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Search results 101 to 174 out of 174 for Dock3

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Type Details Score
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Interaction Experiment
Description: Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity.
Publication  
First Author: Bai N
Year: 2013
Journal: Mol Brain
Title: Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity.
Volume: 6
Pages: 22
Protein Domain
Type: Domain
Description: Rho guanosine triphosphatases (GTPases) are critical regulators of cell motility, polarity, adhesion, cytoskeletal organisation, proliferation, geneexpression, and apoptosis. Conversion of these biomolecular switches to the activated GTP-bound state is controlled by two families of guanine nucleotide exchanges factors (GEFs). DH-PH proteins are a large group of Rho GEFs comprising a catalytic Dbl homology (DH) domain with an adjacent pleckstrin homology (PH) domain within the context of functionally diverse signalling modules. The evolutionarily distinct andsmaller family of DOCK (dedicator of cytokinesis) or CDM (CED-5, DOCK1180, Myoblast city) proteins activate either Rac or Cdc42 to control cell migration, morphogenesis, and phagocytosis. DOCK proteins share the DOCK-type C2 domain (also termed the DOCK-homology region (DHR)-1 or CDM-zizimin homology 1 (CZH1) domain and the DHR-2 domain (also termed the CZH2 or DOCKER domain), [, , , , , ].The ~200 residue DOCK-type C2 domain is located toward the N terminus. It adopts a C2-like architecture and interacts with phosphatidylinositol3,4,5-trisphosphate []to mediate signalling and membrane localization. The central core of the DOCK-type C2 domain domain adopts an antiparallel β-sandwich with the "type II"C2 domain fold (a circular permutation of the more common "type I"topology), in which two 4-stranded sheets with strand order 6-5-2-3 and 7-8-1-4 create convex- and concave-exposed faces, respectively [].Some DOCK proteins are listed below:Mammalian Mammalian dedicator of cytokinesis 180 (DOCK180 or DOCK1),important for cell migration.Mammalian DOCK2, important for lymphocyte development, homong, activation,adhesion, polarization and migration processes.Mammalian DOCK3 (also known as MOCA), is expressed predominantly in neuronsand resides in growth cones and membrane ruffles.Mammalian DOCK4, possesses tumor suppressor properties.Mammalian DOCK9 (zizimin1), plays an important role in dendrite growth inhippocampal neurons through activation of Cdc42.Drosophila melanogaster Myoblast city.Caenorhabditis elegans CED-5.
Protein
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
Publication
First Author: Meller N
Year: 2002
Journal: Nat Cell Biol
Title: Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
Volume: 4
Issue: 9
Pages: 639-47
Publication
First Author: Yang J
Year: 2009
Journal: Science
Title: Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
Volume: 325
Issue: 5946
Pages: 1398-402
Protein
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: true
Publication
First Author: Zhang D
Year: 2010
Journal: Gene
Title: Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes.
Volume: 469
Issue: 1-2
Pages: 18-30
Publication
First Author: Kulkarni K
Year: 2011
Journal: J Biol Chem
Title: Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
Volume: 286
Issue: 28
Pages: 25341-51
Publication
First Author: Premkumar L
Year: 2010
Journal: J Biol Chem
Title: Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).
Volume: 285
Issue: 17
Pages: 13211-22
Protein
Organism: Mus musculus/domesticus
Length: 2080  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2130  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2111  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1909  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1567  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1816  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2098  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2128  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2100  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2130  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1175  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2150  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2073  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1865  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1828  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1868  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2100  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2113  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1942  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 2058  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2008  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2100  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1920  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 2088  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2042  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2058  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1902  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2088  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2175  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2187  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2151  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2042  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2150  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1978  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1940  
Fragment?: false