Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Homo sapiens |
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•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Rattus norvegicus |
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•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Danio rerio |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent ofvoltage-gated channels and comprises six putative transmembrane segments (S1-S6), intracellular N- and C-termini, and a pore-forming reentrant loop between S5 and S6 [].TRP channels represent a superfamily conserved from worms to humans that comprise seven subfamilies []: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin or long TRPs), TRPA (ankyrin, whose only member is Transient receptor potential cation channel subfamily A member 1, TrpA1), TRPP (polycystin), TRPML (mucolipin) and TRPN (Nomp-C homologues), which has a single member that can be found in worms, flies, and zebrafish. TRPs are classified essentially according to their primary amino acid sequence rather than selectivity or ligand affinity, due to their heterogeneous properties and complex regulation.TRP channels are involved in many physiological functions, ranging from pure sensory functions, such as pheromone signalling, taste transduction, nociception, and temperature sensation, over homeostatic functions, such as Ca2+ and Mg2+ reabsorption and osmoregulation, to many other motile functions, such as muscle contraction and vaso-motor control [].The TRPV (vanilloid) subfamily can be divided into two distinct groups. The first, which comprises TrpV1, TrpV2, TrpV3, and TrpV4, with nonselective cation conducting pores, has members which can be activated by temperature as well as chemical stimuli. They are involved in a range of functions including nociception, thermosensing and osmolarity sensing. The second group, which consists of TrpV5 and TrpV6, (also known as epithelial calcium channels 1 and 2), highly calcium selective, are involved in renal Ca2+ absorption/reabsorption [, ].TRPV1 was the first vanilloid receptor identified. It is a nonselective cation channel with a preference for calcium and is activated by noxious stimuli, heat, protons, pH 5.9, and various, mostly obnoxious, natural products []. TRPV1 is predominantly expressed in sensory neurons []and is believed to play a crucial role in temperature sensing and nociception [], qualifying therefore as a molecular target for pain treatment. |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
531
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Phan TX |
Year: |
2016 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Sex-dependent expression of TRPV1 in bladder arterioles. |
Volume: |
311 |
Issue: |
5 |
Pages: |
F1063-F1073 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanack C |
Year: |
2015 |
Journal: |
Cell |
Title: |
GABA blocks pathological but not acute TRPV1 pain signals. |
Volume: |
160 |
Issue: |
4 |
Pages: |
759-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Basso L |
Year: |
2019 |
Journal: |
Sci Signal |
Title: |
TRPV1 promotes opioid analgesia during inflammation. |
Volume: |
12 |
Issue: |
575 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stemkowski P |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity. |
Volume: |
17 |
Issue: |
11 |
Pages: |
2901-2912 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lagerström MC |
Year: |
2010 |
Journal: |
Neuron |
Title: |
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. |
Volume: |
68 |
Issue: |
3 |
Pages: |
529-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lapointe TK |
Year: |
2015 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis. |
Volume: |
309 |
Issue: |
2 |
Pages: |
G87-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cavanaugh DJ |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. |
Volume: |
31 |
Issue: |
13 |
Pages: |
5067-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2019 |
Journal: |
Front Physiol |
Title: |
TRPV1 and TRPV1-Expressing Nociceptors Mediate Orofacial Pain Behaviors in a Mouse Model of Orthodontic Tooth Movement. |
Volume: |
10 |
|
Pages: |
1207 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7388598 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-12-02 |
Strength: |
Trace |
Sex: |
Not Specified |
Emaps: |
EMAPS:3667828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7388622 |
Age: |
postnatal day 30 |
Image: |
4D TRPV1 Tlx3 CKO |
Note: |
Expression largely eliminated, but high level expressing neurons still observed. Neurons with low to medium levels of expression unaffected compared to control. |
Specimen Label: |
4D TRPV1 Tlx3 CKO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7388614 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3667827 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7388634 |
Age: |
postnatal day 0 |
Image: |
5A TRPV1 Control |
Note: |
Extremely high expression levels of expression in some neurons. |
Specimen Label: |
5A TRPV1 Control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7388598 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3667828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7388622 |
Age: |
postnatal day 30 |
Image: |
4D TRPV1 Control |
|
Specimen Label: |
4D TRPV1 Control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7388614 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3667827 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7388634 |
Age: |
postnatal day 0 |
Image: |
5A TRPV1 Tlx3-/- |
Note: |
High level expressing neurons nearly completely eliminated. Medium or low levels of expression in some neurons, unaffected compared to control. |
Specimen Label: |
5A TRPV1 Tlx3-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lakk M |
Year: |
2018 |
Journal: |
Front Cell Neurosci |
Title: |
Polymodal TRPV1 and TRPV4 Sensors Colocalize but Do Not Functionally Interact in a Subpopulation of Mouse Retinal Ganglion Cells. |
Volume: |
12 |
|
Pages: |
353 |
|
•
•
•
•
•
|
Publication |
First Author: |
Caterina MJ |
Year: |
2000 |
Journal: |
Science |
Title: |
Impaired nociception and pain sensation in mice lacking the capsaicin receptor. |
Volume: |
288 |
Issue: |
5464 |
Pages: |
306-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mishra SK |
Year: |
2011 |
Journal: |
EMBO J |
Title: |
TRPV1-lineage neurons are required for thermal sensation. |
Volume: |
30 |
Issue: |
3 |
Pages: |
582-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spencer NJ |
Year: |
2018 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
CGRPα within the Trpv1-Cre population contributes to visceral nociception. |
Volume: |
314 |
Issue: |
2 |
Pages: |
G188-G200 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tränkner D |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways. |
Volume: |
111 |
Issue: |
31 |
Pages: |
11515-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Black CJ |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Automated and rapid self-report of nociception in transgenic mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
13215 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rogoz K |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents. |
Volume: |
10 |
Issue: |
1 |
Pages: |
e0116568 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeong JH |
Year: |
2018 |
Journal: |
PLoS Biol |
Title: |
Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. |
Volume: |
16 |
Issue: |
4 |
Pages: |
e2004399 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2020 |
Journal: |
eNeuro |
Title: |
Ablation of TRPV1+ Afferent Terminals by Capsaicin Mediates Long-Lasting Analgesia for Trigeminal Neuropathic Pain. |
Volume: |
7 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hong J |
Year: |
2020 |
Journal: |
Neurosci Lett |
Title: |
Identification of Cardiac Expression Pattern of Transient Receptor Potential Vanilloid Type 1 (TRPV1) Receptor using a Transgenic Reporter Mouse Model. |
Volume: |
737 |
|
Pages: |
135320 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cobos EJ |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling. |
Volume: |
22 |
Issue: |
5 |
Pages: |
1301-1312 |
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•
•
•
•
•
|
Publication |
First Author: |
Smith-Edwards KM |
Year: |
2019 |
Journal: |
Gastroenterology |
Title: |
Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice. |
Volume: |
157 |
Issue: |
2 |
Pages: |
522-536.e2 |
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•
•
•
•
•
|
Publication |
First Author: |
Xie AX |
Year: |
2022 |
Journal: |
PLoS One |
Title: |
Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain. |
Volume: |
17 |
Issue: |
1 |
Pages: |
e0262769 |
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•
•
•
•
•
|
Publication |
First Author: |
Cavanaugh DJ |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. |
Volume: |
31 |
Issue: |
28 |
Pages: |
10119-27 |
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•
•
•
•
•
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Publication |
First Author: |
Stanford KR |
Year: |
2019 |
Journal: |
Brain Res |
Title: |
Antimycin A-induced mitochondrial dysfunction activates vagal sensory neurons via ROS-dependent activation of TRPA1 and ROS-independent activation of TRPV1. |
Volume: |
1715 |
|
Pages: |
94-105 |
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•
•
•
•
•
|
Publication |
First Author: |
Luo X |
Year: |
2021 |
Journal: |
Neuron |
Title: |
IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. |
Volume: |
109 |
Issue: |
17 |
Pages: |
2691-2706.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patil MJ |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines. |
Volume: |
13 |
Issue: |
6 |
Pages: |
e0198601 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shamsi F |
Year: |
2021 |
Journal: |
Nat Metab |
Title: |
Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes. |
Volume: |
3 |
Issue: |
4 |
Pages: |
485-495 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saloman JL |
Year: |
2016 |
Journal: |
J Neurosci |
Title: |
Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons. |
Volume: |
36 |
Issue: |
42 |
Pages: |
10769-10781 |
|
•
•
•
•
•
|
Publication |
First Author: |
DuBreuil DM |
Year: |
2021 |
Journal: |
Cell Rep Methods |
Title: |
A high-content platform for physiological profiling and unbiased classification of individual neurons. |
Volume: |
1 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
López Soto EJ |
Year: |
2020 |
Journal: |
Elife |
Title: |
Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Makadia PA |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
Optogenetic Activation of Colon Epithelium of the Mouse Produces High-Frequency Bursting in Extrinsic Colon Afferents and Engages Visceromotor Responses. |
Volume: |
38 |
Issue: |
25 |
Pages: |
5788-5798 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang F |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Sensory Afferents Use Different Coding Strategies for Heat and Cold. |
Volume: |
23 |
Issue: |
7 |
Pages: |
2001-2013 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eskilsson A |
Year: |
2021 |
Journal: |
J Neurosci |
Title: |
Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EP3 Receptors. |
Volume: |
41 |
Issue: |
24 |
Pages: |
5206-5218 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim SH |
Year: |
2022 |
Journal: |
eNeuro |
Title: |
Mapping of the Sensory Innervation of the Mouse Lung by Specific Vagal and Dorsal Root Ganglion Neuronal Subsets. |
Volume: |
9 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Davies AJ |
Year: |
2019 |
Journal: |
Cell |
Title: |
Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. |
Volume: |
176 |
Issue: |
4 |
Pages: |
716-728.e18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu C |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage. |
Volume: |
218 |
Issue: |
1 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Matsuwaki T |
Year: |
2017 |
Journal: |
Brain Behav Immun |
Title: |
Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses. |
Volume: |
66 |
|
Pages: |
165-176 |
|
•
•
•
•
•
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Publication |
First Author: |
Browne LE |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses. |
Volume: |
20 |
Issue: |
1 |
Pages: |
89-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abdus-Saboor I |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Development of a Mouse Pain Scale Using Sub-second Behavioral Mapping and Statistical Modeling. |
Volume: |
28 |
Issue: |
6 |
Pages: |
1623-1634.e4 |
|
•
•
•
•
•
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Publication |
First Author: |
Alvarez FJ |
Year: |
2004 |
Journal: |
J Comp Neurol |
Title: |
Vesicular glutamate transporters in the spinal cord, with special reference to sensory primary afferent synapses. |
Volume: |
472 |
Issue: |
3 |
Pages: |
257-80 |
|
•
•
•
•
•
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Publication |
First Author: |
Corder G |
Year: |
2017 |
Journal: |
Nat Med |
Title: |
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. |
Volume: |
23 |
Issue: |
2 |
Pages: |
164-173 |
|
•
•
•
•
•
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Publication |
First Author: |
Ghitani N |
Year: |
2017 |
Journal: |
Neuron |
Title: |
Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair Pull. |
Volume: |
95 |
Issue: |
4 |
Pages: |
944-954.e4 |
|
•
•
•
•
•
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Publication |
First Author: |
Beaulieu-Laroche L |
Year: |
2020 |
Journal: |
Cell |
Title: |
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. |
Volume: |
180 |
Issue: |
5 |
Pages: |
956-967.e17 |
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•
•
•
•
•
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Publication |
First Author: |
Kim SH |
Year: |
2020 |
Journal: |
eNeuro |
Title: |
Mapping of Sensory Nerve Subsets within the Vagal Ganglia and the Brainstem Using Reporter Mice for Pirt, TRPV1, 5-HT3, and Tac1 Expression. |
Volume: |
7 |
Issue: |
2 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Eskilsson A |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis. |
Volume: |
34 |
Issue: |
48 |
Pages: |
15957-61 |
|
•
•
•
•
•
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Publication |
First Author: |
Wang K |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle. |
Volume: |
117 |
Issue: |
10 |
Pages: |
5402-5408 |
|
•
•
•
•
•
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Publication |
First Author: |
Chen X |
Year: |
2022 |
Journal: |
Neuron |
Title: |
Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems. |
Volume: |
110 |
Issue: |
14 |
Pages: |
2242-2257.e6 |
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•
•
•
•
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Publication |
First Author: |
Petitjean H |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons. |
Volume: |
28 |
Issue: |
6 |
Pages: |
1429-1438.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mailhot B |
Year: |
2020 |
Journal: |
J Exp Med |
Title: |
Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases. |
Volume: |
217 |
Issue: |
9 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Delvalle NM |
Year: |
2018 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Communication Between Enteric Neurons, Glia, and Nociceptors Underlies the Effects of Tachykinins on Neuroinflammation. |
Volume: |
6 |
Issue: |
3 |
Pages: |
321-344 |
|
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•
•
•
•
|
Publication |
First Author: |
Solinski HJ |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Nppb Neurons Are Sensors of Mast Cell-Induced Itch. |
Volume: |
26 |
Issue: |
13 |
Pages: |
3561-3573.e4 |
|
•
•
•
•
•
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Publication |
First Author: |
Pinho-Ribeiro FA |
Year: |
2018 |
Journal: |
Cell |
Title: |
Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. |
Volume: |
173 |
Issue: |
5 |
Pages: |
1083-1097.e22 |
|
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•
•
•
•
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Publication |
First Author: |
Borgmann D |
Year: |
2021 |
Journal: |
Cell Metab |
Title: |
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. |
Volume: |
33 |
Issue: |
7 |
Pages: |
1466-1482.e7 |
|
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•
•
•
•
|
Publication |
First Author: |
Mishra SK |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. |
Volume: |
31 |
Issue: |
1 |
Pages: |
107472 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klawonn AM |
Year: |
2021 |
Journal: |
Immunity |
Title: |
Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons. |
Volume: |
54 |
Issue: |
2 |
Pages: |
225-234.e6 |
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•
•
•
•
•
|
Publication |
First Author: |
Angueira AR |
Year: |
2021 |
Journal: |
Nat Metab |
Title: |
Defining the lineage of thermogenic perivascular adipose tissue. |
Volume: |
3 |
Issue: |
4 |
Pages: |
469-484 |
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•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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|
|
|
•
•
•
•
•
|
MGI Directed Relationship Property |
Name: |
Non-mouse_Gene_Symbol |
Value: |
Trpv1 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
839
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Roman K |
Year: |
2020 |
Journal: |
Prostate |
Title: |
TRPV1 in experimental autoimmune prostatitis. |
Volume: |
80 |
Issue: |
1 |
Pages: |
28-37 |
|
•
•
•
•
•
|
Allele |
Name: |
transient receptor potential cation channel, subfamily V, member 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Recombinase |
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•
•
•
•
•
|
Publication |
First Author: |
Tominaga M |
Year: |
1998 |
Journal: |
Neuron |
Title: |
The cloned capsaicin receptor integrates multiple pain-producing stimuli. |
Volume: |
21 |
Issue: |
3 |
Pages: |
531-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Caterina MJ |
Year: |
1997 |
Journal: |
Nature |
Title: |
The capsaicin receptor: a heat-activated ion channel in the pain pathway. |
Volume: |
389 |
Issue: |
6653 |
Pages: |
816-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jia YF |
Year: |
2015 |
Journal: |
Front Cell Neurosci |
Title: |
Interference of TRPV1 function altered the susceptibility of PTZ-induced seizures. |
Volume: |
9 |
|
Pages: |
20 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
474
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
471
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Poitras T |
Year: |
2019 |
Journal: |
Mol Neurobiol |
Title: |
Selective Sensory Axon Reinnervation and TRPV1 Activation. |
Volume: |
56 |
Issue: |
10 |
Pages: |
7144-7158 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tian YH |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects. |
Volume: |
8 |
Issue: |
1 |
Pages: |
882 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
779
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
839
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang SE |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
TRPV1 Regulates Stress Responses through HDAC2. |
Volume: |
19 |
Issue: |
2 |
Pages: |
401-412 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alter BJ |
Year: |
2008 |
Journal: |
Neuron |
Title: |
Hotheaded: TRPV1 as mediator of hippocampal synaptic plasticity. |
Volume: |
57 |
Issue: |
5 |
Pages: |
629-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vriens J |
Year: |
2009 |
Journal: |
Mol Pharmacol |
Title: |
Pharmacology of vanilloid transient receptor potential cation channels. |
Volume: |
75 |
Issue: |
6 |
Pages: |
1262-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Samanta A |
Year: |
2018 |
Journal: |
Subcell Biochem |
Title: |
Transient Receptor Potential (TRP) Channels. |
Volume: |
87 |
|
Pages: |
141-165 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sondermann JR |
Year: |
2019 |
Journal: |
Pain |
Title: |
Vti1b promotes TRPV1 sensitization during inflammatory pain. |
Volume: |
160 |
Issue: |
2 |
Pages: |
508-527 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaudet R |
Year: |
2008 |
Journal: |
J Physiol |
Title: |
TRP channels entering the structural era. |
Volume: |
586 |
Issue: |
15 |
Pages: |
3565-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Latorre R |
Year: |
2009 |
Journal: |
Q Rev Biophys |
Title: |
Structure-functional intimacies of transient receptor potential channels. |
Volume: |
42 |
Issue: |
3 |
Pages: |
201-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gees M |
Year: |
2010 |
Journal: |
Cold Spring Harb Perspect Biol |
Title: |
The role of transient receptor potential cation channels in Ca2+ signaling. |
Volume: |
2 |
Issue: |
10 |
Pages: |
a003962 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Page AJ |
Year: |
2019 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
The TRPV1 channel regulates glucose metabolism. |
Volume: |
317 |
Issue: |
4 |
Pages: |
E667-E676 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhong B |
Year: |
2019 |
Journal: |
In Vivo |
Title: |
TRPV1 Mediates Glucose-induced Insulin Secretion Through Releasing Neuropeptides. |
Volume: |
33 |
Issue: |
5 |
Pages: |
1431-1437 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung MK |
Year: |
2008 |
Journal: |
Nat Neurosci |
Title: |
TRPV1 shows dynamic ionic selectivity during agonist stimulation. |
Volume: |
11 |
Issue: |
5 |
Pages: |
555-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Christoph T |
Year: |
2008 |
Journal: |
Mol Cell Neurosci |
Title: |
Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. |
Volume: |
37 |
Issue: |
3 |
Pages: |
579-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGrady NR |
Year: |
2020 |
Journal: |
Front Physiol |
Title: |
TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma. |
Volume: |
11 |
|
Pages: |
249 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu J |
Year: |
2021 |
Journal: |
EMBO Rep |
Title: |
TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease. |
Volume: |
22 |
Issue: |
6 |
Pages: |
e52013 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gibson HE |
Year: |
2008 |
Journal: |
Neuron |
Title: |
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. |
Volume: |
57 |
Issue: |
5 |
Pages: |
746-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yin S |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. |
Volume: |
123 |
Issue: |
9 |
Pages: |
3941-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riera CE |
Year: |
2014 |
Journal: |
Cell |
Title: |
TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. |
Volume: |
157 |
Issue: |
5 |
Pages: |
1023-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo L |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Molecular basis for heat desensitization of TRPV1 ion channels. |
Volume: |
10 |
Issue: |
1 |
Pages: |
2134 |
|
•
•
•
•
•
|