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Search results 301 to 354 out of 354 for Rock1

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0.047s

Type

Details

Score

UniProt Feature

Begin:	76
Description:	Phosphothreonine; by ROCK1
Type:	modified residue
End:	76

•

UniProt Feature

Begin:	77
Description:	Phosphothreonine; by ROCK1
Type:	modified residue
End:	77

•

UniProt Feature

Begin:	383
Description:	Phosphothreonine; by ROCK1
Type:	modified residue
End:	383

•

UniProt Feature

Begin:	382
Description:	Phosphothreonine; by ROCK1
Type:	modified residue
End:	382

•

UniProt Feature

Begin:	380
Description:	Phosphoserine; by ROCK1
Type:	modified residue
End:	380

•

Publication

24803490 | J:213741

First Author:	Zhang JY
Year:	2014
Journal:	Reproduction
Title:	Distinct roles of ROCK1 and ROCK2 during development of porcine preimplantation embryos.
Volume:	148
Issue:	1
Pages:	99-107

•

UniProt Feature

Begin:	12
Description:	Phosphoserine; by AURKB and ROCK1
Type:	modified residue
End:	12

•

UniProt Feature

Begin:	35
Description:	Phosphoserine; by AURKB and ROCK1
Type:	modified residue
End:	35

•

UniProt Feature

Begin:	7
Description:	Phosphothreonine; by AURKB and ROCK1
Type:	modified residue
End:	7

•

UniProt Feature

Begin:	17
Description:	Phosphothreonine; by AURKB and ROCK1
Type:	modified residue
End:	17

•

UniProt Feature

Begin:	505
Description:	Phosphothreonine; by ROCK1 and CDC42BP
Type:	modified residue
End:	505

•

UniProt Feature

Begin:	153
Description:	Phosphoserine; by PKA, PKC, PKG/PRKG1 and ROCK1
Type:	modified residue
End:	153

•

Publication

19036714 | -

First Author:	Ongusaha PP
Year:	2008
Journal:	Sci Signal
Title:	Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Volume:	1
Issue:	47
Pages:	ra14

•

Protein Domain

IPR037310 | ROCK1_HR1

Type:

Domain

Description:

Rho-associated protein kinases (ROCKs) were originally identified as small GTPase Rho effectors. Later, ROCKs were found actively phosphorylating many actin-binding proteins and intermediate filament proteins to modulate their functions []. Two ROCK isoforms have been identified:ROCK1 (ROKb, p160ROCK) and ROCK2. As major downstream effectors of the small GTPase RhoA, they regulate cellular contraction, motility, morphology, polarity, cell division, and gene expression [, , ].This entry represents the HR1 domain found in Rho-associated protein kinase 1 (ROCK1), which is essential for the formation of stress fibres []. ROCK1 contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a Rho-binding HR1 domain and a pleckstrin homology (PH) domain. ROCK1 is auto-inhibited by HR1 and PH domains interacting with the catalytic domain. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family [].

•

Publication

23601011 | -

First Author:	Schofield AV
Year:	2013
Journal:	Crit Rev Biochem Mol Biol
Title:	Rho-associated coiled-coil kinase (ROCK) signaling and disease.
Volume:	48
Issue:	4
Pages:	301-16

•

Publication

19907920 | -

First Author:	Hahmann C
Year:	2010
Journal:	Cell Mol Life Sci
Title:	Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity.
Volume:	67
Issue:	2
Pages:	171-7

•

Publication

23950574 | -

First Author:	Amin E
Year:	2013
Journal:	Biol Chem
Title:	Rho-kinase: regulation, (dys)function, and inhibition.
Volume:	394
Issue:	11
Pages:	1399-410

•

Publication

20803696 | -

First Author:	Amano M
Year:	2010
Journal:	Cytoskeleton (Hoboken)
Title:	Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.
Volume:	67
Issue:	9
Pages:	545-54

•

Publication

16043513 | -

First Author:	Yoneda A
Year:	2005
Journal:	J Cell Biol
Title:	The Rho kinases I and II regulate different aspects of myosin II activity.
Volume:	170
Issue:	3
Pages:	443-53

•

HT Experiment

GSE102026 | mTORC1 Loss Impairs Epidermal Adhesion via Rho Kinase Activation


Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	GEO

•

Publication

28739902 | J:244650

First Author:	Dyberg C
Year:	2017
Journal:	Proc Natl Acad Sci U S A
Title:	Rho-associated kinase is a therapeutic target in neuroblastoma.
Volume:	114
Issue:	32
Pages:	E6603-E6612

•

Publication

37216099 | J:338922

First Author:	Reilly L
Year:	2023
Journal:	iScience
Title:	Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.
Volume:	26
Issue:	5
Pages:	106623

•

Publication

29496740 | J:261168

First Author:	Zhong Z
Year:	2018
Journal:	EMBO J
Title:	Prion-like protein aggregates exploit the RHO GTPase to cofilin-1 signaling pathway to enter cells.
Volume:	37
Issue:	6

•

Publication

28031255 | J:240629

First Author:	Rath N
Year:	2017
Journal:	EMBO Mol Med
Title:	ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
Volume:	9
Issue:	2
Pages:	198-218

•

Publication

25910808 | J:224630

First Author:	Soliman H
Year:	2015
Journal:	Am J Physiol Heart Circ Physiol
Title:	Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction.
Volume:	309
Issue:	1
Pages:	H70-81

•

Publication

24135024 | J:222206

First Author:	Shimizu T
Year:	2013
Journal:	Arterioscler Thromb Vasc Biol
Title:	Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pulmonary hypertension in mice.
Volume:	33
Issue:	12
Pages:	2780-91

•

Publication

23011471 | J:210071

First Author:	Zhou Q
Year:	2012
Journal:	Circulation
Title:	Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
Volume:	126
Issue:	18
Pages:	2236-47

•

Publication

28945203 | J:255466

First Author:	Asrani K
Year:	2017
Journal:	J Clin Invest
Title:	mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation.
Volume:	127
Issue:	11
Pages:	4001-4017

•

Publication

22903063 | J:189922

First Author:	Lallemend F
Year:	2012
Journal:	EMBO J
Title:	Positional differences of axon growth rates between sensory neurons encoded by Runx3.
Volume:	31
Issue:	18
Pages:	3718-29

•

Publication

22846914 | J:191321

First Author:	Patel RA
Year:	2012
Journal:	Cancer Res
Title:	RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Volume:	72
Issue:	19
Pages:	5025-34

•

Publication

27775859 | J:237624

First Author:	Samuel MS
Year:	2016
Journal:	Genesis
Title:	Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein.
Volume:	54
Issue:	12
Pages:	636-646

•

Publication

20627935 | J:169345

First Author:	Reiniger N
Year:	2010
Journal:	Diabetes
Title:	Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse.
Volume:	59
Issue:	8
Pages:	2043-54

•

Publication

24305806 | J:255339

First Author:	Herskowitz JH
Year:	2013
Journal:	J Neurosci
Title:	Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.
Volume:	33
Issue:	49
Pages:	19086-98

•

Publication

36755029 | J:340161

First Author:	Kang S
Year:	2023
Journal:	Nat Commun
Title:	TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity.
Volume:	14
Issue:	1
Pages:	700

•

Publication

25007875 | J:214236

First Author:	Matoba K
Year:	2014
Journal:	Am J Physiol Renal Physiol
Title:	Rho-kinase regulation of TNF-α-induced nuclear translocation of NF-κB RelA/p65 and M-CSF expression via p38 MAPK in mesangial cells.
Volume:	307
Issue:	5
Pages:	F571-80

•

Publication

30234377 | J:272261

First Author:	Yin J
Year:	2019
Journal:	Am J Physiol Lung Cell Mol Physiol
Title:	Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway.
Volume:	316
Issue:	1
Pages:	L35-L44

•

Publication

31239325 | J:330072

First Author:	Henderson BW
Year:	2019
Journal:	Sci Signal
Title:	Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid.
Volume:	12
Issue:	587

•

Publication

16751189 | J:116473

First Author:	Qin W
Year:	2006
Journal:	J Biol Chem
Title:	Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.
Volume:	281
Issue:	31
Pages:	21745-54

•

Publication

19564418 | J:152614

First Author:	Shu L
Year:	2009
Journal:	Mol Cell Biol
Title:	The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts.
Volume:	29
Issue:	17
Pages:	4691-700

•

Publication

25858457 | J:221425

First Author:	Cao Z
Year:	2015
Journal:	Development
Title:	Transcription factor AP-2γ induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage.
Volume:	142
Issue:	9
Pages:	1606-15

•

Publication

25908861 | J:232660

First Author:	Hyder CL
Year:	2015
Journal:	J Cell Sci
Title:	Sphingolipids inhibit vimentin-dependent cell migration.
Volume:	128
Issue:	11
Pages:	2057-69

•

Publication

26519207 | J:233203

First Author:	Lambert JA
Year:	2015
Journal:	Am J Physiol Lung Cell Mol Physiol
Title:	Ozone-induced airway hyperresponsiveness: roles of ROCK isoforms.
Volume:	309
Issue:	12
Pages:	L1394-7

•

Publication

29382705 | J:260723

First Author:	Unbekandt M
Year:	2018
Journal:	Cancer Res
Title:	Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Volume:	78
Issue:	8
Pages:	2096-2114

•

Publication

31295018 | J:291210

First Author:	Wei S
Year:	2019
Journal:	FASEB J
Title:	RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1-TLR4-NF-κB pathway in macrophages.
Volume:	33
Issue:	10
Pages:	11180-11193

•

Publication

30902967 | J:291445

First Author:	Wang YC
Year:	2019
Journal:	Exp Mol Med
Title:	Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis through the PDGFR/ROCK1 signal pathway.
Volume:	51
Issue:	3
Pages:	1-11

•

Publication

31446620 | J:314678

First Author:	McKerracher L
Year:	2020
Journal:	Transl Stroke Res
Title:	A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
Volume:	11
Issue:	3
Pages:	365-376

•

Publication

34768920 | J:315055

First Author:	Llamas-Granda P
Year:	2021
Journal:	Int J Mol Sci
Title:	Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor.
Volume:	22
Issue:	21

•

Publication

10619026 | -

First Author:	Maesaki R
Year:	1999
Journal:	Mol Cell
Title:	The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Volume:	4
Issue:	5
Pages:	793-803

•

Publication

35198058 | J:327756

First Author:	Tak J
Year:	2022
Journal:	Theranostics
Title:	Gα₁₂ overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation.
Volume:	12
Issue:	4
Pages:	1570-1588

•

Publication

23052206 | J:196918

First Author:	Iskratsch T
Year:	2013
Journal:	Cell Mol Life Sci
Title:	Two distinct phosphorylation events govern the function of muscle FHOD3.
Volume:	70
Issue:	5
Pages:	893-908

•

Publication

30444969 | J:268560

First Author:	Tang J
Year:	2019
Journal:	Exp Cell Res
Title:	ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.
Volume:	374
Issue:	1
Pages:	46-68

•

Publication

31339573 | J:280870

First Author:	Peng Z
Year:	2019
Journal:	J Neurochem
Title:	Inhibition of Notch1 signaling promotes neuronal differentiation and improves functional recovery in spinal cord injury through suppressing the activation of Ras homolog family member A.
Volume:	150
Issue:	6
Pages:	709-722

•

Protein

A0A3Q4EGR2

Organism:	Mus musculus/domesticus
Length:	1089
Fragment?:	false

•

Protein

P70335

Organism:	Mus musculus/domesticus
Length:	1354
Fragment?:	false

•

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