Biosynthesis of heme and chlorophyll requires coproporphyrinogen III to be converted to protoporphyrinogen IX by oxidatively decarboxylating the propionate side chains of rings A and B to the corresponding vinyl group [, , ].This entry includes HemN, HemW, HemZ from bacteria, and Rsad1 from animals. HemN catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX []. HemW may act as a heme chaperone, transferring heme to an unknown acceptor []. HemZ is involved in the biosynthesis of porphyrin-containing compound [].
