Type |
Details |
Score |
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
da Costa KS |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Structural analysis of viral infectivity factor of HIV type 1 and its interaction with A3G, EloC and EloB. |
Volume: |
9 |
Issue: |
2 |
Pages: |
e89116 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
112
 |
Fragment?: |
false |
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Publication |
First Author: |
Guy B |
Year: |
1991 |
Journal: |
J Virol |
Title: |
A specific inhibitor of cysteine proteases impairs a Vif-dependent modification of human immunodeficiency virus type 1 Env protein. |
Volume: |
65 |
Issue: |
3 |
Pages: |
1325-31 |
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Publication |
First Author: |
Gabuzda DH |
Year: |
1992 |
Journal: |
J Virol |
Title: |
Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes. |
Volume: |
66 |
Issue: |
11 |
Pages: |
6489-95 |
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Publication |
First Author: |
Fisher AG |
Year: |
1987 |
Journal: |
Science |
Title: |
The sor gene of HIV-1 is required for efficient virus transmission in vitro. |
Volume: |
237 |
Issue: |
4817 |
Pages: |
888-93 |
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Publication |
First Author: |
Pomerantz RJ |
Year: |
2003 |
Journal: |
Cell Mol Life Sci |
Title: |
The HIV-1 Vif protein: a paradigm for viral:cell interactions. |
Volume: |
60 |
Issue: |
10 |
Pages: |
2017-9 |
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•
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Publication |
First Author: |
Ball KA |
Year: |
2019 |
Journal: |
Biophys J |
Title: |
Conformational Dynamics of the HIV-Vif Protein Complex. |
Volume: |
116 |
Issue: |
8 |
Pages: |
1432-1445 |
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Publication |
First Author: |
Kim DY |
Year: |
2015 |
Journal: |
Arch Pharm Res |
Title: |
The assembly of Vif ubiquitin E3 ligase for APOBEC3 degradation. |
Volume: |
38 |
Issue: |
4 |
Pages: |
435-45 |
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Publication |
First Author: |
Zhao Z |
Year: |
2019 |
Journal: |
Front Microbiol |
Title: |
CAEV Vif Hijacks ElonginB/C, CYPA and Cullin5 to Assemble the E3 Ubiquitin Ligase Complex Stepwise to Degrade oaA3Z2-Z3. |
Volume: |
10 |
|
Pages: |
565 |
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Protein Domain |
Type: |
Family |
Description: |
The virion infectivity factor (vif) is an accessory protein, which is essential for HIV replication in host cells. Vif of Human immunodeficiency virus 1 (HIV-1) affects the infectivity of virus particles []to T lymphocytes and macrophages (in some casesincreasing the infectivity of HIV-1 particles by 100- to 1000-fold), but has no direct effect on transcription, translation or virus release. Vif antibodies are found in the sera of patients at all levels of HIV-1 infection, indicating that vif is expressed in natural infections in vivo. Other lentiviruses, including Simian immunodeficiency virus (SIV-cpz), Visna/Maedi virus, and Feline immunodeficiency virus (FIV), have vif open reading frames, suggestingvif plays an essential role during natural infections [].The expression of vif in BHK-21 cells has been shown to be linked to amodification of the C terminus of gp41env, which modification is inhibited by trans-epoxysuccinyl-L-leucylamido-(4-guanidio)butane (E64), a specific inhibitor of cysteine proteases []. Coupled with sequence analysis and the effects of point mutations in vif, it has been suggested that vif could be a cysteine protease. Virions produced in the absence of Vif have abnormal core morphology and those produced in primary T cells carry immature core proteins and low levels of mature capsid [].In humans, HIV-1 Vif hijacks cellular E3 ligase components containing CUL5, RBX2, ELOB, ELOC and CBFbeta, to poly-ubiquitinate antiviral cellular factors, APOBEC3 proteins [, , ]. In sheep and goats, Caprine arthritis encephalitis virus (CAEV) Vif is responsible for degradation of oaA3Z2-Z3 []. |
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