Type |
Details |
Score |
Protein Domain |
Type: |
Family |
Description: |
Polycomb group RING finger protein 6 (PCGF6 or MBLR) is a transcriptional repressor []. It may activate KDM5D histone demethylase, which modulates the levels of histone H3K4Me3 []. PCGF6 is a component of the Polycomb group (PcG) multiprotein PRC1-like complex [], in which it regulates RNF2 ubiquitin ligase activity [], and the E2F6.com-1 complex []. PCGF6 contains a RING-type zinc finger. |
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•
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Allele |
Name: |
deletion, Chr Y, 6 Harwell |
Allele Type: |
Spontaneous |
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•
•
•
•
•
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Allele |
Name: |
duplication, Chr Y, 1 Harwell |
Allele Type: |
Spontaneous |
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•
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•
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Allele |
Name: |
deletion, Chr Y, 5 Harwell; deletion, Chr Y, Harwell 5 |
Allele Type: |
Spontaneous |
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•
•
•
•
•
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Genotype |
Symbol: |
Del(Y)6H/? |
Background: |
mixed |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Genotype |
Symbol: |
Dp(Y)1H/? |
Background: |
mixed |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Genotype |
Symbol: |
Del(Y)5H/? |
Background: |
mixed |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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•
•
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Publication |
First Author: |
Samanta MK |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. |
Volume: |
13 |
Issue: |
1 |
Pages: |
2602 |
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•
•
•
•
•
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Publication |
First Author: |
Jia H |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation. |
Volume: |
112 |
Issue: |
1 |
Pages: |
E56-64 |
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Publication |
First Author: |
Vandamme J |
Year: |
2011 |
Journal: |
Mol Cell Proteomics |
Title: |
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. |
Volume: |
10 |
Issue: |
4 |
Pages: |
M110.002642 |
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•
•
•
•
•
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Publication |
First Author: |
Ogawa H |
Year: |
2002 |
Journal: |
Science |
Title: |
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. |
Volume: |
296 |
Issue: |
5570 |
Pages: |
1132-6 |
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•
•
•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
239
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
194
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
281
 |
Fragment?: |
false |
|
•
•
•
•
•
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