Type |
Details |
Score |
Publication |
First Author: |
Butler D |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models. |
Volume: |
6 |
Issue: |
6 |
Pages: |
e20501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeuchi H |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. |
Volume: |
6 |
Issue: |
6 |
Pages: |
e21108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Socodato R |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. |
Volume: |
31 |
Issue: |
12 |
Pages: |
107796 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castellano JM |
Year: |
2011 |
Journal: |
Sci Transl Med |
Title: |
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. |
Volume: |
3 |
Issue: |
89 |
Pages: |
89ra57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bales KR |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. |
Volume: |
29 |
Issue: |
21 |
Pages: |
6771-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henjum K |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Analyzing microglial-associated Aβ in Alzheimer's disease transgenic mice with a novel mid-domain Aβ-antibody. |
Volume: |
10 |
Issue: |
1 |
Pages: |
10590 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/? |
Background: |
B6.Cg-Psen1 Tg(APPSwe,tauP301L)1Lfa |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
467
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
467
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
260
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
447
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
118
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
750
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
738
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
39
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
203
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This group of aspartic peptidases belong to MEROPS peptidase family A22 (presenilin family), subfamily A22A, the type example being presenilin 1 from Homo sapiens (Human).Presenilins are polytopic transmembrane (TM) proteins, mutations in whichare associated with the occurrence of early-onset familial Alzheimer'sdisease, a rare form of the disease that results from a single-genemutation [, ]. Alzheimer's disease is associated with the formation of extracellular deposits of amyloid, which contain aggregates of the amyloid-beta peptide. The β-peptides are released from the Alzheimer's amyloid precursor protein (APP) by the action of two peptidase activities: "beta-secretase"cleaves at the N terminus of the peptide, and "gamma-secretase"cleaves at the C terminus. The gamma-secretase cleavage occurs in a transmembrane segment of APP. Presenilin, which exists in a complex with nicastrin, APH-1 and PEN-2, has been identified as gamma-secretase from its deficiency []and mutation of its active site residues [], but proteolytic activity has only been directly demonstrated on a peptide derived from APP [].Presenilin-1 is also known to process notch proteins []and syndecan-3 [].Presenilin has nine transmembrane regions with the active site aspartic acid residues located on TM6, within a Tyr-Asp motif, and TM7, within a Gly-Xaa-Gly-Asp motif []. The protein autoprocesses to form an amino-terminal fragment (TMs 1-6) and a C-terminal fragment (TMs 7-9) []. The tertiary structure of the human gamma-sectretase complex has been solved []. Nicastrin is extracellular, whereas presenilin-1, APH-1 and PEN-2 are all transmembrane proteins. The transmembrane regions of all three proteins form a horseshoe shape.Aspartic peptidases, also known as aspartyl proteases ([intenz:3.4.23.-]), are widely distributed proteolytic enzymes [, , ]known to exist in vertebrates, fungi, plants, protozoa, bacteria, archaea, retroviruses and some plant viruses. All known aspartic peptidases are endopeptidases. A water molecule, activated by two aspartic acid residues, acts as the nucleophile in catalysis. Aspartic peptidases can be grouped into five clans, each of which shows a unique structural fold [].Peptidases in clan AA are either bilobed (family A1 or the pepsin family) or are a homodimer (all other families in the clan, including retropepsin from HIV-1/AIDS) []. Each lobe consists of a single domain with a closed β-barrel and each lobe contributes one Asp to form the active site. Most peptidases in the clan are inhibited by the naturally occurring small-molecule inhibitor pepstatin [].Clan AC contains the single family A8: the signal peptidase 2 family. Members of the family are found in all bacteria. Signal peptidase 2 processes the premurein precursor, removing the signal peptide. The peptidase has four transmembrane domains and the active site is on the periplasmic side of the cell membrane. Cleavage occurs on the amino side of a cysteine where the thiol group has been substituted by a diacylglyceryl group. Site-directed mutagenesis has identified two essential aspartic acid residues which occur in the motifs GNXXDRX and FNXAD (where X is a hydrophobic residue) []. No tertiary structures have been solved for any member of the family, but because of the intramembrane location, the structure is assumed not to be pepsin-like.Clan AD contains two families of transmembrane endopeptidases: A22 and A24. These are also known as "GXGD peptidases"because of a common GXGD motif which includes one of the pair of catalytic aspartic acid residues. Structures are known for members of both families and show a unique, common fold with up to nine transmembrane regions []. The active site aspartic acids are located within a large cavity in the membrane into which water can gain access [].Clan AE contains two families, A25 and A31. Tertiary structures have been solved for members of both families and show a common fold consisting of an α-β-alpha sandwich, in which the beta sheet is five stranded [, ].Clan AF contains the single family A26. Members of the clan are membrane-proteins with a unique fold. Homologues are known only from bacteria. The structure of omptin (also known as OmpT) shows a cylindrical barrel containing ten beta strands inserted in the membrane with the active site residues on the outer surface [].There are two families of aspartic peptidases for which neither structure nor active site residues are known and these are not assigned to clans. Family A5 includes thermopsin, an endopeptidase found only in thermophilic archaea. Family A36 contains sporulation factor SpoIIGA, which is known to process and activate sigma factor E, one of the transcription factors that controls sporulation in bacteria []. |
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•
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Publication |
First Author: |
Bressler SL |
Year: |
1996 |
Journal: |
Hum Mol Genet |
Title: |
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. |
Volume: |
5 |
Issue: |
10 |
Pages: |
1589-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yin T |
Year: |
2024 |
Journal: |
EMBO Rep |
Title: |
Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias. |
Volume: |
25 |
Issue: |
3 |
Pages: |
1326-1360 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poelaert BJ |
Year: |
2021 |
Journal: |
Cancers (Basel) |
Title: |
Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer. |
Volume: |
13 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Goldsworthy M |
Year: |
2016 |
Journal: |
Diabetes |
Title: |
Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes. |
Volume: |
65 |
Issue: |
5 |
Pages: |
1434-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garringer HJ |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. |
Volume: |
8 |
Issue: |
2 |
Pages: |
e56426 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cowan CM |
Year: |
2001 |
Journal: |
J Neurosci |
Title: |
Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons. |
Volume: |
21 |
Issue: |
18 |
Pages: |
7099-109 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fleischer A |
Year: |
2002 |
Journal: |
Oncogene |
Title: |
Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. |
Volume: |
21 |
Issue: |
20 |
Pages: |
3181-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peiris H |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. |
Volume: |
12 |
Issue: |
5 |
Pages: |
e1006033 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schill EM |
Year: |
2019 |
Journal: |
JCI Insight |
Title: |
Down syndrome mouse models have an abnormal enteric nervous system. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kubo A |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain. |
Volume: |
39 |
Issue: |
34 |
Pages: |
6781-6797 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lopez JR |
Year: |
2008 |
Journal: |
J Neurochem |
Title: |
Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice. |
Volume: |
105 |
Issue: |
1 |
Pages: |
262-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Montgomery SL |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain. |
Volume: |
179 |
Issue: |
4 |
Pages: |
2053-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hohsfield LA |
Year: |
2014 |
Journal: |
Mol Cell Neurosci |
Title: |
Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models. |
Volume: |
63 |
|
Pages: |
83-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang S |
Year: |
2017 |
Journal: |
Front Aging Neurosci |
Title: |
Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides. |
Volume: |
9 |
|
Pages: |
435 |
|
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•
•
•
•
|
Publication |
First Author: |
Shibuya Y |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance. |
Volume: |
34 |
Issue: |
43 |
Pages: |
14484-501 |
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•
•
•
•
•
|
Publication |
First Author: |
Medeiros R |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. |
Volume: |
179 |
Issue: |
2 |
Pages: |
980-91 |
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•
•
•
•
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Publication |
First Author: |
Xiang J |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies. |
Volume: |
116 |
Issue: |
18 |
Pages: |
9094-9102 |
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•
•
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•
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Publication |
First Author: |
Manczak M |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. |
Volume: |
21 |
Issue: |
11 |
Pages: |
2538-47 |
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•
•
•
•
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Publication |
First Author: |
Kim SH |
Year: |
2023 |
Journal: |
Autophagy |
Title: |
Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease. |
Volume: |
19 |
Issue: |
8 |
Pages: |
2318-2337 |
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•
•
•
•
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Publication |
First Author: |
Danielyan L |
Year: |
2020 |
Journal: |
EBioMedicine |
Title: |
Cell motility and migration as determinants of stem cell efficacy. |
Volume: |
60 |
|
Pages: |
102989 |
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•
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Publication |
First Author: |
Caberlotto L |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases. |
Volume: |
9 |
Issue: |
1 |
Pages: |
3965 |
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•
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Publication |
First Author: |
Yang H |
Year: |
2022 |
Journal: |
Theranostics |
Title: |
Adoptive therapy with amyloid-β specific regulatory T cells alleviates Alzheimer's disease. |
Volume: |
12 |
Issue: |
18 |
Pages: |
7668-7680 |
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•
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Publication |
First Author: |
Comerota MM |
Year: |
2019 |
Journal: |
Mol Neurobiol |
Title: |
Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies. |
Volume: |
56 |
Issue: |
5 |
Pages: |
3341-3355 |
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Publication |
First Author: |
Wang W |
Year: |
2021 |
Journal: |
Theranostics |
Title: |
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. |
Volume: |
11 |
Issue: |
11 |
Pages: |
5279-5295 |
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Publication |
First Author: |
Hargis KE |
Year: |
2017 |
Journal: |
Behav Brain Res |
Title: |
Transcriptional signatures of brain aging and Alzheimer's disease: What are our rodent models telling us? |
Volume: |
322 |
Issue: |
Pt B |
Pages: |
311-328 |
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•
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Publication |
First Author: |
Bryleva EY |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. |
Volume: |
107 |
Issue: |
7 |
Pages: |
3081-6 |
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•
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Publication |
First Author: |
Ribe EM |
Year: |
2008 |
Journal: |
Biochem J |
Title: |
Mechanisms of neuronal death in disease: defining the models and the players. |
Volume: |
415 |
Issue: |
2 |
Pages: |
165-82 |
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Publication |
First Author: |
Fonseca MI |
Year: |
2011 |
Journal: |
J Neuroinflammation |
Title: |
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease. |
Volume: |
8 |
Issue: |
1 |
Pages: |
4 |
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Publication |
First Author: |
Fuhrmann M |
Year: |
2010 |
Journal: |
Nat Neurosci |
Title: |
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. |
Volume: |
13 |
Issue: |
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Pages: |
411-3 |
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Publication |
First Author: |
Zhao Y |
Year: |
2017 |
Journal: |
Neuron |
Title: |
Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels. |
Volume: |
96 |
Issue: |
2 |
Pages: |
355-372.e6 |
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Publication |
First Author: |
Sabbir MG |
Year: |
2018 |
Journal: |
Front Mol Biosci |
Title: |
Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease. |
Volume: |
5 |
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Pages: |
99 |
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Publication |
First Author: |
Iyaswamy A |
Year: |
2020 |
Journal: |
Front Pharmacol |
Title: |
Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease. |
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Pages: |
584770 |
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Publication |
First Author: |
Bhutta MF |
Year: |
2013 |
Journal: |
Mamm Genome |
Title: |
Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media. |
Volume: |
24 |
Issue: |
11-12 |
Pages: |
439-45 |
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Publication |
First Author: |
Xing Z |
Year: |
2023 |
Journal: |
Hum Mol Genet |
Title: |
Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome. |
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32 |
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13 |
Pages: |
2205-2218 |
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Year: |
2022 |
Journal: |
Nat Aging |
Title: |
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. |
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837-850 |
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Hum Mol Genet |
Title: |
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases. |
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29 |
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17 |
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2882-2898 |
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Journal: |
J Neurosci |
Title: |
Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator. |
Volume: |
32 |
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31 |
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10574-86 |
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Bourdenx M |
Year: |
2021 |
Journal: |
Cell |
Title: |
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. |
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Issue: |
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Pages: |
2696-2714.e25 |
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First Author: |
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Year: |
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Journal: |
Brain Behav Immun |
Title: |
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Volume: |
54 |
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Pages: |
211-225 |
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Publication |
First Author: |
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Year: |
2017 |
Journal: |
Neurobiol Dis |
Title: |
Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. |
Volume: |
108 |
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Publication |
First Author: |
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Year: |
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Journal: |
J Neurosci |
Title: |
No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. |
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Publication |
First Author: |
Meyer-Luehmann M |
Year: |
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Journal: |
Nature |
Title: |
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. |
Volume: |
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7179 |
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Publication |
First Author: |
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Year: |
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J Comp Neurol |
Title: |
Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease. |
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First Author: |
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Nat Med |
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First Author: |
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Year: |
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Nat Commun |
Title: |
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Volume: |
12 |
Issue: |
1 |
Pages: |
3098 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reinders NR |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3. |
Volume: |
113 |
Issue: |
42 |
Pages: |
E6526-E6534 |
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•
•
•
•
•
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Publication |
First Author: |
Hansen HH |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease. |
Volume: |
11 |
Issue: |
7 |
Pages: |
e0158205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kass B |
Year: |
2022 |
Journal: |
Cell Rep Med |
Title: |
Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo. |
Volume: |
3 |
Issue: |
5 |
Pages: |
100630 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun X |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models. |
Volume: |
6 |
Issue: |
2 |
Pages: |
264-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burgess BL |
Year: |
2006 |
Journal: |
Neurobiol Dis |
Title: |
Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. |
Volume: |
24 |
Issue: |
1 |
Pages: |
114-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Le Pichon CE |
Year: |
2017 |
Journal: |
Sci Transl Med |
Title: |
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. |
Volume: |
9 |
Issue: |
403 |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cx3cr1/Cx3cr1 Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/? Tg(Thy1-YFP)HJrs/? |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cx3cr1/Cx3cr1<+> Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/? Tg(Thy1-YFP)HJrs/? |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 85, David R Borchelt |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(CMV-IghvaD11)DCat/? Tg(CMV-IgkvaD11)ACat/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin GM |
Year: |
1998 |
Journal: |
Cell Mol Life Sci |
Title: |
Introduction: genetic determinants of mid- and late-life dementias. |
Volume: |
54 |
Issue: |
9 |
Pages: |
895-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cruts M |
Year: |
1998 |
Journal: |
Hum Mutat |
Title: |
Presenilin mutations in Alzheimer's disease. |
Volume: |
11 |
Issue: |
3 |
Pages: |
183-90 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
842
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
843
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
NIH Mouse Knockout Inventory |
Year: |
2004 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the NIH Mouse Knockout Inventory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sugino H |
Year: |
1997 |
Journal: |
Genomics |
Title: |
Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family. |
Volume: |
43 |
Issue: |
2 |
Pages: |
209-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han C |
Year: |
2011 |
Journal: |
J Cell Physiol |
Title: |
Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm. |
Volume: |
226 |
Issue: |
5 |
Pages: |
1186-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu Z |
Year: |
2000 |
Journal: |
Cytogenet Cell Genet |
Title: |
The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9. |
Volume: |
89 |
Issue: |
3-4 |
Pages: |
230-3 |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Csf1/Csf1 |
Background: |
B6C3Fe a/a-Csf1/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ldlr/Ldlr |
Background: |
B6.129S7-Ldlr |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Adorno M |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation. |
Volume: |
8 |
Issue: |
1 |
Pages: |
17506 |
|
•
•
•
•
•
|
Publication |
First Author: |
Orre M |
Year: |
2014 |
Journal: |
Neurobiol Aging |
Title: |
Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. |
Volume: |
35 |
Issue: |
12 |
Pages: |
2746-2760 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou LT |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease. |
Volume: |
9 |
Issue: |
16 |
Pages: |
eabq7105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamphuis W |
Year: |
2016 |
Journal: |
Biochim Biophys Acta |
Title: |
Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease. |
Volume: |
1862 |
Issue: |
10 |
Pages: |
1847-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marinho D |
Year: |
2023 |
Journal: |
Aging Cell |
Title: |
Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease. |
Volume: |
22 |
Issue: |
8 |
Pages: |
e13895 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liebmann T |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Three-Dimensional Study of Alzheimer's Disease Hallmarks Using the iDISCO Clearing Method. |
Volume: |
16 |
Issue: |
4 |
Pages: |
1138-1152 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang X |
Year: |
2021 |
Journal: |
Front Cell Dev Biol |
Title: |
Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease. |
Volume: |
9 |
|
Pages: |
632843 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jadiya P |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease. |
Volume: |
10 |
Issue: |
1 |
Pages: |
3885 |
|
•
•
•
•
•
|