Type |
Details |
Score |
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
722
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
686
|
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Spyros Artavanis-Tsakonas |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
notch 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Pdx1-Notch3)1Heed/? |
Background: |
involves: C57BL/6 * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notch3/Notch3 |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notch3/Notch3<+> |
Background: |
Not Specified |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notch3/Notch3 |
Background: |
C57BL/6J-Notch3/GrsrJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notch3/Notch3<+> |
Background: |
involves: 129S/SvEv * Swiss |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notch3/Notch3 |
Background: |
involves: 129S/SvEv * Swiss |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notch3/Notch3 |
Background: |
involves: 129S1/Sv * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notch1/Notch1<+> Notch3/Notch3 |
Background: |
involves: 129S1/Sv * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1247
|
Fragment?: |
false |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, targeted mutation, coisogenic |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Spyros Artavanis-Tsakonas |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Silvia Fre |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Constitutively active, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE36437 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Joutel A |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. |
Volume: |
120 |
Issue: |
2 |
Pages: |
433-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dabertrand F |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease. |
Volume: |
112 |
Issue: |
7 |
Pages: |
E796-805 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klein C |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Stimulation of adult hippocampal neurogenesis by physical exercise and enriched environment is disturbed in a CADASIL mouse model. |
Volume: |
7 |
|
Pages: |
45372 |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE58244 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1218
|
Fragment?: |
false |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, coisogenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Rosehart AC |
Year: |
2021 |
Journal: |
Front Aging Neurosci |
Title: |
Prostaglandin E2 Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases. |
Volume: |
13 |
|
Pages: |
695965 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2318
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu XY |
Year: |
2015 |
Journal: |
Neurobiol Dis |
Title: |
Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL. |
Volume: |
73 |
|
Pages: |
189-203 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
749
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
870
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
322
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lacombe P |
Year: |
2005 |
Journal: |
Stroke |
Title: |
Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. |
Volume: |
36 |
Issue: |
5 |
Pages: |
1053-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dubroca C |
Year: |
2005 |
Journal: |
Stroke |
Title: |
Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy. |
Volume: |
36 |
Issue: |
1 |
Pages: |
113-7 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Elisabeth Tournier-Lasserve |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 2, Elisabeth Tournier-Lasserve |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
257
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
101
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
265
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
467
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
708
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1217
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Koch U |
Year: |
2020 |
Journal: |
J Exp Med |
Title: |
A third Notch in colorectal cancer progression and metastasis. |
Volume: |
217 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Capone C |
Year: |
2016 |
Journal: |
Elife |
Title: |
Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Notch3/Notch3 Tg(Tagln-cre)1Her/? |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Notch3/Notch3 Tg(Tagln-cre)1Her/? |
Background: |
involves: 129 * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1020
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1135
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
739
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1170
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Nam Y |
Year: |
2006 |
Journal: |
Cell |
Title: |
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. |
Volume: |
124 |
Issue: |
5 |
Pages: |
973-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kovall RA |
Year: |
2008 |
Journal: |
Oncogene |
Title: |
More complicated than it looks: assembly of Notch pathway transcription complexes. |
Volume: |
27 |
Issue: |
38 |
Pages: |
5099-109 |
|
•
•
•
•
•
|
Publication |
First Author: |
McElhinny AS |
Year: |
2008 |
Journal: |
Oncogene |
Title: |
Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways. |
Volume: |
27 |
Issue: |
38 |
Pages: |
5138-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen H |
Year: |
2006 |
Journal: |
Genes Dev |
Title: |
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. |
Volume: |
20 |
Issue: |
6 |
Pages: |
675-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao Y |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
The notch regulator MAML1 interacts with p53 and functions as a coactivator. |
Volume: |
282 |
Issue: |
16 |
Pages: |
11969-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alves-Guerra MC |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. |
Volume: |
67 |
Issue: |
18 |
Pages: |
8690-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiang MY |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. |
Volume: |
26 |
Issue: |
16 |
Pages: |
6261-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu L |
Year: |
2007 |
Journal: |
Blood |
Title: |
The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development. |
Volume: |
110 |
Issue: |
10 |
Pages: |
3618-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu L |
Year: |
2005 |
Journal: |
EMBO J |
Title: |
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. |
Volume: |
24 |
Issue: |
13 |
Pages: |
2391-402 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fryer CJ |
Year: |
2004 |
Journal: |
Mol Cell |
Title: |
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. |
Volume: |
16 |
Issue: |
4 |
Pages: |
509-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu L |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. |
Volume: |
22 |
Issue: |
21 |
Pages: |
7688-700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Felli MP |
Year: |
2005 |
Journal: |
Oncogene |
Title: |
PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. |
Volume: |
24 |
Issue: |
6 |
Pages: |
992-1000 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cameron B |
Year: |
2021 |
Journal: |
Biol Open |
Title: |
Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway. |
Volume: |
10 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Talora C |
Year: |
2003 |
Journal: |
EMBO Rep |
Title: |
Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma. |
Volume: |
4 |
Issue: |
11 |
Pages: |
1067-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kared H |
Year: |
2006 |
Journal: |
Immunity |
Title: |
Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. |
Volume: |
25 |
Issue: |
5 |
Pages: |
823-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu MY |
Year: |
2013 |
Journal: |
Gene Expr Patterns |
Title: |
The expression of NOTCH2, HES1 and SOX9 during mouse retinal development. |
Volume: |
13 |
Issue: |
3-4 |
Pages: |
78-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu B |
Year: |
2013 |
Journal: |
Cell Stem Cell |
Title: |
Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. |
Volume: |
13 |
Issue: |
1 |
Pages: |
48-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Low S |
Year: |
2018 |
Journal: |
Stem Cells |
Title: |
Delta-Like 4 Activates Notch 3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells. |
Volume: |
36 |
Issue: |
3 |
Pages: |
458-466 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pang J |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression. |
Volume: |
34 |
Issue: |
2 |
Pages: |
108603 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gopinath SD |
Year: |
2014 |
Journal: |
Stem Cell Reports |
Title: |
FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. |
Volume: |
2 |
Issue: |
4 |
Pages: |
414-26 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
489
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
826
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
585
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
414
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
680
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
443
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
500
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
249
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
414
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Fryer CJ |
Year: |
2002 |
Journal: |
Genes Dev |
Title: |
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. |
Volume: |
16 |
Issue: |
11 |
Pages: |
1397-411 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation. |
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