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Search results 2201 to 2300 out of 7122 for App

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Brabq3/Brabq3 Tg(APPSw)40Btla/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brabq1/Brabq1 Tg(APPSw)40Btla/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brabq1/Brabq1 Tg(APPSw)40Btla/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brabq1/Brabq1 Tg(APPSw)40Btla/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brabq2/Brabq2 Tg(APPSw)40Btla/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brabq2/Brabq2 Tg(APPSw)40Btla/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brabq2/Brabq2 Tg(APPSw)40Btla/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brabq3/Brabq3 Tg(APPSw)40Btla/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APP695)3Dbo/? Tg(PSEN1dE9)S9Dbo/?
Background: B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
Zygosity: cx
Has Mutant Allele: true
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Publication
34302009 | J:359845
First Author: Nash A
Year: 2021
Journal: Sci Rep
Title: BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory.
Volume: 11
Issue: 1
Pages: 15084
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Publication
28111074 | -
First Author: Huang YA
Year: 2017
Journal: Cell
Title: ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.
Volume: 168
Issue: 3
Pages: 427-441.e21
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Publication
28197073 | -
 
First Author: Canu N
Year: 2017
Journal: Front Mol Neurosci
Title: Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents.
Volume: 10
Pages: 15
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Publication
21538175 | J:173252
First Author: Mody N
Year: 2011
Journal: Diabetologia
Title: Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein.
Volume: 54
Issue: 8
Pages: 2143-51
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Genotype
Genotype
Symbol: Bace1/Bace1 Tg(APP695)3Dbo/? Tg(PSEN1dE9)S9Dbo/?
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSw)40Btla/? Tg(PSEN1H163R)G9Btla/?
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSw)40Btla/Tg(APPSw)40Btla Tg(PSEN1H163R)G9Btla/?
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sorl1/Sorl1 Tg(APP695)3Dbo/? Tg(PSEN1dE9)S9Dbo/?
Background: involves: 129 * C3H/HeJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
19737556 | J:153764
First Author: Bloch L
Year: 2009
Journal: FEBS Lett
Title: Klotho is a substrate for alpha-, beta- and gamma-secretase.
Volume: 583
Issue: 19
Pages: 3221-4
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Genotype
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? Tg(Thy1-QPCT)#Tbay/?
Background: B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Thy1-QPCT)#Tbay
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: involves: 129S4/SvJae * C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: involves: C57BL/6 * C57BL/6J * SJL
Zygosity: ot
Has Mutant Allele: true
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Publication
19744962 | J:153970
First Author: Mitchell JC
Year: 2009
Journal: Hum Mol Genet
Title: X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
Volume: 18
Issue: 23
Pages: 4492-500
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Publication
23792428 | J:199150
First Author: Cheret C
Year: 2013
Journal: EMBO J
Title: Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Volume: 32
Issue: 14
Pages: 2015-28
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Allele
App<tm1(APP)Smoc> | MGI:7288309
Name: amyloid beta precursor protein; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
App<tm3(APP)Smoc> | MGI:7288310
Name: amyloid beta precursor protein; targeted mutation 3, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Eno2-APPSwe)1223-3Ykk | MGI:3603946
Name: transgene insertion 1223-3, Yong K Kim
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(PSEN1H163R)G9Btla | MGI:3693364
Name: transgene insertion G9, Bruce Lamb
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Sorl1<Gt(Ex255)Byg> | MGI:3759785
Name: sortilin-related receptor, LDLR class A repeats-containing; gene trap Ex255, BayGenomics
Allele Type: Gene trapped
Attribute String: Hypomorph, Reporter
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Allele
Sorcs1<tm1.1Gndy> | MGI:4836913
Name: sortilin-related VPS10 domain containing receptor 1; targeted mutation 1.1, Samuel Gandy
Allele Type: Targeted
Attribute String: Hypomorph
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MP Term
MP:0021150 | increased amyloid beta protein level
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MP Term
MP:0021149 | abnormal amyloid beta protein level
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MP Term
MP:0021151 | decreased amyloid beta protein level
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Genotype
Genotype
Symbol: Bace1/Bace1 Bace2/Bace2
Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J) or (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1<+>
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1<+>
Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Transgene
MGI:3720648 | Tg(DMD-APP*)18Neve
Type: transgene
Organism: mouse, laboratory
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Publication
29062914 | J:297213
 
First Author: Tosh JL
Year: 2017
Journal: Wellcome Open Res
Title: The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease.
Volume: 2
Pages: 84
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Allele
Tg(PDGFB-APPSweIndArc)48Lms | MGI:3603941
Name: transgene insertion 48, Lennart Mucke
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(THY1-APP)2Somm/?
Background: involves: C57BL/6J * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PDGFB-APPSweIndArc)6Lms/?
Background: B6.Cg-Tg(PDGFB-APPSweIndArc)6Lms
Zygosity: ot
Has Mutant Allele: true
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Transgene
MGI:3720647 | Tg(DMD-APP*)7Neve
Type: transgene
Organism: mouse, laboratory
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Publication
8744400 | J:100978
First Author: Neve RL
Year: 1996
Journal: Neurobiol Aging
Title: Transgenic mice expressing APP-C100 in the brain.
Volume: 17
Issue: 2
Pages: 191-203
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Genotype
Genotype
Symbol: Cdk5r1/? Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Protein
P12023-2
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
P12023-3
Organism: Mus musculus/domesticus
Length: 735  
Fragment?: false
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Allele
Tg(Eno2-APP*Ind)#Kakiz | MGI:5634330
Name: transgene insertion, Akira Kakizuka
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
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Publication
27707970 | J:235934
First Author: Fleming MS
Year: 2016
Journal: J Neurosci
Title: A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles.
Volume: 36
Issue: 40
Pages: 10337-10355
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Publication
1438289 | J:105050
First Author: Kammesheidt A
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.
Volume: 89
Issue: 22
Pages: 10857-61
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Publication
20453200 | J:164465
First Author: Liu M
Year: 2010
Journal: J Lipid Res
Title: PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.
Volume: 51
Issue: 9
Pages: 2611-8
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Publication
17332754 | J:119815
First Author: Araki Y
Year: 2007
Journal: EMBO J
Title: The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.
Volume: 26
Issue: 6
Pages: 1475-86
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Publication
23554170 | J:350547
First Author: Pierrot N
Year: 2013
Journal: EMBO Mol Med
Title: Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.
Volume: 5
Issue: 4
Pages: 608-25
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/?
Background: involves: C57BL/6 * DBA/2 * SJL * SW
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APP)6209Kha/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APP)6209Kha/?
Background: (CAST/Ei x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Slc30a3/Slc30a3 Tg(APPSWE)2576Kha/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1<+> Tg(APPSWE)2576Kha/?
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/Cd40lg Tg(APPSWE)2576Kha/?
Background: involves: 129S2/SvPas * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPV717F)109Ili/?
Background: B6.Cg-Tg(APPV717F)109Ili
Zygosity: ot
Has Mutant Allele: true
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Publication
22836275 | J:186537
First Author: Walker KR
Year: 2012
Journal: J Neurosci
Title: Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
Volume: 32
Issue: 30
Pages: 10423-37
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Publication
25080588 | J:223172
First Author: Eisele YS
Year: 2014
Journal: J Neurosci
Title: Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.
Volume: 34
Issue: 31
Pages: 10264-73
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Publication
20696495 | J:188232
First Author: Wilkinson BL
Year: 2012
Journal: Neurobiol Aging
Title: Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease.
Volume: 33
Issue: 1
Pages: 197.e21-32
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Publication
29328926 | J:351690
First Author: Tse KH
Year: 2018
Journal: Alzheimers Dement
Title: DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia.
Volume: 14
Issue: 5
Pages: 664-679
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Publication
33009641 | -
First Author: da Rocha JF
Year: 2021
Journal: Mol Neurobiol
Title: APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis.
Volume: 58
Issue: 2
Pages: 668-688
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Genotype
Genotype
Symbol: Apoa4/Apoa4 Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: involves: 129S4/SvJae * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
Zygosity: ot
Has Mutant Allele: true
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Publication
29725016 | J:262986
First Author: Wang ZH
Year: 2018
Journal: Nat Commun
Title: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 1784
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Publication
16421297 | J:104514
First Author: Yang Y
Year: 2006
Journal: J Neurosci
Title: Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models.
Volume: 26
Issue: 3
Pages: 775-84
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Publication
22413000 | J:186926
First Author: Chen J
Year: 2012
Journal: PLoS One
Title: Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress.
Volume: 7
Issue: 3
Pages: e33177
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Publication
31306446 | J:277701
First Author: Lee JS
Year: 2019
Journal: PLoS One
Title: Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice.
Volume: 14
Issue: 7
Pages: e0219691
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Publication
29078331 | J:254186
First Author: Andrew RJ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
Volume: 114
Issue: 45
Pages: E9665-E9674
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Allele
Tg(APP)6209Kha | MGI:2183649
Name: transgene insertion 6209, Karen Hsiao Ashe
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Lrpap1/Lrpap1 Tg(APPV717F)109Ili/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: C57BL/6 * DBA/2 * SJL * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PDGFB-APPSwInd)J9Lms/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Azdm1/Azdm1 Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: A/J * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Azdm1/Azdm1 Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: A/J * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSweArc)BLngn/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Protein Coding Gene
MGI:1929666 | Sorcs1
Type: protein_coding_gene
Organism: mouse, laboratory
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Transgene
MGI:3693363 | Tg(PSEN1H163R)G9Btla
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:4420242 | Tg(Thy1-APPSwe)1Lngn
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5003452 | Tg(PDGFB-APPSwDutLon)46Lpr
Type: transgene
Organism: mouse, laboratory
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MP Term
MP:0003329 | amyloid beta deposits
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Genotype
Genotype
Symbol: App/App Psen1/Psen1
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PSEN1H163R)G9Btla/?
Background: involves: 129S4/SvJae
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sorl1/Sorl1
Background: B6.129P2-Sorl1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Tg(Prnp-Abca1)EHol/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nr1h2/Nr1h2 Tg(APPswe,PSEN1dE9)85Dbo/?
Background: involves: 129S6/SvEvTac * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nr1h3/Nr1h3 Tg(APPswe,PSEN1dE9)85Dbo/?
Background: involves: 129S6/SvEvTac * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sorcs1/Sorcs1
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Psen1/Psen1
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rtn4rl2/Rtn4rl2 Tg(APPswe,PSEN1dE9)85Dbo/?
Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Qpct/Qpct Trib2/Trib2
Background: involves: 129S2/SvPas * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Qpctl/Qpctl Trib2/Trib2
Background: involves: C3HeB/FeJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(APPswe,PSEN1dE9)85Dbo/?
Background: involves: 129S6/SvEvTac * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abcb1a/Abcb1a Abcb1b/Abcb1b Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: FVB.Cg-Abcb1b Abcb1a Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abcg2/Abcg2 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: FVB.Cg-Abcg2 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abcb1a/Abcb1a Abcb1b/Abcb1b Tg(Thy1-APPDutch)#Jckr/?
Background: FVB.Cg-Abcb1b Abcb1a Tg(Thy1-APPDutch)#Jckr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abcg2/Abcg2 Tg(Thy1-APPDutch)#Jckr/?
Background: FVB.Cg-Abcg2 Tg(Thy1-APPDutch)#Jckr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Zbtb20/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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