Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Goytain A |
Year: |
2005 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Functional characterization of the mouse [corrected] solute carrier, SLC41A2. |
Volume: |
330 |
Issue: |
3 |
Pages: |
701-5 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2813026 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3157126 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2828126 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3156626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1794826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2828726 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1867626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4422938 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-02-18 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603923 |
|
Stage: |
TS23 |
Assay Id: |
MGI:4888726 |
Age: |
embryonic day 14.5 |
Image: |
Table S1 |
|
Specimen Label: |
Table S1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1795226 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2800326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3128126 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2837026 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2834626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299060 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1897626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5543044 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14537 |
|
Specimen Label: |
GUDMAP:14537 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Centre for Modeling Human Disease |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Willnow T |
Year: |
2005 |
Journal: |
Organogenesis |
Title: |
The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. |
Volume: |
2 |
Issue: |
2 |
Pages: |
42-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The SLC41 superfamily of divalent cation transporters includes MgtE (SLC41A1), SLC41A2 and SLC41A3. The prokaryote orthologue, MgtE, is a magnesium transporter []. MgtE consists of a C-terminal transmembrane domain and a N-terminal cytosolic domain, and adopts a homodimeric architecture in bateria []. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ [].This entry represents the integral membrane region of SLC41 transporter proteins. Bacterial family members have one copy of this region while archaeal and eukaryotic sequences have two. This suggests that the bacterial proteins may act as dimers. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
512
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
573
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
488
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
488
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
573
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the integral membrane region of SLC41 transporter proteins. SLC41 family of divalent cation transporters includes SLC41A1/2/3 from eukaryotes and MgtE from prokaryotes [, , , , ]. MgtE is the prokaryote homologue of SLC41A1 magnesium transporter which adopts a homodimeric architecture with five transmembrane domains in the C terminus and cytosolic N terminus domains [, ]. Bacterial family members have one copy of this region while archaeal and eukaryotic sequences have two. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
131
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin CH |
Year: |
2014 |
Journal: |
Parkinsonism Relat Disord |
Title: |
Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function. |
Volume: |
20 |
Issue: |
6 |
Pages: |
600-3 |
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Publication |
First Author: |
Kolisek M |
Year: |
2012 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Human gene SLC41A1 encodes for the Na+/Mg²+ exchanger. |
Volume: |
302 |
Issue: |
1 |
Pages: |
C318-26 |
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Publication |
First Author: |
Schweigel-Röntgen M |
Year: |
2014 |
Journal: |
Curr Top Membr |
Title: |
SLC41 transporters--molecular identification and functional role. |
Volume: |
73 |
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Pages: |
383-410 |
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Publication |
First Author: |
Feeney KA |
Year: |
2016 |
Journal: |
Nature |
Title: |
Daily magnesium fluxes regulate cellular timekeeping and energy balance. |
Volume: |
532 |
Issue: |
7599 |
Pages: |
375-9 |
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Publication |
First Author: |
Tsao YT |
Year: |
2017 |
Journal: |
Stem Cell Res Ther |
Title: |
Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. |
Volume: |
8 |
Issue: |
1 |
Pages: |
39 |
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Publication |
First Author: |
Kolisek M |
Year: |
2013 |
Journal: |
Hypertens Pregnancy |
Title: |
SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women. |
Volume: |
32 |
Issue: |
4 |
Pages: |
378-89 |
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Protein Domain |
Type: |
Family |
Description: |
This entry includes the SLC41A family members mostly from eukaryotes and archaea. Some proteins are from bacteria. The SLC41A family of divalent cation transporters includes SLC41A1, SLC41A2 and SLC41A3 and MgtE [, , , ]. MgtE, the SLC41A1 orthologue found in prokaryotes, consists of a homodimer architecture with five transmembrane domains at the C terminus and the cytosolic domains at the N terminus. Structural and functional analyses showed MgtE conserved acidic side-chains play a key role as part of its selectivity filter [, ]. In humans, SLC41A1 is a Na+/Mg2+ ion exchanger that acts as a predominant Mg2+ efflux system at the plasma membrane. The transporter activity is driven by the inwardly directed electrochemical gradient for Na+ ions, thus directly depends on the extracellular Na+ ion concentration set by the Na+/K+ pump. In this way, it generates circadian cellular Mg2+ fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. This protein is located in the cell membrane [, ]. Its expression level has been linked to diverse disorders such as preeclampsia in pregnant woman, nephronophthisis, Parkinson's disease and bone mass loss. Hence, it has been suggested this protein might be a great therapeutic target [, , , ]. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ []. |
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Publication |
First Author: |
Wabakken T |
Year: |
2003 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. |
Volume: |
306 |
Issue: |
3 |
Pages: |
718-24 |
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Publication |
First Author: |
de Baaij JH |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Identification of SLC41A3 as a novel player in magnesium homeostasis. |
Volume: |
6 |
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Pages: |
28565 |
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Publication |
First Author: |
Jin F |
Year: |
2021 |
Journal: |
PLoS Biol |
Title: |
The structure of MgtE in the absence of magnesium provides new insights into channel gating. |
Volume: |
19 |
Issue: |
4 |
Pages: |
e3001231 |
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Publication |
First Author: |
Payandeh J |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
The structure and regulation of magnesium selective ion channels. |
Volume: |
1828 |
Issue: |
11 |
Pages: |
2778-92 |
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Publication |
First Author: |
Sahni J |
Year: |
2013 |
Journal: |
Mol Aspects Med |
Title: |
The SLC41 family of MgtE-like magnesium transporters. |
Volume: |
34 |
Issue: |
2-3 |
Pages: |
620-8 |
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Publication |
First Author: |
Hattori M |
Year: |
2007 |
Journal: |
Nature |
Title: |
Crystal structure of the MgtE Mg2+ transporter. |
Volume: |
448 |
Issue: |
7157 |
Pages: |
1072-5 |
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