Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1202
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1153
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1104
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1112
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Osman A |
Year: |
2023 |
Journal: |
Brain Behav Immun |
Title: |
Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice. |
Volume: |
114 |
|
Pages: |
311-324 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1730
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1322
|
Fragment?: |
false |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Allele |
Name: |
SH3 and multiple ankyrin repeat domains 3; targeted mutation 5.1, Guoping Feng |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
SH3 and multiple ankyrin repeat domains 3; targeted mutation 1.1, Mouse Clinical Institute |
Allele Type: |
Targeted |
Attribute String: |
Modified isoform(s), Reporter |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Shank3/Shank3 |
Background: |
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
SH3 and multiple ankyrin repeat domains 3; targeted mutation 3.2, Joseph D Buxbaum |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
transcription factor 20; endonuclease-mediated mutation 1, Jianwei Jiao |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
SH3 and multiple ankyrin repeat domains 3; targeted mutation 2, Guoping Feng |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Allele |
Name: |
SH3 and multiple ankyrin repeat domains 3; targeted mutation 3.2, Craig M Powell |
Allele Type: |
Targeted |
Attribute String: |
Modified isoform(s) |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Shank3/Shank3 |
Background: |
B6(Cg)-Shank3 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
SH3 and multiple ankyrin repeat domains 3; targeted mutation 1.1, Paul Worley |
Allele Type: |
Targeted |
Attribute String: |
Hypomorph |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Shank3/Shank3<+> |
Background: |
B6.129-Shank3/J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Shank3/Shank3 |
Background: |
B6.129S6(Cg)-Shank3 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Shank3/Shank3<+> |
Background: |
B6.129S6(Cg)-Shank3 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcf20/Tcf20<+> |
Background: |
Not Specified |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Shank3/Shank3 Tg(CAG-cre/Esr1*)1Lbe/? |
Background: |
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant stock, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Shank3/Shank3<+> |
Background: |
B6.129S6-Shank3 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Shank3/Shank3 |
Background: |
B6.129S6-Shank3 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Giza J |
Year: |
2010 |
Journal: |
J Neurosci |
Title: |
Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2. |
Volume: |
30 |
Issue: |
44 |
Pages: |
14805-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stillman M |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Activity dependent dissociation of the Homer1 interactome. |
Volume: |
12 |
Issue: |
1 |
Pages: |
3207 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng Z |
Year: |
2022 |
Journal: |
J Cell Biol |
Title: |
IRSp53 promotes postsynaptic density formation and actin filament bundling. |
Volume: |
221 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hung AY |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. |
Volume: |
28 |
Issue: |
7 |
Pages: |
1697-708 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wöhr M |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior. |
Volume: |
6 |
Issue: |
6 |
Pages: |
e20631 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsushita Y |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. |
Volume: |
6 |
|
Pages: |
22991 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morice E |
Year: |
2013 |
Journal: |
Neurobiol Dis |
Title: |
Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome. |
Volume: |
58 |
|
Pages: |
156-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pham E |
Year: |
2010 |
Journal: |
FEBS J |
Title: |
Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. |
Volume: |
277 |
Issue: |
14 |
Pages: |
3051-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bertaso F |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons. |
Volume: |
5 |
Issue: |
3 |
Pages: |
e9755 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han KA |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions. |
Volume: |
9 |
Issue: |
1 |
Pages: |
17094 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stephenson JR |
Year: |
2017 |
Journal: |
J Neurosci |
Title: |
A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. |
Volume: |
37 |
Issue: |
8 |
Pages: |
2216-2233 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sungur AÖ |
Year: |
2018 |
Journal: |
Front Mol Neurosci |
Title: |
Reduced Efficacy of d-Amphetamine and 3,4-Methylenedioxymethamphetamine in Inducing Hyperactivity in Mice Lacking the Postsynaptic Scaffolding Protein SHANK1. |
Volume: |
11 |
|
Pages: |
419 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SY |
Year: |
2020 |
Journal: |
Exp Mol Med |
Title: |
PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors. |
Volume: |
52 |
Issue: |
4 |
Pages: |
604-614 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoon S |
Year: |
2021 |
Journal: |
Mol Psychiatry |
Title: |
Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome. |
Volume: |
26 |
Issue: |
6 |
Pages: |
1775-1789 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee K |
Year: |
2022 |
Journal: |
Mol Autism |
Title: |
Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1(+/-) mouse model of autism spectrum disorders. |
Volume: |
13 |
Issue: |
1 |
Pages: |
13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Napoli E |
Year: |
2016 |
Journal: |
Front Neurosci |
Title: |
Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding. |
Volume: |
10 |
|
Pages: |
159 |
|
•
•
•
•
•
|