1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3585157
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3585944
Age: embryonic day 14.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E14
Detected: true
Specimen Num: 1
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein UXT
Type: chain
End: 157
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Publication
21862448 | J:198109
First Author: Oeschger FM
Year: 2012
Journal: Cereb Cortex
Title: Gene expression analysis of the embryonic subplate.
Volume: 22
Issue: 6
Pages: 1343-59
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
24021647 | J:201875
First Author: Sethurathinam S
Year: 2013
Journal: FEBS Lett
Title: UXT plays dual opposing roles on SARM-induced apoptosis.
Volume: 587
Issue: 20
Pages: 3296-302
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Interaction Experiment
McGilvray R (2007)
Description: UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation.
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Interaction Experiment
Chen S (2013)
Description: Regulation of the transcriptional activation of the androgen receptor by the UXT binding protein VHL.
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Publication
11827465 | J:73823
First Author: Liu L
Year: 2002
Journal: Genomics
Title: Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity.
Volume: 79
Issue: 1
Pages: 124-36
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Protein Domain
IPR004127 | Prefoldin_subunit_alpha
Type: Family
Description: This entry represents prefoldin subunit alpha-like proteins. Prefoldin (PFD) is a chaperone that interacts exclusively with type II chaperonins, hetero-oligomers lacking an obligate co-chaperonin that are found only in eukaryotes (chaperonin-containing T-complex polypeptide-1 (CCT)) and archaea. Eukaryotic PFD is a multi-subunit complex containing six polypeptides in the molecular mass range of 14-23kDa. In archaea, on the other hand, PFD is composed of two types of subunits, two alpha and four beta. The six subunits associate to form two back-to-back up-and-down eight-stranded barrels, from which hang six coiled coils. Each subunit contributes one (beta subunits) or two (alpha subunits) beta hairpin turns to the barrels. The coiled coils are formed by the N and C termini of an individual subunit. Overall, this unique arrangement resembles a jellyfish. The eukaryotic PFD hexamer is composed of six different subunits; however, these can be grouped into two alpha-like (PFD3 and -5) and four beta-like (PFD1, -2, -4, and -6) subunits based on amino acid sequence similarity with their archaeal counterparts. Eukaryotic PFD has a six-legged structure similar to that seen in the archaeal homologue [, ]. This family contains the archaeal alpha subunit, eukaryotic prefoldin subunits 3 and 5 and the UXT (ubiquitously expressed transcript) family. Eukaryotic PFD has been shown to bind both actin and tubulin co-translationally. The chaperone then delivers the target protein to CCT, interacting with the chaperonin through the tips of the coiled coils. No authentic target proteins of any archaeal PFD have been identified, to date.
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Protein
Q3TLD5
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Protein
A0A0U1RNX4
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: true
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Protein
Q3TC36
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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