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Search results 201 to 292 out of 292 for Ros1

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0.029s
Type Details Score
GXD Expression  
Probe: MGI:6506833
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:6506834
Age: embryonic day 15.5
Note: There is a broad domain of tip expression.
Specimen Label: 3 - Class II
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6506833
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6506834
Age: embryonic day 15.5
Specimen Label: 6 - Category C - E15.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6506833
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6506834
Age: embryonic day 12.5
Specimen Label: 5 - E12.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6506833
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6506834
Age: embryonic day 15.5
Specimen Label: 5 - E15.5
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6506833
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6506834
Age: embryonic day 15.5
Note: Expression is restricted to the ureteric bud tips.
Specimen Label: 2 - Category 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2823925
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8D
Specimen Label: 8D
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2823925
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8E
Specimen Label: 8E
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2823925
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8F
Specimen Label: 8F
Detected: false
Specimen Num: 7
GXD Expression  
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8G
Specimen Label: 8G
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8H
Specimen Label: 8H
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8I
Specimen Label: 8I
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8J
Specimen Label: 8J
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Male
Emaps: EMAPS:3148828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3809680
Age: postnatal adult
Image: 7A,B
Specimen Label: 7A,B
Detected: true
Specimen Num: 1
Publication
First Author: Ali ZA
Year: 2014
Journal: J Clin Invest
Title: Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1.
Volume: 124
Issue: 12
Pages: 5159-74
Publication
First Author: Kiyozumi D
Year: 2020
Journal: Science
Title: NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility.
Volume: 368
Issue: 6495
Pages: 1132-1135
Publication
First Author: Cooper TG
Year: 2003
Journal: Biol Reprod
Title: Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice.
Volume: 69
Issue: 5
Pages: 1750-62
Publication
First Author: Keilhack H
Year: 2001
Journal: J Cell Biol
Title: Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Volume: 152
Issue: 2
Pages: 325-34
Publication
First Author: Bryda EC
Year: 1997
Journal: Mamm Genome
Title: A high-resolution genetic map around waltzer on mouse chromosome 10 and identification of a new allele of waltzer.
Volume: 8
Issue: 1
Pages: 1-4
Publication
First Author: Vacher J
Year: 1999
Journal: Mamm Genome
Title: Genetic localization and transmission of the mouse osteopetrotic grey-lethal mutation.
Volume: 10
Issue: 3
Pages: 239-43
Publication
First Author: Chen F
Year: 1994
Journal: Mol Endocrinol
Title: Cloning of a novel orphan receptor (GCNF) expressed during germ cell development.
Volume: 8
Issue: 10
Pages: 1434-44
Publication
First Author: Lee GH
Year: 1995
Journal: Genetics
Title: Identification of hepatocarcinogen-resistance genes in DBA/2 mice.
Volume: 139
Issue: 1
Pages: 387-95
Publication
First Author: Stark K
Year: 1994
Journal: Nature
Title: Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.
Volume: 372
Issue: 6507
Pages: 679-83
Publication
First Author: Su J
Year: 2021
Journal: Biol Reprod
Title: ZC3H4-a novel Cys-Cys-Cys-His-type zinc finger protein-is essential for early embryogenesis in mice†.
Volume: 104
Issue: 2
Pages: 325-335
Publication
First Author: Fan CM
Year: 1996
Journal: Mol Cell Neurosci
Title: Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.
Volume: 7
Issue: 1
Pages: 1-16
Publication
First Author: Karayianni E
Year: 1999
Journal: Cytogenet Cell Genet
Title: Transcriptional map of chromosome region 6q16-->q21.
Volume: 86
Issue: 3-4
Pages: 263-6
Publication
First Author: Miner JH
Year: 1997
Journal: J Cell Biol
Title: The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.
Volume: 137
Issue: 3
Pages: 685-701
Publication
First Author: Justice MJ
Year: 1990
Journal: Genetics
Title: A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.
Volume: 125
Issue: 4
Pages: 855-66
Publication
First Author: Haefliger JA
Year: 1992
Journal: J Biol Chem
Title: Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.
Volume: 267
Issue: 3
Pages: 2057-64
Publication
First Author: Siracusa LD
Year: 1991
Journal: Genetics
Title: Identification and applications of repetitive probes for gene mapping in the mouse.
Volume: 127
Issue: 1
Pages: 169-79
Publication
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
Publication
First Author: Rutledge EA
Year: 2017
Journal: Development
Title: Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Volume: 144
Issue: 17
Pages: 3177-3188
Publication        
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication
First Author: Davare MA
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.
Volume: 112
Issue: 39
Pages: E5381-90
Publication
First Author: Ogura H
Year: 2017
Journal: Sci Rep
Title: TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
Volume: 7
Issue: 1
Pages: 5519
Allele    
Name: Ros1 proto-oncogene; wild type
Allele
Name: Ros1 proto-oncogene; targeted mutation 1, Carmen Birchmeier
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: Ros1 proto-oncogene; targeted mutation 2, Carmen Birchmeier
Allele Type: Targeted
Attribute String: Null/knockout
Allele  
Name: Ros1 proto-oncogene; targeted mutation 1, Alain Charest
Allele Type: Targeted
Allele
Name: Ros1 proto-oncogene; targeted mutation 1.1, Alain Charest
Allele Type: Targeted
Attribute String: Hypomorph
Publication  
First Author: Qüesta JI
Year: 2013
Journal: Front Plant Sci
Title: DDM1 and ROS1 have a role in UV-B induced- and oxidative DNA damage in A. thaliana.
Volume: 4
Pages: 420
Publication
First Author: Hong S
Year: 2014
Journal: J Mol Biol
Title: The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activity.
Volume: 426
Issue: 22
Pages: 3703-3712
Publication    
First Author: Halter T
Year: 2021
Journal: Elife
Title: The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions.
Volume: 10
Allele
Name: Ros1 proto-oncogene; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: Ros1 proto-oncogene; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Genotype
Symbol: Ros1/Ros1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ros1/Ros1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ros1/Ros1
Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ros1/Ros1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Allele
Name: Ros1 proto-oncogene; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Strain
Attribute String: endonuclease-mediated mutation, mutant stock
Genotype
Symbol: Ros1/Ros1
Background: involves: C57BL/6NJcl * DBA/2NJcl
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ros1/Ros1<+>
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Allele
Name: transgene insertion 125, Tetsuo Noda
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Protein Domain
Type: Domain
Description: This is a permuted version of a single unit of the zf-CXXC domain that is detected in the Demeter-like proteins and ROS1 (REPRESSOR OF SILENCING 1) from plants []. Demeter and ROS1 proteins catalyse the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism []. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases []. The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides.
Strain
Attribute String: transgenic, mutant strain, coisogenic
Genotype
Symbol: Tg(SFTPC-CD74/ROS1)125Tno/?
Background: C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Morales-Ruiz T
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases.
Volume: 103
Issue: 18
Pages: 6853-8
Publication
First Author: Lee J
Year: 2014
Journal: Nucleic Acids Res
Title: AP endonucleases process 5-methylcytosine excision intermediates during active DNA demethylation in Arabidopsis.
Volume: 42
Issue: 18
Pages: 11408-18
Publication
First Author: Liu J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Mutations in the DNA demethylase OsROS1 result in a thickened aleurone and improved nutritional value in rice grains.
Volume: 115
Issue: 44
Pages: 11327-11332
Publication  
First Author: Kong W
Year: 2020
Journal: Front Genet
Title: Impact of DNA Demethylases on the DNA Methylation and Transcription of Arabidopsis NLR Genes.
Volume: 11
Pages: 460
Publication
First Author: Zhang H
Year: 2018
Journal: Nat Rev Mol Cell Biol
Title: Dynamics and function of DNA methylation in plants.
Volume: 19
Issue: 8
Pages: 489-506
Publication
First Author: Gong Z
Year: 2002
Journal: Cell
Title: ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase.
Volume: 111
Issue: 6
Pages: 803-14
Protein Domain
Type: Family
Description: DNA glycosylases are required to regulate the DNA methylation pathway at discrete regions across the plant genome, and probably protect the genome from excess methylation []. Arabidopsis encodes four active demethylases with 5-methylcytosine DNA glycosylase/lyase activities, namely DEMETER (DME), DME-Like 1 (DML1)/ROS1 (Repressor of Silencing 1), DML2 and DML3 [, , , ]. Both ROS1 and DME actively remove DNA methylation in all methylated cytosine contexts through a base excision repair (BER) mechanism [, ]. DML2/3 and ROS1 play important roles in the regulation of nucleotide-binding leucine-rich repeat (NLR) genes, a class of important plant disease resistance genes [].DEMETER functions mainly in the central cells of female gametophytes involved in gene imprinting, which allows the expression of the maternal copy of the imprinted MEA gene before fertilization, possibly by antagonizing or suppressing DNA methylation on target promoter []and acts in a sequence nonspecific manner. The other three demethylases, ROS1, DML2, and DML3, were shown to be largely active in somatic cells []. ROS1 is constitutively expressed and regulates gene expression by preventing the spread of DNA methylation and transcriptional silencing from transposons and is involved in UV-B induced- and oxidative DNA damage repair []. It also regulates defence genes by demethylation of RMG1 (disease resistance gene) and RLP43 (an orphan immune receptor gene) promoters [].
Publication
First Author: Inoue M
Year: 2016
Journal: Carcinogenesis
Title: Mouse models for ROS1-fusion-positive lung cancers and their application to the analysis of multikinase inhibitor efficiency.
Volume: 37
Issue: 5
Pages: 452-60
Publication
First Author: Shaw AT
Year: 2013
Journal: Nat Rev Cancer
Title: Tyrosine kinase gene rearrangements in epithelial malignancies.
Volume: 13
Issue: 11
Pages: 772-87
Publication
First Author: Saborowski A
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target.
Volume: 110
Issue: 48
Pages: 19513-8
Publication  
First Author: Iyer LM
Year: 2011
Journal: Prog Mol Biol Transl Sci
Title: Natural history of eukaryotic DNA methylation systems.
Volume: 101
Pages: 25-104
Publication
First Author: Arai Y
Year: 2013
Journal: PLoS One
Title: Mouse model for ROS1-rearranged lung cancer.
Volume: 8
Issue: 2
Pages: e56010
Publication
First Author: Bajrami I
Year: 2018
Journal: Cancer Discov
Title: E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.
Volume: 8
Issue: 4
Pages: 498-515
Publication
First Author: Clarke M
Year: 2020
Journal: Cancer Discov
Title: Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.
Volume: 10
Issue: 7
Pages: 942-963